Assen Marintchev | Profiles RNS

Assen G. Marintchev, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, University of Connecticut
MS, Sofia University
BS, Sofia University

Websites

	Pharmacology, Physiology & Biophysics Faculty
	LinkedIn
	ResearchGate

ORCID : 0000-0002-9901-3500

Assen Marintchev, PhD, Physiology & Biophysics, is a scientist whose long-standing objective has been to provide a detailed structural and dynamic picture of the protein translation initiation in human cells, and its regulation. These interactions and the mechanisms they entail underlie pathological processes disrupting the integrated stress response, which, in turn, leads to a wide range of diseases, and neurodegenerative disorders in particular. His current research builds on his prior training to study the structure and dynamics of translation initiation complexes and involves his extensive training in NMR methodology and state-of-the-art understanding of biophysical chemistry.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Mechanisms of action of human translation initiation factors and their regulation
09/01/2020 - 08/31/2024 (PI)
NIH/National Institute of General Medical Sciences
5R01GM134113-04

Mechanisms of assembly and remodeling of human translation initiation complexes
09/25/2011 - 08/31/2017 (PI)
NIH/National Institute of General Medical Sciences
5R01GM095720-05

Design of target-specific libraries for fragment based drug discovery
06/01/2016 - 05/31/2017 (Subcontract PI)
Acpharis, Inc. NIH NIGMS
1R43GM119901-01

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Mechanisms of action of human translation initiation factors and their regulation	5R01GM134113-04
2022	Mechanisms of action of human translation initiation factors and their regulation	5R01GM134113-03
2021	Mechanisms of action of human translation initiation factors and their regulation	5R01GM134113-02
2020	Mechanisms of action of human translation initiation factors and their regulation	1R01GM134113-01A1
2015	Mechanisms of assembly and remodeling of human translation initiation complexes	5R01GM095720-05	11
2014	Mechanisms of assembly and remodeling of human translation initiation complexes	5R01GM095720-04	11
2013	Mechanisms of assembly and remodeling of human translation initiation complexes	5R01GM095720-03	11
2012	Mechanisms of assembly and remodeling of human translation initiation complexes	5R01GM095720-02	11
2011	Mechanisms of assembly and remodeling of human translation initiation complexes	1R01GM095720-01	11
2010	Regulation of translation through the human translation initiation factor eIF5B	5K01CA119107-06	6

Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Gamble N, Paul EE, Anand B, Marintchev A. Regulation of the interactions between human eIF5 and eIF1A by the CK2 kinase. Curr Res Struct Biol. 2022; 4:308-319. PMID: 36164648; PMCID: PMC9508154; DOI: 10.1016/j.crstbi.2022.09.003;

Paul EE, Marintchev A. The PCI domains are "winged" HEAT domains. PLoS One. 2022; 17(9):e0268664. PMID: 36094910; PMCID: PMC9467303; DOI: 10.1371/journal.pone.0268664;

Friedrich D, Marintchev A, Arthanari H. The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation. Nucleic Acids Res. 2022 Jun 10; 50(10):5424-5442. PMID: 35552740; PMCID: PMC9177959; DOI: 10.1093/nar/gkac342;

Paul EE, Lin KY, Gamble N, Tsai AW, Swan SHK, Yang Y, Doran M, Marintchev A. Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5. Biophys Chem. 2022 02; 281:106740. PMID: 34923394; PMCID: PMC8741751; DOI: 10.1016/j.bpc.2021.106740;

Marintchev A, Ito T. eIF2B and the Integrated Stress Response: A Structural and Mechanistic View. Biochemistry. 2020 04 07; 59(13):1299-1308. PMID: 32200625; PMCID: PMC7189779; DOI: 10.1021/acs.biochem.0c00132;

Lin KY, Nag N, Pestova TV, Marintchev A. Human eIF5 and eIF1A Compete for Binding to eIF5B. Biochemistry. 2018 10 09; 57(40):5910-5920. PMID: 30211544; PMCID: PMC6177315; DOI: 10.1021/acs.biochem.8b00839;

Yu J, Marintchev A. Comparative sequence and structure analysis of eIF1A and eIF1AD. BMC Struct Biol. 2018 09 04; 18(1):11. PMID: 30180896; PMCID: PMC6122471; DOI: 10.1186/s12900-018-0091-6;

Bogorad AM, Lin KY, Marintchev A. eIF2B Mechanisms of Action and Regulation: A Thermodynamic View. Biochemistry. 2018 03 06; 57(9):1426-1435.View Related Profiles.

