Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). Dr. Hagedorn received his PhD from Duke University for his work on basement membrane transmigration in the laboratory of Dr. David Sherwood. He completed postdoctoral training with Dr. Leonard Zon at Boston Children’s Hospital/Harvard Medical School. Dr. Hagedorn has taught in courses at Purdue, Duke, Harvard and in the Embryology Course at the MBL in Woods Hole, MA; his research has been funded by grants from the National Institutes of Health, Howard Hughes Medical Institute and the Helen Hay Whitney Foundation.
Diversity, Equity, Inclusion and Accessibility
My research group is a diverse team of scientists from different countries and from different parts of the U.S. Our lab culture is defined by the unique perspectives and experiences that we each bring with us. We aim to create a safe space for all members to learn, grow and succeed in their life goals, and we are committed to promoting diversity, equity, and inclusion in the sciences. Acknowledging that we all have a role to play, the members of our lab are dedicated to welcoming and celebrating individuals of all races, ethnicities, social backgrounds, religion, gender, sex, age, disability, sexual orientation, veteran status and national origin. Myself and several members of my group serve on a BU-BMC anti-racism committee and we also lead a summer research program for local high school students from underserved and underrepresented backgrounds. You can learn more about our outreach program here: https://sites.bu.edu/hagedornlab/community-outreach/
This tab shows grant data from BMC Sponsored Research. It includes:
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Deconstructing The Hematopoietic Stem Cell Niche09/01/2021 - 11/30/2023 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS5K01DK111790-06
Deconstructing The Hematopoietic Stem Cell Niche01/01/2021 - 11/30/2023 (PI)
National Institutes of Health/DHHS/NIH7K01DK111790-05
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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to make corrections and additions.
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Binder V, Li W, Faisal M, Oyman K, Calkins DL, Shaffer J, Teets EM, Sher S, Magnotte A, Belardo A, Deruelle W, Gregory TC, Orwick S, Hagedorn EJ, Perlin JR, Avagyan S, Lichtig A, Barrett F, Ammerman M, Yang S, Zhou Y, Carson WE, Shive HR, Blachly JS, Lapalombella R, Zon LI, Blaser BW. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 May 30; 42(5):112528. PMID: 37209097; PMCID: PMC10824047; DOI: 10.1016/j.celrep.2023.112528;
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Hagedorn EJ, Perlin JR, Freeman RJ, Wattrus SJ, Han T, Mao C, Kim JW, Fernández-Maestre I, Daily ML, D'Amato C, Fairchild MJ, Riquelme R, Li B, Ragoonanan DAVE, Enkhbayar K, Henault EL, Wang HG, Redfield SE, Collins SH, Lichtig A, Yang S, Zhou Y, Kunar B, Gomez-Salinero JM, Dinh TT, Pan J, Holler K, Feldman HA, Butcher EC, van Oudenaarden A, Rafii S, Junker JP, Zon LI. Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 Jun 19; 58(12):1037-1051.e4. PMID: 37119815; PMCID: PMC10330626; DOI: 10.1016/j.devcel.2023.04.007;
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Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Kim JW, Budnik B, Zon LI. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 Sep 23; 377(6613):1413-1419. PMID: 36137040; PMCID: PMC9524573; DOI: 10.1126/science.abo4837;
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Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. PMID: 33986176; PMCID: PMC8177078; DOI: 10.1126/science.aaz2740;
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Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. PMID: 31479239; PMCID: PMC7169949; DOI: 10.1021/acsnano.9b04397;
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Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). PMID: 30266803; PMCID: PMC6262816; DOI: 10.1242/dmm.034876;
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Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. PMID: 29899448; PMCID: PMC6093292; DOI: 10.1038/s41586-018-0213-0;
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Kelley LC, Wang Z, Hagedorn EJ, Wang L, Shen W, Lei S, Johnson SA, Sherwood DR. Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans. Nat Protoc. 2017 Oct; 12(10):2081-2096. PMID: 28880279; PMCID: PMC5915360; DOI: 10.1038/nprot.2017.093;
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Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. PMID: 28416284; PMCID: PMC5425629; DOI: 10.1016/j.stemcr.2017.03.016;
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Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. PMID: 28351983; PMCID: PMC5379982; DOI: 10.1084/jem.20161616;
Showing 10 of 32 results.
