| Profiles RNS

Profile

PhD, Vrije Universiteit Amsterdam
MS, Vrije Universiteit Amsterdam
BS, Hogeschool van Amsterdam

Websites

Dental Medicine Periodontology & Oral Biology Faculty

Research
Publications

BU Research
NIH RePORTER Research

Oral microbial enzymes for the treatment of celiac disease
06/01/2016 - 09/15/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5K02AI101067-05

Oral microbial enzymes for the treatment of celiac disease
06/15/2013 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5K02AI101067-03

Gastro-Intestinal Microbes Degrading Dietary Gluten
06/01/2010 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI087803-05

Oral Yeast Carriage and Salivary Antifungal Activity
02/05/2007 - 01/31/2010 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R03 DE16699 02

Title

Yr	Title	Project-Sub Proj	Pubs
2017	Oral microbial enzymes for the treatment of celiac disease	5K02AI101067-05	16
2016	Oral microbial enzymes for the treatment of celiac disease	4K02AI101067-04	16
2015	Oral microbial enzymes for the treatment of celiac disease	5K02AI101067-03	16
2014	Oral microbial enzymes for the treatment of celiac disease	5K02AI101067-02	16
2014	Gastro-intestinal microbes degrading dietary gluten	5R01AI087803-05	22
2013	Oral microbial enzymes for the treatment of celiac disease	1K02AI101067-01A1	16
2013	Gastro-intestinal microbes degrading dietary gluten	5R01AI087803-04	22
2012	Gastro-intestinal microbes degrading dietary gluten	5R01AI087803-03	22
2011	Gastro-intestinal microbes degrading dietary gluten	5R01AI087803-02	22
2010	Gastro-intestinal microbes degrading dietary gluten	1R01AI087803-01A1	22

Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E. A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli. J Infect Dis. 2018 04 11; 217(9):1435-1441.View Related Profiles.

Bullitt, Esther
Helmerhorst, Eva
Oppenheim, Frank

PMID: 29528423; PMCID: PMC5894089; DOI: 10.1093/infdis/jiy032;

Spinell T, DeMayo F, Cato M, Thai A, Helmerhorst EJ, Green PHR, Lebwohl B, Demmer RT. The association between coeliac disease and periodontitis: Results from NHANES 2009-2012. J Clin Periodontol. 2018 03; 45(3):303-310. PMID: 29243293

Helmerhorst EJ, Dawes C, Oppenheim FG. The complexity of oral physiology and its impact on salivary diagnostics. Oral Dis. 2018 Apr; 24(3):363-371.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 28922514; PMCID: PMC6858792; DOI: 10.1111/odi.12780;

Tian N, Faller L, Leffler DA, Kelly CP, Hansen J, Bosch JA, Wei G, Paster BJ, Schuppan D, Helmerhorst EJ. Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients. Appl Environ Microbiol. 2017 Mar 15; 83(6).View Related Profiles.

Helmerhorst, Eva
Wei, Guoxian
Tian, Na

PMID: 28087531; PMCID: PMC5335528; DOI: 10.1128/AEM.03330-16;

Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Billings ME, Goldsmith CM, Tandon M, Helmerhorst EJ, Catalán MA, Danielides SJ, Perez P, Nikolov NP, Chiorini JA, Melvin JE, Oppenheim FG, Illei GG, Baum BJ. Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction. Gene Ther. 2017 Mar; 24(3):176-186.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 27996967; PMCID: PMC5373995; DOI: 10.1038/gt.2016.87;

Heller D, Helmerhorst EJ, Oppenheim FG. Saliva and Serum Protein Exchange at the Tooth Enamel Surface. J Dent Res. 2017 Apr; 96(4):437-443.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 27879420; PMCID: PMC5384486; DOI: 10.1177/0022034516680771;

Wei G, Tian N, Siezen R, Schuppan D, Helmerhorst EJ. Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 01; 311(3):G571-80.View Related Profiles.

