Janardhan Karapurkar

Postdoctoral Associate

Boston University Chobanian & Avedisian School of Medicine

Medicine

Rheumatology

Websites

ORCID : 0000-0002-0198-4035

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Birappa G, Perumalsamy H, Hong SH, Gowda DAA, Chandrasekaran AP, Karapurkar JK, Rajkumar S, Balusamy SR, Jayachandran A, Baek KH, Lee J, Matam V, Kim WJ, Kim KS, Ramakrishna S, Suresh B. Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis in vitro and in vivo. Theranostics. 2026; 16(2):986-1005. PMID: 41356798; PMCID: PMC12675009; DOI: 10.7150/thno.117900;

Rhie BH, Karapurkar JK, Kim HY, Woo SH, Gowda DAA, Kim DH, Choi MJ, Park YJ, Matam V, Hong Y, Hong SH, Ramakrishna S, Kim KS. A Multikinase Inhibitor AX-0085 Blocks FGFR1 Activation to Overcomes Osimertinib Resistance in Non-Small Cell Lung Cancer. Biomedicines. 2025 Dec 28; 14(1). PMID: 41595602; PMCID: PMC12838157; DOI: 10.3390/biomedicines14010066;

Rhie BH, Woo SH, Kim HY, Karapurkar JK, Jo WJ, Kim J, Kim DH, Kim J, Choi MJ, Park YJ, Hong Y, Hong SH, Ramakrishna S, Kim KS. EGFR inhibitor suppresses tumor growth by blocking lipid uptake and cholesterol synthesis in non-small cell lung cancer. Biochim Biophys Acta Mol Basis Dis. 2025 Oct; 1871(7):167957. PMID: 40544893

Rajkumar S, Jung JH, Kim JY, Karapurkar JK, Birappa G, Gowda DAA, Ajaykumar CB, Perumalsamy H, Suresh B, Kim KS, Hong SH, Ramakrishna S. Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids. Int J Stem Cells. 2025 May 30; 18(2):205-213. PMID: 40189830; PMCID: PMC12122244; DOI: 10.15283/ijsc25011;

Karapurkar JK, Rajkumar S, Jung JH, Kim JY, Birappa G, Gowda DAA, Colaco JC, Suresh B, Choi JY, Woo SH, Jo WJ, Lee JH, Kim KS, Hong SH, Ramakrishna S. Targeting USP11 counteracts SFTPCI73T -associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models. Theranostics. 2025; 15(10):4526-4549. PMID: 40225577; PMCID: PMC11984411; DOI: 10.7150/thno.105994;

Woo SH, Kim DH, Karapurkar JK, Kim SJ, Jang HY, Jang JY, Han BW, Kim JS, Park YJ, Choi MJ, Ramakrishna S, Kim KS. AXL kinase inhibitor exhibits antitumor activity by inducing apoptotic cell death in triple-negative breast cancer cells. Biochim Biophys Acta Mol Cell Res. 2025 Apr; 1872(4):119928. PMID: 40044045

Jo KS, Jo WJ, Antao AM, Karapurkar JK, Park YJ, Choi MJ, Ramakrishna S, Kim KS. An Efficient Endothelial Cell Differentiation Protocol Using Bioactive Lipid O-Cyclic Phytosphingosine-1-Phosphate in Human Embryonic Stem Cells. Int J Stem Cells. 2025 May 30; 18(2):194-204. PMID: 39252477; PMCID: PMC12122251; DOI: 10.15283/ijsc24068;

Karapurkar JK, Colaco JC, Suresh B, Tyagi A, Woo SH, Jo WJ, Ko N, Singh V, Hong SH, Oh SJ, Kim KS, Ramakrishna S. USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells. Cell Mol Life Sci. 2024 Mar 18; 81(1):145. PMID: 38498222; PMCID: PMC10948558; DOI: 10.1007/s00018-024-05187-2;

Colaco JC, Chandrasekaran AP, Karapurkar JK, Birappa G, Rajkumar S, Gowda DAA, Suresh B, Lee J, Singh V, Hong SH, Kim KS, Ramakrishna S. ßTrCP1 promotes SLC35F2 protein ubiquitination and inhibits cancer progression in HeLa cells. Biochem Biophys Res Commun. 2023 Nov 19; 682:27-38. PMID: 37801987

Colaco JC, Chandrasekaran AP, Karapurkar JK, Gowda DAA, Birappa G, Rajkumar S, Suresh B, Ko N, Hong SH, Oh SJ, Kim KS, Ramakrishna S. E3 ubiquitin ligase APC/CCdh1 regulates SLC35F2 protein turnover and inhibits cancer progression in HeLa cells. Biochim Biophys Acta Gen Subj. 2023 Nov; 1867(11):130454. PMID: 37689217

