Eric Denovellis
Bioinformatics Specialist
Howard Hughes Medical Institute




Dr. Denovellis is an experienced researcher in computational neuroscience. Skilled in Signal Processing, Python, Statistics, Probabilistic Machine Learning, Brain-Computer Interfaces and Neuroscience.

He is a computational research scientist in Dr. Loren Frank's lab at UCSF. His work focuses on developing scalable, interpretable algorithms and tools to categorize, decode and visualize neural representations. This work extends and applies marked point process switching state space models He developed during his postdoc with Dr. Uri T. Eden. He works closely with experimental collaborators to ensure these algorithms and tools are usable on large scale data.

Previously, he completed my Ph.D. in computational neuroscience at Boston University with Drs. Daniel H. Bullock and Earl K. Miller. There he developed computational tools and models to understand how prefrontal cortex supports the underlying neural comptuations necessary to switch between contexts.

Specifically, he showed how synchronous network oscillations in the prefrontal cortex provide a mechanism to flexibly coordinate context representations between groups of neurons during task switching. He used generalized additive models to show that anterior cingulate neurons can represent context, but do not play a significant role in switching between contexts. Finally, he developed a set of web-enabled interactive visualization tools designed to provide a multi-dimensional integrated view of electrophysiological datasets.

Predoctoral Trainee (formerly held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Computational Neuroscience


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Coulter ME, Gillespie AK, Chu J, Denovellis EL, Nguyen TTK, Liu DF, Wadhwani K, Sharma B, Wang K, Deng X, Eden UT, Kemere C, Frank LM. Closed-loop modulation of remote hippocampal representations with neurofeedback. Neuron. 2025 Mar 19; 113(6):949-961.e3. PMID: 39837322
     
  2. Comrie AE, Monroe EJ, Kahn AE, Denovellis EL, Joshi A, Guidera JA, Krausz TA, Berke JD, Daw ND, Frank LM. Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands. bioRxiv. 2024 Sep 23. PMID: 39386651; PMCID: PMC11463554; DOI: 10.1101/2024.09.23.613567;
     
  3. Gillespie AK, Astudillo Maya D, Denovellis EL, Desse S, Frank LM. Neurofeedback training can modulate task-relevant memory replay rate in rats. Elife. 2024 Jul 03; 12. PMID: 38958562; PMCID: PMC11221834; DOI: 10.7554/eLife.90944;
     
  4. Coulter ME, Gillespie AK, Chu J, Denovellis EL, Nguyen TTK, Liu DF, Wadhwani K, Sharma B, Wang K, Deng X, Eden UT, Kemere C, Frank LM. Closed-loop modulation of remote hippocampal representations with neurofeedback. bioRxiv. 2024 May 08. PMID: 38766135; PMCID: PMC11100667; DOI: 10.1101/2024.05.08.593085;
     
  5. Lee KH, Denovellis E, Ly R, Magland J, Soules J, Comrie AE, Gramling DP, Guidera JA, Nevers R, Adenekan P, Brozdowski C, Bray S, Monroe E, Bak JH, Coulter M, Sun X, Tritt A, Rübel O, Nguyen T, Yatsenko D, Chu J, Kemere C, Garcia S, Buccino A, Frank LM. Spyglass: a data analysis framework for reproducible and shareable neuroscience research. bioRxiv. 2024 Jan 26. PMID: 38328074; PMCID: PMC10849637; DOI: 10.1101/2024.01.25.577295;
     
  6. Guidera JA, Gramling DP, Comrie AE, Joshi A, Denovellis EL, Lee KH, Zhou J, Thompson P, Hernandez J, Yorita A, Haque R, Kirst C, Frank LM. Regional specialization manifests in the reliability of neural population codes. bioRxiv. 2024 Jan 26. PMID: 38328245; PMCID: PMC10849741; DOI: 10.1101/2024.01.25.576941;
     
  7. Joshi A, Denovellis EL, Mankili A, Meneksedag Y, Davidson TJ, Gillespie AK, Guidera JA, Roumis D, Frank LM. Dynamic synchronization between hippocampal representations and stepping. Nature. 2023 May; 617(7959):125-131. PMID: 37046088; PMCID: PMC10156593; DOI: 10.1038/s41586-023-05928-6;
     
  8. Denovellis EL, Gillespie AK, Coulter ME, Sosa M, Chung JE, Eden UT, Frank LM. Hippocampal replay of experience at real-world speeds. Elife. 2021 09 27; 10. PMID: 34570699; PMCID: PMC8476125; DOI: 10.7554/eLife.64505;
     
  9. Gillespie AK, Astudillo Maya DA, Denovellis EL, Liu DF, Kastner DB, Coulter ME, Roumis DK, Eden UT, Frank LM. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice. Neuron. 2021 10 06; 109(19):3149-3163.e6. PMID: 34450026; PMCID: PMC8497431; DOI: 10.1016/j.neuron.2021.07.029;
     
  10. Buschman TJ, Denovellis EL, Diogo C, Bullock D, Miller EK. Synchronous oscillatory neural ensembles for rules in the prefrontal cortex. Neuron. 2012 Nov 21; 76(4):838-46. PMID: 23177967; PMCID: PMC3907768; DOI: 10.1016/j.neuron.2012.09.029;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 10 publications over 5 distinct years, with a maximum of 5 publications in 2024

YearPublications
20121
20212
20231
20245
20251

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111 Cummington St
Boston MA 02215
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