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Volpi S, Yamazaki Y, Brauer PM, van Rooijen E, Hayashida A, Slavotinek A, Sun Kuehn H, Di Rocco M, Rivolta C, Bortolomai I, Du L, Felgentreff K, Ott de Bruin L, Hayashida K, Freedman G, Marcovecchio GE, Capuder K, Rath P, Luche N, Hagedorn EJ, Buoncompagni A, Royer-Bertrand B, Giliani S, Poliani PL, Imberti L, Dobbs K, Poulain FE, Martini A, Manis J, Linhardt RJ, Bosticardo M, Rosenzweig SD, Lee H, Puck JM, Zúñiga-Pflücker JC, Zon L, Park PW, Superti-Furga A, Notarangelo LD. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. J Exp Med. 2017 03 06; 214(3):623-637. PMID: 28148688; PMCID: PMC5339678; DOI: 10.1084/jem.20161525;
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Hagedorn EJ, Cillis JL, Curley CR, Patch TC, Li B, Blaser BW, Riquelme R, Zon LI, Shah DI. Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. J Vis Exp. 2016 06 11; (112). PMID: 27341538; PMCID: PMC4927786; DOI: 10.3791/54168;
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Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. PMID: 27058786; PMCID: PMC4836061; DOI: 10.1016/j.molcel.2016.03.013;
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Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. PMID: 26823433; PMCID: PMC4868069; DOI: 10.1126/science.aad2197;
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Lohmer LL, Clay MR, Naegeli KM, Chi Q, Ziel JW, Hagedorn EJ, Park JE, Jayadev R, Sherwood DR. A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. PLoS Genet. 2016 Jan; 12(1):e1005786. PMID: 26765257; PMCID: PMC4713207; DOI: 10.1371/journal.pgen.1005786;
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Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. PMID: 26385351; PMCID: PMC4692141; DOI: 10.1182/blood-2015-07-659276;
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Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, Bernstein ID, Aster JC, White RM, Zon LI. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. PMID: 25714926; PMCID: PMC4371382; DOI: 10.7554/eLife.05544;
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Tamplin OJ, Durand EM, Carr LA, Childs SJ, Hagedorn EJ, Li P, Yzaguirre AD, Speck NA, Zon LI. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15; 160(1-2):241-52. PMID: 25594182; PMCID: PMC4346256; DOI: 10.1016/j.cell.2014.12.032;
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Morrissey MA, Keeley DP, Hagedorn EJ, McClatchey STH, Chi Q, Hall DH, Sherwood DR. B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. Dev Cell. 2014 Nov 10; 31(3):319-331. PMID: 25443298; PMCID: PMC4254419; DOI: 10.1016/j.devcel.2014.08.024;
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Wang Z, Linden LM, Naegeli KM, Ziel JW, Chi Q, Hagedorn EJ, Savage NS, Sherwood DR. UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. J Cell Biol. 2014 Sep 01; 206(5):619-33. PMID: 25154398; PMCID: PMC4151141; DOI: 10.1083/jcb.201405026;
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Hagedorn EJ, Durand EM, Fast EM, Zon LI. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. Exp Cell Res. 2014 Dec 10; 329(2):220-6. PMID: 25094063; PMCID: PMC4250398; DOI: 10.1016/j.yexcr.2014.07.030;
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Hagedorn EJ, Kelley LC, Naegeli KM, Wang Z, Chi Q, Sherwood DR. ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. J Cell Biol. 2014 Mar 31; 204(7):1209-18. PMID: 24662568; PMCID: PMC3971745; DOI: 10.1083/jcb.201312098;
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Hagedorn EJ, Zon LI. Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones. J Exp Med. 2014 Mar 10; 211(3):384-5. PMID: 24616474; PMCID: PMC3949574; DOI: 10.1084/jem.2113insight2;
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Kelley LC, Lohmer LL, Hagedorn EJ, Sherwood DR. Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol. 2014 Feb 03; 204(3):291-302. PMID: 24493586; PMCID: PMC3912525; DOI: 10.1083/jcb.201311112;
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Lohmer LL, Kelley LC, Hagedorn EJ, Sherwood DR. Invadopodia and basement membrane invasion in vivo. Cell Adh Migr. 2014; 8(3):246-55. PMID: 24717190; PMCID: PMC4198348; DOI: 10.4161/cam.28406;
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Morrissey MA, Hagedorn EJ, Sherwood DR. Cell invasion through basement membrane: The netrin receptor DCC guides the way. Worm. 2013 Jul 01; 2(3):e26169. PMID: 24778942; PMCID: PMC3875654; DOI: 10.4161/worm.26169;
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Hagedorn EJ, Ziel JW, Morrissey MA, Linden LM, Wang Z, Chi Q, Johnson SA, Sherwood DR. The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. J Cell Biol. 2013 Jun 10; 201(6):903-13. PMID: 23751497; PMCID: PMC3678161; DOI: 10.1083/jcb.201301091;
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Hagedorn EJ, Sherwood DR. Cell invasion through basement membrane: the anchor cell breaches the barrier. Curr Opin Cell Biol. 2011 Oct; 23(5):589-96. PMID: 21632231; PMCID: PMC3167953; DOI: 10.1016/j.ceb.2011.05.002;
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Ihara S, Hagedorn EJ, Morrissey MA, Chi Q, Motegi F, Kramer JM, Sherwood DR. Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans. Nat Cell Biol. 2011 Jun; 13(6):641-51. PMID: 21572423; PMCID: PMC3107347; DOI: 10.1038/ncb2233;
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Hagedorn EJ, Yashiro H, Ziel JW, Ihara S, Wang Z, Sherwood DR. Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev Cell. 2009 Aug; 17(2):187-98. PMID: 19686680; PMCID: PMC2729287; DOI: 10.1016/j.devcel.2009.06.006;
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Ziel JW, Hagedorn EJ, Audhya A, Sherwood DR. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Nat Cell Biol. 2009 Feb; 11(2):183-9. PMID: 19098902; PMCID: PMC2635427; DOI: 10.1038/ncb1825;
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Hagedorn EJ, Bayraktar JL, Kandachar VR, Bai T, Englert DM, Chang HC. Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J Cell Biol. 2006 May 08; 173(3):443-52. PMID: 16682530; PMCID: PMC2063844; DOI: 10.1083/jcb.200602054;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2006 | 1 |
| 2008 | 1 |
| 2009 | 1 |
| 2011 | 2 |
| 2013 | 2 |
| 2014 | 7 |
| 2015 | 3 |
| 2016 | 4 |
| 2017 | 4 |
| 2018 | 2 |
| 2019 | 1 |
| 2021 | 1 |
| 2022 | 1 |
| 2023 | 2 |