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PhD, Vrije Universiteit Amsterdam
MS, Vrije Universiteit Amsterdam




Oral microbial enzymes for the treatment of celiac disease
06/01/2016 - 09/15/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4K02AI101067-04

Oral microbial enzymes for the treatment of celiac disease
06/15/2013 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5K02AI101067-03

Gastro-Intestinal Microbes Degrading Dietary Gluten
06/01/2010 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI087803-05

Oral Yeast Carriage and Salivary Antifungal Activity
02/05/2007 - 01/31/2010 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R03 DE16699 02




Yr Title Project-Sub Proj Pubs
2016 Oral microbial enzymes for the treatment of celiac disease 4K02AI101067-04 6
2014 Oral microbial enzymes for the treatment of celiac disease 5K02AI101067-02 6
2014 Gastro-intestinal microbes degrading dietary gluten 5R01AI087803-05 14
2013 Oral microbial enzymes for the treatment of celiac disease 1K02AI101067-01A1 6
2013 Gastro-intestinal microbes degrading dietary gluten 5R01AI087803-04 14
2012 Gastro-intestinal microbes degrading dietary gluten 5R01AI087803-03 14
2011 Gastro-intestinal microbes degrading dietary gluten 5R01AI087803-02 14
2010 Gastro-intestinal microbes degrading dietary gluten 1R01AI087803-01A1 14
2009 Oral Fluid Proteolytic Effects on Salivary Protein Structure and Function 5R21DE018132-02 13
2008 Oral Fluid Proteolytic Effects on Salivary Protein Structure and Function 1R21DE018132-01A1 13
Showing 10 of 12 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E. A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli. J Infect Dis. 2018 Apr 11; 217(9):1435-1441.View Related Profiles. PMID: 29528423.
     
  2. Spinell T, DeMayo F, Cato M, Thai A, Helmerhorst EJ, Green PHR, Lebwohl B, Demmer RT. The association between coeliac disease and periodontitis: Results from NHANES 2009-2012. J Clin Periodontol. 2018 Mar; 45(3):303-310. PMID: 29243293.
     
  3. Helmerhorst EJ, Dawes C, Oppenheim FG. The complexity of oral physiology and its impact on salivary diagnostics. Oral Dis. 2018 Apr; 24(3):363-371.View Related Profiles. PMID: 28922514.
     
  4. Tian N, Faller L, Leffler DA, Kelly CP, Hansen J, Bosch JA, Wei G, Paster BJ, Schuppan D, Helmerhorst EJ. Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients. Appl Environ Microbiol. 2017 Mar 15; 83(6).View Related Profiles. PMID: 28087531; DOI: 10.1128/AEM.03330-16;.
     
  5. Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Billings ME, Goldsmith CM, Tandon M, Helmerhorst EJ, Catalán MA, Danielides SJ, Perez P, Nikolov NP, Chiorini JA, Melvin JE, Oppenheim FG, Illei GG, Baum BJ. Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction. Gene Ther. 2017 Mar; 24(3):176-186.View Related Profiles. PMID: 27996967; DOI: 10.1038/gt.2016.87;.
     
  6. Heller D, Helmerhorst EJ, Oppenheim FG. Saliva and Serum Protein Exchange at the Tooth Enamel Surface. J Dent Res. 2017 Apr; 96(4):437-443.View Related Profiles. PMID: 27879420; DOI: 10.1177/0022034516680771;.
     
  7. Wei G, Tian N, Siezen R, Schuppan D, Helmerhorst EJ. Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 01; 311(3):G571-80.View Related Profiles. PMID: 27469368; DOI: 10.1152/ajpgi.00185.2016;.
     
  8. Heller D, Helmerhorst EJ, Gower AC, Siqueira WL, Paster BJ, Oppenheim FG. Microbial Diversity in the Early In Vivo-Formed Dental Biofilm. Appl Environ Microbiol. 2016 Jan 08; 82(6):1881-8.View Related Profiles. PMID: 26746720; PMCID: PMC4784052; DOI: 10.1128/AEM.03984-15;.
     
  9. Tian N, Leffler DA, Kelly CP, Hansen J, Marietta EV, Murray JA, Schuppan D, Helmerhorst EJ. Despite sequence homologies to gluten, salivary proline-rich proteins do not elicit immune responses central to the pathogenesis of celiac disease. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1; 309(11):G910-7.View Related Profiles. PMID: 26505973; PMCID: PMC4669355; DOI: 10.1152/ajpgi.00157.2015;.
     
  10. Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A, Schuppan D, Castagnola M, Helmerhorst EJ. Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease? Proteomics Clin Appl. 2015 Oct; 9(9-10):953-64.View Related Profiles. PMID: 25726832; PMCID: PMC4551613; DOI: 10.1002/prca.201400170;.
     
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This graph shows the total number of publications by year, by first, middle/unknown, or last author.


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