Showing 10 of 23 results. Show More

Tyagi A, Karapurkar JK, Colaco JC, Sarodaya N, Antao AM, Kaushal K, Haq S, Chandrasekaran AP, Das S, Singh V, Hong SH, Suresh B, Kim KS, Ramakrishna S. USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression. Mol Biotechnol. 2024 Aug; 66(8):2032-2045. PMID: 37572221

Karapurkar JK, Kim MS, Colaco JC, Suresh B, Sarodaya N, Kim DH, Park CH, Hong SH, Kim KS, Ramakrishna S. CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis. J Exp Clin Cancer Res. 2023 May 12; 42(1):121. PMID: 37170124; PMCID: PMC10176696; DOI: 10.1186/s13046-023-02694-1;

Khambhati K, Bhattacharjee G, Gohil N, Dhanoa GK, Sagona AP, Mani I, Bui NL, Chu DT, Karapurkar JK, Jang SH, Chung HY, Maurya R, Alzahrani KJ, Ramakrishna S, Singh V. Phage engineering and phage-assisted CRISPR-Cas delivery to combat multidrug-resistant pathogens. Bioeng Transl Med. 2023 Mar; 8(2):e10381. PMID: 36925687; PMCID: PMC10013820; DOI: 10.1002/btm2.10381;

Chandrasekaran AP, Tyagi A, Poondla N, Sarodaya N, Karapurkar JK, Kaushal K, Park CH, Hong SH, Kim KS, Ramakrishna S. Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin. Mol Ther. 2022 Nov 02; 30(11):3414-3429. PMID: 35918893; PMCID: PMC9637645; DOI: 10.1016/j.ymthe.2022.07.019;

Kaushal K, Kim EJ, Tyagi A, Karapurkar JK, Haq S, Jung HS, Kim KS, Ramakrishna S. Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis. Cell Death Differ. 2022 Sep; 29(9):1689-1704. PMID: 35273362; PMCID: PMC9433428; DOI: 10.1038/s41418-022-00956-7;

Chandrasekaran AP, Karapurkar JK, Chung HY, Ramakrishna S. The role of the CRISPR-Cas system in cancer drug development: Mechanisms of action and therapy. Biotechnol J. 2022 Jul; 17(7):e2100468. PMID: 35157790

Bhattacharjee G, Gohil N, Khambhati K, Mani I, Maurya R, Karapurkar JK, Gohil J, Chu DT, Vu-Thi H, Alzahrani KJ, Show PL, Rawal RM, Ramakrishna S, Singh V. Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications. J Control Release. 2022 Mar; 343:703-723. PMID: 35149141

Kaushal K, Tyagi A, Karapurkar JK, Kim EJ, Tanguturi P, Kim KS, Jung HS, Ramakrishna S. Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation. Int J Mol Sci. 2022 Jan 13; 23(2). PMID: 35055037; PMCID: PMC8778097; DOI: 10.3390/ijms23020856;

Haq S, Sarodaya N, Karapurkar JK, Suresh B, Jo JK, Singh V, Bae YS, Kim KS, Ramakrishna S. CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression. Cancer Lett. 2022 Jan 28; 525:146-157. PMID: 34742871

Rhie BH, Antao AM, Karapurkar JK, Kim MS, Jo WJ, Ramakrishna S, Kim KS. Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. Int J Mol Sci. 2021 May 25; 22(11). PMID: 34070420; PMCID: PMC8197518; DOI: 10.3390/ijms22115584;

Karapurkar JK, Antao AM, Kim KS, Ramakrishna S. CRISPR-Cas9 based genome editing for defective gene correction in humans and other mammals. Prog Mol Biol Transl Sci. 2021; 181:185-229. PMID: 34127194

Antao AM, Karapurkar JK, Lee DR, Kim KS, Ramakrishna S. Disease modeling and stem cell immunoengineering in regenerative medicine using CRISPR/Cas9 systems. Comput Struct Biotechnol J. 2020; 18:3649-3665. PMID: 33304462; PMCID: PMC7710510; DOI: 10.1016/j.csbj.2020.11.026;

Sarodaya N, Karapurkar J, Kim KS, Hong SH, Ramakrishna S. The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies. Cancers (Basel). 2020 Apr 28; 12(5). PMID: 32354135; PMCID: PMC7281754; DOI: 10.3390/cancers12051103;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 7 distinct years, with a maximum of 6 publications in 2022

Bar chart showing 23 publications over 7 distinct years, with a maximum of 6 publications in 2022

Year	Publications
2020	2
2021	3
2022	6
2023	4
2024	2
2025	5
2026	1

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