Keywords
Last Name

Karen M. Harnett, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rieder F, Nonevski I, Ma J, Ouyang Z, West G, Protheroe C, DePetris G, Schirbel A, Lapinski J, Goldblum J, Bonfield T, Lopez R, Harnett K, Lee J, Hirano I, Falk G, Biancani P, Fiocchi C. T-helper 2 cytokines, transforming growth factor ß1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis. Gastroenterology. 2014 May; 146(5):1266-77.e1-9. PMID: 24486052.
    View in: PubMed
  2. Ma J, Altomare A, Guarino M, Cicala M, Rieder F, Fiocchi C, Li D, Cao W, Behar J, Biancani P, Harnett KM. HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1; 303(5):G635-45. PMID: 22790593.
    View in: PubMed
  3. Altomare A, Ma J, Guarino MP, Cheng L, Rieder F, Ribolsi M, Fiocchi C, Biancani P, Harnett K, Cicala M. Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. Neurogastroenterol Motil. 2012 Oct; 24(10):943-e463. PMID: 22734465.
    View in: PubMed
  4. Ma J, Altomare A, Rieder F, Behar J, Biancani P, Harnett KM. ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1075-82. PMID: 21960521.
    View in: PubMed
  5. Orlando RC, Paterson WG, Harnett KM, Ma J, Behar J, Biancani P, Guarino MP, Altomare A, Cicala M, Cao W. Esophageal disease: updated information on inflammation. Ann N Y Acad Sci. 2011 Sep; 1232:369-75. PMID: 21950828.
    View in: PubMed
  6. Harnett KM, Rieder F, Behar J, Biancani P. Viewpoints on Acid-induced inflammatory mediators in esophageal mucosa. J Neurogastroenterol Motil. 2010 Oct; 16(4):374-88. PMID: 21103419.
    View in: PubMed
  7. Ma J, Altomare A, de la Monte S, Tong M, Rieder F, Fiocchi C, Behar J, Shindou H, Biancani P, Harnett KM. HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G791-8. PMID: 20616304.
    View in: PubMed
  8. Guarino MP, Cheng L, Ma J, Harnett K, Biancani P, Altomare A, Panzera F, Behar J, Cicala M. Increased TRPV1 gene expression in esophageal mucosa of patients with non-erosive and erosive reflux disease. Neurogastroenterol Motil. 2010 Jul; 22(7):746-51, e219. PMID: 20456759.
    View in: PubMed
  9. Rieder F, Biancani P, Harnett K, Yerian L, Falk GW. Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G571-81. PMID: 20299604.
    View in: PubMed
  10. Ma J, Harnett KM, Behar J, Biancani P, Cao W. Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G233-40. PMID: 19959817.
    View in: PubMed
  11. Cheng L, de la Monte S, Ma J, Hong J, Tong M, Cao W, Behar J, Biancani P, Harnett KM. HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol. 2009 Jul; 297(1):G135-43. PMID: 19389802.
    View in: PubMed
  12. Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C. Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology. 2007 Jan; 132(1):154-65. PMID: 17241868.
    View in: PubMed
  13. Cheng L, Cao W, Behar J, Fiocchi C, Biancani P, Harnett KM. Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. J Pharmacol Exp Ther. 2006 Oct; 319(1):117-26. PMID: 16807360.
    View in: PubMed
  14. Cao W, Cheng L, Behar J, Biancani P, Harnett KM. IL-1beta signaling in cat lower esophageal sphincter circular muscle. Am J Physiol Gastrointest Liver Physiol. 2006 Oct; 291(4):G672-80. PMID: 16645161.
    View in: PubMed
  15. Cao W, Harnett KM, Pricolo VE. NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. J Pharmacol Exp Ther. 2006 Jun; 317(3):1349-55. PMID: 16554357.
    View in: PubMed
  16. Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM. HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 290(6):G1307-17. PMID: 16439466.
    View in: PubMed
  17. Cheng L, Harnett KM, Cao W, Liu F, Behar J, Fiocchi C, Biancani P. Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. Gastroenterology. 2005 Nov; 129(5):1675-85. PMID: 16285965.
    View in: PubMed
  18. Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM. In vitro model of acute esophagitis in the cat. Am J Physiol Gastrointest Liver Physiol. 2005 Nov; 289(5):G860-9. PMID: 16037543.
    View in: PubMed
  19. Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM. Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G418-28. PMID: 15890711.
    View in: PubMed
  20. Harnett KM, Cao W, Biancani P. Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles. Am J Physiol Gastrointest Liver Physiol. 2005 Mar; 288(3):G407-16. PMID: 15701619.
    View in: PubMed
  21. Cao W, Harnett KM, Cheng L, Kirber MT, Behar J, Biancani P. H(2)O(2): a mediator of esophagitis-induced damage to calcium-release mechanisms in cat lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol. 2005 Jun; 288(6):G1170-8. PMID: 15662047.
    View in: PubMed
  22. Cheng L, Cao W, Behar J, Biancani P, Harnett KM. Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G787-97. PMID: 15550558.
    View in: PubMed
  23. Cao W, Cheng L, Behar J, Fiocchi C, Biancani P, Harnett KM. Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis. Am J Physiol Gastrointest Liver Physiol. 2004 Dec; 287(6):G1131-9. PMID: 15271650.
    View in: PubMed
  24. Cao W, Vrees MD, Potenti FM, Harnett KM, Fiocchi C, Pricolo VE. Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. J Pharmacol Exp Ther. 2004 Oct; 311(1):60-70. PMID: 15205451.
    View in: PubMed
  25. Kim N, Cao W, Song IS, Kim CY, Harnett KM, Cheng L, Walsh MP, Biancani P. Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C384-94. PMID: 15128504.
