Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). Dr. Hagedorn received his PhD from Duke University for his work on basement membrane transmigration in the laboratory of Dr. David Sherwood. He completed postdoctoral training with Dr. Leonard Zon at Boston Children’s Hospital/Harvard Medical School. Dr. Hagedorn has taught in courses at Purdue, Duke, Harvard and in the Embryology Course at the MBL in Woods Hole, MA; his research has been funded by grants from the National Institutes of Health, Howard Hughes Medical Institute and the Helen Hay Whitney Foundation.
Diversity, Equity, Inclusion and Accessibility
My research group is a diverse team of scientists from different countries and from different parts of the U.S. Our lab culture is defined by the unique perspectives and experiences that we each bring with us. We aim to create a safe space for all members to learn, grow and succeed in their life goals, and we are committed to promoting diversity, equity, and inclusion in the sciences. Acknowledging that we all have a role to play, the members of our lab are dedicated to welcoming and celebrating individuals of all races, ethnicities, social backgrounds, religion, gender, sex, age, disability, sexual orientation, veteran status and national origin. Myself and several members of my group serve on a BU-BMC anti-racism committee and we also lead a summer research program for local high school students from underserved and underrepresented backgrounds. You can learn more about our outreach program here: https://sites.bu.edu/hagedornlab/community-outreach/
Deconstructing The Hematopoietic Stem Cell Niche
09/01/2021 - 11/30/2023 (PI)National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS5K01DK111790-06
Deconstructing The Hematopoietic Stem Cell Niche
01/01/2021 - 11/30/2023 (PI)National Institutes of Health/DHHS/NIH7K01DK111790-05
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 32 results.
Binder V, Li W, Faisal M, Oyman K, Calkins DL, Shaffer J, Teets EM, Sher S, Magnotte A, Belardo A, Deruelle W, Gregory TC, Orwick S, Hagedorn EJ, Perlin JR, Avagyan S, Lichtig A, Barrett F, Ammerman M, Yang S, Zhou Y, Carson WE, Shive HR, Blachly JS, Lapalombella R, Zon LI, Blaser BW. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 May 30; 42(5):112528. PMID: 37209097
Hagedorn EJ, Perlin JR, Freeman RJ, Wattrus SJ, Han T, Mao C, Kim JW, Fernández-Maestre I, Daily ML, D'Amato C, Fairchild MJ, Riquelme R, Li B, Ragoonanan DAVE, Enkhbayar K, Henault EL, Wang HG, Redfield SE, Collins SH, Lichtig A, Yang S, Zhou Y, Kunar B, Gomez-Salinero JM, Dinh TT, Pan J, Holler K, Feldman HA, Butcher EC, van Oudenaarden A, Rafii S, Junker JP, Zon LI. Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 Jun 19; 58(12):1037-1051.e4. PMID: 37119815; PMCID: PMC10330626; DOI: 10.1016/j.devcel.2023.04.007;
Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Kim JW, Budnik B, Zon LI. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 Sep 23; 377(6613):1413-1419. PMID: 36137040; PMCID: PMC9524573; DOI: 10.1126/science.abo4837;
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. PMID: 33986176; PMCID: PMC8177078; DOI: 10.1126/science.aaz2740;
Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. PMID: 31479239; PMCID: PMC7169949; DOI: 10.1021/acsnano.9b04397;
Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). PMID: 30266803; PMCID: PMC6262816; DOI: 10.1242/dmm.034876;
Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. PMID: 29899448; PMCID: PMC6093292; DOI: 10.1038/s41586-018-0213-0;
Kelley LC, Wang Z, Hagedorn EJ, Wang L, Shen W, Lei S, Johnson SA, Sherwood DR. Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans. Nat Protoc. 2017 Oct; 12(10):2081-2096. PMID: 28880279; PMCID: PMC5915360; DOI: 10.1038/nprot.2017.093;
Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. PMID: 28416284; PMCID: PMC5425629; DOI: 10.1016/j.stemcr.2017.03.016;
Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. PMID: 28351983; PMCID: PMC5379982; DOI: 10.1084/jem.20161616;
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