Bogorad, Andrew
Marintchev, Assen

PMID: 29425030; PMCID: PMC5840040; DOI: 10.1021/acs.biochem.7b00957;

Bogorad AM, Lin KY, Marintchev A. Novel mechanisms of eIF2B action and regulation by eIF2a phosphorylation. Nucleic Acids Res. 2017 Nov 16; 45(20):11962-11979.View Related Profiles.

Bogorad, Andrew
Marintchev, Assen

PMID: 29036434; PMCID: PMC5714165; DOI: 10.1093/nar/gkx845;

Nag N, Lin KY, Edmonds KA, Yu J, Nadkarni D, Marintcheva B, Marintchev A. eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling. Nucleic Acids Res. 2016 Sep 06; 44(15):7441-56. PMID: 27325746; PMCID: PMC5009744; DOI: 10.1093/nar/gkw552;

Showing 10 of 41 results. Show More

Bogorad AM, Xia B, Sandor DG, Mamonov AB, Cafarella TR, Jehle S, Vajda S, Kozakov D, Marintchev A. Insights into the architecture of the eIF2Ba/ß/d regulatory subcomplex. Biochemistry. 2014 Jun 3; 53(21):3432-45.View Related Profiles.

Bogorad, Andrew
Marintchev, Assen
Sandor, Dana
Vajda, Sandor

PMID: 24811713; PMCID: PMC4045321; DOI: 10.1021/bi500346u;

Marintchev A. Roles of helicases in translation initiation: a mechanistic view. Biochim Biophys Acta. 2013 Aug; 1829(8):799-809. PMID: 23337854; PMCID: PMC3640703; DOI: 10.1016/j.bbagrm.2013.01.005;

Marintchev, A. In: Dinman, J.D. (Ed.) Biophysical approaches to translational control of gene expression. Methods for studying the interactions of translation factors with the ribosome. Springer. New York, NY. 2013; 1:pp 83-101. View Publication

Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G. The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2ß. Cell Rep. 2012 Jun 28; 1(6):689-702. PMID: 22813744; PMCID: PMC3401385; DOI: 10.1016/j.celrep.2012.04.007;

Marintchev A. Fidelity and quality control in gene expression. Preface. Adv Protein Chem Struct Biol. 2012; 86:ix. PMID: 22243586; DOI: 10.1016/B978-0-12-386497-0.00013-X;

Yu Y, Abaeva IS, Marintchev A, Pestova TV, Hellen CU. Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors. Nucleic Acids Res. 2011 Jun; 39(11):4851-65. PMID: 21306989; PMCID: PMC3113573; DOI: 10.1093/nar/gkr045;

Abaeva IS, Marintchev A, Pisareva VP, Hellen CU, Pestova TV. Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning. EMBO J. 2011 Jan 5; 30(1):115-29. PMID: 21113134; PMCID: PMC3020121; DOI: 10.1038/emboj.2010.302;

Yu Y, Marintchev A, Kolupaeva VG, Unbehaun A, Veryasova T, Lai SC, Hong P, Wagner G, Hellen CU, Pestova TV. Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing. Nucleic Acids Res. 2009 Aug; 37(15):5167-82. PMID: 19561193; PMCID: PMC2731904; DOI: 10.1093/nar/gkp519;

Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G. Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell. 2009 Feb 6; 136(3):447-60.View Related Profiles.

Marintchev, Assen
Edmonds, Katherine

PMID: 19203580; PMCID: PMC2656774; DOI: 10.1016/j.cell.2009.01.014;

Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A. 2008 Mar 4; 105(9):3274-9.View Related Profiles.

Marintchev, Assen
Edmonds, Katherine

PMID: 18296639; PMCID: PMC2265113; DOI: 10.1073/pnas.0712235105;

Lindqvist L, Oberer M, Reibarkh M, Cencic R, Bordeleau ME, Vogt E, Marintchev A, Tanaka J, Fagotto F, Altmann M, Wagner G, Pelletier J. Selective pharmacological targeting of a DEAD box RNA helicase. PLoS One. 2008; 3(2):e1583. PMID: 18270573; PMCID: PMC2216682; DOI: 10.1371/journal.pone.0001583;

Marintcheva B, Marintchev A, Wagner G, Richardson CC. Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1855-60. PMID: 18238893; PMCID: PMC2538852; DOI: 10.1073/pnas.0711919105;

Unbehaun A, Marintchev A, Lomakin IB, Didenko T, Wagner G, Hellen CU, Pestova TV. Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing. EMBO J. 2007 Jul 11; 26(13):3109-23. PMID: 17568775; PMCID: PMC1914099; DOI: 10.1038/sj.emboj.7601751;

Marintchev A, Frueh D, Wagner G. NMR methods for studying protein-protein interactions involved in translation initiation. Methods Enzymol. 2007; 430:283-331. PMID: 17913643

