Chunlei Zheng | Profiles RNS

Chunlei Zheng, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

General Internal Medicine

PhD, Chinese Academy of Sciences
BS, Shaanxi Normal University

Websites

	LinkedIn
	ResearchGate

ORCID : 0000-0002-9737-461X

Chunlei Zheng is an Assistant Professor of Medicine at Chobanian and Avedisian School of Medicine. He is also a Health Science Specialist at VA Boston Healthcare System. Dr. Zheng completed his PhD in Biophysics at Chinese Academy of Sciences. After graduation, he moved to Cleveland Clinic, where he received a postdoctoral fellowship from American Heart Association to study the protein trafficking in human diseases. Before joining Boston University, Dr. Zheng is a research scientist at Case Western Reserve University, where he received intensive biomedical informatics training.

With solid background in biology and medicine and expertise in genomics, computer science, and statistics, Dr. Zheng has great passion for data-driven biomedical discovery. In particular, he has great interest on developing/applying computational algorithm, machine learning and statistical modeling into large-scale biomedical data to facilitate disease understanding and drug discovery. Currently, his research focuses on using artificial intelligence (AI) on Alzheimer’s Disease and Cancer.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Zheng C, Khan A, Ritter D, Marks DS, Do NV, Fillmore NR, Sander C. Pancreatic cancer risk prediction using deep sequential modeling of longitudinal diagnostic and medication records. Cell Rep Med. 2025 Sep 16; 6(9):102359.View Related Profiles.

Zheng, Chunlei
Fillmore, Nathanael

PMID: 40961920; PMCID: PMC12490214; DOI: 10.1016/j.xcrm.2025.102359;

Schuster E, Dashzeveg NK, Tong F, Jia Y, El-Shennawy L, Zhang T, Hoffman AD, Kitata RB, Kibria G, Zhang Y, Squires JR, Zheng C, Ramos E, Taftaf R, Scholten D, Almubarak HF, Adorno-Cruz V, Sullivan DP, Reduzzi C, Minor AC, Purev-Ochir W, Spahija S, Xu R, Siziopikou KP, Platanias LC, Shah A, Muller WA, Gradishar WJ, Cristofanilli M, Tsai CF, Shi T, Liu H. Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis. Nat Commun. 2025 Aug 16; 16(1):7649. PMID: 40818975; PMCID: PMC12357858; DOI: 10.1038/s41467-025-62862-z;

Larsen JR, Zheng C, La J, Wu JT, Kelley M, Gaziano JM, Brophy M, Do NV, Kim DH, Driver JA, DuMontier C, Fillmore NR. Multimorbidity and Its Impact in Older U.S. Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer. Ann Am Thorac Soc. 2025 Apr; 22(4):598-608.View Related Profiles.

Zheng, Chunlei
Gaziano, J. Michael
La, Jennifer
Brophy, Mary
Fillmore, Nathanael

PMID: 39680869; PMCID: PMC12005025; DOI: 10.1513/AnnalsATS.202406-587OC;

Pu JJ, Berger KN, Zheng C, Do N, Claxton DF, Ehmann WC, Drabick JJ, Li H, Loughran TP, Epner EM. A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma. Front Oncol. 2024; 14:1449401. PMID: 39737396; PMCID: PMC11683081; DOI: 10.3389/fonc.2024.1449401;

Ramos-Cejudo J, Corrigan JK, Zheng C, Swinnerton KN, Jacobson SR, La J, Betensky RA, Osorio RS, Madanes S, Pomara N, Iosifescu D, Brophy M, Do NV, Fillmore NR. Antidepressant exposure and long-term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder. Alzheimers Dement. 2024 Jun; 20(6):4106-4114.View Related Profiles.

Zheng, Chunlei
La, Jennifer
Brophy, Mary
Fillmore, Nathanael

PMID: 38717046; PMCID: PMC11180845; DOI: 10.1002/alz.13853;

Do NV, Elbers DC, Fillmore NR, Ajjarapu S, Bergstrom SJ, Bihn J, Corrigan JK, Dhond R, Dipietro S, Dolgin A, Feldman TC, Goryachev SD, Huhmann LB, La J, Marcantonio PA, McGrath KM, Miller SJ, Nguyen VQ, Schneeloch GR, Sung FC, Swinnerton KN, Tarren AH, Tosi HM, Valley D, Vo AD, Yildirim C, Zheng C, Zwolinski R, Sarosy GA, Loose D, Shannon C, Brophy MT. Matching Patients to Accelerate Clinical Trials (MPACT): Enabling Technology for Oncology Clinical Trial Workflow. Stud Health Technol Inform. 2024 Jan 25; 310:1086-1090.View Related Profiles.

