Keywords
Last Name

A. Frackelton, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology
Address25 Buick St
Boston MA
Other Positions
InstitutionRoger Williams Medical Center

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Quinn JA, Graeber CT, Frackelton AR, Kim M, Schwarzbauer JE, Filardo EJ. Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. Mol Endocrinol. 2009 Jul; 23(7):1052-64. PMID: 19342448.
    View in: PubMed
  2. Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR, Hafer LJ. p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. Clin Cancer Res. 2007 Oct 1; 13(19):5798-804. PMID: 17908971.
    View in: PubMed
  3. Wanebo HJ, Frackelton AR, Hafer LJ, Bagdasaryan R, Lis R, Sabo E, Resnick MB. Shc test as a strong prognostic indicator of disease outcome in early stage gastric cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10090. PMID: 27954030.
    View in: PubMed
  4. Frackelton AR, Lu L, Davol PA, Bagdasaryan R, Hafer LJ, Sgroi DC. p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy. Breast Cancer Res. 2006; 8(6):R73. PMID: 17196107.
    View in: PubMed
  5. Davol PA, Bagdasaryan R, Elfenbein GJ, Maizel AL, Frackelton AR. Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer. Cancer Res. 2003 Oct 15; 63(20):6772-83. PMID: 14583473.
    View in: PubMed
  6. Filardo EJ, Quinn JA, Frackelton AR, Bland KI. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol. 2002 Jan; 16(1):70-84. PMID: 11773440.
    View in: PubMed
  7. Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR. Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells. Cell Growth Differ. 2001 Jul; 12(7):379-86. PMID: 11457735.
    View in: PubMed
  8. Filardo EJ, Quinn JA, Bland KI, Frackelton AR. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 2000 Oct; 14(10):1649-60. PMID: 11043579.
    View in: PubMed
  9. Boney CM, Gruppuso PA, Faris RA, Frackelton AR. The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes. Mol Endocrinol. 2000 Jun; 14(6):805-13. PMID: 10847583.
    View in: PubMed
  10. Davol PA, Garza S, Frackelton AR. Combining suramin and a chimeric toxin directed to basic fibroblast growth factor receptors increases therapeutic efficacy against human melanoma in an animal model. Cancer. 1999 Nov 1; 86(9):1733-41. PMID: 10547546.
    View in: PubMed
  11. Davol PA, Frackelton AR. Targeting human prostatic carcinoma through basic fibroblast growth factor receptors in an animal model: characterizing and circumventing mechanisms of tumor resistance. Prostate. 1999 Aug 1; 40(3):178-91. PMID: 10398280.
    View in: PubMed
  12. Davol PA, Bizuneh A, Frackelton AR. Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo. Anticancer Res. 1999 May-Jun; 19(3A):1705-13. PMID: 10470104.
    View in: PubMed
  13. Stevenson LE, Ravichandran KS, Frackelton AR. Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells. Cell Growth Differ. 1999 Jan; 10(1):61-71. PMID: 9950219.
    View in: PubMed
  14. Stevenson LE, Frackelton AR. Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression. Breast Cancer Res Treat. 1998 May; 49(2):119-28. PMID: 9696394.
    View in: PubMed
  15. Davol P, Frackelton AR. The mitotoxin, basic fibroblast growth factor-saporin, effectively targets human prostatic carcinoma in an animal model. J Urol. 1996 Sep; 156(3):1174-9. PMID: 8709341.
    View in: PubMed
  16. Davol PA, Goulette FA, Frackelton AR, Darnowski JW. Modulation of p53 expression by human recombinant interferon-alpha2a correlates with abrogation of cisplatin resistance in a human melanoma cell line. Cancer Res. 1996 Jun 1; 56(11):2522-6. PMID: 8653690.
    View in: PubMed
  17. Nici L, Medina M, Frackelton AR. The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. Am J Physiol. 1996 Feb; 270(2 Pt 1):L242-50. PMID: 8779993.
    View in: PubMed
  18. Clark JW, Santos-Moore A, Stevenson LE, Frackelton AR. Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the ras signaling pathway. Int J Cancer. 1996 Jan 17; 65(2):186-91. PMID: 8567115.
    View in: PubMed
  19. Davol P, Beitz JG, Mohler M, Ying W, Cook J, Lappi DA, Frackelton AR. Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model. Cancer. 1995 Jul 1; 76(1):79-85. PMID: 8630880.
