Search Results to Elena Losina, PhD

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Research Expertise & Professional Interests For nearly two decades I have been dedicated to bringing rigorous research methods to bear on pressing clinical and policy questions. I enjoy working closely with clinical investigators in two spheres – rheumatology and orthopaedics. I serve as the principal investigator on several NIH-funded projects and as the collaborating methodologist on several others. My work focuses on: application of decision analytic models to the analysis of long-term clinical and economic implications of treatment or prevention strategies; statistical analysis of data collected longitudinally or via complex hierarchical surveys; design and conduct of non-pharmacologic clinical trials. I am the principal investigator of a multidisciplinary team that has developed the Osteoarthritis (OA) Policy Model, a computer simulation model of prevention, natural history and treatment for knee OA. This model is supported by an RO1 from NIAMS. I am also the Analytic Core Director of a multidisciplinary, international project assessing the prognostic value of serum and imaging biomarkers in knee OA. Studies of surgery raise especially challenging methodologic problems. I serve as the principal statistician of a NIAMS-funded multicenter RCT of the efficacy of arthroscopic partial meniscectomy in persons with meniscal tear and knee osteoarthritis; principal investigator of an RCT that investigates the efficacy of a patient navigator intervention to enhance recovery following total knee replacement; and principal statistician on a multidimensional population-based study examining the association of hospital volume and outcomes of total hip and knee replacement. I am a passionate, dedicated educator. Since 2007 I have served as a Core faculty member of EPI 208, the keystone course of the Harvard School of Public Health Program in Clinical Effectiveness. As a core faculty member I lead workshops and seminars and help students to shape research ideas into feasible research projects. I am also a co-Director of a T32 funded training program in musculoskeletal clinical research based at Brigham and Women’s Hospital. For more than a decade I have served as Principal Investigator of the Methodology Core of the NIAMSfunded P60 Multidisciplinary Clinical Research Center at Brigham and Women’s Hospital. The core provides direction and support for study design, data management, programming, statistical analysis, psychometric testing, training and education of post-doctoral fellows and other trainees. In recent years I became interested in implementing methods of behavior economics into workplace wellness programs and to increase physical activity in persons with arthritis. I led the R21 supported pilot RCT and currently work on planning a multicenter RCT to examine the efficacy of two interventions – financial incentives and telephonic coaching to improve physical activity post total knee replacements. I spend about a quarter of my time providing methodological mentorship to fellows, medical and doctoral students, and junior faculty. This work is funded in part by a NIAMS K24 Mentoring award. I co-founded and co-directed a short course “Essentials of Clinical Research in Orthopaedics” for orthopaedic fellows. I lead monthly research seminars and co-direct the PRIDE (Pilot Research Incubation and Development) Program in the Department of Orthopedic Surgery at Brigham and Women’s Hospital. This innovative program creates collaborations between clinical investigators and our methodology team to move the clinicians’ research ideas toward feasible projects and publications. I also serve as a Deputy Editor for Methodology and Biostatistics for the premier orthopaedic journal, the Journal of Bone and Joint Surgery. The breadth of clinical and methodological topics encompassed in my research and mentoring has enabled me to translate methods and concepts across disciplines and cultures.

One or more keywords matched the following items that are connected to Losina, Elena

Item TypeName
Concept Health Services Research
Concept Outcome and Process Assessment (Health Care)
Concept Pregnancy Outcome
Concept Research Design
Concept Research Support as Topic
Concept Treatment Outcome
Concept Outcome Assessment (Health Care)
Concept Neurosurgical Procedures
Concept Ethics, Research
Concept Biomedical Research
Concept Empirical Research
Concept Qualitative Research
Concept Comparative Effectiveness Research
Concept Research Report
Academic Article Tutorial in biostatistics. An introduction to hierarchical linear modelling.
Academic Article Treatment for primary HIV infection: projecting outcomes of immediate, interrupted, or delayed therapy.
Academic Article Rates and outcomes of primary and revision total hip replacement in the United States medicare population.
Academic Article Association between hospital and surgeon procedure volume and outcomes of total hip replacement in the United States medicare population.
Academic Article Association of hospital and surgeon volume of total hip replacement with functional status and satisfaction three years following surgery.
Academic Article Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection.
Academic Article Clinical impact and cost-effectiveness of antiretroviral therapy in India: starting criteria and second-line therapy.
