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Research Expertise & Professional Interests Matthew Kulke MD is the Chief of Hematology/Oncology, Co-Director of the BU/BMC Cancer Center and Zoltan Kohn Professor at the Boston University School of Medicine. Dr. Kulke is an internationally recognized for his work in the field of neuroendocrine tumors. He has led or co-led both early and late stage clinical trials leading to the development of telotristat ethyl, temozolomide, sunitinib, everolimus and peptide receptor radiotherapy for the treatment of neuroendocrine tumors. His work has additionally included characterization of neuroendocrine tumors at the molecular level, and has resulted in over 200 peer-reviewed publications. Dr. Kulke received his undergraduate degree in molecular biology from Princeton University magna cum laude, and his medical degree with a thesis honors award from the University of California, San Francisco School of Medicine where he also was a Regent’s scholar and received a research training fellowship from the Howard Hughes Medical Institute. He performed his internship and residency at Brigham and Women’s Hospital, a medical oncology fellowship at Dana-Farber Cancer Institute, and received a Masters in Medical Science Degree from Harvard Medical School. Prior to coming to Boston University he was a Professor of Medicine at Harvard Medical School and Director of the Neuroendocrine Tumor Program at Dana-Farber Cancer Institute. He has served as principal investigator for NCI cooperative group trials in both neuroendocrine tumors and pancreatic cancer, served as chair of the National Cancer Institute’s Neuroendocrine Tumor Clinical Trial Task Force, chair of the North American Neuroendocrine Tumor Society, and chair of the National Comprehensive Cancer Network’s neuroendocrine tumor guidelines committee.

One or more keywords matched the following items that are connected to Kulke, Matthew

Item TypeName
Concept Enzyme-Linked Immunosorbent Assay
Concept Immunoenzyme Techniques
Concept Immunohistochemistry
Concept Immunosuppressive Agents
Concept Biomedical Research
Academic Article Neuroendocrine tumors.
Academic Article A phase II study of epirubicin and thalidomide in unresectable or metastatic hepatocellular carcinoma.
Academic Article Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer.
Academic Article Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Academic Article Targeted therapy in advanced well-differentiated neuroendocrine tumors.
Academic Article Clinical benefits of above-standard dose of octreotide LAR in patients with neuroendocrine tumors for control of carcinoid syndrome symptoms: a multicenter retrospective chart review study.
Academic Article Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab.
Academic Article Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.
Academic Article Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus.
Academic Article Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set.
Academic Article Phase I study of pasireotide (SOM 230) and everolimus (RAD001) in advanced neuroendocrine tumors.
Academic Article High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss.
Academic Article Targeted therapies in neuroendocrine tumors (NET): clinical trial challenges and lessons learned.
Academic Article Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma.
Academic Article Association Between Tumor Progression Endpoints and Overall Survival in Patients with Advanced Neuroendocrine Tumors.
Academic Article Glycemic control in patients with insulinoma treated with everolimus.
Academic Article In reply.
Academic Article Activity of sunitinib in patients with advanced neuroendocrine tumors.
Academic Article Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies.
Academic Article Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index.
Award or Honor Receipt Lauren Erb Award for Contributions to Neuroendocrine Tumor Research
Award or Honor Receipt Ruth Brufsky Award for Excellence in Clinical Research on Pancreatic Cancer Research
Award or Honor Receipt George Canellos Award for Contributions to Clinical Research
Academic Article Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms.
Academic Article Real-World Treatment Patterns and Clinical Outcomes in Advanced Gastrointestinal Neuroendocrine Tumors (GI NET): A Multicenter Retrospective Chart Review Study.
Academic Article Treatment Patterns and Clinical Outcomes in Advanced Lung Neuroendocrine Tumors in Real-World Settings: A Multicenter Retrospective Chart Review Study.
Academic Article Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome.
Academic Article Treatment Patterns and Health Resource Use Among Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors Treated at a Tertiary Referral Center.

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