Search Results to Ralph D'Agostino, PhD

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Research Expertise & Professional Interests Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research. He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use. He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association. He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study. He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

One or more keywords matched the following items that are connected to D'Agostino, Ralph

Item TypeName
Concept Activities of Daily Living
Concept Ambulatory Care
Concept Angiography
Concept Angioplasty, Balloon
Concept Anthropometry
Concept Coronary Artery Bypass
Concept Aortography
Concept Audiometry
Concept Biometry
Concept Biopsy
Concept Blood Chemical Analysis
Concept Blood Pressure Determination
Concept Brachytherapy
Concept Brain Mapping
Concept Catheterization
Concept Centrifugation
Concept Cesarean Section
Concept Chromatography, High Pressure Liquid
Concept Chromatography, Liquid
Concept Chromosome Mapping
Concept Clinical Protocols
Concept Clinical Trials as Topic
Concept Combined Modality Therapy
Concept Communicable Disease Control
Concept Community Health Services
Concept Cross-Sectional Studies
Concept Data Collection
Concept Decision Making, Computer-Assisted
Concept Delivery of Health Care
Concept Demography
Concept Denervation
Concept Diagnosis
Concept Diagnosis, Computer-Assisted
Concept Diagnosis, Differential
Concept Diagnostic Tests, Routine
Concept Diet Surveys
Concept Diet, Reducing
Concept Disability Evaluation
Concept Double-Blind Method
Concept Drug Evaluation
Concept Drug Therapy
Concept Drug Therapy, Combination
Concept Echocardiography
Concept Education
Concept Electrocardiography
Concept Electrodiagnosis
Concept Emergency Medical Services
Concept Enzyme-Linked Immunosorbent Assay
Concept Epidemiologic Methods
Concept Erythrocyte Indices
Concept Evaluation Studies as Topic
Concept Family
Concept Family Characteristics
Concept Fasting
Concept Follow-Up Studies
Concept Food Habits
Concept Genetic Testing
Concept Glomerular Filtration Rate
Concept Glucose Tolerance Test
Concept Medicare
Concept Health Promotion
Concept Health Services for the Aged
Concept Health Services Research
Concept Health Status Indicators
Concept Health Surveys
Concept Heterozygote Detection
Concept Hospitalization
Concept Information Systems
Concept Informed Consent
Concept Infusions, Intravenous
Concept Injections, Subcutaneous
Concept Institutionalization
Concept Insurance, Health, Reimbursement
Concept Intelligence Tests
Concept Internship and Residency
Concept Kidney Function Tests
Concept Leukocyte Count
Concept Life Support Care
Concept Longitudinal Studies
Concept Magnetic Resonance Imaging
Concept Marriage
Concept Mass Screening
Concept Medical History Taking
Concept Phytotherapy
Concept Mental Status Schedule
Concept Methods
Concept Models, Theoretical
Concept Monte Carlo Method
Concept Myocardial Revascularization
Concept National Health Programs
Concept Nephelometry and Turbidimetry
Concept Nephrostomy, Percutaneous
Concept Neuropsychological Tests
Concept Magnetic Resonance Spectroscopy
Concept Nursing Assessment
Concept Nutrition Surveys
Concept Office Visits
Concept Outcome and Process Assessment (Health Care)
Concept Palliative Care
Concept Patient Admission
Concept Patient Discharge
Concept Patient Education as Topic
Concept Patient Participation
Concept Personality Inventory
Concept Physical Examination
Concept Pilot Projects
Concept Placebos
Concept Population Surveillance
Concept Postoperative Care
Concept Primary Health Care
Concept Primary Prevention
Concept Product Surveillance, Postmarketing
Concept Prognosis
Concept Prospective Studies
Concept Prosthesis Design
Concept Psychological Tests
Concept Pulse
Concept Radiography
Concept Radionuclide Imaging
Concept Random Allocation
Concept Reading
Concept Rehabilitation, Vocational
Concept Research Design
Concept Respiration, Artificial
Concept Respiratory Function Tests
Concept Resuscitation
Concept Sampling Studies
Concept Self Care
Concept Skinfold Thickness
Concept Mass Spectrometry
Concept Statistics as Topic
Concept Sympathectomy
Concept Technology Assessment, Biomedical
Concept Terminal Care
Concept Therapy, Computer-Assisted
Concept Tomography
Concept Tomography, X-Ray Computed
Concept Toothbrushing
Concept Triage
Concept Ultracentrifugation
Concept Ultrasonography
Concept Urography
Concept Vaccination
Concept Weights and Measures
