Alexander Marzilli, PhD
Postdoctoral Researcher
Boston University College of Engineering

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I’m a synthetic biologist and biomolecular engineer passionate about understanding and engineering biology from molecular mechanisms to cellular systems. My work spans multiple disciplines, with strong expertise in nucleic acid engineering, protein design, and synthetic biology. As an NSF Graduate Research Fellow and now a postdoctoral researcher, I’ve developed novel mRNA circuits using custom, modular allosteric regulatory proteins, as well as conditionally stable RNA-binding proteins for live-cell imaging. I’ve co-authored multiple publications and patents, mentored emerging scientists, and presented research at leading conferences. I’m especially motivated by building tools that bridge molecular design and cellular function, with the potential to advance both fundamental discovery and therapeutic innovation.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Tran JC, Kuffner CJ, Marzilli AM, Miller RE, Silfen ZE, McMahan JB, Sloas DC, Chen CS, Ngo JT. Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues. Nat Commun. 2025 Jan 20; 16(1):852.View Related Profiles. PMID: 39833147; PMCID: PMC11756391; DOI: 10.1038/s41467-025-56148-7;
     
  2. Kuffner CJ, Marzilli AM, Ngo JT. RNA-Stabilized Coat Proteins for Sensitive and Simultaneous Imaging of Distinct Single mRNAs in Live Cells. bioRxiv. 2024 Nov 21.View Related Profiles. PMID: 39605486; PMCID: PMC11601628; DOI: 10.1101/2024.11.21.624393;
     
  3. Tran JC, Kuffner CJ, Marzilli AM, Miller RE, Silfen ZE, McMahan JB, Sloas DC, Chen CS, Ngo JT. Fluorescein-Based SynNotch Adaptors for Regulating Gene Expression Responses to Diverse Extracellular Cues. bioRxiv. 2024 Jun 12.View Related Profiles. PMID: 38915575; PMCID: PMC11195177; DOI: 10.1101/2024.06.12.598538;
     
  4. Sloas DC, Tran JC, Marzilli AM, Ngo JT. Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection. Nat Biotechnol. 2023 Sep; 41(9):1287-1295.View Related Profiles. PMID: 36646932; PMCID: PMC10499187; DOI: 10.1038/s41587-022-01638-y;
     
  5. Marzilli AM, McMahan JB, Ngo JT. Precision control of intrabodies in live cells. Nat Methods. 2020 03; 17(3):259-260.View Related Profiles. PMID: 32076290; DOI: 10.1038/s41592-020-0767-2;
     
  6. Spirito CM, Marzilli AM, Angenent LT. Higher Substrate Ratios of Ethanol to Acetate Steered Chain Elongation toward n-Caprylate in a Bioreactor with Product Extraction. Environ Sci Technol. 2018 Nov 20; 52(22):13438-13447. PMID: 30335369; DOI: 10.1021/acs.est.8b03856;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2024

YearPublications
20181
20201
20231
20242
20251

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