Helmerhorst, Eva
Wei, Guoxian
Tian, Na

PMID: 27469368; PMCID: PMC5076000; DOI: 10.1152/ajpgi.00185.2016;

Heller D, Helmerhorst EJ, Gower AC, Siqueira WL, Paster BJ, Oppenheim FG. Microbial Diversity in the Early In Vivo-Formed Dental Biofilm. Appl Environ Microbiol. 2016 Jan 08; 82(6):1881-8.View Related Profiles.

Gower, Adam
Helmerhorst, Eva
Oppenheim, Frank

PMID: 26746720; PMCID: PMC4784052; DOI: 10.1128/AEM.03984-15;

Tian N, Leffler DA, Kelly CP, Hansen J, Marietta EV, Murray JA, Schuppan D, Helmerhorst EJ. Despite sequence homologies to gluten, salivary proline-rich proteins do not elicit immune responses central to the pathogenesis of celiac disease. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1; 309(11):G910-7.View Related Profiles.

Helmerhorst, Eva
Tian, Na

PMID: 26505973; PMCID: PMC4669355; DOI: 10.1152/ajpgi.00157.2015;

Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A, Schuppan D, Castagnola M, Helmerhorst EJ. Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease? Proteomics Clin Appl. 2015 Oct; 9(9-10):953-64.View Related Profiles.

Helmerhorst, Eva
Tian, Na

PMID: 25726832; PMCID: PMC4551613; DOI: 10.1002/prca.201400170;

Showing 10 of 72 results. Show More

Wei G, Tian N, Valery AC, Zhong Y, Schuppan D, Helmerhorst EJ. Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease. Am J Gastroenterol. 2015 Jun; 110(6):899-908.View Related Profiles.

Helmerhorst, Eva
Wei, Guoxian
Tian, Na
Zhong, Yi

PMID: 25895519; PMCID: PMC4461489; DOI: 10.1038/ajg.2015.97;

Tian N, Wei G, Schuppan D, Helmerhorst EJ. Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G769-76.View Related Profiles.

Helmerhorst, Eva
Wei, Guoxian
Tian, Na

PMID: 25147233; PMCID: PMC4200315; DOI: 10.1152/ajpgi.00144.2014;

Trindade F, Oppenheim FG, Helmerhorst EJ, Amado F, Gomes PS, Vitorino R. Uncovering the molecular networks in periodontitis. Proteomics Clin Appl. 2014 Oct; 8(9-10):748-61.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 24828325; PMCID: PMC4426160; DOI: 10.1002/prca.201400028;

Iavarone F, D'Alessandro A, Tian N, Cabras T, Messana I, Helmerhorst EJ, Oppenheim FG, Castagnola M. High-resolution high-performance liquid chromatography with electrospray ionization mass spectrometry and tandem mass spectrometry characterization of a new isoform of human salivary acidic proline-rich proteins named Roma-Boston Ser22 (Phos) ? Phe variant. J Sep Sci. 2014 Jul; 37(14):1896-902.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 24771659; PMCID: PMC4419831; DOI: 10.1002/jssc.201400227;

Helmerhorst EJ, Wei G. Experimental Strategy to Discover Microbes with Gluten-degrading Enzyme Activities. Proc SPIE Int Soc Opt Eng. 2014 May 05; 9112.View Related Profiles.

Helmerhorst, Eva
Wei, Guoxian

PMID: 26113763; PMCID: PMC4477194; DOI: 10.1117/12.2058730;

Vukosavljevic D, Hutter JL, Helmerhorst EJ, Xiao Y, Custodio W, Zaidan FC, Oppenheim FG, Siqueira WL. Nanoscale adhesion forces between enamel pellicle proteins and hydroxyapatite. J Dent Res. 2014 May; 93(5):514-9.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 24591293; PMCID: PMC3988626; DOI: 10.1177/0022034514526599;

