Lu Huang | Profiles RNS

Lu Huang, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Virology, Immunology & Microbiology

Websites

	Virology, Immunology and Microbiology Faculty
	Google Scholar
	ResearchGate
	Linkedin

ORCID : 0000-0002-7820-2177

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj
2025	Single-cell spatial-temporal understanding of the role of macrophage subsets in maintenance of lesion biology and local Mycobacterium tuberculosis infection outcome	1R21AI188044-01A1
2025	Ontogeny and metabolism of lung alveolar macrophages in tuberculosis	5R01AI184960-02
2025	Defining the Role of the Plasminogen Activator Protease in the Early Events that Establish Primary Pneumonic Plague	5R01AI153252-06
2024	Ontogeny and metabolism of lung alveolar macrophages in tuberculosis	1R01AI184960-01
2024	Macrophage metabolism in diabetes and tuberculosis comorbidity	5R21AI175738-02
2024	Defining the Role of the Plasminogen Activator Protease in the Early Events that Establish Primary Pneumonic Plague	7R01AI153252-05
2023	Macrophage metabolism in diabetes and tuberculosis comorbidity	1R21AI175738-01

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Appell KT, Guo W, Scott M, Blevins JS, Pechous RD. Yersinia pestis plasminogen activator protease is regulated by the PhoP/PhoQ two-component system. J Bacteriol. 2026 Jan 22; 208(1):e0035725. PMID: 41432430; PMCID: PMC12826059; DOI: 10.1128/jb.00357-25;

Adhvaryu H, Huang L, Long CM, Voth DE. The intracellular agent of Q fever, Coxiella burnetii, alters human alveolar macrophage metabolism and mitochondrial physiology. mBio. 2025 Sep 10; 16(9):e0143625. PMID: 40823830; PMCID: PMC12421863; DOI: 10.1128/mbio.01436-25;

Zhang Z, Huang L, Brayboy L, Birrer M. Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics†. Biol Reprod. 2025 Aug 13; 113(2):373-386. PMID: 40459236; DOI: 10.1093/biolre/ioaf122;

Scott MG, Guo W, Blevins JS, Appell KT, Pechous RD. Yersinia pestis BipA is a novel regulator of pesticin and a type 6 secretion system. Infect Immun. 2025 Sep 09; 93(9):e0019125. PMID: 40788128; PMCID: PMC12418749; DOI: 10.1128/iai.00191-25;

Dai L, Choudhary A, Fan J, Huang L, Lin Z, Qin Z. Identification of RP-54745, an IL-1 Inhibitor Displaying Anticancer Activities for KSHV-Related Primary Effusion Lymphoma. J Med Virol. 2025 Feb; 97(2):e70200. PMID: 39891599; PMCID: PMC12326551; DOI: 10.1002/jmv.70200;

Murphy B, Miyamoto T, Manning BS, Mirji G, Ugolini A, Kannan T, Hamada K, Zhu YP, Claiborne DT, Huang L, Zhang R, Nefedova Y, Kossenkov A, Veglia F, Shinde R, Zhang N. Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer. J Exp Med. 2024 Dec 02; 221(12). PMID: 39570374; PMCID: PMC11586802; DOI: 10.1084/jem.20231967;

Venugopal G, Pechous RD. Yersinia pestis and pneumonic plague: Insight into how a lethal pathogen interfaces with innate immune populations in the lung to cause severe disease. Cell Immunol. 2024; 403-404:104856. PMID: 39002222; DOI: 10.1016/j.cellimm.2024.104856;

Murphy B, Miyamoto T, Manning BS, Mirji G, Ugolini A, Kannan T, Hamada K, Zhu YP, Claiborne DT, Huang L, Zhang R, Nefedova Y, Kossenkov A, Veglia F, Shinde R, Zhang N. Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer. bioRxiv. 2024 Jun 29. PMID: 38979222; PMCID: PMC11230450; DOI: 10.1101/2024.06.25.600597;

Zhang Z, Huang L, Brayboy L, Birrer M. Single-cell analysis of ovarian myeloid cells identifies aging associated changes in macrophages and signaling dynamics. bioRxiv. 2024 Jun 16. PMID: 38915572; PMCID: PMC11195259; DOI: 10.1101/2024.06.13.598667;

Andrews JT, Zhang Z, Prasad GVRK, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Huang SC, Zhang N, Argüello RJ, Philips JA, Mattila JT, Huang L. Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis. Mucosal Immunol. 2024 Oct; 17(5):825-842. PMID: 38844208; PMCID: PMC11493682; DOI: 10.1016/j.mucimm.2024.05.007;

Showing 10 of 44 results. Show More

Pechous RD, Malaviarachchi PA, Xing Z, Douglas A, Crane SD, Theriot HM, Zhang Z, Ghaffarieh A, Huang L, Yu YE, Zhang X. SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome. Biomedicines. 2024 Feb 28; 12(3). PMID: 38540156; PMCID: PMC10967796; DOI: 10.3390/biomedicines12030543;