    View in: PubMed
  20. Davol P, Beitz JG, Frackelton AR. Autocrine down-regulation of basic fibroblast growth factor receptors causes mitotoxin resistance in a human melanoma cell line. J Invest Dermatol. 1995 Jun; 104(6):916-21. PMID: 7769258.
    View in: PubMed
  21. Cheng JC, Frackelton AR, Bearer EL, Kumar PS, Kannan B, Santos-Moore A, Rifai A, Settleman J, Clark JW. Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells. Cell Growth Differ. 1995 Feb; 6(2):139-48. PMID: 7756172.
    View in: PubMed
  22. Sato N, Beitz JG, Kato J, Yamamoto M, Clark JW, Calabresi P, Raymond A, Frackelton AR. Platelet-derived growth factor indirectly stimulates angiogenesis in vitro. Am J Pathol. 1993 Apr; 142(4):1119-30. PMID: 7682762.
    View in: PubMed
  23. Frackelton AR, Kumar PS, Kannan B, Clark JW. Tyrosine phosphorylated proteins in chronic myelogenous leukemia. Leuk Lymphoma. 1993; 11 Suppl 1:125-9. PMID: 7504542.
    View in: PubMed
  24. Buzzi M, Lu L, Lombardi AJ, Posner MR, Brautigan DL, Fast LD, Frackelton AR. Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines. Cancer Res. 1992 Jul 15; 52(14):4027-35. PMID: 1535552.
    View in: PubMed
  25. Beitz JG, Kim IS, Calabresi P, Frackelton AR. Receptors for platelet-derived growth factor on microvascular endothelial cells. EXS. 1992; 61:85-90. PMID: 1319780.
    View in: PubMed
  26. Beitz JG, Davol P, Clark JW, Kato J, Medina M, Frackelton AR, Lappi DA, Baird A, Calabresi P. Antitumor activity of basic fibroblast growth factor-saporin mitotoxin in vitro and in vivo. Cancer Res. 1992 Jan 1; 52(1):227-30. PMID: 1309225.
    View in: PubMed
  27. Beitz JG, Kim IS, Calabresi P, Frackelton AR. Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc Natl Acad Sci U S A. 1991 Mar 1; 88(5):2021-5. PMID: 1848018.
    View in: PubMed
  28. Frackelton AR, Posner M, Kannan B, Mermelstein F. Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins. Methods Enzymol. 1991; 201:79-92. PMID: 1719350.
    View in: PubMed
  29. Sato N, Nariuchi H, Tsuruoka N, Nishihara T, Beitz JG, Calabresi P, Frackelton AR. Actions of TNF and IFN-gamma on angiogenesis in vitro. J Invest Dermatol. 1990 Dec; 95(6 Suppl):85S-89S. PMID: 1701814.
    View in: PubMed
  30. Posner MR, Santos DJ, Elboim HS, Tumber MB, Frackelton AR. Human monoclonal antibodies reactive with human myelomonocytic leukemia cells. Cancer Res. 1989 Apr 1; 49(7):1665-70. PMID: 2924315.
    View in: PubMed
  31. Huhn RD, Cicione ME, Frackelton AR. Identification of tyrosine-phosphorylated colony-stimulating factor 1 (CSF-1) receptor and a 56-kilodalton protein phosphorylated in intact human cells in response to CSF-1. J Cell Biochem. 1989 Feb; 39(2):129-37. PMID: 2469691.
    View in: PubMed
  32. Posner MR, Santos DJ, Elboim HS, Frackelton AR. Human monoclonal antibodies to human leukemias. Initial characterization of specificities and antigens. Prog Clin Biol Res. 1989; 288:95-9. PMID: 2717644.
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  33. Isfort R, Huhn RD, Frackelton AR, Ihle JN. Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates. J Biol Chem. 1988 Dec 15; 263(35):19203-9. PMID: 2461935.
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  34. Sengupta A, Liu WK, Yeung YG, Yeung DC, Frackelton AR, Stanley ER. Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8062-6. PMID: 2460861.
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  35. Preis PN, Waldman FM, Frackelton AR, Saya H, Levin VA. Protein-tyrosine kinase activity and pp60v-src expression in whole cells measured by flow cytometry. Cancer Res. 1988 Aug 15; 48(16):4633-8. PMID: 3135116.
    View in: PubMed
  36. Tornqvist HE, Gunsalus JR, Nemenoff RA, Frackelton AR, Pierce MW, Avruch J. Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells. J Biol Chem. 1988 Jan 5; 263(1):350-9. PMID: 3275643.
