James A. Hamilton, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Indiana University Bloomington



Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Radiology


Research Associate Professor
Boston University School of Medicine
Biochemistry


Research Associate Professor
Boston University School of Medicine
Medicine
General Internal Medicine

Boston Medical Center




How CD36 and Caveloin-1 Affect Fatty Acid Uptake
01/01/2011 - 12/31/2013 (PI)
American Diabetes Association


NMR and MR Imaging Studies of Plaque Rupture
08/08/2000 - 03/31/2010 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL61825 04

Investigation of Pepducin Membrane “Flip-Flop” -- Effects of Peptide Sequence and Lipid Composition
01/01/2009 - 12/31/2009 (PI)
Ascent Therapeutics

Transport and Metabolism of Fatty Acids in Adipocytes
04/16/2001 - 03/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL67188 04

NMR Studies of Lipids in Disease
12/08/1997 - 11/30/2000 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL41904 08




Yr Title Project-Sub Proj Pubs
2010 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-05-3 54
2009 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-04-3 54
2008 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-03-3 54
2007 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-02-3 54
2006 Imaging the Vascular Consequences of Lipid Deposition 1P50HL083801-01-3 54
2005 FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY 5P01HL026335-25-7 225
2004 FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY 5P01HL026335-24-7 225
2004 Transport and Metabolism of Fatty Acids in Adipocytes 5R01HL067188-04 8
2003 Transport and Metabolism of Fatty Acids in Adipocytes 5R01HL067188-03 8
2003 NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE 5R01HL061825-04 5
Showing 10 of 33 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Taylor E, Huang N, Bodde J, Ellison A, Killiany R, Bachschmid MM, Hamilton J. MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits. J Transl Med. 2018 Aug 01; 16(1):215.View Related Profiles. PMID: 30068362.
     
  2. Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 Feb 01; 141(2):422-458.View Related Profiles. PMID: 29360998; DOI: 10.1093/brain/awx350;.
     
  3. Hamilton JA, Hasturk H, Kantarci A, Serhan CN, Van Dyke T. Atherosclerosis, Periodontal Disease, and Treatment with Resolvins. Curr Atheroscler Rep. 2017 Nov 06; 19(12):57.View Related Profiles. PMID: 29110146.
     
  4. Hamilton J, Hasturk H, Kantarci A, Van Dyke T, Phinikaridou A. Atherothrombosis: Resolution of vessel wall inflammation and limitation of thrombosis and thrombus propagation by resolvins. Atherosclerosis. 2017 Aug; 263:e144-e145.View Related Profiles. PMID: 29365572.
     
  5. Hua N, Takahashi H, Yee GM, Kitajima Y, Katagiri S, Kojima M, Anzai K, Eguchi Y, Hamilton JA. Influence of muscle fiber type composition on early fat accumulation under high-fat diet challenge. PLoS One. 2017; 12(8):e0182430.View Related Profiles. PMID: 28763507.
     
  6. Stein-Merlob AF, Hara T, McCarthy JR, Mauskapf A, Hamilton JA, Ntziachristos V, Libby P, Jaffer FA. Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging. Circ Cardiovasc Imaging. 2017 May; 10(5). PMID: 28487316.
     
  7. Hamilton J, Brustovetsky T, Brustovetsky N. Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease. Neurochem Int. 2017 Oct; 109:24-33. PMID: 28062223.
     
  8. Jay AG, Hamilton JA. Disorder Amidst Membrane Order: Standardizing Laurdan Generalized Polarization and Membrane Fluidity Terms. J Fluoresc. 2017 Jan; 27(1):243-249.View Related Profiles. PMID: 27738919; DOI: 10.1007/s10895-016-1951-8;.
     
  9. Jay AG, Hamilton JA. The enigmatic membrane fatty acid transporter CD36: New insights into fatty acid binding and their effects on uptake of oxidized LDL. Prostaglandins Leukot Essent Fatty Acids. 2016 May 20.View Related Profiles. PMID: 27288302; DOI: 10.1016/j.plefa.2016.05.005;.
     
  10. Pham TA, Hua N, Phinikaridou A, Killiany R, Hamilton J. Early in vivo discrimination of vulnerable atherosclerotic plaques that disrupt: A serial MRI study. Atherosclerosis. 2016 Jan; 244:101-7.View Related Profiles. PMID: 26606442; DOI: 10.1016/j.atherosclerosis.2015.11.013;.
     
Showing 10 of 231 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 215 publications over 39 distinct years, with a maximum of 15 publications in 2007

YearPublications
19801
19811
19825
19833
19843
19851
19865
19875
19884
19893
19904
19916
19926
19937
19945
19958
199611
19976
19988
19995
20006
200111
20026
20038
20045
20055
20067
200715
20087
20098
20106
20116
20124
20136
20146
20154
20162
20175
20181
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

heart disease
diabetes
obesity
fatty acid
metabolism
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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