Search Results to David A. Boas, PhD

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Research Expertise & Professional Interests David Boas, Ph.D. (Professor, Biomedical Engineering) is Director of the Neurophotonics Center at Boston University. He received his BS in Physics at Rensselear Polytechnic Institute and PhD in Physics at the University of Pennsylvania. During his academic career, he has supervised 44 students and post-doctoral fellows, and he has published over 250 papers that have received over 30,000 citations and an h-index of 101. He is the founding President of the Society for Functional Near Infrared Spectroscopy and founding Editor-in-Chief of the journal Neurophotonics published by SPIE. Dr. Boas was awarded the Britton Chance Award in Biomedical Optics in 2016 for his development of several novel, high-impact biomedical optical technologies in the neurosciences, as well as following through with impactful application studies, and fostering the widespread adoption of these technologies. He was elected a Fellow of AIMBE, SPIE, and OSA in 2017. As Director of the Neurophotonics Center, he facilitates the development and application of novel optical methods to address a broad range of neuroscience questions from basic science to clinical translation. His own research efforts focus on neurovascular coupling, cerebral oxygen delivery and consumption, functional near infrared spectroscopy (fNIRS), and physiological modeling. Studies are done in rodents and humans, invasively and non-invasively, microscopically and macroscopically, providing a powerful ability to translate findings from animals to humans, and conversely to address in animals questions raised during human studies. One example of this that will tie together many of Dr. Boas’ activities is studying functional brain recovery in survivors of stroke. Human neuroimaging by fMRI and fNIRS measures hemodynamic functional recovery but it is not known if neuro-vascular coupling differs in these patients compared to healthy subjects. Animal studies will answer this question enabling more quantitative interpretation of the human neuroimaging studies.

One or more keywords matched the following items that are connected to Boas, David

Item TypeName
Concept Magnetic Resonance Imaging
Concept Diffusion Magnetic Resonance Imaging
Academic Article Magnetic resonance fingerprinting based on realistic vasculature in mice.
Academic Article Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception.
Academic Article Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy.
Academic Article The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.
Academic Article Cell type specificity of neurovascular coupling in cerebral cortex.
Academic Article The pulsatility volume index: an indicator of cerebrovascular compliance based on fast magnetic resonance imaging of cardiac and respiratory pulsatility.
Academic Article Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe.
Academic Article Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue.
Academic Article Validation of the hypercapnic calibrated fMRI method using DOT-fMRI fusion imaging.
Academic Article Comparison of a layered slab and an atlas head model for Monte Carlo fitting of time-domain near-infrared spectroscopy data of the adult head.
Academic Article Validating atlas-guided DOT: a comparison of diffuse optical tomography informed by atlas and subject-specific anatomies.
Academic Article Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data.
Academic Article The utility of near-infrared spectroscopy in the regression of low-frequency physiological noise from functional magnetic resonance imaging data.
Academic Article Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements.
Academic Article Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies.
Academic Article MRI parcellation of ex vivo medial temporal lobe.
Academic Article Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.
Academic Article Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging.
Academic Article Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation.
Academic Article Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal.
Academic Article Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity.
Academic Article A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans.
Academic Article Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model.
Academic Article Assessing the future of diffuse optical imaging technologies for breast cancer management.
Academic Article Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin.
Academic Article Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging.
Academic Article Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging.
Academic Article Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging.
Academic Article Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging.
Academic Article Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation.
Academic Article Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation.
Academic Article Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy.
Academic Article Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI.
Academic Article Optimal linear inverse solution with multiple priors in diffuse optical tomography.
Academic Article Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function.
Academic Article Noninvasive functional imaging of human brain using light.
Academic Article Direct estimation of evoked hemoglobin changes by multimodality fusion imaging.
Academic Article Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling.
Academic Article Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information.
Academic Article Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition.
Academic Article Physiological system identification with the Kalman filter in diffuse optical tomography.
Academic Article A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation.
Academic Article Dependence of the MR signal on the magnetic susceptibility of blood studied with models based on real microvascular networks.
Academic Article Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging.
Grant Improving human FMRI through modeling and imaging microvascular dynamics

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  • Magnetic Resonance Imaging