Concept Echocardiography, Doppler
Concept Fluoroimmunoassay
Concept Health Care Rationing
Concept Cohort Studies
Concept Multicenter Studies as Topic
Concept Epidemiologic Research Design
Concept Analgesia, Epidural
Concept Nursing Evaluation Research
Concept Absorptiometry, Photon
Concept Geriatric Assessment
Concept Nutrition Assessment
Concept Tomography, Emission-Computed, Single-Photon
Concept Angioplasty, Balloon, Coronary
Concept Thrombolytic Therapy
Concept Estrogen Replacement Therapy
Concept Discriminant Analysis
Concept Logistic Models
Concept Epidemiologic Studies
Concept Case-Control Studies
Concept Randomized Controlled Trials as Topic
Concept Single-Blind Method
Concept Walking
Concept Analgesia, Obstetrical
Concept Drug Monitoring
Concept Coronary Angiography
Concept Outcome Assessment (Health Care)
Concept Catheter Ablation
Concept Polysomnography
Concept Clinical Trials, Phase III as Topic
Concept Elective Surgical Procedures
Concept Hematopoietic Stem Cell Transplantation
Concept Risk Assessment
Concept Patient Selection
Concept Cross-Over Studies
Concept Ultrasonography, Doppler
Concept Ultrasonography, Doppler, Duplex
Concept Echocardiography, Doppler, Color
Concept Blood Pressure Monitoring, Ambulatory
Concept Patient-Centered Care
Concept Controlled Clinical Trials as Topic
Concept Magnetic Resonance Imaging, Cine
Concept Observation
Concept Disease Management
Concept Blood Vessel Prosthesis Implantation
Concept Guideline Adherence
Concept Hormone Replacement Therapy
Concept Antiretroviral Therapy, Highly Active
Concept Endpoint Determination
Concept Advance Care Planning
Concept Genetic Research
Concept Tomography, Spiral Computed
Concept After-Hours Care
Concept Risk Reduction Behavior
Concept Early Diagnosis
Concept Nutrition Therapy
Concept Biopsy, Fine-Needle
Concept Nomograms
Concept Tandem Mass Spectrometry
Concept Early Detection of Cancer
Concept Genome-Wide Association Study
Concept Cardiac-Gated Imaging Techniques
Concept Secondary Prevention
Concept Drug Discovery
Concept Enzyme Replacement Therapy
Concept Intention to Treat Analysis
Concept Endovascular Procedures
Concept Molecular Targeted Therapy
Concept Multidetector Computed Tomography
Concept Percutaneous Coronary Intervention
Concept Pulse Wave Analysis
Concept Pragmatic Clinical Trials as Topic
Concept Social Determinants of Health
Concept Interrupted Time Series Analysis
Concept In Vitro Techniques
Academic Article Left atrial size and the risk of stroke and death. The Framingham Heart Study.
Academic Article Stroke severity in atrial fibrillation. The Framingham Study.
Academic Article Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.
Academic Article Role of age, education, and gender on cognitive performance in the Framingham Heart Study: community-based norms.
Academic Article Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis.
Academic Article Multiple comparisons in over-the-counter drug clinical trials with both positive and placebo controls.
Academic Article How important is functional status as a predictor of service use by older people?
Academic Article Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores.
Academic Article Validation of a dietary pattern approach for evaluating nutritional risk: the Framingham Nutrition Studies.
Academic Article Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis.
Academic Article Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study.
Academic Article Non-inferiority trials: design concepts and issues - the encounters of academic consultants in statistics.
Academic Article Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study.
Academic Article Robustness of the t test applied to data distorted from normality by floor effects.
Academic Article The internal validity of a dietary pattern analysis. The Framingham Nutrition Studies.
Academic Article Dietary patterns predict the development of overweight in women: The Framingham Nutrition Studies.
Academic Article Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study.
Academic Article Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study.
Academic Article Mitral annular calcification and the risk of stroke in an elderly cohort.
Academic Article Does job strain increase the risk for coronary heart disease or death in men and women? The Framingham Offspring Study.
Academic Article Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study.
Academic Article Obesity, diabetes and cognitive deficit: The Framingham Heart Study.