Academic Article Potential risks and benefits of HIV treatment simplification: a simulation model of a proposed clinical trial.
Academic Article The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV.
Academic Article HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness.
Academic Article A SAS macro for a clustered permutation test.
Academic Article Improving outcomes in state AIDS drug assistance programs.
Academic Article A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials.
Academic Article The "ART" of linkage: pre-treatment loss to care after HIV diagnosis at two PEPFAR sites in Durban, South Africa.
Academic Article Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC.
Academic Article Cost effectiveness of venous thromboembolism pharmacological prophylaxis in total hip and knee replacement: a systematic review.
Academic Article Quantifying the risks and benefits of efavirenz use in HIV-infected women of childbearing age in the USA.
Academic Article Counselor- versus provider-based HIV screening in the emergency department: results from the universal screening for HIV infection in the emergency room (USHER) randomized controlled trial.
Academic Article A comparison of statistical approaches for physician-randomized trials with survival outcomes.
Academic Article The cost-effectiveness of pre-exposure prophylaxis for HIV infection in South African women.
Academic Article The cost-effectiveness of tuberculosis preventive therapy for HIV-infected individuals in southern India: a trial-based analysis.
Academic Article The MeTeOR trial (Meniscal Tear in Osteoarthritis Research): rationale and design features.
Academic Article Impact of misspecifying the distribution of a prognostic factor on power and sample size for testing treatment interactions in clinical trials.
Academic Article A randomized trial to optimize HIV/TB care in South Africa: design of the Sizanani trial.
Academic Article Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
Academic Article Relationship Between Patient-Reported Swelling and Magnetic Resonance Imaging-Defined Effusion-Synovitis in Patients With Meniscus Tears and Knee Osteoarthritis.
Award or Honor Receipt Mentored Quantitative Research Career Development Award
Award or Honor Receipt Innovative Research Grant
Award or Honor Receipt Clinical Research Award
Academic Article Trends in procedure type, patient characteristics, and outcomes among persons with knee osteoarthritis undergoing bariatric surgery, 2005-2014.
Academic Article Cost-Effectiveness of Diet and Exercise for Overweight and Obese Patients With Knee Osteoarthritis.
Academic Article Cost-effectiveness of generic celecoxib in knee osteoarthritis for average-risk patients: a model-based evaluation.
Academic Article Management of Reducible Ventral Hernias: Clinical Outcomes and Cost-effectiveness of Repair at Diagnosis Versus Watchful Waiting.
Academic Article Participant-Reported Benefits of Involvement in an Adaptive Sports Program: A Qualitative Study.
Academic Article Outcomes of safe patient handling and mobilization programs: A meta-analysis.
Academic Article Uses and Misuses of the P Value in Reporting Results of Orthopaedic Research Studies.
Academic Article Financial Incentives and Health Coaching to Improve Physical Activity Following Total Knee Replacement: A Randomized Controlled Trial.
Academic Article Improvement at Any Cost? The Art and Science of Choosing Treatment Strategies for Rheumatoid Arthritis.
Academic Article Impact of Preoperative Opioid Use on Total Knee Arthroplasty Outcomes.
Academic Article Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial.
Academic Article The Evolution of Implant Design Decreases the Incidence of Lateral Release in Primary Total Knee Arthroplasty.
Academic Article The association of pre-operative body pain diagram scores with pain outcomes following total knee arthroplasty.
Academic Article Predictors and Outcomes of Crossover to Surgery from Physical Therapy for Meniscal Tear and Osteoarthritis: A Randomized Trial Comparing Physical Therapy and Surgery.
Academic Article Randomized Controlled Trial of an Educational Intervention Using an Online Risk Calculator for Knee Osteoarthritis: Effect on Risk Perception.
Academic Article Age Matters: Increased Risk of Inconsistent HIV Care and Viremia Among Adolescents and Young Adults on Antiretroviral Therapy in Nigeria.
Academic Article American College of Rheumatology White Paper on Performance Outcome Measures in Rheumatology.
Academic Article Implementation of treat-to-target in rheumatoid arthritis through a Learning Collaborative: Rationale and design of the TRACTION trial.
Academic Article Model-based evaluation of cost-effectiveness of nerve growth factor inhibitors in knee osteoarthritis: impact of drug cost, toxicity, and means of administration.
