1. Microenvironment in Tissue Regeneration

Focus: Analysis of the microenvironment around biosynthetic scaffolds during skin wound healing and its influence on cellular behavior and tissue regeneration.
Key Studies: Dissecting the role of microenvironment factors in wound healing and evaluating how biosynthetic materials interact with the host tissue.

2. Single-Cell Sequencing and Spatial Transcriptomics

Focus: Utilizing advanced sequencing technologies to study aging markers and immune system alterations, aiming to improve understanding of wound healing processes in elderly populations.
Key Studies: Employing single-cell RNA sequencing and spatial transcriptomics to map expression patterns and identify therapeutic targets for enhancing wound repair.

3. Bone Regeneration and Wound Healing

Focus: Development and evaluation of biomaterials such as collagen membranes, particularly those modified with epigallocatechin-3-gallate (EGCG), for enhancing bone regeneration and wound healing.
Key Studies: Investigation of collagen membranes' efficacy in guided bone regeneration and their impact on macrophage phenotypes and immune responses.

4. Immune Response Modulation

Focus: Understanding how different materials and their modifications affect immune responses, specifically the polarization of macrophages and inflammatory reactions.
Key Studies: Modulation of foreign body reactions through material properties and assessment of macrophage recruitment and polarization in response to modified scaffolds.

5. Clinical Applications and Translational Research

Focus: Bridging experimental research with clinical applications, including the development of advanced dental materials and surgical techniques for improved patient outcomes.
Key Studies: Application of research findings to optimize clinical materials and procedures, enhancing the efficacy and safety of treatments in regenerative medicine.