Academic Article Unique dietary patterns and chronic disease risk profiles of adult men: the Framingham nutrition studies.
Academic Article Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study.
Academic Article Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants.
Academic Article Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence.
Academic Article Temporal trends in the incidence of intermittent claudication from 1950 to 1999.
Academic Article Relations of insulin sensitivity to longitudinal blood pressure tracking: variations with baseline age, body mass index, and blood pressure.
Academic Article Tension and anxiety and the prediction of the 10-year incidence of coronary heart disease, atrial fibrillation, and total mortality: the Framingham Offspring Study.
Academic Article Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease.
Academic Article Association of parental heart failure with risk of heart failure in offspring.
Academic Article Choice of time scale and its effect on significance of predictors in longitudinal studies.
Academic Article Dietary quality predicts adult weight gain: findings from the Framingham Offspring Study.
Academic Article Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
Academic Article Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study.
Academic Article A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study.
Academic Article Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study.
Academic Article General cardiovascular risk profile for use in primary care: the Framingham Heart Study.
Academic Article BMI vs. waist circumference for identifying vascular risk.
Academic Article Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life.
Academic Article Vitamin D deficiency and risk of cardiovascular disease.
Academic Article Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample.
Academic Article Performance of a method for identifying the unique dietary patterns of adult women and men: the Framingham nutrition studies.
Academic Article Interindividual variation in serum sodium and longitudinal blood pressure tracking in the Framingham Heart Study.
Academic Article Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study.
Academic Article Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort--invited commentary.
Academic Article Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study.
Academic Article Using survival methods to estimate age-at-onset distributions for genetic diseases with an application to Huntington disease.
Academic Article Blood pressure as a risk factor for cardiovascular disease. The Framingham Study--30 years of follow-up.
Academic Article Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study.
Academic Article Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study.
Academic Article Statistical methods for assessment of added usefulness of new biomarkers.
Academic Article Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers.
Academic Article On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data.
Academic Article A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study.
Academic Article Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial.
Academic Article A risk score for chronic kidney disease in the general population.
Academic Article Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndromes in emergency medical services.
Academic Article Chronic kidney disease defined by cystatin C predicts mobility disability and changes in gait speed: the Framingham Offspring Study.
Academic Article Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants.
Academic Article Trends in the association of parental history of obesity over 60 years.
Academic Article Cigarette smoking as a risk factor for stroke. The Framingham Study.
Academic Article Fibrinogen and risk of cardiovascular disease. The Framingham Study.
Academic Article Dietary lipid predictors of coronary heart disease in men. The Framingham Study.
Academic Article Re-using Mini-Sentinel data following rapid assessments of potential safety signals via modular analytic programs.
Academic Article Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events.
Academic Article RE: Drug risk assessment and data reuse.
Academic Article One-year outcomes of out-of-hospital administration of intravenous glucose, insulin, and potassium (GIK) in patients with suspected acute coronary syndromes (from the IMMEDIATE [Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care] Trial).
Academic Article Pitavastatin 4 mg Provides Significantly Greater Reduction in Remnant Lipoprotein Cholesterol Compared With Pravastatin 40 mg: Results from the Short-term Phase IV PREVAIL US Trial in Patients With Primary Hyperlipidemia or Mixed Dyslipidemia.
Academic Article Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions).
Academic Article Remnant Lipoprotein Cholesterol and Incident Coronary Heart Disease: The Jackson Heart and Framingham Offspring Cohort Studies.
Academic Article Myocardial Infarction Risk After Discontinuation of Thienopyridine Therapy in the Randomized DAPT Study (Dual Antiplatelet Therapy).
Academic Article Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study.
Academic Article Greater remnant lipoprotein cholesterol reduction with pitavastatin compared with pravastatin in HIV-infected patients.
Academic Article Guideline-Based Statin Eligibility, Cancer Events, and Noncardiovascular Mortality in the Framingham Heart Study.
Academic Article Association of Multiorgan Computed Tomographic Phenomap With Adverse Cardiovascular Health Outcomes: The Framingham Heart Study.
Academic Article Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib.
Academic Article Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection.
Academic Article External validation of the TIMI risk score for secondary cardiovascular events among patients with recent myocardial infarction.
Academic Article A longitudinal study of body mass index and lens opacities. The Framingham Studies.
Academic Article Multiplicity Considerations in Clinical Trials.