Gelev V, Aktas H, Marintchev A, Ito T, Frueh D, Hemond M, Rovnyak D, Debus M, Hyberts S, Usheva A, Halperin J, Wagner G. Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol. 2006 Dec 1; 364(3):352-63. PMID: 17011579; PMCID: PMC3622519; DOI: 10.1016/j.jmb.2006.08.077;

Yamamoto Y, Singh CR, Marintchev A, Hall NS, Hannig EM, Wagner G, Asano K. The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16164-9. PMID: 16254050; PMCID: PMC1283452; DOI: 10.1073/pnas.0507960102;

Marintchev A, Wagner G. eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G. Biochemistry. 2005 Sep 20; 44(37):12265-72. PMID: 16156639

Oberer M, Marintchev A, Wagner G. Structural basis for the enhancement of eIF4A helicase activity by eIF4G. Genes Dev. 2005 Sep 15; 19(18):2212-23. PMID: 16166382; PMCID: PMC1221891; DOI: 10.1101/gad.1335305;

Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep; 12(9):1693-704. PMID: 15341733

Marintchev A, Wagner G. Translation initiation: structures, mechanisms and evolution. Q Rev Biophys. 2004 Aug-Nov; 37(3-4):197-284. PMID: 16194295

Lomakin IB, Kolupaeva VG, Marintchev A, Wagner G, Pestova TV. Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Genes Dev. 2003 Nov 15; 17(22):2786-97. PMID: 14600024; PMCID: PMC280627

Marintchev A, Kolupaeva VG, Pestova TV, Wagner G. Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1535-40. PMID: 12569173; PMCID: PMC149867

Marintchev A, Gryk MR, Mullen GP. Site-directed mutagenesis analysis of the structural interaction of the single-strand-break repair protein, X-ray cross-complementing group 1, with DNA polymerase beta. Nucleic Acids Res. 2003 Jan 15; 31(2):580-8. PMID: 12527765; PMCID: PMC140523

Gryk MR, Marintchev A, Maciejewski MW, Robertson A, Wilson SH, Mullen GP. Mapping of the interaction interface of DNA polymerase beta with XRCC1. Structure. 2002 Dec; 10(12):1709-20. PMID: 12467578

Maciejewski MW, Shin R, Pan B, Marintchev A, Denninger A, Mullen MA, Chen K, Gryk MR, Mullen GP. Solution structure of a viral DNA repair polymerase. Nat Struct Biol. 2001 Nov; 8(11):936-41. PMID: 11685238

Pan B, Maciejewski MW, Marintchev A, Mullen GP. Solution structure of the catalytic domain of gammadelta resolvase. Implications for the mechanism of catalysis. J Mol Biol. 2001 Jul 27; 310(5):1089-107. PMID: 11501998

Wu H, Maciejewski MW, Marintchev A, Benashski SE, Mullen GP, King SM. Solution structure of a dynein motor domain associated light chain. Nat Struct Biol. 2000 Jul; 7(7):575-9. PMID: 10876244

Marintchev A, Robertson A, Dimitriadis EK, Prasad R, Wilson SH, Mullen GP. Domain specific interaction in the XRCC1-DNA polymerase beta complex. Nucleic Acids Res. 2000 May 15; 28(10):2049-59. PMID: 10773072; PMCID: PMC105377

Marintchev A, Mullen MA, Maciejewski MW, Pan B, Gryk MR, Mullen GP. Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nat Struct Biol. 1999 Sep; 6(9):884-93. PMID: 10467102

Marintchev A, Maciejewski MW, Mullen GP. 1H, 15N, and 13C resonance assignments for the N-terminal 20 kDa domain of the DNA single-strand break repair protein XRCC1. J Biomol NMR. 1999 Apr; 13(4):393-4. PMID: 10353199

Marintchev A, Mirtcheva J, Sidjimov A, Haimova M. Induction of lymphoproliferative popliteal lymph node reaction by hydantoin derivatives: structure-activity relationships. Int J Immunopharmacol. 1995 Dec; 17(12):981-4. PMID: 8964657

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 23 distinct years, with a maximum of 3 publications in 2003 and 2005 and 2008 and 2018 and 2022

Bar chart showing 41 publications over 23 distinct years, with a maximum of 3 publications in 2003 and 2005 and 2008 and 2018 and 2022

Year	Publications
1995	1
1999	2
2000	2
2001	2
2002	1
2003	3
2004	2
2005	3
2006	1
2007	2
2008	3
2009	2
2010	1
2011	1
2012	2
2013	2
2014	1
2016	1
2017	1
2018	3
2020	1
2021	1
2022	3

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bioinformatics
Fluorescence anisotropy
FRET
NMR
Protein structure
Translation

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