Fernandez-Feo M, Wei G, Blumenkranz G, Dewhirst FE, Schuppan D, Oppenheim FG, Helmerhorst EJ. The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity. Clin Microbiol Infect. 2013 Sep; 19(9):E386-94.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Wei, Guoxian
Fernandez-Feo, Martin

PMID: 23714165; PMCID: PMC3749263; DOI: 10.1111/1469-0691.12249;

Oppenheim FG, Helmerhorst EJ, Lendenmann U, Offner GD. Anti-candidal activity of genetically engineered histatin variants with multiple functional domains. PLoS One. 2012; 7(12):e51479.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Offner, Gwynneth

PMID: 23251551; PMCID: PMC3520795; DOI: 10.1371/journal.pone.0051479;

Zamakhchari M, Wei G, Dewhirst F, Lee J, Schuppan D, Oppenheim FG, Helmerhorst EJ. Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract. PLoS One. 2011; 6(9):e24455.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Wei, Guoxian

PMID: 21957450; PMCID: PMC3177827; DOI: 10.1371/journal.pone.0024455;

Thomadaki K, Helmerhorst EJ, Tian N, Sun X, Siqueira WL, Walt DR, Oppenheim FG. Whole-saliva proteolysis and its impact on salivary diagnostics. J Dent Res. 2011 Nov; 90(11):1325-30.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Thomadaki, Konstantina
Tian, Na

PMID: 21917601; PMCID: PMC3188460; DOI: 10.1177/0022034511420721;

Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank
Offner, Gwynneth

PMID: 21080726; PMCID: PMC3033980; DOI: 10.1021/pr100861k;

Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One. 2010; 5(10):e13264.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 20948997; PMCID: PMC2952584; DOI: 10.1371/journal.pone.0013264;

Helmerhorst EJ, Traboulsi G, Salih E, Oppenheim FG. Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains. J Proteome Res. 2010 Oct 1; 9(10):5413-21.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 20731414; PMCID: PMC2948583; DOI: 10.1021/pr100653r;

Hanasab H, Jammal D, Oppenheim FG, Helmerhorst EJ. The antifungal activity of human parotid secretion is species-specific. Med Mycol. 2011 Feb; 49(2):218-21.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 20807025; PMCID: PMC3098444; DOI: 10.3109/13693786.2010.512299;

Salih E, Siqueira WL, Helmerhorst EJ, Oppenheim FG. Large-scale phosphoproteome of human whole saliva using disulfide-thiol interchange covalent chromatography and mass spectrometry. Anal Biochem. 2010 Dec 1; 407(1):19-33.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 20659418; PMCID: PMC2954488; DOI: 10.1016/j.ab.2010.07.012;

Siqueira WL, Margolis HC, Helmerhorst EJ, Mendes FM, Oppenheim FG. Evidence of intact histatins in the in vivo acquired enamel pellicle. J Dent Res. 2010 Jun; 89(6):626-30.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 20351356; PMCID: PMC2873135; DOI: 10.1177/0022034510363384;

Bosch JA, de Geus EJ, Carroll D, Goedhart AD, Anane LA, van Zanten JJ, Helmerhorst EJ, Edwards KM. A general enhancement of autonomic and cortisol responses during social evaluative threat. Psychosom Med. 2009 Oct; 71(8):877-85. PMID: 19779143; DOI: 10.1097/PSY.0b013e3181baef05;

Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Activity-based mass spectrometric characterization of proteases and inhibitors in human saliva. Proteomics Clin Appl. 2009 Jul 01; 3(7):810-820.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 20011683; PMCID: PMC2790210; DOI: 10.1002/prca.200800242;

Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties. FASEB J. 2009 Aug; 23(8):2691-701.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 19339663; PMCID: PMC2717783; DOI: 10.1096/fj.09-131045;

Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Wexler PJ, Little FF, Walt DR. Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem. 2009 Mar 15; 81(6):2106-14.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Little, Frederic

PMID: 19192965; PMCID: PMC2765577; DOI: 10.1021/ac802181j;