Zheng, Chunlei
Elbers, Danne
La, Jennifer
Brophy, Mary
Fillmore, Nathanael
Ajjarapu, Samuel

PMID: 38269982; PMCID: PMC11128308; DOI: 10.3233/SHTI231132;

Chen C, Luo L, Zheng C, Ding P, Liu H, Luo H. Self-prediction of relations in GO facilitates its quality auditing. J Biomed Inform. 2023 Aug; 144:104441. PMID: 37437682

Placido D, Yuan B, Hjaltelin JX, Zheng C, Haue AD, Chmura PJ, Yuan C, Kim J, Umeton R, Antell G, Chowdhury A, Franz A, Brais L, Andrews E, Marks DS, Regev A, Ayandeh S, Brophy MT, Do NV, Kraft P, Wolpin BM, Rosenthal MH, Fillmore NR, Brunak S, Sander C. A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories. Nat Med. 2023 May; 29(5):1113-1122.View Related Profiles.

Zheng, Chunlei
Brophy, Mary
Fillmore, Nathanael
Van Do, Nhan

PMID: 37156936; PMCID: PMC10202814; DOI: 10.1038/s41591-023-02332-5;

Ramos-Cejudo J, Johnson AD, Beiser A, Seshadri S, Salinas J, Berger JS, Fillmore NR, Do N, Zheng C, Kovbasyuk Z, Ardekani BA, Nunzio P, Bubu OM, Parekh A, Convit A, Betensky RA, Wisniewski TM, Osorio RS. Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study. J Am Heart Assoc. 2022 May 03; 11(9):e023918.View Related Profiles.

Beiser, Alexa
Zheng, Chunlei
Fillmore, Nathanael
Seshadri, Sudha

PMID: 35470685; PMCID: PMC9238609; DOI: 10.1161/JAHA.121.023918;

Zhang Y, Zhu M, Zheng C, Wei W, Emmer BT, Zhang B. LMAN1-MCFD2 complex is a cargo receptor for the ER-Golgi transport of a1-antitrypsin. Biochem J. 2022 Apr 14; 479(7):839-855. PMID: 35322856; PMCID: PMC9022998; DOI: 10.1042/BCJ20220055;

Showing 10 of 40 results. Show More

Li LL, Zheng C, La J, Do NV, Monach PA, Strymish JM, Fillmore NR, Branch-Elliman W. Impact of prior SARS-CoV-2 infection on incidence of hospitalization and adverse events following mRNA SARS-CoV-2 vaccination: A nationwide, retrospective cohort study. Vaccine. 2022 02 16; 40(8):1082-1089.View Related Profiles.

Zheng, Chunlei
La, Jennifer
Fillmore, Nathanael
Branch-Elliman, Westyn

PMID: 35078665; PMCID: PMC8768509; DOI: 10.1016/j.vaccine.2022.01.026;

Fillmore NR, La J, Zheng C, Doron S, Do NV, Monach PA, Branch-Elliman W. The COVID-19 hospitalization metric in the pre- and postvaccination eras as a measure of pandemic severity: A retrospective, nationwide cohort study. Infect Control Hosp Epidemiol. 2022 Dec; 43(12):1767-1772.View Related Profiles.

Zheng, Chunlei
La, Jennifer
Fillmore, Nathanael
Van Do, Nhan
Branch-Elliman, Westyn

PMID: 35012694; PMCID: PMC9021586; DOI: 10.1017/ice.2022.13;

Ramos-Cejudo J, Johnson AD, Beiser A, Seshadri S, Salinas J, Berger JS, Fillmore NR, Do N, Zheng C, Kovbasyuk Z, Ardekani BA, Bubu OM, Parekh A, Convit A, Betensky RA, Wisniewski TM, Osorio RS. The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study. Front Aging Neurosci. 2021; 13:773984.View Related Profiles.