Academic Article Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities.
Academic Article High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria.
Academic Article Effect of smoking and soft tissue release on risk of revision after total knee arthroplasty: a case- control study.
Academic Article Comparison of Care Provided in Practices With Nurse Practitioners and Physician Assistants Versus Subspecialist Physicians Only: A Cohort Study of Rheumatoid Arthritis.
Academic Article Defining the Value of Future Research to Identify the Preferred Treatment of Meniscal Tear in the Presence of Knee Osteoarthritis.
Academic Article OARSI Clinical Trials Recommendations: Key analytic considerations in design, analysis, and reporting of randomized controlled trials in osteoarthritis.
Academic Article The Linkage Outcomes of a Large-scale, Rapid Transfer of HIV-infected Patients From Hospital-based to Community-based Clinics in South Africa.
Academic Article The clinical role and cost-effectiveness of long-acting antiretroviral therapy.
Academic Article A comparison of patient-reported and measured range of motion in a cohort of total knee arthroplasty patients.
Academic Article Pharmacologic regimens for knee osteoarthritis prevention: can they be cost-effective?
Academic Article Mobile HIV screening in Cape Town, South Africa: clinical impact, cost and cost-effectiveness.
Academic Article Neighborhoods matter: use of hospitals with worse outcomes following total knee replacement by patients from vulnerable populations.
Academic Article Association between socioeconomic status and pain, function and pain catastrophizing at presentation for total knee arthroplasty.
Academic Article Trends in prescription of opioids from 2003-2009 in persons with knee osteoarthritis.
Academic Article The potential economic benefits of improved postfracture care: a cost-effectiveness analysis of a fracture liaison service in the US health-care system.
Academic Article A randomized controlled trial of an internal family systems-based psychotherapeutic intervention on outcomes in rheumatoid arthritis: a proof-of-concept study.
Academic Article The economics of improving medication adherence in osteoporosis: validation and application of a simulation model.
Academic Article Medical decision-making among Hispanics and non-Hispanic Whites with chronic back and knee pain: a qualitative study.
Academic Article Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: a Côte d'Ivoire appraisal.
Academic Article HIV testing rates and outcomes in a South African community, 2001-2006: implications for expanded screening policies.
Academic Article Development and validation of an index of musculoskeletal functional limitations.
Academic Article Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review.
Academic Article A blinded randomized controlled trial of motivational interviewing to improve adherence with osteoporosis medications: design of the OPTIMA trial.
Academic Article HIV drug resistance surveillance for prioritizing treatment in resource-limited settings.
Academic Article Factors predicting functional and radiographic outcomes after arthroscopic partial meniscectomy: a review of the literature.
Academic Article Psychosocial and geriatric correlates of functional status after total hip replacement.
Academic Article Accuracy of Medicare claims data for rheumatologic diagnoses in total hip replacement recipients.
Academic Article Predictors of outcomes of carpal tunnel release.
Academic Article Epidemiology of musculoskeletal upper extremity ambulatory surgery in the United States.
Academic Article The AViKA (Adding Value in Knee Arthroplasty) postoperative care navigation trial: rationale and design features.
Academic Article Studies of pain management in osteoarthritis: bedside to policy.
Academic Article Good accuracy of the Phase III Oxford Mobile Bearing Unicompartmental Knee Instrumentation.
Academic Article Outcomes of open carpal tunnel release at a minimum of ten years.
Academic Article Reliability of medical record abstraction by non-physicians for orthopedic research.
Academic Article Cost-effectiveness of earlier initiation of antiretroviral therapy for uninsured HIV-infected adults.
Academic Article Optimal frequency of CD4 cell count and HIV RNA monitoring prior to initiation of antiretroviral therapy in HIV-infected patients.
Academic Article Effectiveness of antiretroviral therapy after protease inhibitor failure: an analytic overview.
Academic Article Early outcomes and the virological effect of delayed treatment switching to second-line therapy in an antiretroviral roll-out programme in South Africa.
Academic Article Assessing the performance of a computer-based policy model of HIV and AIDS.
Academic Article First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trial.
Academic Article CD4+ T-cell-guided structured treatment interruptions of antiretroviral therapy in HIV disease: projecting beyond clinical trials.
Academic Article Type II odontoid fractures of the cervical spine: do treatment type and medical comorbidities affect mortality in elderly patients?