Academic Article Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials.
Academic Article Duration and Degree of Weight Gain and Incident Diabetes in Younger Versus Middle-Aged Black and White Adults: ARIC, CARDIA, and the Framingham Heart Study.
Academic Article Albuminuria according to status of autoimmunity and insulin sensitivity among youth with type 1 and type 2 diabetes.
Academic Article Extension of adaptive alpha allocation methods for strong control of the family-wise error rate.
Academic Article Pioglitazone-mediated changes in lipoprotein particle composition are predicted by changes in adiponectin level in type 2 diabetes.
Academic Article Comments from the editors.
Academic Article Efficacy endpoint selection and multiplicity adjustment methods in clinical trials with inherent multiple endpoint issues.
Academic Article Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial.
Academic Article Longitudinal association of glycemia and microalbuminuria: the Framingham Offspring Study.
Academic Article The statistician and the data monitoring committee.
Academic Article Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3.
Academic Article Updating our aims and scope for the future.
Academic Article Traditional multiplicity adjustment methods in clinical trials.
Academic Article Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study.
Academic Article The Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study: rationale and methods.
Academic Article A controlled trial of renal denervation for resistant hypertension.
Academic Article Serum lipids and age-related lens opacities: a longitudinal investigation: the Framingham Studies.
Academic Article Maximum likelihood estimation for interval-censored data using a Weibull-based accelerated failure time model.
Academic Article A technique for summarizing longitudinal data.
Academic Article A comparison of performance of mathematical predictive methods for medical diagnosis: identifying acute cardiac ischemia among emergency department patients.
Academic Article Meta-analysis: a method for synthesizing research.
Academic Article Longitudinal threshold changes in older men with audiometric notches.
Academic Article Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension?
Academic Article Trends in CHD and risk factors at age 55-64 in the Framingham Study.
Academic Article G-estimation of causal effects: isolated systolic hypertension and cardiovascular death in the Framingham Heart Study.
Academic Article Decisive factors in the tolbutamide controversy.
Academic Article Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989.
Academic Article Benefits and adverse effects of weight loss. Observations from the Framingham Study.
Academic Article Does number of children increase the rate of coronary heart disease in men?
Academic Article Physical activity and physical demand on the job and risk of cardiovascular disease and death: the Framingham Study.
Academic Article Issues of study design and data analysis.
Academic Article A logistic regression model when some events precede treatment: the effect of thrombolytic therapy for acute myocardial infarction on the risk of cardiac arrest.
Academic Article The usefulness of a predictive instrument to reduce inappropriate admissions to the coronary care unit.
Academic Article A fluoride dose-response evaluation in an anticaries clinical trial.
Academic Article Relation of low diastolic blood pressure to coronary heart disease death in presence of myocardial infarction: the Framingham Study.
Academic Article Physical activity and mortality in women in the Framingham Heart Study.
Academic Article Does exercise reduce mortality rates in the elderly? Experience from the Framingham Heart Study.
Academic Article New method for simultaneous placement of antegrade ureteral stent and nephrostomy tube.
Academic Article Results from a three-year caries clinical trial comparing NaF and SMFP fluoride formulations.
Academic Article Cardiac nuclear imaging. Adoption of an evolving technology.
Academic Article Secular trends in long-term sustained hypertension, long-term treatment, and cardiovascular mortality. The Framingham Heart Study 1950 to 1990.
Academic Article The logistic function as an aid in the detection of acute coronary disease in emergency patients (a case study).
Academic Article A comparison between lovastatin and gemfibrozil in the treatment of primary hypercholesterolemia.
Academic Article An analytic method for the evaluation of rural Emergency Medical Service development.
Academic Article The appropriateness of analysis of variance to the statistical analyses of dental clinical trials.
Academic Article Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus-Rationale, design, and baseline characteristics.
Academic Article Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.
Academic Article Association of Maternal Prepregnancy Weight with Offspring Adiposity Throughout Adulthood over 37 Years of Follow-up.
Academic Article Widespread pain is a risk factor for cardiovascular mortality: results from the Framingham Heart Study.
Academic Article Simulation of impact on cardiovascular events due to lipid-lowering therapy intensification in a population with atherosclerotic cardiovascular disease.
Academic Article Early Rapid Decline in Kidney Function in Medically Managed Patients With Atherosclerotic Renal Artery Stenosis.
Academic Article Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis.

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