L. Adrienne Cupples, PhD
Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MA, Boston University




L. Adrienne Cupples, Ph.D. is Professor of Biostatistics and of Epidemiology. She has a long standing interest in statistical methods for epidemiologic studies, for survival data analysis and for genetic epidemiology. She has taught for thirty years at both the introductory and advanced levels. She developed several of the courses in the Biostatistics curriculum, including Statistical Methods for Epidemiology (BS852) and has received numerous teaching awards, including the Norman A Scotch Award for Excellence in Teaching at the School of Public Health. For her efforts in research she received the BUSPH Faculty Career Award in Research & Scholarship as the First Recipient. And she received the Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences as the ninth recipient in 2010 and the 2012 L. Adrienne Cupples Award for Excellence in Teaching, Research and Service in Biostatistics. In 2014 she received the AHA Richard Remington Lecturer and in 2017 she received the International Genetic Epidemiology Society Leadership Award. She has collaborated in the Framingham Heart Study for more than 30 years on a variety of topics from risk factors for sudden death, nutritional epidemiology and most recently the genetic etiology of cardiovascular disease and its risk factors. She has served as Co-Principal Investigator of the NHLBI Contract to Boston University for the Framingham Heart Study and Co-Chair of the Framingham Genetics Steering Committee. She also has a long history with the study of the genetic etiology of Alzheimer’s disease in the MIRAGE Study (Multi-Institutional Research of Alzheimer’s Genetic Epidemiology) and of Huntington disease. She has been actively involved in genetic risk prediction and evaluation of how people interpret and respond to such predictions, particularly in the context of Alzheimer's disease through the REVEAL (Risk Evaluation and Education for Alzheimer's Disease) Study. She has directly mentored 15 students on their doctoral research and has served on many thesis committees.

Professor
Boston University School of Public Health
Epidemiology


Investigator
Framingham Heart Study


Boston Medical Center


Member
Boston University
Genome Science Institute



2017 International Genetic Epidemiology Society : International Genetic Epidemiology Society Leadership Award
2014 American Heart Association: EPI/NPAM 2014 Richard Remington Lecturer
2012 Boston University, Department of Biostatistics, School of Public Health: L. Adrienne Cupples Award for Excellence in Teaching, Research, and Service in Biostatistics
2010 Boston University School of Public Health: Faculty Career Award in Research & Scholarship, First Recipient
2010 University of Alabama: Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences, 9th award
2007 National U of Singapore: Visiting Professor
2006 University of Leeds, UK: Visiting Professor
1995 Boston University School of Public Health: Norman Scotch Award for Excellence in Teaching


Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals(REVEAL 5)
08/20/2015 - 05/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
3RF1AG047866-01A1S4

Mechanism and Clinical Importance of Hyperkyphosis: The Framingham Study
09/30/2011 - 05/31/2017 (Subcontract PI)
Hebrew Rehabilitation Center For Aged, Inc. NIH NIA
5R01AG041658-04

DCC Supplement for Rare Variants and NHLBI Traits
04/01/2015 - 03/31/2017 (Subcontract PI)
University of Washington NIH NHLBI
5R01HL120393-03

Whole Genome Sequence Imputation in Families for Echocardiographic Traits
09/20/2013 - 07/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R21HL121589-02

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2015 - 03/31/2016 (Subcontract PI)
University of Washington NIH NHLBI
5R01HL120393-02

A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular Traits
01/01/2015 - 12/31/2015 (Subcontract PI)
The Washington University NIH NHLBI
5R01HL118305-02

Interdisciplinary Training for Biostatisticians
07/01/2010 - 06/30/2015 (PI of Sub-Project / SP)
PI: Paola Sebastiani, PhD
NIH/National Institute of General Medical Sciences
5T32GM074905-10

The Role of Eicosanoids in Renal Function Project 5: Human Hypertension and P450 Omega/Omega-1 Hydroxylases and Epoxygenases
07/01/2009 - 06/30/2015 (Subcontract PI)
Vanderbilt University NIH NIDDK
3P01DK038226-27S1

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2014 - 03/31/2015 (Subcontract PI)
University of Washington NIH NHLBI
1R01HL120393-01A1

A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular Traits
01/15/2014 - 12/31/2014 (Subcontract PI)
The Washington University NIH NHLBI
1R01HL118305-01A1