Beiser, Alexa
Zheng, Chunlei
Fillmore, Nathanael
Van Do, Nhan
Seshadri, Sudha

PMID: 34916927; PMCID: PMC8670436; DOI: 10.3389/fnagi.2021.773984;

Zheng C, Fillmore NR, Ramos-Cejudo J, Brophy M, Osorio R, Gurney ME, Qiu WQ, Au R, Perry G, Dubreuil M, Chen SG, Qi X, Davis PB, Do N, Xu R. Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans. Alzheimers Dement. 2022 Jun; 18(6):1248-1259.View Related Profiles.

Zheng, Chunlei
Brophy, Mary
Dubreuil, Maureen
Fillmore, Nathanael
Van Do, Nhan
Au, Rhoda
Qiu, Wendy

PMID: 34569707; PMCID: PMC8957621; DOI: 10.1002/alz.12465;

Zheng C, Xu R. Molecular subtyping of Alzheimer's disease with consensus non-negative matrix factorization. PLoS One. 2021; 16(5):e0250278. PMID: 34014928; PMCID: PMC8136734; DOI: 10.1371/journal.pone.0250278;

Wang Q, Li Y, Zheng C, Xu R. DenseCNN: A Densely Connected CNN Model for Alzheimer's Disease Classification Based on Hippocampus MRI Data. AMIA Annu Symp Proc. 2020; 2020:1277-1286. PMID: 33936504; PMCID: PMC8075423

Zhou M, Wang Q, Zheng C, John Rush A, Volkow ND, Xu R. Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses. Mol Psychiatry. 2021 09; 26(9):5286-5296. PMID: 33432189; PMCID: PMC7797705; DOI: 10.1038/s41380-020-01011-y;

Zheng C, Berger NA, Li L, Xu R. Epigenetic age acceleration and clinical outcomes in gliomas. PLoS One. 2020; 15(7):e0236045. PMID: 32692766; PMCID: PMC7373289; DOI: 10.1371/journal.pone.0236045;

Zhou M, Zheng C, Xu R. Combining phenome-driven drug-target interaction prediction with patients' electronic health records-based clinical corroboration toward drug discovery. Bioinformatics. 2020 07 01; 36(Suppl_1):i436-i444. PMID: 32657406; PMCID: PMC7355254; DOI: 10.1093/bioinformatics/btaa451;

Zheng C, Xu R. Predicting cancer origins with a DNA methylation-based deep neural network model. PLoS One. 2020; 15(5):e0226461. PMID: 32384093; PMCID: PMC7209244; DOI: 10.1371/journal.pone.0226461;

Conic RR, Damiani G, Schrom KP, Ramser AE, Zheng C, Xu R, McCormick TS, Cooper KD. Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume. J Clin Med. 2020 Jan 09; 9(1). PMID: 31936662; PMCID: PMC7019311; DOI: 10.3390/jcm9010186;

Zheng C, Li L, Xu R. Association of Epigenetic Clock with Consensus Molecular Subtypes and Overall Survival of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2019 10; 28(10):1720-1724. PMID: 31375479; PMCID: PMC6774810; DOI: 10.1158/1055-9965.EPI-19-0208;

Luo L, Zheng C, Wang J, Tan M, Li Y, Xu R. Analysis of disease organ as a novel phenotype towards disease genetics understanding. J Biomed Inform. 2019 07; 95:103235. PMID: 31207382; PMCID: PMC6644057; DOI: 10.1016/j.jbi.2019.103235;

Zheng C, Xu R. Large-scale mining disease comorbidity relationships from post-market drug adverse events surveillance data. BMC Bioinformatics. 2018 Dec 28; 19(Suppl 17):500. PMID: 30591027; PMCID: PMC6309066; DOI: 10.1186/s12859-018-2468-8;

Zheng C, Xu R. The Alzheimer's comorbidity phenome: mining from a large patient database and phenome-driven genetics prediction. JAMIA Open. 2019 Apr; 2(1):131-138. PMID: 30944912; PMCID: PMC6434979; DOI: 10.1093/jamiaopen/ooy050;

Zhu M, Zheng C, Wei W, Everett L, Ginsburg D, Zhang B. Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo. Blood Adv. 2018 05 08; 2(9):1014-1021. PMID: 29735583; PMCID: PMC5942004; DOI: 10.1182/bloodadvances.2018018317;

Nagaraj AB, Wang QQ, Joseph P, Zheng C, Chen Y, Kovalenko O, Singh S, Armstrong A, Resnick K, Zanotti K, Waggoner S, Xu R, DiFeo A. Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment. Oncogene. 2018 01 18; 37(3):403-414. PMID: 28967908; PMCID: PMC5799769; DOI: 10.1038/onc.2017.328;

