Keywords
Last Name

Patrycja Dubielecka-Szczerba, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGeneral Internal Medicine
Other Positions
InstitutionRoger Williams Medical Center

 Research Expertise & Professional Interests
Dr. Dubielecka is an Assistant Professor of Medicine at the Alpert Medical School of Brown University and head of the Signal Transduction Lab. She is also an Assistant Professor of Medicine at the Boston University School of Medicine, and holds an adjunct appointment in the Division of Hematology/Oncology in the Department of Medicine at Rhode Island Hospital.

Dr. Dubielecka received her undergraduate and PhD degrees from the University of Wroclaw, Poland. She was a scholar of the Socrates/Erasmus Programme established by the European Commission, and trained at the University of Helsinki, Finland and at Charles University in Hradec Kralove, Czech Republic. Dr. Dubielecka did her postdoctoral training in the Lindsley F. Kimball Research Institute in New York. During her training she collaborated closely with colleagues at the University of Michigan, Ann Arbor and Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany. Dr. Dubielecka received extensive training in biochemistry, biophysics, cell biology, and protein chemistry. Prior to joining the faculty at Brown University, Dr. Dubielecka was a project leader in the NIH Center of Biomedical Research Excellence (COBRE) in Stem Cell Biology at the Roger Williams Medical Center, Boston University School of Medicine. Dr. Dubielecka has mentored undergraduate students, medical students, residents, fellows, and post-doctoral fellows.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Du J, Zhang L, Wang Z, Yano N, Zhao YT, Wei L, Dubielecka-Szczerba P, Liu PY, Zhuang S, Qin G, Zhao TC. Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts. Am J Physiol Cell Physiol. 2016 Feb 15; 310(4):C270-83. PMID: 26739490.
    View in: PubMed
  2. Chorzalska A, Salloum I, Shafqat H, Khan S, Marjon P, Treaba D, Schorl C, Morgan J, Bryke CR, Falanga V, Zhao TC, Reagan J, Winer E, Olszewski AJ, Al-Homsi AS, Kouttab N, Dubielecka PM. Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia. Leukemia. 2014 Nov; 28(11):2165-77. PMID: 24699303.
    View in: PubMed
  3. Bartos A, Dubielecka PM. The emerging role of Bcr-Abl-induced cystoskeletal remodeling in systemic persistence of leukemic stem cells. Curr Drug Deliv. 2014; 11(5):582-91. PMID: 23517626.
    View in: PubMed
  4. Toporkiewicz M, Grzybek M, Meissner J, Michalczyk I, Dubielecka PM, Korycka J, Seweryn E, Sikorski AF. Release of an ~55kDa fragment containing the actin-binding domain of ß-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1. Arch Biochem Biophys. 2013 Jul 15; 535(2):205-13. PMID: 23578573.
    View in: PubMed
  5. Michalczyk I, Sikorski AF, Kotula L, Junghans RP, Dubielecka PM. The emerging role of protein kinase C? in cytoskeletal signaling. J Leukoc Biol. 2013 Mar; 93(3):319-27. PMID: 23192428.
    View in: PubMed
  6. Zhang L, Chen B, Zhao Y, Dubielecka PM, Wei L, Qin GJ, Chin YE, Wang Y, Zhao TC. Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts. J Biol Chem. 2012 Nov 16; 287(47):39338-48. PMID: 23024362.
    View in: PubMed
  7. Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA, Kotula L. Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice. Oncogenesis. 2012; 1:e26. PMID: 23552839.
    View in: PubMed
  8. Hossain S, Dubielecka PM, Sikorski AF, Birge RB, Kotula L. Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton. Genes Cancer. 2012 May; 3(5-6):402-13. PMID: 23226578.