Showing 10 of 30 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2015 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-06 72
2014 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 5R21HL121589-02 1
2014 Genetic Architecture of Adiposity in Multiple Large Cohorts 2R01DK089256-05 72
2013 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 1R21HL121589-01 1
2013 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-04 72
2012 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-03 72
2011 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-02 72
2011 Interdisciplinary Training for Biostatisticians 5T32GM074905-07 104
2010 Genetic Architecture of Adiposity in Multiple Large Cohorts 1R01DK089256-01 72
2010 Interdisciplinary Training for Biostatisticians 2T32GM074905-06 104
Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zhao X, Qiao D, Yang C, Kasela S, Kim W, Ma Y, Shrine N, Batini C, Sofer T, Taliun SAG, Sakornsakolpat P, Balte PP, Prokopenko D, Yu B, Lange LA, Dupuis J, Cade BE, Lee J, Gharib SA, Daya M, Laurie CA, Ruczinski I, Cupples LA, Loehr LR, Bartz TM, Morrison AC, Psaty BM, Vasan RS, Wilson JG, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy RP, Ardlie KG, Aguet F, VanDenBerg DJ, Papanicolaou GJ, Rotter JI, Barnes KC, Jain D, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Dugan-Perez S, Gupta N, Gabriel S, Rich SS, O'Connor GT, Redline S, Reed RM, Laurie CC, Daviglus ML, Preudhomme LK, Burkart KM, Kaplan RC, Wain LV, Tobin MD, London SJ, Lappalainen T, Oelsner EC, Abecasis GR, Silverman EK, Barr RG, Cho MH, Manichaikul A. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 10 14; 11(1):5182.View Related Profiles. PMID: 33057025
     
  2. Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, Taub MA, Aguet F, Ardlie K, Mitchell BD, Barnes KC, Moscati A, Fornage M, Redline S, Psaty BM, Silverman EK, Weiss ST, Palmer ND, Vasan RS, Burchard EG, Kardia SLR, He J, Kaplan RC, Smith NL, Arnett DK, Schwartz DA, Correa A, de Andrade M, Guo X, Konkle BA, Custer B, Peralta JM, Gui H, Meyers DA, McGarvey ST, Chen IY, Shoemaker MB, Peyser PA, Broome JG, Gogarten SM, Wang FF, Wong Q, Montasser ME, Daya M, Kenny EE, North KE, Launer LJ, Cade BE, Bis JC, Cho MH, Lasky-Su J, Bowden DW, Cupples LA, Mak ACY, Becker LC, Smith JA, Kelly TN, Aslibekyan S, Heckbert SR, Tiwari HK, Yang IV, Heit JA, Lubitz SA, Johnsen JM, Curran JE, Wenzel SE, Weeks DE, Rao DC, Darbar D, Moon JY, Tracy RP, Buth EJ, Rafaels N, Loos RJF, Durda P, Liu Y, Hou L, Lee J, Kachroo P, Freedman BI, Levy D, Bielak LF, Hixson JE, Floyd JS, Whitsel EA, Ellinor PT, Irvin MR, Fingerlin TE, Raffield LM, Armasu SM, Wheeler MM, Sabino EC, Blangero J, Williams LK, Levy BD, Sheu WH, Roden DM, Boerwinkle E, Manson JE, Mathias RA, Desai P, Taylor KD, Johnson AD, Auer PL, Kooperberg C, Laurie CC, Blackwell TW, Smith AV, Zhao H, Lange E, Lange L, Rich SS, Rotter JI, Wilson JG, Scheet P, Kitzman JO, Lander ES, Engreitz JM, Ebert BL, Reiner AP, Jaiswal S, Abecasis G, Sankaran VG, Kathiresan S, Natarajan P. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 Oct 14. PMID: 33057201
     
  3. Justice AE, Chittoor G, Gondalia R, Melton PE, Lim E, Grove ML, Whitsel EA, Liu CT, Cupples LA, Fernandez-Rhodes L, Guan W, Bressler J, Fornage M, Boerwinkle E, Li Y, Demerath E, Heard-Costa N, Levy D, Stewart JD, Baccarelli A, Hou L, Conneely K, Mori TA, Beilin LJ, Huang RC, Gordon-Larsen P, Howard AG, North KE. Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. Epigenomics. 2020 Sep; 12(17):1483-1499.View Related Profiles. PMID: 32901515
     
  4. Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O'Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 09; 52(9):969-983.View Related Profiles. PMID: 32839606
     
