James A. Hamilton, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Indiana University Bloomington




Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.

Professor
Boston University School of Medicine
Radiology


Research Associate Professor
Boston University School of Medicine
Biochemistry


Research Associate Professor
Boston University School of Medicine
Medicine
General Internal Medicine

Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Boston Medical Center




Synergistic Effects of Medium-chain and Omega-3 Triglycerides on Cellular Omega-3 Fatty Acid Enrichment: Characterization, Mechanisms, and Optimization
01/10/2020 - 12/31/2024 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIDDK
5R01DK119389-02

Elucidating the effects of statins on pancreatic B-cell metabolism and functions
08/02/2018 - 09/30/2022 (PI)
Kowa Pharmaceuticals America, Inc.


n-3 Diglyceride Emulsions: Characterization of a Novel Neuroprotectant
08/15/2019 - 07/31/2021 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NINDS
1R21NS109717-01A1

Effects of MCT on Enhancing n-3 Fatty Acid Incorporation into Membranes
01/01/2019 - 08/31/2020 (Subcontract PI)
Trustees Of Columbia University In The City Of New York BeijingSciecurePharm


How CD36 and Caveloin-1 Affect Fatty Acid Uptake
01/01/2011 - 12/31/2013 (PI)
American Diabetes Association


NMR and MR Imaging Studies of Plaque Rupture
08/08/2000 - 03/31/2010 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL61825 04

Investigation of Pepducin Membrane “Flip-Flop” -- Effects of Peptide Sequence and Lipid Composition
01/01/2009 - 12/31/2009 (PI)
Ascent Therapeutics

Transport and Metabolism of Fatty Acids in Adipocytes
04/16/2001 - 03/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL67188 04

NMR Studies of Lipids in Disease
12/08/1997 - 11/30/2000 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL41904 08



Title


Yr Title Project-Sub Proj Pubs
2010 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-05-3 57
2009 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-04-3 57
2008 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-03-3 57
2007 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-02-3 57
2006 Imaging the Vascular Consequences of Lipid Deposition 1P50HL083801-01-3 57
2005 FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY 5P01HL026335-25-7 235
2004 FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY 5P01HL026335-24-7 235
2004 Transport and Metabolism of Fatty Acids in Adipocytes 5R01HL067188-04 8
2003 Transport and Metabolism of Fatty Acids in Adipocytes 5R01HL067188-03 8
2003 NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE 5R01HL061825-04 5
Showing 10 of 33 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Jayaraj A, Schwanz HA, Spencer DJ, Bhasin S, Hamilton JA, Jayaram B, Goldman AL, Krishna M, Krishnan M, Shah A, Jin Z, Krenzel E, Nair SN, Ramesh S, Guo W, Wagner G, Arthanari H, Peng L, Lawney B, Jasuja R. Allosterically Coupled Multisite Binding of Testosterone to Human Serum Albumin. Endocrinology. 2021 02 01; 162(2).View Related Profiles. PMID: 33125473; PMCID: PMC7774055; DOI: 10.1210/endocr/bqaa199;
     
  2. Wang Y, Taylor E, Zikopoulos B, Seta F, Huang N, Hamilton JA, Kantak KM, Morgan KG. Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects. Neurobiol Aging. 2021 04; 100:39-47.View Related Profiles. PMID: 33477010; PMCID: PMC8162167; DOI: 10.1016/j.neurobiolaging.2020.11.017;
     
  3. Taylor EN, Huang N, Wisco J, Wang Y, Morgan KG, Hamilton JA. The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds. J Transl Med. 2020 07 08; 18(1):277.View Related Profiles. PMID: 32641073; PMCID: PMC7346388; DOI: 10.1186/s12967-020-02441-6;
     
  4. Jay AG, Simard JR, Huang N, Hamilton JA. SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation. J Lipid Res. 2020 05; 61(5):790-807.View Related Profiles. PMID: 32102800; PMCID: PMC7193964; DOI: 10.1194/jlr.RA120000648;
     
  5. Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP. Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E749-E772. PMID: 30645175; PMCID: PMC6580174; DOI: 10.1152/ajpendo.00343.2018;
     
  6. Zeng B, Liao J, Zhang H, Fu S, Chen W, Pan G, Li Q, Chen W, Ferrone S, Wu B, Sun S, Hu J, Ahn MH, Lin Z, Yu D, Ou Z, Wang X, Mo F, Huang N, Hamilton JA, Li J, Fan S. Novel ANO5 mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia. Head Neck. 2019 01; 41(1):230-238. PMID: 30554457
     
  7. Mitra R, Qiao J, Madhavan S, O'Neil GL, Ritchie B, Kulkarni P, Sridhar S, van de Ven AL, Kemmerling EMC, Ferris C, Hamilton JA, Ebong EE. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Transl Med Commun. 2018; 3. PMID: 30957020; PMCID: PMC6447085; DOI: 10.1186/s41231-018-0029-9;
     
  8. Ronodeep Mitra, Ju Qiao, Sudharsan Madhavan, Gerard L. O’Neil, Bailey Ritchie, Praveen Kulkarni, Srinivas Sridhar, Anne L. van de Ven, Erica M. Cherry Kemmerling, Craig Ferris, James A. Hamilton and Eno E. Ebong. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Translational Medicine Communications. 2018; 10(3).
  9. Taylor E, Huang N, Bodde J, Ellison A, Killiany R, Bachschmid MM, Hamilton J. MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits. J Transl Med. 2018 08 01; 16(1):215.View Related Profiles. PMID: 30068362; PMCID: PMC6071403; DOI: 10.1186/s12967-018-1587-3;
     
  10. EA Kolar, E Gajrawala, J Deeney, J Hamilton. FASEB JOURNAL. Understanding the role of pancreatic beta-cell CD36 in the development of Type 2 Diabetes . 2018; 32(1).
Showing 10 of 224 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 213 publications over 42 distinct years, with a maximum of 15 publications in 2007

YearPublications
19801
19811
19825
19833
19843
19851
19865
19875
19884
19893
19902
19915
19925
19933
19945
19958
19968
19975
19983
19994
20005
200111
20026
20038
20045
20055
20067
200715
20087
20098
20106
20115
20124
20139
20146
20156
20163
20176
20187
20191
20203
20211
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

heart disease
diabetes
obesity
fatty acid
metabolism
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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