    View in: PubMed
  9. Dubielecka PM, Ladwein KI, Xiong X, Migeotte I, Chorzalska A, Anderson KV, Sawicki JA, Rottner K, Stradal TE, Kotula L. Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7022-7. PMID: 21482783.
    View in: PubMed
  10. Dubielecka PM, Hwynn N, Sengun C, Lee S, Lomas-Francis C, Singer C, Fernandez HH, Walker RH. Two McLeod patients with novel mutations in XK. J Neurol Sci. 2011 Jun 15; 305(1-2):160-4. PMID: 21463873.
    View in: PubMed
  11. Dubielecka PM, Machida K, Xiong X, Hossain S, Ogiue-Ikeda M, Carrera AC, Mayer BJ, Kotula L. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett. 2010 Aug 4; 584(15):3279-86. PMID: 20598684.
    View in: PubMed
  12. Dubielecka PM, Cui P, Xiong X, Hossain S, Heck S, Angelov L, Kotula L. Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms. PLoS One. 2010; 5(5):e10430. PMID: 20479892.
    View in: PubMed
  13. Dubielecka PM, Grzybek M, Kolondra A, Jazwiec B, Draga A, Aleksandrowicz P, Kolodziejczyk M, Serwotka A, Dolinska-Krajewska B, Warchol J, Kuliczkowski K, Sikorski AF. Aggregation of spectrin and PKCtheta is an early hallmark of fludarabine/mitoxantrone/dexamethasone-induced apoptosis in Jurkat T and HL60 cells. Mol Cell Biochem. 2010 Jun; 339(1-2):63-77. PMID: 20058056.
    View in: PubMed
  14. Bok E, Plazuk E, Hryniewicz-Jankowska A, Chorzalska A, Szmaj A, Dubielecka PM, Stebelska K, Diakowski W, Lisowski M, Langner M, Sikorski AF. Lipid-binding role of betaII-spectrin ankyrin-binding domain. Cell Biol Int. 2007 Dec; 31(12):1482-94. PMID: 17716929.
    View in: PubMed
  15. Dubielecka PM, Trusz A, Diakowski W, Grzybek M, Chorzalska A, Jazwiec B, Lisowski M, Jezierski A, Sikorski AF. Mitoxantrone changes spectrin-aminophospholipid interactions. Mol Membr Biol. 2006 May-Jun; 23(3):235-43. PMID: 16785207.
    View in: PubMed
  16. Stebelska K, Dubielecka PM, Sikorski AF. The effect of PS content on the ability of natural membranes to fuse with positively charged liposomes and lipoplexes. J Membr Biol. 2005 Aug; 206(3):203-14. PMID: 16456715.
    View in: PubMed
  17. Dubielecka PM, Jazwiec B, Potoczek S, Wróbel T, Miloszewska J, Haus O, Kuliczkowski K, Sikorski AF. Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy. Biochem Pharmacol. 2005 Jan 1; 69(1):73-85. PMID: 15588716.
    View in: PubMed
  18. Grzybek M, Kozubek A, Dubielecka P, Sikorski AF. Rafts--the current picture. Folia Histochem Cytobiol. 2005; 43(1):3-10. PMID: 15871556.
    View in: PubMed
  19. Hryniewicz-Jankowska A, Bok E, Dubielecka P, Chorzalska A, Diakowski W, Jezierski A, Lisowski M, Sikorski AF. Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid beta-spectrin. Biochem J. 2004 Sep 1; 382(Pt 2):677-85. PMID: 15171729.
    View in: PubMed
  20. Dubielecka PM, Stebelska K, Jazwiec B, Sikorski AF. Cystocyte and lymphocyte derived fusomes/spectrosomes: analogies and differences: a mini-review. Cell Mol Biol Lett. 2003; 8(1):221-9. PMID: 12655376.
    View in: PubMed
  21. Zhao H, Dubielecka PM, Söderlund T, Kinnunen PK. Interactions of adriamycin, cytochrome c, and serum albumin with lipid monolayers containing poly(ethylene glycol)-ceramide. Biophys J. 2002 Aug; 83(2):954-67. PMID: 12124277.
    View in: PubMed
  22. Dubielecka P, Potoczek S, Jazwiec B, Miloszewska J, Kuliczkowski K, Sikorski AF. The Effect Of Chemotherapy With Fluodarabine/Mitoxantrone/Dexamethasone On The Distribution Of Spectrin In Lymphocytes Of Non-Hodgkin Lymphoma Patients. Cell Mol Biol Lett. 2001; 6(2):200. PMID: 11544653.
    View in: PubMed
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