White MR, Helmerhorst EJ, Ligtenberg A, Karpel M, Tecle T, Siqueira WL, Oppenheim FG, Hartshorn KL. Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral Microbiol Immunol. 2009 Feb; 24(1):18-24.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Hartshorn, Kevan
Tecle, Tesfaldet

PMID: 19121065; PMCID: PMC2848456; DOI: 10.1111/j.1399-302X.2008.00468.x;

Campese M, Sun X, Bosch JA, Oppenheim FG, Helmerhorst EJ. Concentration and fate of histatins and acidic proline-rich proteins in the oral environment. Arch Oral Biol. 2009 Apr; 54(4):345-53.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 19159863; PMCID: PMC2680473; DOI: 10.1016/j.archoralbio.2008.11.010;

Blicharz TM, Rissin DM, Bowden M, Hayman RB, DiCesare C, Bhatia JS, Grand-Pierre N, Siqueira WL, Helmerhorst EJ, Loscalzo J, Oppenheim FG, Walt DR. Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle. Clin Chem. 2008 Sep; 54(9):1473-80.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Bhatia, Jasvinder

PMID: 18676588; PMCID: PMC2710817; DOI: 10.1373/clinchem.2008.105320;

Helmerhorst EJ, Sun X, Salih E, Oppenheim FG. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. J Biol Chem. 2008 Jul 18; 283(29):19957-66.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 18463091; PMCID: PMC2459269; DOI: 10.1074/jbc.M708282200;

Siqueira WL, Salih E, Wan DL, Helmerhorst EJ, Oppenheim FG. Proteome of human minor salivary gland secretion. J Dent Res. 2008 May; 87(5):445-50.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 18434574; PMCID: PMC2857507; DOI: 10.1177/154405910808700508;

Helmerhorst EJ, Oppenheim FG. Saliva: a dynamic proteome. J Dent Res. 2007 Aug; 86(8):680-93.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 17652194

Siqueira WL, Zhang W, Helmerhorst EJ, Gygi SP, Oppenheim FG. Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS. J Proteome Res. 2007 Jun; 6(6):2152-60.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 17447804

Helmerhorst EJ. Whole saliva proteolysis: wealth of information for diagnostic exploitation. Ann N Y Acad Sci. 2007 Mar; 1098:454-60. PMID: 17435151

Siqueira WL, Helmerhorst EJ, Zhang W, Salih E, Oppenheim FG. Acquired enamel pellicle and its potential role in oral diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:504-9.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 17435160

Walt DR, Blicharz TM, Hayman RB, Rissin DM, Bowden M, Siqueira WL, Helmerhorst EJ, Grand-Pierre N, Oppenheim FG, Bhatia JS, Little FF, Brody JS. Microsensor arrays for saliva diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:389-400.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Little, Frederic
Bhatia, Jasvinder
Brody, Jerome

PMID: 17435144; PMCID: PMC7168095; DOI: 10.1196/annals.1384.031;

Oppenheim FG, Salih E, Siqueira WL, Zhang W, Helmerhorst EJ. Salivary proteome and its genetic polymorphisms. Ann N Y Acad Sci. 2007 Mar; 1098:22-50.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 17303824

Helmerhorst EJ, Alagl AS, Siqueira WL, Oppenheim FG. Oral fluid proteolytic effects on histatin 5 structure and function. Arch Oral Biol. 2006 Dec; 51(12):1061-70.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 16901460

Piludu M, Lantini MS, Cossu M, Piras M, Oppenheim FG, Helmerhorst EJ, Siqueira W, Hand AR. Salivary histatins in human deep posterior lingual glands (of von Ebner). Arch Oral Biol. 2006 Nov; 51(11):967-73.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 16859632

Helmerhorst EJ, Venuleo C, Sanglard D, Oppenheim FG. Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5. Antimicrob Agents Chemother. 2006 Mar; 50(3):1100-3.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 16495279; PMCID: PMC1426449; DOI: 10.1128/AAC.50.3.1100-1103.2006;

