Daniel Dempsey, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Dermatology

PhD, University of South Florida
MS, State University of New York at Oswego
BA, State University of New York at Oswego



The mission of Prof. Dempsey's lab is to understand the basic biological mechanisms of proteins that are essential to human health and disease. The lab focuses on investigating the structure, function, and regulation of proteins involved in cell signaling, epigenetics, and gene regulation. Prof. Dempsey and his team use chemical, semi-synthetic, biophysical, and cellular approaches to elucidate mechanisms for how post-translational modifications regulate protein function. They are also interested in advancing new chemical strategies to investigate PTMs and protein function.

Prof. Dempsey's current focus is on understanding the function and regulation of deubiquitinases and RNA-modifying proteins, which are emerging as attractive therapeutic targets in several cancers. Their work will shed light on the mechanistic consequence of PTMs, and how dysregulation of these proteins may lead to disease. The team's goal is that these findings will pave the way for the rational design of new therapies for the treatment of cancer.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics




Molecular mechanisms of RNA methyltransferases.
07/01/2024 - 06/30/2029 (PI)
NIH/National Institute of General Medical Sciences
1R35GM155301-01

Molecular Mechanisms of PTEN and USP7 Regulation
03/01/2022 - 02/28/2025 (PI)
NIH/National Institute of General Medical Sciences
5R00GM130961-05



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Iwase R, Dempsey DR, Whedon SD, Jiang H, Palanski BA, Deng B, Cole PA. Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination. J Am Chem Soc. 2023 Mar 22; 145(11):6039-6044. PMID: 36897111; PMCID: PMC10071500; DOI: 10.1021/jacs.2c13871;
     
  2. Viennet T, Rodriguez Ospina S, Lu Y, Cui A, Arthanari H, Dempsey DR. Chemical and structural approaches to investigate PTEN function and regulation. Methods Enzymol. 2023; 682:289-318.View Related Profiles. PMID: 36948705; PMCID: PMC10037535; DOI: 10.1016/bs.mie.2022.09.007;
     
  3. Viennet T, Rodriguez Ospina S, Lu Y, Cui A, Arthanari H, Dempsey DR. Chemical and structural approaches to investigate PTEN function and regulation. Methods Enzymol. 2023; 682:289-318.View Related Profiles. PMID: 36948705; PMCID: PMC10037535; DOI: 10.1016/bs.mie.2022.09.007;
     
  4. Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 2021 10; 28(10):858-868. PMID: 34625746; PMCID: PMC8549118; DOI: 10.1038/s41594-021-00668-5;
     
  5. Jiang H, Dempsey DR, Cole PA. Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S. Biochemistry. 2021 02 09; 60(5):357-364. PMID: 33470109; PMCID: PMC8262107; DOI: 10.1021/acs.biochem.0c00869;
     
  6. Jiang H, D'Agostino GD, Cole PA, Dempsey DR. Selective protein N-terminal labeling with N-hydroxysuccinimide esters. Methods Enzymol. 2020; 639:333-353. PMID: 32475408; PMCID: PMC7340118; DOI: 10.1016/bs.mie.2020.04.018;
     
  7. Henager SH, Henriquez S, Dempsey DR, Cole PA. Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation. Chembiochem. 2020 01 15; 21(1-2):64-68. PMID: 31206229; PMCID: PMC7012368; DOI: 10.1002/cbic.201900316;
     
  8. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14. PMID: 30078705; PMCID: PMC6139374; DOI: 10.1016/j.cell.2018.07.003;
     
  9. Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA. Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms. J Am Chem Soc. 2018 08 01; 140(30):9374-9378. PMID: 30016585; PMCID: PMC6093203; DOI: 10.1021/jacs.8b05098;
     
  10. Dempsey DR, Cole PA. Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation. Methods Enzymol. 2018; 607:405-422. PMID: 30149868; PMCID: PMC6231048; DOI: 10.1016/bs.mie.2018.05.007;
     
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 15 distinct years, with a maximum of 6 publications in 2014

YearPublications
19901
20041
20101
20111
20121
20146
20153
20163
20172
20184
20191
20201
20212
20221
20231

2019 Brigham and Women’s Hospital, Boston, MA: Chair’s Research Award
2015 National Institutes of Health: Ruth L. Kirschstein National Research Service Award
2014 University of South Florida, Tampa, FL: Drug Discovery and Infectious Disease Travel Award
2014 University of South Florida, Tampa, FL: Dissertation Completion Fellowship
2014 Steenbock Symposium: Best Poser Prize
2014 International Conference on the Bioscience of Lipids: Travel Grant
2014 International Conference on the Bioscience of Lipids: Young Investigator Award
Boston University School of Medicine: Dahod Pilot Grant
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670 Albany Street
Boston MA 02118
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