Search Results to Ralph D'Agostino, PhD

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Research Expertise & Professional Interests Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research. He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use. He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association. He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study. He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

One or more keywords matched the following items that are connected to D'Agostino, Ralph

Item TypeName
Concept Clinical Decision-Making
Concept Chemistry, Clinical
Concept Clinical Competence
Concept Clinical Protocols
Concept Clinical Trials as Topic
Concept Clinical Trials, Phase III as Topic
Concept Controlled Clinical Trials as Topic
Concept Decision Support Systems, Clinical
Concept Clinical Trials Data Monitoring Committees
Concept Ethics, Clinical
Concept Pragmatic Clinical Trials as Topic
Academic Article The uses of outcomes research for medical effectiveness, quality of care, and reimbursement in type II diabetes.
Academic Article The Stroke Prevention Policy Model: linking evidence and clinical decisions.
Academic Article Multiple comparisons in over-the-counter drug clinical trials with both positive and placebo controls.
Academic Article Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis.
Academic Article Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study.
Academic Article Non-inferiority trials: design concepts and issues - the encounters of academic consultants in statistics.
Academic Article Robustness of the t test applied to data distorted from normality by floor effects.
Academic Article Central auditory dysfunction may precede the onset of clinical dementia in people with probable Alzheimer's disease.
Academic Article Presentation of multivariate data for clinical use: The Framingham Study risk score functions.
Academic Article New developments in medical clinical trials.
Academic Article Clinical research in primary stroke prevention: needs, opportunities, and challenges.
Academic Article Stent thrombosis in randomized clinical trials of drug-eluting stents.
Academic Article Clinical utility of different lipid measures for prediction of coronary heart disease in men and women.
Academic Article Prior cardiovascular interventions are not associated with worsened clinical outcomes in patients with symptomatic atherothrombosis.
Academic Article Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts.
Academic Article Emergency medical service predictive instrument-aided diagnosis and treatment of acute coronary syndromes and ST-segment elevation myocardial infarction in the IMMEDIATE trial.
Academic Article Objective performance goals of safety and blood pressure efficacy for clinical trials of renal artery bare metal stents in hypertensive patients with atherosclerotic renal artery stenosis.
Academic Article Invited commentary: Clinical usefulness of the Framingham cardiovascular risk profile beyond its statistical performance.
Academic Article Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community.
Academic Article Pencina et al. respond to "The incremental value of new markers" and "Clinically relevant measures? A note of caution".
Academic Article A randomized control trial of cardiac rehabilitation.
Academic Article Hypertension, antihypertensive treatment, and sudden coronary death. The Framingham Study.
Academic Article Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.
Academic Article Inference of equivalence for the ratio of two normal means with unspecified variances.
Academic Article Covariate effect on constancy assumption in noninferiority clinical trials.
Academic Article Effects of Stenting for Atherosclerotic Renal Artery Stenosis on eGFR and Predictors of Clinical Events in the CORAL Trial.
Academic Article Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions).
Academic Article Multiplicity Considerations in Clinical Trials.
Academic Article Editorial: Multiplicity issues in clinical trials.
Academic Article Composite and multicomponent end points in clinical trials.
Academic Article Relationship between therapeutic effects on infarct size in acute myocardial infarction and therapeutic effects on 1-year outcomes: A patient-level analysis of randomized clinical trials.
Academic Article Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials.
Academic Article Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.
Academic Article Use of composite endpoints in clinical trials.
Academic Article Multiplicity adjustments in testing for bioequivalence.
Academic Article Use of composite endpoints in clinical trials.
Academic Article Clinical decisions. The guidelines battle on starting statins.
Academic Article Risk estimation for recurrent Clostridium difficile infection based on clinical factors.
Academic Article The randomized registry trial--the next disruptive technology in clinical research?
Academic Article Key multiplicity issues in clinical drug development.
Academic Article The effectiveness of antihistamines in reducing the severity of runny nose and sneezing: a meta-analysis.
Academic Article The prevention and treatment of missing data in clinical trials.
Academic Article Efficacy endpoint selection and multiplicity adjustment methods in clinical trials with inherent multiple endpoint issues.
Academic Article The statistician and the data monitoring committee.
Academic Article Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis.
Academic Article Global risk assessment for cardiovascular disease and astute clinical judgement.
Academic Article Traditional multiplicity adjustment methods in clinical trials.
Academic Article Assessment of mortality in patients enrolled in a risedronate clinical trial program: a retrospective cohort study.
Academic Article Surfactant trials.
Academic Article Controlling alpha in a clinical trial: the case for secondary endpoints.
Academic Article Decisive factors in the tolbutamide controversy.
Academic Article A proposal for integrated efficacy-to-effectiveness (E2E) clinical trials.
Academic Article Physician electrocardiogram reading in the emergency department--accuracy and effect on triage decisions: findings from a multicenter study.
Academic Article Clinical findings associated with radiographic pneumonia in nursing home residents.
Academic Article A predictive instrument to improve coronary-care-unit admission practices in acute ischemic heart disease. A prospective multicenter clinical trial.
Academic Article A logistic regression model when some events precede treatment: the effect of thrombolytic therapy for acute myocardial infarction on the risk of cardiac arrest.
Academic Article Editorial: quantifying the comparison of two groups.
Academic Article A fluoride dose-response evaluation in an anticaries clinical trial.
Academic Article Measuring effectiveness. What to expect without a randomized control group.
Academic Article The exclusion of women from clinical trials of thrombolytic therapy: implications for developing the thrombolytic predictive instrument database.
Academic Article Results from a three-year caries clinical trial comparing NaF and SMFP fluoride formulations.
Academic Article The appropriateness of analysis of variance to the statistical analyses of dental clinical trials.
Academic Article Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results.
Academic Article Recommended revisions to American Dental Association guidelines for acceptance of chemotherapeutic products for gingivitis control. Report of the Task Force on Design and Analysis in Dental and Oral Research to the Council on Therapeutics of the American Dental Association.
Academic Article Deriving Real-World Insights From Real-World Data: Biostatistics to the Rescue.
Academic Article Efficacy and Effectiveness Too Trials: Clinical Trial Designs to Generate Evidence on Efficacy and on Effectiveness in Wide Practice.
Academic Article The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement: Explanation and Elaboration.
Academic Article The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement.
Academic Article Prediction Models - Development, Evaluation, and Clinical Application.
Grant Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao

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