Helmerhorst EJ, Venuleo C, Beri A, Oppenheim FG. Candida glabrata is unusual with respect to its resistance to cationic antifungal proteins. Yeast. 2005 Jul 15; 22(9):705-14.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 16034806

Helmerhorst EJ, Stan M, Murphy MP, Sherman F, Oppenheim FG. The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicans. Mitochondrion. 2005 Jun; 5(3):200-11.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 16050985

Mendelsohn RD, Helmerhorst EJ, Cipollo JF, Kukuruzinska MA. A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast. Biochim Biophys Acta. 2005 May 25; 1723(1-3):33-44.View Related Profiles.

Helmerhorst, Eva
Kukuruzinska, Maria

PMID: 15794922

Helmerhorst EJ, Flora B, Troxler RF, Oppenheim FG. Dialysis unmasks the fungicidal properties of glandular salivary secretions. Infect Immun. 2004 May; 72(5):2703-9.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 15102779; PMCID: PMC387858

Li J, Helmerhorst EJ, Yao Y, Nunn ME, Troxler RF, Oppenheim FG. Statherin is an in vivo pellicle constituent: identification and immuno-quantification. Arch Oral Biol. 2004 May; 49(5):379-85.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 15041485

Ahmad M, Piludu M, Oppenheim FG, Helmerhorst EJ, Hand AR. Immunocytochemical localization of histatins in human salivary glands. J Histochem Cytochem. 2004 Mar; 52(3):361-70.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 14966203

Li J, Helmerhorst EJ, Troxler RF, Oppenheim FG. Identification of in vivo pellicle constituents by analysis of serum immune responses. J Dent Res. 2004 Jan; 83(1):60-4.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 14691115

Gusman H, Leone C, Helmerhorst EJ, Nunn M, Flora B, Troxler RF, Oppenheim FG. Human salivary gland-specific daily variations in histatin concentrations determined by a novel quantitation technique. Arch Oral Biol. 2004 Jan; 49(1):11-22.View Related Profiles.

Leone, Cataldo
Helmerhorst, Eva
Oppenheim, Frank

PMID: 14693192

Li J, Helmerhorst EJ, Leone CW, Troxler RF, Yaskell T, Haffajee AD, Socransky SS, Oppenheim FG. Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol. 2004; 97(6):1311-8.View Related Profiles.

Leone, Cataldo
Helmerhorst, Eva
Oppenheim, Frank

PMID: 15546422

Li J, Helmerhorst EJ, Corley RB, Luus LE, Troxler RF, Oppenheim FG. Characterization of the immunologic responses to human in vivo acquired enamel pellicle as a novel means to investigate its composition. Oral Microbiol Immunol. 2003 Jun; 18(3):183-91.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Corley, Ronald

PMID: 12753471

Helmerhorst EJ, Murphy MP, Troxler RF, Oppenheim FG. Characterization of the mitochondrial respiratory pathways in Candida albicans. Biochim Biophys Acta. 2002 Oct 3; 1556(1):73-80.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 12351220

Murakami Y, Xu T, Helmerhorst EJ, Ori G, Troxler RF, Lally ET, Oppenheim FG. Inhibitory effect of synthetic histatin 5 on leukotoxin from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002 Jun; 17(3):143-9.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 12030965

Rothstein DM, Helmerhorst EJ, Spacciapoli P, Oppenheim FG, Friden P. Histatin-derived peptides: potential agents to treat localised infections. Expert Opin Emerg Drugs. 2002 May; 7(1):47-59.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 15989535

Helmerhorst EJ, Troxler RF, Oppenheim FG. The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4; 98(25):14637-42.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 11717389; PMCID: PMC64734

Flora B, Gusman H, Helmerhorst EJ, Troxler RF, Oppenheim FG. A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation. Protein Expr Purif. 2001 Oct; 23(1):198-206.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 11570863