  5. Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Cantwell L, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues JF, Debette S, Deleuze JF, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havulinna AS, Helisalmi S, Hiltunen M, Howrigan DP, Ikram MA, Kaprio J, Konrad J, Kuzma A, Lander ES, Lathrop M, Lehtimäki T, Lin H, Mattila K, Mayeux R, Muzny DM, Nasser W, Neale B, Nho K, Nicolas G, Patel D, Pericak-Vance MA, Perola M, Psaty BM, Quenez O, Rajabli F, Redon R, Reitz C, Remes AM, Salomaa V, Sarnowski C, Schmidt H, Schmidt M, Schmidt R, Soininen H, Thornton TA, Tosto G, Tzourio C, van der Lee SJ, van Duijn CM, Valladares O, Vardarajan B, Wang LS, Wang W, Wijsman E, Wilson RK, Witten D, Worley KC, Zhang X, Bellenguez C, Lambert JC, Kurki MI, Palotie A, Daly M, Boerwinkle E, Lunetta KL, Destefano AL, Dupuis J, Martin ER, Schellenberg GD, Seshadri S, Naj AC, Fornage M, Farrer LA. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry. 2020 Aug; 25(8):1901-1903.View Related Profiles. PMID: 31636380
     
  6. Wang Z, Chen H, Bartz TM, Bielak LF, Chasman DI, Feitosa MF, Franceschini N, Guo X, Lim E, Noordam R, Richard MA, Wang H, Cade B, Cupples LA, de Vries PS, Giulanini F, Lee J, Lemaitre RN, Martin LW, Reiner AP, Rich SS, Schreiner PJ, Sidney S, Sitlani CM, Smith JA, Willems van Dijk K, Yao J, Zhao W, Fornage M, Kardia SLR, Kooperberg C, Liu CT, Mook-Kanamori DO, Province MA, Psaty BM, Redline S, Ridker PM, Rotter JI, Boerwinkle E, Morrison AC. Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels. Circ Genom Precis Med. 2020 Aug; 13(4):e002772.View Related Profiles. PMID: 32510982
     
  7. Zekavat SM, Ruotsalainen S, Handsaker RE, Alver M, Bloom J, Poterba T, Seed C, Ernst J, Chaffin M, Engreitz J, Peloso GM, Manichaikul A, Yang C, Ryan KA, Fu M, Johnson WC, Tsai M, Budoff M, Vasan RS, Cupples LA, Rotter JI, Rich SS, Post W, Mitchell BD, Correa A, Metspalu A, Wilson JG, Salomaa V, Kellis M, Daly MJ, Neale BM, McCarroll S, Surakka I, Esko T, Ganna A, Ripatti S, Kathiresan S, Natarajan P. Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2020 Apr 01; 11(1):1715. PMID: 32238811
     
  8. Christensen KD, Karlawish J, Roberts JS, Uhlmann WR, Harkins K, Wood EM, Obisesan TO, Le LQ, Cupples LA, Zoltick ES, Johnson MS, Bradbury MK, Waterston LB, Chen CA, Feldman S, Perry DL, Green RC. Disclosing genetic risk for Alzheimer's dementia to individuals with mild cognitive impairment. Alzheimers Dement (N Y). 2020; 6(1):e12002.View Related Profiles. PMID: 32211507
     
  9. Kowalski MH, Qian H, Hou Z, Rosen JD, Tapia AL, Shan Y, Jain D, Argos M, Arnett DK, Avery C, Barnes KC, Becker LC, Bien SA, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Buyske S, Cai J, Cho MH, Choi SH, Choquet H, Cupples LA, Cushman M, Daya M, de Vries PS, Ellinor PT, Faraday N, Fornage M, Gabriel S, Ganesh SK, Graff M, Gupta N, He J, Heckbert SR, Hidalgo B, Hodonsky CJ, Irvin MR, Johnson AD, Jorgenson E, Kaplan R, Kardia SLR, Kelly TN, Kooperberg C, Lasky-Su JA, Loos RJF, Lubitz SA, Mathias RA, McHugh CP, Montgomery C, Moon JY, Morrison AC, Palmer ND, Pankratz N, Papanicolaou GJ, Peralta JM, Peyser PA, Rich SS, Rotter JI, Silverman EK, Smith JA, Smith NL, Taylor KD, Thornton TA, Tiwari HK, Tracy RP, Wang T, Weiss ST, Weng LC, Wiggins KL, Wilson JG, Yanek LR, Zöllner S, North KE, Auer PL, Raffield LM, Reiner AP, Li Y. Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations. PLoS Genet. 2019 12; 15(12):e1008500. PMID: 31869403
     
  10. Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, Feng Q, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Psaty BM, Rotter JI, Cessie SL, Stein CM, Jukema JW. Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Pharmacogenomics J. 2020 06; 20(3):462-470. PMID: 31801993
     
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