Mercado MAB, Li Q, Quick CM, Kim Y, Palmer R, Huang L, Li LX. BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia. PLoS Pathog. 2024 Jan; 20(1):e1011983. PMID: 38271477; PMCID: PMC10846703; DOI: 10.1371/journal.ppat.1011983;

Benson LN, Deck KS, Mora CJ, Guo Y, Rafferty TM, Li LX, Huang L, Andrews JT, Qin Z, Trott DW, Hoover RS, Liu Y, Mu S. P2X7-Mediated Antigen-Independent Activation of CD8+ T Cells Promotes Salt-Sensitive Hypertension. Hypertension. 2024 Mar; 81(3):530-540. PMID: 38193292; PMCID: PMC10922507; DOI: 10.1161/HYPERTENSIONAHA.123.21819;

Mercado MAB, Li Q, Quick CM, Kim Y, Palmer R, Huang L, Li LX. BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia. bioRxiv. 2023 Nov 05. PMID: 37961221; PMCID: PMC10635079; DOI: 10.1101/2023.11.02.565369;

Andrews JT, Voth DE, Huang SC, Huang L. Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection. Front Cell Infect Microbiol. 2022; 12:934460. PMID: 35899042; PMCID: PMC9309258; DOI: 10.3389/fcimb.2022.934460;

Benson LN, Liu Y, Wang X, Xiong Y, Rhee SW, Guo Y, Deck KS, Mora CJ, Li LX, Huang L, Andrews JT, Qin Z, Hoover RS, Ko B, Williams RM, Heller DA, Jaimes EA, Mu S. The IFN?-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circ Res. 2022 May 13; 130(10):1550-1564. PMID: 35430873; PMCID: PMC9106883; DOI: 10.1161/CIRCRESAHA.121.320373;

Wilburn KM, Montague CR, Qin B, Woods AK, Love MS, McNamara CW, Schultz PG, Southard TL, Huang L, Petrassi HM, VanderVen BC. Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis. PLoS Pathog. 2022 Feb; 18(2):e1009862. PMID: 35134095; PMCID: PMC8856561; DOI: 10.1371/journal.ppat.1009862;

Pisu D, Huang L, Narang V, Theriault M, Lê-Bury G, Lee B, Lakudzala AE, Mzinza DT, Mhango DV, Mitini-Nkhoma SC, Jambo KC, Singhal A, Mwandumba HC, Russell DG. Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung. J Exp Med. 2021 Sep 06; 218(9). PMID: 34292313; PMCID: PMC8302446; DOI: 10.1084/jem.20210615;

Zhang Z, Huang L, Brayboy L. Macrophages: an indispensable piece of ovarian health. Biol Reprod. 2021 Mar 11; 104(3):527-538. PMID: 33274732; PMCID: PMC7962765; DOI: 10.1093/biolre/ioaa219;

Giacalone D, Huang L, Tan S. Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology. Methods Mol Biol. 2021; 2314:365-383. PMID: 34235663; PMCID: PMC8381720; DOI: 10.1007/978-1-0716-1460-0_17;

Pisu D, Huang L, Rin Lee BN, Grenier JK, Russell DG. Dual RNA-Sequencing of Mycobacterium tuberculosis-Infected Cells from a Murine Infection Model. STAR Protoc. 2020 Dec 18; 1(3):100123. PMID: 33377017; PMCID: PMC7756974; DOI: 10.1016/j.xpro.2020.100123;

Zhang Z, Schlamp F, Huang L, Clark H, Brayboy L. Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary. Reproduction. 2020 Mar; 159(3):325-337. PMID: 31940276; PMCID: PMC7066623; DOI: 10.1530/REP-19-0330;

Huang L, Ye K, McGee MC, Nidetz NF, Elmore JP, Limper CB, Southard TL, Russell DG, August A, Huang W. Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection. Front Immunol. 2019; 10:3103. PMID: 32038633; PMCID: PMC6993117; DOI: 10.3389/fimmu.2019.03103;

Pisu D, Huang L, Grenier JK, Russell DG. Dual RNA-Seq of Mtb-Infected Macrophages In Vivo Reveals Ontologically Distinct Host-Pathogen Interactions. Cell Rep. 2020 Jan 14; 30(2):335-350.e4. PMID: 31940480; PMCID: PMC7032562; DOI: 10.1016/j.celrep.2019.12.033;

Russell DG, Huang L, VanderVen BC. Immunometabolism at the interface between macrophages and pathogens. Nat Rev Immunol. 2019 May; 19(5):291-304. PMID: 30679807; PMCID: PMC7032560; DOI: 10.1038/s41577-019-0124-9;

Huang L, Nazarova EV, Russell DG. Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage. Microbiol Spectr. 2019 Mar; 7(2). PMID: 30848232; PMCID: PMC6459685; DOI: 10.1128/microbiolspec.BAI-0001-2019;

