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Research Expertise & Professional Interests Professor Ian Matthias Sanne is a South African born infectious diseases doctor and has been involved in HIV and TB research since qualifying as internist in 1996. Since 2003 he has led the Wits HIV Research Group Clinical Trials Unit, and from 2003- 2012 led the Adult Treatment Research Site. He currently holds the AIDS Clinical Trials Group International Vice-Chair position and is responsible for overseeing the network’s research at 25 international sites in 13 countries and assisting in the prioritization of the research agenda. The focus of his research attention is an integrated program of HIV and TB research from prospective phase I-IV clinical trials, conducted predominantly through international collaborations with the NIH, EDCTP, Global TB Alliance and the Medical Research Council of South Africa. The key focus in the ACTG collaboration is prospective research to inform diagnostic, prevention and treatment interventions to optimize the diagnosis and treatment of HIV and tuberculosis. In addition through programs of implementation sciences and monitoring evaluation data produced as part of the Right to Care PEPFAR implementation program epidemiologic and health economic evaluation of health care interventions. The overall aim is to develop evidence based health system strengthening interventions to address the public health emergencies facing the resource poor setting. At the intersection of clinical care, and clinical trial administration, Professor Sanne continues to provide expertise to the ACTG leadership from the experience gained as the founding Director and Chief Executive Officer of Right to Care.

One or more keywords matched the following items that are connected to Sanne, Ian

Item TypeName
Concept Mycobacterium tuberculosis
Concept Tuberculosis
Concept Tuberculosis, Lymph Node
Concept Tuberculosis, Pulmonary
Concept Tuberculosis, Multidrug-Resistant
Concept Latent Tuberculosis
Academic Article Initiating patients on antiretroviral therapy at CD4 cell counts above 200 cells/microl is associated with improved treatment outcomes in South Africa.
Academic Article Scaling up Xpert MTB/RIF technology: the costs of laboratory- vs. clinic-based roll-out in South Africa.
Academic Article The impact and cost of scaling up GeneXpert MTB/RIF in South Africa.
Academic Article Diagnosing Xpert MTB/RIF negative TB: impact and cost of alternative algorithms for South Africa.
Academic Article Impact and costs of algorithms for the diagnosis of adults with pulmonary tuberculosis in South Africa.
Academic Article Initiating antiretroviral therapy when presenting with higher CD4 cell counts results in reduced loss to follow-up in a resource-limited setting.
Academic Article Costs of inpatient treatment for multi-drug-resistant tuberculosis in South Africa.
Academic Article Incident tuberculosis in HIV-positive children, adolescents and adults on antiretroviral therapy in South Africa.
Academic Article Early Outcomes Of Decentralized Care for Rifampicin-Resistant Tuberculosis in Johannesburg, South Africa: An Observational Cohort Study.
Academic Article Efavirenz and rifampicin in the South African context: is there a need to dose-increase efavirenz with concurrent rifampicin therapy?
Academic Article Scale-up of services and research priorities for diagnosis, management, and control of tuberculosis: a call to action.
Academic Article The impact of Xpert(®) MTB/RIF in sparsely populated rural settings.
Academic Article Prolonged deferral of antiretroviral therapy in the SAPIT trial: did we need a clinical trial to tell us that this would increase mortality?
Academic Article Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study.
Academic Article Xpert(®) MTB/RIF for point-of-care diagnosis of TB in high-HIV burden, resource-limited countries: hype or hope?
Academic Article Human Immunodeficiency Virus Type 1 and Tuberculosis Coinfection in Multinational, Resource-limited Settings: Increased Neurological Dysfunction.
Academic Article Implementation of Xpert MTB/RIF for routine point-of-care diagnosis of tuberculosis at the primary care level.
Academic Article Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.
Academic Article Evaluation of Xpert MTB/RIF Versus AFB Smear and Culture to Identify Pulmonary Tuberculosis in Patients With Suspected Tuberculosis From Low and Higher Prevalence Settings.
Academic Article Point-of-care Xpert® MTB/RIF for smear-negative tuberculosis suspects at a primary care clinic in South Africa.
Academic Article The patient impact of point-of-care vs. laboratory placement of Xpert(®) MTB/RIF.
Academic Article Diagnostic accuracy and effectiveness of the Xpert MTB/RIF assay for the diagnosis of HIV-associated lymph node tuberculosis.
Academic Article Antiretroviral therapy initiation during tuberculosis treatment and HIV-RNA and CD4 T-lymphocyte responses.
Academic Article Does Disseminated Nontuberculous Mycobacterial Disease Cause False-Positive Determine TB-LAM Lateral Flow Assay Results? A Retrospective Review.
Academic Article Opportunities and challenges for HIV care in overlapping HIV and TB epidemics.
Academic Article Tuberculosis immune reconstitution inflammatory syndrome in A5221 STRIDE: timing, severity, and implications for HIV-TB programs.
Academic Article Xpert MTB/RIF as a measure of sputum bacillary burden. Variation by HIV status and immunosuppression.
Academic Article Linkage to care and treatment for TB and HIV among people newly diagnosed with TB or HIV-associated TB at a large, inner city South African hospital.
Academic Article High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial.
Academic Article Relationship between weight, efavirenz exposure, and virologic suppression in HIV-infected patients on rifampin-based tuberculosis treatment in the AIDS Clinical Trials Group A5221 STRIDE Study.
Academic Article Identification of Mycobacterium tuberculosis from pericardial fluid using the new Xpert MTB/RIF assay.
Academic Article High tuberculosis and HIV coinfection rate, Johannesburg.
Academic Article Tuberculosis treatment and risk of stavudine substitution in first-line antiretroviral therapy.
Academic Article High uptake of systematic HIV counseling and testing and TB symptom screening at a primary care clinic in South Africa.
Academic Article Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis.
Academic Article Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study.
Academic Article Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB.
Academic Article Identification of a 251 gene expression signature that can accurately detect M. tuberculosis in patients with and without HIV co-infection.
Academic Article Comparison of Xpert MTB/RIF with other nucleic acid technologies for diagnosing pulmonary tuberculosis in a high HIV prevalence setting: a prospective study.
Academic Article Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial.
Academic Article Natural killer cell activation distinguishes Mycobacterium tuberculosis-mediated immune reconstitution syndrome from chronic HIV and HIV/MTB coinfection.
Academic Article Towards host-directed therapies for tuberculosis.
Academic Article Effect of pulmonary tuberculosis on mortality in patients receiving HAART.
Academic Article Time to treatment and patient outcomes among TB suspects screened by a single point-of-care xpert MTB/RIF at a primary care clinic in Johannesburg, South Africa.
Academic Article Impact of three empirical anti-tuberculosis treatment strategies for people initiating antiretroviral therapy.
Academic Article A home tracing program for contacts of people with tuberculosis or HIV and patients lost to care.
Academic Article The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.
Academic Article Predictive and prognostic properties of TB-LAM among HIV-positive patients initiating ART in Johannesburg, South Africa.
Academic Article Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.
Academic Article Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors, and prevention strategies.
Academic Article A hospital-based tuberculosis focal point to improve tuberculosis care provision in a very high burden setting.
Academic Article Performance of Xpert MTB/RIF, Xpert Ultra, and Abbott RealTime MTB for Diagnosis of Pulmonary Tuberculosis in a High-HIV-Burden Setting.
Academic Article High rates of death and loss to follow-up by 12 months of rifampicin resistant TB treatment in South Africa.
Academic Article TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - a study protocol.

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  • Tuberculosis