    View in: PubMed
  26. Harnett KM, Biancani P. Calcium-dependent and calcium-independent contractions in smooth muscles. Am J Med. 2003 Aug 18; 115 Suppl 3A:24S-30S. PMID: 12928071.
    View in: PubMed
  27. Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, Harnett KM. MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2003 Jul; 285(1):G86-95. PMID: 12799309.
    View in: PubMed
  28. Cao W, Harnett KM, Behar J, Biancani P. PGF(2alpha)-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2002 Aug; 283(2):G282-91. PMID: 12121874.
    View in: PubMed
  29. Sohn UD, Cao W, Tang DC, Stull JT, Haeberle JR, Wang CL, Harnett KM, Behar J, Biancani P. Myosin light chain kinase- and PKC-dependent contraction of LES and esophageal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2):G467-78. PMID: 11447027.
    View in: PubMed
  30. Cao W, Chen Q, Sohn UD, Kim N, Kirber MT, Harnett KM, Behar J, Biancani P. Ca2+-induced contraction of cat esophageal circular smooth muscle cells. Am J Physiol Cell Physiol. 2001 Apr; 280(4):C980-92. PMID: 11245615.
    View in: PubMed
  31. Cao W, Harnett KM, Behar J, Biancani P. Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone. Gastroenterology. 2000 Nov; 119(5):1243-52. PMID: 11054382.
    View in: PubMed
  32. Warach S, Pettigrew LC, Dashe JF, Pullicino P, Lefkowitz DM, Sabounjian L, Harnett K, Schwiderski U, Gammans R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators. Ann Neurol. 2000 Nov; 48(5):713-22. PMID: 11079534.
    View in: PubMed
  33. Cao WB, Harnett KM, Chen Q, Jain MK, Behar J, Biancani P. Group I secreted PLA2 and arachidonic acid metabolites in the maintenance of cat LES tone. Am J Physiol. 1999 Sep; 277(3 Pt 1):G585-98. PMID: 10484384.
    View in: PubMed
  34. Harnett KM, Cao W, Kim N, Sohn UD, Rich H, Behar J, Biancani P. Signal transduction in esophageal and LES circular muscle contraction. Yale J Biol Med. 1999 Mar-Jun; 72(2-3):153-68. PMID: 10780577.
    View in: PubMed
  35. Kim N, Cao W, Song IS, Kim CY, Sohn UD, Harnett KM, Biancani P. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Gastroenterology. 1998 Oct; 115(4):919-28. PMID: 9753495.
    View in: PubMed
  36. Yu P, Chen Q, Xiao Z, Harnett K, Biancani P, Behar J. Signal transduction pathways mediating CCK-induced gallbladder muscle contraction. Am J Physiol. 1998 Aug; 275(2 Pt 1):G203-11. PMID: 9688646.
    View in: PubMed
  37. Sohn UD, Harnett KM, Cao W, Rich H, Kim N, Behar J, Biancani P. Acute experimental esophagitis activates a second signal transduction pathway in cat smooth muscle from the lower esophageal sphincter. J Pharmacol Exp Ther. 1997 Dec; 283(3):1293-304. PMID: 9400005.
    View in: PubMed
  38. Biancani P, Sohn UD, Rich HG, Harnett KM, Behar J. Signal transduction pathways in esophageal and lower esophageal sphincter circular muscle. Am J Med. 1997 Nov 24; 103(5A):23S-28S. PMID: 9422618.
    View in: PubMed
  39. Sohn UD, Zoukhri D, Dartt D, Sergheraert C, Harnett KM, Behar J, Biancani P. Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle. Mol Pharmacol. 1997 Mar; 51(3):462-70. PMID: 9058601.
    View in: PubMed
  40. Yu P, Chen Q, Harnett KM, Amaral J, Biancani P, Behar J. Direct G protein activation reverses impaired CCK signaling in human gallbladders with cholesterol stones. Am J Physiol. 1995 Nov; 269(5 Pt 1):G659-65. PMID: 7491956.
    View in: PubMed
  41. Biancani P, Harnett KM, Sohn UD, Rhim BY, Behar J, Hillemeier C, Bitar KN. Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh. Am J Physiol. 1994 May; 266(5 Pt 1):G767-74. PMID: 8203523.
    View in: PubMed
  42. Sohn UD, Harnett KM, De Petris G, Behar J, Biancani P. Distinct muscarinic receptors, G proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle. J Pharmacol Exp Ther. 1993 Dec; 267(3):1205-14. PMID: 8263781.
    View in: PubMed
  43. Yu P, Harnett KM, Biancani P, De Petris G, Behar J. Interaction between signal transduction pathways contributing to gallbladder tonic contraction. Am J Physiol. 1993 Dec; 265(6 Pt 1):G1082-9. PMID: 8279559.
    View in: PubMed
  44. Harnett KM, Walsh CT, Zhang LH. Effects of Bay o 2752, a hypocholesterolemic agent, on intestinal taurocholate absorption and cholesterol esterification. J Pharmacol Exp Ther. 1989 Nov; 251(2):502-9. PMID: 2810110.
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  45. Shaikh ZA, Harnett KM, Perlin SA, Huang PC. Chronic cadmium intake results in dose-related excretion of metallothionein in urine. Experientia. 1989 Feb 15; 45(2):146-8. PMID: 2920800.
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  46. Walsh CT, Harnett KM. Inhibitory effect of lead acetate on contractility of longitudinal smooth muscle from rat ileum. Toxicol Appl Pharmacol. 1986 Mar 30; 83(1):62-8. PMID: 3952751.
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