Dennis Jones, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

PhD, Yale University School of Medicine
BS, Morehouse College

Dennis Jones, PhD is an Assistant Professor of Pathology & Laboratory Medicine at the Chobanian and Avedisian School of Medicine.Our research focuses on understanding how tumors impact the functionality of blood vessels, which are essential for immune cells, such as T cells, to infiltrate tumors. Our previous studies have found that tumors can cause the compression and dysfunction of blood vessels, which ultimately limits T cell entry into the tumor. Therefore, our lab aims to develop approaches to improve vascular function within tumors, with the goal of increasing T cell entry. In combination, we will use immunotherapy to enhance the killing ability of T cells. Currently, we are testing this combination therapy in preclinical models. Our ultimate goal is to improve outcomes for patients with metastatic breast cancer.
Our lab is comprised of a multidisciplinary team of trainees with expertise in cancer biology, immunology, and vascular biology. We employ a range of techniques, including in vitro and in vivo experiments, imaging, and molecular and cellular biology assays, to better understand the complex mechanisms underlying tumor-induced vascular dysfunction and immune suppression.

Diversity, Equity, Inclusion and Accessibility

As a scientist from a historically underrepresented minority group, promoting diversity and inclusion within biomedical research is a deeply ingrained part of my values and mission.
My efforts to expose other underrepresented persons to research began during my graduate studies. Over three years, I co-coordinated an NIH-funded summer research program that was designed to provide research experiences for historically underrepresented minorities. I managed research experiences for 35 of the 70 undergraduates who participated, and 93% of these students went on to graduate from college, with nearly one-quarter pursuing PhD and MD/PhD programs. As a postdoctoral fellow, I spent three summers working with high school and college students enrolled in the NCI’s CURE program at the Dana Farber Cancer Institute. As a faculty member at Boston University, I have continued my commitment to increasing diversity and inclusion by hosting historically underrepresented students in my laboratory through BU STaRS Program, PREP Program, and through the Medical Sciences and Education Department's partnership with local public high schools.
I believe in the importance of Black representation in academia to inspire confidence among trainees of color, and I intentionally maintain visibility through profile features and speaking engagements. I strive to create a more inclusive research culture by fostering a welcoming and encouraging space in my own laboratory where all individuals, including those from historically underrepresented groups, can do great science. While my race adds to the diversity in science, my primary focus and passion is to achieve significant breakthroughs in breast cancer treatment. I hope that my scientific productivity and commitment to diversity and inclusion will inspire other historically underrepresented scientists in their academic pursuits.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston University
BU-BMC Cancer Center

Improving anti-breast cancer immunity by targeting solid stress
07/01/2022 - 06/30/2024 (Subcontract PI)
American Association for Cancer Research Breast Cancer ResFdn

Targeting breast cancer plasticity and immunosuppression in metastatic lymph nodes
07/07/2021 - 07/06/2023 (PI)

Understanding the mechanisms of immune suppression in lymph node metastases
09/30/2018 - 08/31/2022 (PI)
NIH/National Cancer Institute


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Arroyo-Ataz G, Jones D. Dissection of murine collecting lymphatic vessels for imaging, single-cell analysis, and tissue culture of lymphatic muscle cells. STAR Protoc. 2022 Dec 16; 3(4):101800. PMID: 36353362; PMCID: PMC9637822; DOI: 10.1016/j.xpro.2022.101800;
  2. Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP. Solid stress impairs lymphocyte infiltration into lymph-node metastases. Nat Biomed Eng. 2021 12; 5(12):1426-1436.View Related Profiles. PMID: 34282290; PMCID: PMC8678215; DOI: 10.1038/s41551-021-00766-1;
  3. Jana S, Muscarella RA, Jones D. The Multifaceted Effects of Breast Cancer on Tumor-Draining Lymph Nodes. Am J Pathol. 2021 08; 191(8):1353-1363. PMID: 34043978; PMCID: PMC8351123; DOI: 10.1016/j.ajpath.2021.05.006;
  4. Saeboe AM, Nikiforov AY, Toufanian R, Kays JC, Chern M, Casas JP, Han K, Piryatinski A, Jones D, Dennis AM. Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging. Nano Lett. 2021 04 14; 21(7):3271-3279.View Related Profiles. PMID: 33755481; PMCID: PMC8243857; DOI: 10.1021/acs.nanolett.1c00600;
  5. Gustine JN, Jones D. Immunopathology of Hyperinflammation in COVID-19. Am J Pathol. 2021 01; 191(1):4-17. PMID: 32919977; PMCID: PMC7484812; DOI: 10.1016/j.ajpath.2020.08.009;
  6. Jones D. Parallels of Resistance between Angiogenesis and Lymphangiogenesis Inhibition in Cancer Therapy. Cells. 2020 03 20; 9(3). PMID: 32244922; PMCID: PMC7140636; DOI: 10.3390/cells9030762;
  7. Liu T, Li Y, Su H, Zhang H, Jones D, Zhou HJ, Ji W, Min W. Nuclear localization of the tyrosine kinase BMX mediates VEGFR2 expression. J Cell Mol Med. 2020 01; 24(1):126-138. PMID: 31642192; PMCID: PMC6933376; DOI: 10.1111/jcmm.14663;
  8. Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2210-2219.View Related Profiles. PMID: 30659155; PMCID: PMC6369817; DOI: 10.1073/pnas.1818357116;
  9. Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP. Inducible Nitric Oxide Synthase and CD11b+Gr1+ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Lymphat Res Biol. 2019 06; 17(3):294-300. PMID: 30358484; PMCID: PMC6589499; DOI: 10.1089/lrb.2018.0013;
  10. Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. 2018 03 23; 359(6382):1403-1407. PMID: 29567713; PMCID: PMC6002772; DOI: 10.1126/science.aal3622;
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 14 distinct years, with a maximum of 4 publications in 2018


2018 Gordon Research Conference (Lymphatics) Poster Award
2018 Massachusetts General Hospital Outstanding Research Award
2018 NIH Transition Career Development Award (K22)
2017 NIH Future Research Leader
2017 Massachusetts Institute of Technology Rising Star in Biomedical
2015 NIH National Research Service Award (F32) Postdoctoral Fellow
2014 UNCF-Merck Postdoctoral Fellow
2014 Burroughs Wellcome Fund Postdoctoral Enrichment Program Fellow
2012 NIH Institutional Training Grant (T32) Fellow
2008 NIH National Research Service Award (F31) Predoctoral Fellow
2007 Anna Fuller Fellow
2005 Achievement Rewards for College Scientists (ARCS) Scholar
2004 Minority Biomedical Research Support (MBRS) Fellow
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