Academic Article Clinical trials in orthopaedics research. Part I. Cultural and practical barriers to randomized trials in orthopaedics.
Academic Article Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using magnetic resonance imaging.
Academic Article Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis.
Academic Article Outcomes after virologic failure of first-line ART in South Africa.
Academic Article Contribution of hospital characteristics to the volume-outcome relationship: dislocation and infection following total hip replacement surgery.
Academic Article Effectiveness of clinical pathways for total knee and total hip arthroplasty: literature review.
Academic Article Association of hospital and surgeon procedure volume with patient-centered outcomes of total knee replacement in a population-based cohort of patients age 65 years and older.
Academic Article Clinical trials in orthopaedics research. Part III. Overcoming operational challenges in the design and conduct of randomized clinical trials in orthopaedic surgery.
Academic Article Association between hospital and surgeon procedure volume and the outcomes of total knee replacement.
Academic Article Total joint replacement outcomes in patients with concomitant comorbidities: a glass half empty or half full?
Academic Article Extent of followup care after elective total hip replacement.
Academic Article Clinical trials in orthopaedics research. Part II. Prioritization for randomized controlled clinical trials.
Academic Article Utilization of low-volume hospitals for total hip replacement.
Academic Article Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group.
Academic Article Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review.
Academic Article Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis.
Academic Article Validity and responsiveness of radiographic joint space width metric measurement in hip osteoarthritis: a systematic review.
Academic Article Associations among preoperative MRI features and functional status following arthroscopic partial meniscectomy.
Academic Article Ambulatory care-sensitive hospitalizations: does one size fit all?
Academic Article Case mix and outcomes of total knee replacement in orthopaedic specialty hospitals.
Academic Article Decreasing medical complications for total knee arthroplasty: effect of critical pathways on outcomes.
Academic Article Risk factors for revision of primary total hip arthroplasty: a systematic review.
Academic Article Cost-effectiveness of spine surgery: the jury is out.
Academic Article Clinical outcome of metastatic spinal cord compression treated with surgical excision ± radiation versus radiation therapy alone: a systematic review of literature.
Academic Article Adverse Events and Resource Use Before and After Treat-to-Target in Rheumatoid Arthritis: A Post Hoc Analysis of a Randomized Controlled Trial.
Academic Article Why past research successes do not translate to clinical reality: gaps in evidence on exercise program efficacy.
Academic Article Cost-utility studies in upper limb orthopaedic surgery.
Academic Article Influence of Baseline Magnetic Resonance Imaging Features on Outcome of Arthroscopic Meniscectomy and Physical Therapy Treatment of Meniscal Tears in Osteoarthritis.
Academic Article Clinical outcomes and risk-factor analysis of the Ponseti Method in a low-resource setting: Clubfoot care in Haiti.
Academic Article Early Magnetic Resonance Imaging-Based Changes in Patients With Meniscal Tear and Osteoarthritis: Eighteen-Month Data From a Randomized Controlled Trial of Arthroscopic Partial Meniscectomy Versus Physical Therapy.
Academic Article Ambulatory status after surgical and nonsurgical treatment for spinal metastasis.
Academic Article Stability of Measures of Pain Catastrophizing and Widespread Pain Following Total Knee Replacement.
Academic Article Establishing outcome measures in early knee osteoarthritis.
Academic Article Five-Year Outcome of Operative and Nonoperative Management of Meniscal Tear in Persons Older Than Forty-Five Years.
Academic Article A consensus-based process identifying physical therapy and exercise treatments for patients with degenerative meniscal tears and knee OA: the TeMPO physical therapy interventions and home exercise program.
Academic Article Clinical and Economic Impact of Ibalizumab for People With Multidrug-Resistant HIV in the United States.
Academic Article Long-term clinical and economic outcomes of a short-term physical activity program in knee osteoarthritis patients.
Academic Article A consensus-based framework for conducting and reporting osteoarthritis phenotype research.
Academic Article Pain Management Research.
Academic Article Pain Management Research.
Academic Article Pain management research.
Academic Article Association Between Preoperative Radiographic Severity of Osteoarthritis and Patient-Reported Outcomes of Total Knee Replacement.
Academic Article Management Strategies for People Experiencing Sheltered Homelessness during the COVID-19 Pandemic: Clinical Outcomes and Costs.

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