Nazarova EV, Montague CR, Huang L, La T, Russell D, VanderVen BC. The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages. Elife. 2019 Feb 08; 8. PMID: 30735132; PMCID: PMC6368401; DOI: 10.7554/eLife.43621;

Xu Y, Huang L, Kirschman JL, Vanover DA, Tiwari PM, Santangelo PJ, Shen X, Russell DG. Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo. J Immunol. 2019 Jan 15; 202(2):608-617. PMID: 30541883; PMCID: PMC6325005; DOI: 10.4049/jimmunol.1800924;

Huang L, Kushner NL, Theriault ME, Pisu D, Tan S, McNamara CW, Petrassi HM, Russell DG, Brown AC. The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis. Front Cell Infect Microbiol. 2018; 8:275. PMID: 30155446; PMCID: PMC6102409; DOI: 10.3389/fcimb.2018.00275;

Xu Y, Wang L, Zimmerman MD, Chen KY, Huang L, Fu DJ, Kaya F, Rakhilin N, Nazarova EV, Bu P, Dartois V, Russell DG, Shen X. Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis. PLoS Pathog. 2018 Apr; 14(4):e1006974. PMID: 29698476; PMCID: PMC5919409; DOI: 10.1371/journal.ppat.1006974;

Huang L, Nazarova EV, Tan S, Liu Y, Russell DG. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018 Apr 02; 215(4):1135-1152. PMID: 29500179; PMCID: PMC5881470; DOI: 10.1084/jem.20172020;

Huang L, Russell DG. Protective immunity against tuberculosis: what does it look like and how do we find it? Curr Opin Immunol. 2017 Oct; 48:44-50. PMID: 28826036; PMCID: PMC5697896; DOI: 10.1016/j.coi.2017.08.001;

Kannan AK, Mohinta S, Huang W, Huang L, Koylass N, Appleton JA, August A. T-Bet independent development of IFN? secreting natural T helper 1 cell population in the absence of Itk. Sci Rep. 2017 Apr 13; 7:45935. PMID: 28406139; PMCID: PMC5390256; DOI: 10.1038/srep45935;

VanderVen BC, Huang L, Rohde KH, Russell DG. The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage. Microbiol Spectr. 2016 Dec; 4(6). PMID: 28084213; PMCID: PMC5245711; DOI: 10.1128/microbiolspec.TBTB2-0025-2016;

Huang L, Appleton JA. Eosinophils in Helminth Infection: Defenders and Dupes. Trends Parasitol. 2016 Oct; 32(10):798-807. PMID: 27262918; PMCID: PMC5048491; DOI: 10.1016/j.pt.2016.05.004;

Liu Y, Tan S, Huang L, Abramovitch RB, Rohde KH, Zimmerman MD, Chen C, Dartois V, VanderVen BC, Russell DG. Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo. J Exp Med. 2016 May 02; 213(5):809-25. PMID: 27114608; PMCID: PMC4854729; DOI: 10.1084/jem.20151248;

Huang L, Beiting DP, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury. PLoS Pathog. 2015 Dec; 11(12):e1005347. PMID: 26720604; PMCID: PMC4697774; DOI: 10.1371/journal.ppat.1005347;

Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. J Virol. 2015 Jul; 89(13):6860-73. PMID: 25903329; PMCID: PMC4468500; DOI: 10.1128/JVI.00521-15;

Huang L, Hinchman M, Mendez S. Coinjection with TLR2 agonist Pam3CSK4 reduces the pathology of leishmanization in mice. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003546. PMID: 25738770; PMCID: PMC4354918; DOI: 10.1371/journal.pntd.0003546;

Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Luber KL, Lee NA, Lee JJ, Appleton JA. Eosinophils mediate protective immunity against secondary nematode infection. J Immunol. 2015 Jan 01; 194(1):283-90. PMID: 25429065; PMCID: PMC4272919; DOI: 10.4049/jimmunol.1402219;

Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. Eosinophil-derived IL-10 supports chronic nematode infection. J Immunol. 2014 Oct 15; 193(8):4178-87. PMID: 25210122; PMCID: PMC4241261; DOI: 10.4049/jimmunol.1400852;

Huang W, Jeong AR, Kannan AK, Huang L, August A. IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function. J Immunol. 2014 Sep 01; 193(5):2267-72. PMID: 25063868; PMCID: PMC4352551; DOI: 10.4049/jimmunol.1400968;

Wu W, Huang L, Mendez S. A live Leishmania major vaccine containing CpG motifs induces the de novo generation of Th17 cells in C57BL/6 mice. Eur J Immunol. 2010 Sep; 40(9):2517-27. PMID: 20683901; DOI: 10.1002/eji.201040484;

Mendez S, Traslavina R, Hinchman M, Huang L, Green P, Cynamon MH, Welch JT. The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells. Antimicrob Agents Chemother. 2009 Dec; 53(12):5114-21. PMID: 19770283; PMCID: PMC2786368; DOI: 10.1128/AAC.01146-09;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 44 publications over 14 distinct years, with a maximum of 8 publications in 2024