    View in: PubMed
  37. Bell JC, Mahadevan L, Colledge WH, Fry MJ, Frackelton AR, Sargent MG, Foulkes JG. Mechanisms of transformation by protein-tyrosine kinases. Adv Exp Med Biol. 1988; 231:475-80. PMID: 2843010.
    View in: PubMed
  38. Tornqvist HE, Pierce MW, Frackelton AR, Nemenoff RA, Avruch J. Identification of insulin receptor tyrosine residues autophosphorylated in vitro. J Biol Chem. 1987 Jul 25; 262(21):10212-9. PMID: 3038872.
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  39. Huhn RD, Posner MR, Rayter SI, Foulkes JG, Frackelton AR. Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues. Proc Natl Acad Sci U S A. 1987 Jul; 84(13):4408-12. PMID: 2440021.
    View in: PubMed
  40. Bell JC, Mahadevan LC, Colledge WH, Frackelton AR, Sargent MG, Foulkes JG. Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA. Nature. 1987 Feb 5-11; 325(6104):552-4. PMID: 2433597.
    View in: PubMed
  41. Foulkes JG, Chow M, Gorka C, Frackelton AR, Baltimore D. Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus. J Biol Chem. 1985 Jul 5; 260(13):8070-7. PMID: 2989275.
    View in: PubMed
  42. Daniel TO, Tremble PM, Frackelton AR, Williams LT. Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody. Proc Natl Acad Sci U S A. 1985 May; 82(9):2684-7. PMID: 2581254.
    View in: PubMed
  43. Frackelton AR, Tremble PM, Williams LT. Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine. J Biol Chem. 1984 Jun 25; 259(12):7909-15. PMID: 6203898.
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  44. Friedman B, Frackelton AR, Ross AH, Connors JM, Fujiki H, Sugimura T, Rosner MR. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1984 May; 81(10):3034-8. PMID: 6328489.
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  45. Frackelton AR, Ross AH, Eisen HN. Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells. Mol Cell Biol. 1983 Aug; 3(8):1343-52. PMID: 6194425.
    View in: PubMed
  46. Wall KA, Frackelton AR, Reilly EB, Azuma T, Chang TW, Eisen HN. Quantitative of anti-NP (4-hydroxy-3-nitrophenyl)-acetyl idiotype expression on spleen and thymus cells. Eur J Immunol. 1983 Jun; 13(6):441-8. PMID: 6602707.
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  47. Reilly EB, Frackelton AR, Eisen HN. Synthesis of lambda 1, lambda 2, and lambda 3 light chains by mouse spleen B cells. Eur J Immunol. 1982 Jul; 12(7):552-7. PMID: 6811287.
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  48. Frackelton AR, Rotman B. Functional diversity of antibodies elicited by bacterial beta-D-galactosidase. Monoclonal activating, inactivating, protecting, and null antibodies to normal enzyme. J Biol Chem. 1980 Jun 10; 255(11):5286-90. PMID: 6768737.
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  49. Frackelton AR, Weltman JK. Diffusion control of the binding of carcinoembryonic antigen (CEA) with insoluble anti-CEA antibody. J Immunol. 1980 Apr; 124(4):2048-54. PMID: 7365247.
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  50. Herbert TJ, Weltman JK, Frackelton AR, Dowben RM. Dielectric dispersion of actin. J Mechanochem Cell Motil. 1977 Mar; 4(1):79-85. PMID: 572854.
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  51. Weltman JK, Frackelton AR, Szaro RP, Rotman B. A galactosidase immunosorbent test for human immunoglobulin E. J Allergy Clin Immunol. 1976 Sep; 58(3):426-31. PMID: 987089.
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  52. Frackelton AR, Szaro RP, Weltman JK. A galactosidase immunosorbent test for carcinoembryonic antigen. Cancer Res. 1976 Aug; 36(8):2845-9. PMID: 1277194.
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  53. Weltman JK, Frackelton AR. Application of a galactosidase immunosorbent test to carcinoembryonic antigen in plasma. Cancer Res. 1976 Aug; 36(8):2850-3. PMID: 1277195.
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  54. Weltman JK, Szaro RP, Frackelton AR, Dowben RM, Bunting JR, Cathou BE. N-(3-pyrene)maleimide: a long lifetime fluorescent sulfhydryl reagent. J Biol Chem. 1973 May 10; 248(9):3173-7. PMID: 4121698.
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  55. Weltman JK, Frackelton AR, Szaro RP, Dowben RM. Synthesis and fluorescence polarization analysis of an organomercurial derivative of actin. J Lab Clin Med. 1971 Nov; 78(5):808. PMID: 5166934.
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