Gyurko C, Lendenmann U, Helmerhorst EJ, Troxler RF, Oppenheim FG. Killing of Candida albicans by histatin 5: cellular uptake and energy requirement. Antonie Van Leeuwenhoek. 2001 Sep; 79(3-4):297-309.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 11816973

Ruissen AL, Groenink J, Helmerhorst EJ, Walgreen-Weterings E, Van't Hof W, Veerman EC, Nieuw Amerongen AV. Effects of histatin 5 and derived peptides on Candida albicans. Biochem J. 2001 Jun 1; 356(Pt 2):361-8. PMID: 11368762; PMCID: PMC1221846

van 't Hof W, Veerman EC, Helmerhorst EJ, Amerongen AV. Antimicrobial peptides: properties and applicability. Biol Chem. 2001 Apr; 382(4):597-619. PMID: 11405223

Gusman H, Travis J, Helmerhorst EJ, Potempa J, Troxler RF, Oppenheim FG. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. Infect Immun. 2001 Mar; 69(3):1402-8.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 11179305; PMCID: PMC98034

Helmerhorst EJ, van't Hof W, Breeuwer P, Veerman EC, Abee T, Troxler RF, Amerongen AV, Oppenheim FG. Characterization of histatin 5 with respect to amphipathicity, hydrophobicity, and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation. J Biol Chem. 2001 Feb 23; 276(8):5643-9.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank

PMID: 11099499

van't Hof W, Reijnders IM, Helmerhorst EJ, Walgreen-Weterings E, Simoons-Smit IM, Veerman EC, Amerongen AV. Synergistic effects of low doses of histatin 5 and its analogues on amphotericin B anti-mycotic activity. Antonie Van Leeuwenhoek. 2000 Aug; 78(2):163-9. PMID: 11204768

Helmerhorst EJ, Hodgson R, van 't Hof W, Veerman EC, Allison C, Nieuw Amerongen AV. The effects of histatin-derived basic antimicrobial peptides on oral biofilms. J Dent Res. 1999 Jun; 78(6):1245-50. PMID: 10371248

Helmerhorst EJ, Reijnders IM, van 't Hof W, Veerman EC, Nieuw Amerongen AV. A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides. FEBS Lett. 1999 Apr 23; 449(2-3):105-10. PMID: 10338113

Helmerhorst EJ, Breeuwer P, van't Hof W, Walgreen-Weterings E, Oomen LC, Veerman EC, Amerongen AV, Abee T. The cellular target of histatin 5 on Candida albicans is the energized mitochondrion. J Biol Chem. 1999 Mar 12; 274(11):7286-91. PMID: 10066791

Helmerhorst EJ, Reijnders IM, van't Hof W, Simoons-Smit I, Veerman EC, Amerongen AV. Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides. Antimicrob Agents Chemother. 1999 Mar; 43(3):702-4. PMID: 10049295; PMCID: PMC89188

Helmerhorst EJ, Maaskant JJ, Appelmelk BJ. Anti-lipid A monoclonal antibody centoxin (HA-1A) binds to a wide variety of hydrophobic ligands. Infect Immun. 1998 Feb; 66(2):870-3. PMID: 9453659; PMCID: PMC107987

Helmerhorst EJ, Van't Hof W, Veerman EC, Simoons-Smit I, Nieuw Amerongen AV. Synthetic histatin analogues with broad-spectrum antimicrobial activity. Biochem J. 1997 Aug 15; 326 ( Pt 1):39-45. PMID: 9337848; PMCID: PMC1218634

Appelmelk BJ, Qing AY, Helmerhorst EJ, Maaskant JJ, Abraham PR, Thijs LG, MacLaren DM. Diversity in lipid A binding ligands: comparison of lipid A monoclonal antibodies with rBPI23. Prog Clin Biol Res. 1995; 392:453-63. PMID: 8524952

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Contact for Mentoring: