Elliott Hagedorn | Profiles RNS

Elliott J. Hagedorn, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Hematology & Medical Oncology

PhD, Duke University
BS, Purdue University

Pronouns: he/him/his

Websites

Hagedorn Lab Website

ORCID : 0000-0002-3824-3249

Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). Dr. Hagedorn received his PhD from Duke University for his work on basement membrane transmigration in the laboratory of Dr. David Sherwood. He completed postdoctoral training with Dr. Leonard Zon at Boston Children’s Hospital/Harvard Medical School. Dr. Hagedorn has taught in courses at Purdue, Duke, Harvard and in the Embryology Course at the MBL in Woods Hole, MA; his research has been funded by grants from the National Institutes of Health, Howard Hughes Medical Institute and the Helen Hay Whitney Foundation.

BMC Research
NIH RePORTER Research

Stabilin scavenger receptors and the trans-endothelial migration of blood stem cells
07/01/2023 - 06/30/2025 (PI)
National Blood Foundation

Deconstructing The Hematopoietic Stem Cell Niche
01/01/2021 - 11/30/2024 (PI)
National Institutes of Health/DHHS/NIH
7K01DK111790-05

Deconstructing The Hematopoietic Stem Cell Niche
09/01/2021 - 11/30/2023 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
5K01DK111790-06

Title

Yr	Title	Project-Sub Proj	Pubs
2025	Niche-specific endothelial mechanisms regulating the extravasation of hematopoietic stem cells	1R01HL178832-01
2021	CHANGE OF GRANTEE INSTITUTION - Deconstructing The Hematopoietic Stem Cell Niche	3K01DK111790-06S1	2
2021	CHANGE OF GRANTEE INSTITUTION - Deconstructing The Hematopoietic Stem Cell Niche	5K01DK111790-06	2
2020	Deconstructing the Hematopoietic Stem Cell Niche	5K01DK111790-04	2
2020	CHANGE OF GRANTEE INSTITUTION - Deconstructing The Hematopoietic Stem Cell Niche	7K01DK111790-05	2
2019	Deconstructing the Hematopoietic Stem Cell Niche	5K01DK111790-03	2
2018	Deconstructing the Hematopoietic Stem Cell Niche	5K01DK111790-02	2
2017	Deconstructing the Hematopoietic Stem Cell Niche	1K01DK111790-01	2

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Santis Larrain O, Alhaj Kadour A, Agarwala S, Li W, Blaser BW, Lasarev MR, Alexandridis R, Veltri A, Enkhbayar K, Hagedorn EJ, Tamplin OJ. Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche. bioRxiv. 2025 Sep 04. PMID: 40949991; PMCID: PMC12424709; DOI: 10.1101/2025.08.30.673252;

Scapin G, Cillis JL, Goulard MC, Patch TC, Gomez Limia CE, Ding Y, Du W, Dharampuriya PR, Hagedorn EJ, Anderson H, Musso GA, Curley CR, Teets EM, MacRae CA, Sehgal L, Hsiai TK, Blaser BW, Shah DI. PIEZO1 Activation-Mediated Generation of Transgene-Free Long-Term Hematopoietic Stem Cells. Am J Hematol. 2025 Jun; 100(6):963-979. PMID: 40320799

Binder V, Li W, Faisal M, Oyman K, Calkins DL, Shaffer J, Teets EM, Sher S, Magnotte A, Belardo A, Deruelle W, Gregory TC, Orwick S, Hagedorn EJ, Perlin JR, Avagyan S, Lichtig A, Barrett F, Ammerman M, Yang S, Zhou Y, Carson WE, Shive HR, Blachly JS, Lapalombella R, Zon LI, Blaser BW. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 May 30; 42(5):112528. PMID: 37209097; PMCID: PMC10824047; DOI: 10.1016/j.celrep.2023.112528;

Hagedorn EJ, Perlin JR, Freeman RJ, Wattrus SJ, Han T, Mao C, Kim JW, Fernández-Maestre I, Daily ML, D'Amato C, Fairchild MJ, Riquelme R, Li B, Ragoonanan DAVE, Enkhbayar K, Henault EL, Wang HG, Redfield SE, Collins SH, Lichtig A, Yang S, Zhou Y, Kunar B, Gomez-Salinero JM, Dinh TT, Pan J, Holler K, Feldman HA, Butcher EC, van Oudenaarden A, Rafii S, Junker JP, Zon LI. Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 Jun 19; 58(12):1037-1051.e4. PMID: 37119815; PMCID: PMC10330626; DOI: 10.1016/j.devcel.2023.04.007;

Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Kim JW, Budnik B, Zon LI. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 Sep 23; 377(6613):1413-1419. PMID: 36137040; PMCID: PMC9524573; DOI: 10.1126/science.abo4837;

Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. PMID: 33986176; PMCID: PMC8177078; DOI: 10.1126/science.aaz2740;

Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. PMID: 31479239; PMCID: PMC7169949; DOI: 10.1021/acsnano.9b04397;

Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). PMID: 30266803; PMCID: PMC6262816; DOI: 10.1242/dmm.034876;

Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. PMID: 29899448; PMCID: PMC6093292; DOI: 10.1038/s41586-018-0213-0;

Kelley LC, Wang Z, Hagedorn EJ, Wang L, Shen W, Lei S, Johnson SA, Sherwood DR. Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans. Nat Protoc. 2017 Oct; 12(10):2081-2096. PMID: 28880279; PMCID: PMC5915360; DOI: 10.1038/nprot.2017.093;

Showing 10 of 34 results. Show More

Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. PMID: 28416284; PMCID: PMC5425629; DOI: 10.1016/j.stemcr.2017.03.016;

Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. PMID: 28351983; PMCID: PMC5379982; DOI: 10.1084/jem.20161616;

Volpi S, Yamazaki Y, Brauer PM, van Rooijen E, Hayashida A, Slavotinek A, Sun Kuehn H, Di Rocco M, Rivolta C, Bortolomai I, Du L, Felgentreff K, Ott de Bruin L, Hayashida K, Freedman G, Marcovecchio GE, Capuder K, Rath P, Luche N, Hagedorn EJ, Buoncompagni A, Royer-Bertrand B, Giliani S, Poliani PL, Imberti L, Dobbs K, Poulain FE, Martini A, Manis J, Linhardt RJ, Bosticardo M, Rosenzweig SD, Lee H, Puck JM, Zúñiga-Pflücker JC, Zon L, Park PW, Superti-Furga A, Notarangelo LD. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. J Exp Med. 2017 03 06; 214(3):623-637. PMID: 28148688; PMCID: PMC5339678; DOI: 10.1084/jem.20161525;

Hagedorn EJ, Cillis JL, Curley CR, Patch TC, Li B, Blaser BW, Riquelme R, Zon LI, Shah DI. Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. J Vis Exp. 2016 06 11; (112). PMID: 27341538; PMCID: PMC4927786; DOI: 10.3791/54168;

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. PMID: 27058786; PMCID: PMC4836061; DOI: 10.1016/j.molcel.2016.03.013;

Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. PMID: 26823433; PMCID: PMC4868069; DOI: 10.1126/science.aad2197;

Lohmer LL, Clay MR, Naegeli KM, Chi Q, Ziel JW, Hagedorn EJ, Park JE, Jayadev R, Sherwood DR. A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. PLoS Genet. 2016 Jan; 12(1):e1005786. PMID: 26765257; PMCID: PMC4713207; DOI: 10.1371/journal.pgen.1005786;

Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. PMID: 26385351; PMCID: PMC4692141; DOI: 10.1182/blood-2015-07-659276;

Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, Bernstein ID, Aster JC, White RM, Zon LI. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. PMID: 25714926; PMCID: PMC4371382; DOI: 10.7554/eLife.05544;

Tamplin OJ, Durand EM, Carr LA, Childs SJ, Hagedorn EJ, Li P, Yzaguirre AD, Speck NA, Zon LI. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15; 160(1-2):241-52. PMID: 25594182; PMCID: PMC4346256; DOI: 10.1016/j.cell.2014.12.032;

Morrissey MA, Keeley DP, Hagedorn EJ, McClatchey STH, Chi Q, Hall DH, Sherwood DR. B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. Dev Cell. 2014 Nov 10; 31(3):319-331. PMID: 25443298; PMCID: PMC4254419; DOI: 10.1016/j.devcel.2014.08.024;

Wang Z, Linden LM, Naegeli KM, Ziel JW, Chi Q, Hagedorn EJ, Savage NS, Sherwood DR. UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. J Cell Biol. 2014 Sep 01; 206(5):619-33. PMID: 25154398; PMCID: PMC4151141; DOI: 10.1083/jcb.201405026;

Hagedorn EJ, Durand EM, Fast EM, Zon LI. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. Exp Cell Res. 2014 Dec 10; 329(2):220-6. PMID: 25094063; PMCID: PMC4250398; DOI: 10.1016/j.yexcr.2014.07.030;

Hagedorn EJ, Kelley LC, Naegeli KM, Wang Z, Chi Q, Sherwood DR. ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. J Cell Biol. 2014 Mar 31; 204(7):1209-18. PMID: 24662568; PMCID: PMC3971745; DOI: 10.1083/jcb.201312098;

Hagedorn EJ, Zon LI. Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones. J Exp Med. 2014 Mar 10; 211(3):384-5. PMID: 24616474; PMCID: PMC3949574; DOI: 10.1084/jem.2113insight2;

Kelley LC, Lohmer LL, Hagedorn EJ, Sherwood DR. Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol. 2014 Feb 03; 204(3):291-302. PMID: 24493586; PMCID: PMC3912525; DOI: 10.1083/jcb.201311112;

Lohmer LL, Kelley LC, Hagedorn EJ, Sherwood DR. Invadopodia and basement membrane invasion in vivo. Cell Adh Migr. 2014; 8(3):246-55. PMID: 24717190; PMCID: PMC4198348; DOI: 10.4161/cam.28406;

Morrissey MA, Hagedorn EJ, Sherwood DR. Cell invasion through basement membrane: The netrin receptor DCC guides the way. Worm. 2013 Jul 01; 2(3):e26169. PMID: 24778942; PMCID: PMC3875654; DOI: 10.4161/worm.26169;

Hagedorn EJ, Ziel JW, Morrissey MA, Linden LM, Wang Z, Chi Q, Johnson SA, Sherwood DR. The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. J Cell Biol. 2013 Jun 10; 201(6):903-13. PMID: 23751497; PMCID: PMC3678161; DOI: 10.1083/jcb.201301091;

Hagedorn EJ, Sherwood DR. Cell invasion through basement membrane: the anchor cell breaches the barrier. Curr Opin Cell Biol. 2011 Oct; 23(5):589-96. PMID: 21632231; PMCID: PMC3167953; DOI: 10.1016/j.ceb.2011.05.002;

Ihara S, Hagedorn EJ, Morrissey MA, Chi Q, Motegi F, Kramer JM, Sherwood DR. Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans. Nat Cell Biol. 2011 Jun; 13(6):641-51. PMID: 21572423; PMCID: PMC3107347; DOI: 10.1038/ncb2233;

Hagedorn EJ, Yashiro H, Ziel JW, Ihara S, Wang Z, Sherwood DR. Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev Cell. 2009 Aug; 17(2):187-98. PMID: 19686680; PMCID: PMC2729287; DOI: 10.1016/j.devcel.2009.06.006;

Ziel JW, Hagedorn EJ, Audhya A, Sherwood DR. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Nat Cell Biol. 2009 Feb; 11(2):183-9. PMID: 19098902; PMCID: PMC2635427; DOI: 10.1038/ncb1825;

Hagedorn EJ, Bayraktar JL, Kandachar VR, Bai T, Englert DM, Chang HC. Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J Cell Biol. 2006 May 08; 173(3):443-52. PMID: 16682530; PMCID: PMC2063844; DOI: 10.1083/jcb.200602054;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 15 distinct years, with a maximum of 7 publications in 2014

Bar chart showing 34 publications over 15 distinct years, with a maximum of 7 publications in 2014

Year	Publications
2006	1
2008	1
2009	1
2011	2
2013	2
2014	7
2015	3
2016	4
2017	4
2018	2
2019	1
2021	1
2022	1
2023	2
2025	2

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