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Research Expertise & Professional Interests David Boas, Ph.D. (Professor, Biomedical Engineering) is Director of the Neurophotonics Center at Boston University. He received his BS in Physics at Rensselear Polytechnic Institute and PhD in Physics at the University of Pennsylvania. During his academic career, he has supervised 44 students and post-doctoral fellows, and he has published over 250 papers that have received over 30,000 citations and an h-index of 101. He is the founding President of the Society for Functional Near Infrared Spectroscopy and founding Editor-in-Chief of the journal Neurophotonics published by SPIE. Dr. Boas was awarded the Britton Chance Award in Biomedical Optics in 2016 for his development of several novel, high-impact biomedical optical technologies in the neurosciences, as well as following through with impactful application studies, and fostering the widespread adoption of these technologies. He was elected a Fellow of AIMBE, SPIE, and OSA in 2017. As Director of the Neurophotonics Center, he facilitates the development and application of novel optical methods to address a broad range of neuroscience questions from basic science to clinical translation. His own research efforts focus on neurovascular coupling, cerebral oxygen delivery and consumption, functional near infrared spectroscopy (fNIRS), and physiological modeling. Studies are done in rodents and humans, invasively and non-invasively, microscopically and macroscopically, providing a powerful ability to translate findings from animals to humans, and conversely to address in animals questions raised during human studies. One example of this that will tie together many of Dr. Boas’ activities is studying functional brain recovery in survivors of stroke. Human neuroimaging by fMRI and fNIRS measures hemodynamic functional recovery but it is not known if neuro-vascular coupling differs in these patients compared to healthy subjects. Animal studies will answer this question enabling more quantitative interpretation of the human neuroimaging studies.

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Item TypeName
Concept Acoustic Stimulation
Concept Algorithms
Concept Anesthesia
Concept Anesthesia, General
Concept Angiography
Concept Autoradiography
Concept Blood Volume Determination
Concept Brain Mapping
Concept Cerebral Angiography
Concept Clinical Trials as Topic
Concept Colonoscopy
Concept Computer Simulation
Concept Demography
Concept Diagnosis, Computer-Assisted
Concept Diagnostic Imaging
Concept Electric Stimulation
Concept Electrocardiography
Concept Electroencephalography
Concept Electron Spin Resonance Spectroscopy
Concept Evoked Potentials
Concept Evoked Potentials, Somatosensory
Concept Feasibility Studies
Concept Fetal Monitoring
Concept Filtration
Concept Follow-Up Studies
Concept Fourier Analysis
Concept Hemoglobinometry
Concept Image Interpretation, Computer-Assisted
Concept Image Processing, Computer-Assisted
Concept Injections, Intravenous
Concept Language Tests
Concept Luminescent Measurements
Concept Magnetic Resonance Imaging
Concept Mammography
Concept Mass Screening
Concept Mathematical Computing
Concept Microscopy
Concept Microscopy, Fluorescence
Concept Microscopy, Polarization
Concept Models, Theoretical
Concept Monte Carlo Method
Concept Nephelometry and Turbidimetry
Concept Neuropsychological Tests
Concept Oscillometry
Concept Oximetry
Concept Oxygen Inhalation Therapy
Concept Perfusion
Concept Photic Stimulation
Concept Pilot Projects
Concept Prospective Studies
Concept Radiographic Image Enhancement
Concept Radiographic Image Interpretation, Computer-Assisted
Concept Radiometry
Concept Reading
Concept Rheology
Concept Signal Processing, Computer-Assisted
Concept Spectrometry, Fluorescence
Concept Spectrophotometry, Infrared
Concept Spectrum Analysis
Concept Spirometry
Concept Staining and Labeling
Concept Statistics as Topic
Concept Subtraction Technique
Concept Tomography
Concept Tomography, Emission-Computed
Concept Tomography, X-Ray Computed
Concept Magnetoencephalography
Concept Molecular Probe Techniques
Concept Reperfusion
Concept Tomography, Emission-Computed, Single-Photon
Concept Intensive Care, Neonatal
Concept Logistic Models
Concept Case-Control Studies
Concept Conscious Sedation
Concept Drug Monitoring
Concept Chemotherapy, Adjuvant
Concept Computer-Aided Design
Concept Laser-Doppler Flowmetry
Concept Catheter Ablation
Concept Ultrasonography, Doppler, Transcranial
Concept Microscopy, Confocal
Concept Microscopy, Video
Concept Magnetic Resonance Angiography
Concept Evoked Potentials, Motor
Concept Point-of-Care Systems
Concept Spectroscopy, Near-Infrared
Concept Finite Element Analysis
Concept Neoadjuvant Therapy
Concept Microscopic Angioscopy
Concept Imaging, Three-Dimensional
Concept Biomedical Research
Concept Microscopy, Fluorescence, Multiphoton
Concept Diffusion Magnetic Resonance Imaging
Concept Tomography, Optical
Concept Tomography, Optical Coherence
Concept Continuous Positive Airway Pressure
Concept Positron-Emission Tomography
Concept Whole Body Imaging
Concept Diffusion Tensor Imaging
Concept Wavelet Analysis
Concept Pain Management
Concept Neuroimaging
Concept Functional Neuroimaging
Concept Optical Imaging
Concept Optogenetics
Concept Multimodal Imaging
Concept In Vitro Techniques
Academic Article Motion artifact detection and correction in functional near-infrared spectroscopy: a new hybrid method based on spline interpolation method and Savitzky-Golay filtering.
Academic Article as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity.
Academic Article fNIRS can robustly measure brain activity during memory encoding and retrieval in healthy subjects.
Academic Article Non-invasive methods for measuring vascular changes in neurovascular headaches.
