Daniel Dempsey, PhD
Assistant Professor
Boston University School of Medicine
Dept of Dermatology

PhD, University of South Florida
MS, State University of New York at Oswego




The mission of Prof. Dempsey's lab is to understand the basic biological mechanisms of proteins that are essential to human health and disease. The lab focuses on investigating the structure, function, and regulation of proteins involved in cell signaling, epigenetics, and gene regulation. Prof. Dempsey and his team use chemical, semi-synthetic, biophysical, and cellular approaches to elucidate mechanisms for how post-translational modifications regulate protein function. They are also interested in advancing new chemical strategies to investigate PTMs and protein function.

Prof. Dempsey's current focus is on understanding the function and regulation of deubiquitinases and RNA-modifying proteins, which are emerging as attractive therapeutic targets in several cancers. Their work will shed light on the mechanistic consequence of PTMs, and how dysregulation of these proteins may lead to disease. The team's goal is that these findings will pave the way for the rational design of new therapies for the treatment of cancer.

Assistant Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics




Molecular Mechanisms of PTEN and USP7 Regulation
03/01/2022 - 02/28/2025 (PI)
NIH/National Institute of General Medical Sciences
4R00GM130961-03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 2021 10; 28(10):858-868. PMID: 34625746; PMCID: PMC8549118; DOI: 10.1038/s41594-021-00668-5;
     
  2. Jiang H, Dempsey DR, Cole PA. Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S. Biochemistry. 2021 02 09; 60(5):357-364. PMID: 33470109; PMCID: PMC8262107; DOI: 10.1021/acs.biochem.0c00869;
     
  3. Jiang H, D'Agostino GD, Cole PA, Dempsey DR. Selective protein N-terminal labeling with N-hydroxysuccinimide esters. Methods Enzymol. 2020; 639:333-353. PMID: 32475408; PMCID: PMC7340118; DOI: 10.1016/bs.mie.2020.04.018;
     
  4. Henager SH, Henriquez S, Dempsey DR, Cole PA. Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation. Chembiochem. 2020 01 15; 21(1-2):64-68. PMID: 31206229; PMCID: PMC7012368; DOI: 10.1002/cbic.201900316;
     
  5. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14. PMID: 30078705; PMCID: PMC6139374; DOI: 10.1016/j.cell.2018.07.003;
     
  6. Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA. Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms. J Am Chem Soc. 2018 08 01; 140(30):9374-9378. PMID: 30016585; PMCID: PMC6093203; DOI: 10.1021/jacs.8b05098;
     
  7. Dempsey DR, Cole PA. Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation. Methods Enzymol. 2018; 607:405-422. PMID: 30149868; PMCID: PMC6231048; DOI: 10.1016/bs.mie.2018.05.007;
     
  8. Handa S, Dempsey DR, Ramamoorthy D, Cook N, Guida WC, Spradling TJ, White JK, Woodcock HL, Merkler DJ. Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans. Biochem Mol Biol J. 2018; 4(1). PMID: 29552677; PMCID: PMC5851014; DOI: 10.21767/2471-8084.100051;
     
  9. Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine. Sci Rep. 2017 10 18; 7(1):13432. PMID: 29044148; PMCID: PMC5647378; DOI: 10.1038/s41598-017-13669-6;
     
  10. Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 2017 May 04; 66(3):345-357.e6. PMID: 28475870; PMCID: PMC5489419; DOI: 10.1016/j.molcel.2017.03.020;
     
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 13 distinct years, with a maximum of 6 publications in 2014

YearPublications
19901
20041
20101
20111
20121
20146
20153
20163
20172
20184
20191
20201
20212

2019 Brigham and Women’s Hospital, Boston, MA: Chair’s Research Award
2015 National Institutes of Health: Ruth L. Kirschstein National Research Service Award
2014 University of South Florida, Tampa, FL: Drug Discovery and Infectious Disease Travel Award
2014 University of South Florida, Tampa, FL: Dissertation Completion Fellowship
2014 Steenbock Symposium: Best Poser Prize
2014 International Conference on the Bioscience of Lipids: Travel Grant
2014 International Conference on the Bioscience of Lipids: Young Investigator Award
Boston University School of Medicine: Dahod Pilot Grant
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670 Albany Street
Boston MA 02118
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