Cai X, Chen Y, Zheng C, Xu R. Interrogating Patient-level Genomics and Mouse Phenomics towards Understanding Cytokines in Colorectal Cancer Metastasis. AMIA Jt Summits Transl Sci Proc. 2017; 2017:227-236. PMID: 28815134; PMCID: PMC5543389

Wei W, Zheng C, Zhu M, Zhu X, Yang R, Misra S, Zhang B. Missense mutations near the N-glycosylation site of the A2 domain lead to various intracellular trafficking defects in coagulation factor VIII. Sci Rep. 2017 03 22; 7:45033. PMID: 28327546; PMCID: PMC5361195; DOI: 10.1038/srep45033;

Klaus JP, Eisenhauer P, Russo J, Mason AB, Do D, King B, Taatjes D, Cornillez-Ty C, Boyson JE, Thali M, Zheng C, Liao L, Yates JR, Zhang B, Ballif BA, Botten JW. The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles. Cell Host Microbe. 2013 Nov 13; 14(5):522-34. PMID: 24237698; PMCID: PMC3999090; DOI: 10.1016/j.chom.2013.10.010;

Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. Semin Thromb Hemost. 2013 Sep; 39(6):613-20. PMID: 23852824; PMCID: PMC4446966; DOI: 10.1055/s-0033-1349223;

Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B. Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII). J Biol Chem. 2013 Jul 12; 288(28):20499-509. PMID: 23709226; PMCID: PMC3711315; DOI: 10.1074/jbc.M113.461434;

Zhu M, DAS V, Zheng C, Majumdar S, Zhang B. A synonymous mutation in LMAN1 creates an ectopic splice donor site and causes combined deficiency of FV and FVIII. J Thromb Haemost. 2012 Nov; 10(11):2407-9. PMID: 23006835; PMCID: PMC3563766; DOI: 10.1111/jth.12002;

Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of a1-antitrypsin. Blood. 2011 Sep 22; 118(12):3384-91. PMID: 21795745; PMCID: PMC3179404; DOI: 10.1182/blood-2011-05-352815;

Zheng C, Liu HH, Yuan S, Zhou J, Zhang B. Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII. Blood. 2010 Dec 16; 116(25):5698-706. PMID: 20817851; PMCID: PMC3031414; DOI: 10.1182/blood-2010-04-278325;

Zheng C, Liu HH, Zhou J, Zhang B. EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII. Blood. 2010 Feb 04; 115(5):1081-7. PMID: 20007547; PMCID: PMC2817634; DOI: 10.1182/blood-2009-09-241877;

Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EG, Seligsohn U, Peyvandi F, Ginsburg D. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. Blood. 2008 Jun 15; 111(12):5592-600. PMID: 18391077; PMCID: PMC2424156; DOI: 10.1182/blood-2007-10-113951;

Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H, Shen X. MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27. J Biol Chem. 2006 Dec 01; 281(48):37215-26. PMID: 17015449; DOI: 10.1074/jbc.M603622200;

Chen H, Zheng C, Zhang Y, Chang YZ, Qian ZM, Shen X. Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake. Int J Biochem Cell Biol. 2006; 38(8):1402-16. PMID: 16546437; DOI: 10.1016/j.biocel.2006.02.006;

Shen X, Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H. Biophotonics-Optical Science and Engineering for 21st Century. Fluorescence Resonance Energy transfer (FRET) study on protein-protein interaction in single living cells. Springer. New York, NY. 2005.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 17 distinct years, with a maximum of 5 publications in 2021

Bar chart showing 40 publications over 17 distinct years, with a maximum of 5 publications in 2021

Year	Publications
2005	1
2006	2
2008	1
2009	1
2010	1
2011	1
2012	1
2013	3
2017	3
2018	3
2019	2
2020	4
2021	5
2022	4
2023	2
2024	3
2025	3

2010-2012 American Heart Association: Postdoctoral fellowship

2010 51st American Society Cell Biology annual meeting, Philadelphia, PA: Travel award for poster presentation

2009 50th American Society of Hematology annual meeting, New Orleans, LA: Travel award for poster presentation

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Artificial Intelligence
Statistical Model
Alzheimer's Disease
Cancer

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