Academic Article Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis.
Academic Article Theoretical model of blood flow measurement by diffuse correlation spectroscopy.
Academic Article Magnetic resonance fingerprinting based on realistic vasculature in mice.
Academic Article Model-based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach.
Academic Article Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation.
Academic Article Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion.
Academic Article Early capillary flux homogenization in response to neural activation.
Academic Article Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging.
Academic Article Effect of motion artifacts and their correction on near-infrared spectroscopy oscillation data: a study in healthy subjects and stroke patients.
Academic Article Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe.
Academic Article Validation of the hypercapnic calibrated fMRI method using DOT-fMRI fusion imaging.
Academic Article Comparison of a layered slab and an atlas head model for Monte Carlo fitting of time-domain near-infrared spectroscopy data of the adult head.
Academic Article Twenty years of functional near-infrared spectroscopy: introduction for the special issue.
Academic Article Blockface histology with optical coherence tomography: a comparison with Nissl staining.
Academic Article The effect of color priming on infant brain and behavior.
Academic Article Reducing motion artifacts for long-term clinical NIRS monitoring using collodion-fixed prism-based optical fibers.
Academic Article Probing the early development of visual working memory capacity with functional near-infrared spectroscopy.
Academic Article Motion artifacts in functional near-infrared spectroscopy: a comparison of motion correction techniques applied to real cognitive data.
Academic Article Further improvement in reducing superficial contamination in NIRS using double short separation measurements.
Academic Article Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates.
Academic Article Frequency-domain measurement of neuronal activity using dynamic optical coherence tomography.
Academic Article Dynamic light scattering optical coherence tomography.
Academic Article Functional activation of the infant cortex during object processing.
Academic Article Validating atlas-guided DOT: a comparison of diffuse optical tomography informed by atlas and subject-specific anatomies.
Academic Article Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data.
Academic Article Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex.
Academic Article Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements.
Academic Article Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response.
Academic Article Short separation channel location impacts the performance of short channel regression in NIRS.
Academic Article Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography.
Academic Article Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia.
Academic Article Laser speckle contrast imaging in biomedical optics.
Academic Article Tomographic optical breast imaging guided by three-dimensional mammography.
Academic Article Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography.
Academic Article Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters.
Academic Article Image reconstruction in optical tomography in the presence of coupling errors.
Academic Article Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations.
Academic Article Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.
Academic Article Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties.
Academic Article Volumetric diffuse optical tomography of brain activity.
Academic Article Does the photon-diffusion coefficient depend on absorption?
Academic Article Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging.
Academic Article Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue.
Academic Article A vascular anatomical network model of the spatio-temporal response to brain activation.
Academic Article Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography.
Academic Article Comparison of frequency-domain and time-domain fluorescence lifetime tomography.
Academic Article Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain.
Academic Article Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult.
Academic Article Coregistered tomographic x-ray and optical breast imaging: initial results.
Academic Article Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model.
Academic Article Dynamic functional and mechanical response of breast tissue to compression.
Academic Article Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence.
Academic Article Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin.
Academic Article Dynamic physiological modeling for functional diffuse optical tomography.
Academic Article A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation.
Academic Article Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT.
Academic Article Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects.
Academic Article Fluorescence optical diffusion tomography.
Academic Article Optode positional calibration in diffuse optical tomography.
Academic Article Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging.
Academic Article A fundamental limitation of linearized algorithms for diffuse optical tomography.
Academic Article Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy.
Academic Article Diffuse optical imaging of the whole head.
Academic Article Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging.
Academic Article Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging.
Academic Article Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation.
Academic Article Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates'' brains in the first six weeks of life.
Academic Article Time-series estimation of biological factors in optical diffusion tomography.
Academic Article Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units.
Academic Article Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer''s disease mouse models.
Academic Article The effect of different anesthetics on neurovascular coupling.
Academic Article Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans.
Academic Article Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy.
Academic Article Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography.
Academic Article Noninvasive measurement of neuronal activity with near-infrared optical imaging.
Academic Article Fluorescence optical diffusion tomography using multiple-frequency data.
Academic Article Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography.
Academic Article Lifetime-based tomographic multiplexing.
Academic Article Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media.
Academic Article A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient.
Academic Article Combined optical and X-ray tomosynthesis breast imaging.
Academic Article Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI.
Academic Article Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging.
Academic Article Optimal linear inverse solution with multiple priors in diffuse optical tomography.
Academic Article Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function.
Academic Article Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex.
Academic Article Noninvasive functional imaging of human brain using light.
Academic Article Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia.
Academic Article Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system.
Academic Article Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling.
Academic Article Compositional-prior-guided image reconstruction algorithm for multi-modality imaging.
Academic Article Trans-abdominal monitoring of fetal arterial blood oxygenation using pulse oximetry.
Academic Article HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain.
Academic Article The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics.
Academic Article A haemodynamic response function model in spatio-temporal diffuse optical tomography.
Academic Article Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information.
Academic Article Dynamic imaging of cerebral blood flow using laser speckle.
Academic Article Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation.
Academic Article Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression.
Academic Article Effects of autoregulation and CO2 reactivity on cerebral oxygen transport.
Academic Article Bedside functional imaging of the premature infant brain during passive motor activation.
Academic Article Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition.
Academic Article Anatomical atlas-guided diffuse optical tomography of brain activation.
Academic Article Fluorescence-lifetime-based tomography for turbid media.
Academic Article Multiphysics neuron model for cellular volume dynamics.
Academic Article Physiological system identification with the Kalman filter in diffuse optical tomography.
Academic Article Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications.
Academic Article Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex.
Academic Article Determination of optical properties and blood oxygenation in tissue using continuous NIR light.

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