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Search Results to Tonya Colpitts, PhD

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Research Expertise & Professional Interests My research focuses on arbovirus pathogenesis and cellular interactions during infection in the mosquito and the mammal, examining the host-virus-vector interface. Arboviral diseases are one of the leading causes of morbidity and disability in the developing world. The majority of these diseases lack an effective vaccine or specific treatment to prevent infection and control transmission. We aim to uncover mechanisms at play during the entire arboviral transmission cycle, from infection in the mammal to acquisition in the mosquito vector, and transmission from the mosquito back to the mammal. Currently our research is focused on dengue and Zika viruses, both flaviviruses transmitted by Aedes mosquitoes. Dengue virus causes serious human disease and mortality worldwide. Infection results in a severe febrile illness, occasionally leading to lethal hemorrhagic fever, especially in children. In recent years, there has been increased epidemic activity and geographic expansion of dengue infection along with its mosquito vector, and it is considered a serious emerging global health problem. The disease has an enormous impact on the health and economies of tropical and subtropical regions, with dengue infections occurring in Asia, the Americas, Africa, Pacific and Mediterranean regions. While most cases in the United States occur in travelers returning from endemic areas, there have been recent outbreaks in Texas, Florida and Hawaii, where transmission occurred on American soil. Zika virus is a rapidly emerging flavivirus that has recently been responsible for severe disease outbreaks in the Western hemisphere. Zika fever is characterized by mild headache, rash, fever, malaise, conjunctivitis, and joint pain. There are no targeted therapeutics or prophylactic drugs, and treatment is generally palliative. Recently described neurological complications of Zika virus infection include babies born with microcephaly and the development of Guillain-Barre syndrome in adults. As climate change continues, the range of Aedes, the mosquito vectors of dengue and Zika viruses, is expected to expand northwards, placing an increased proportion of the US public at risk for disease. There are no vaccines or specific therapeutic agents approved for dengue or Zika virus infection. The development of a safe and effective vaccine for dengue has been hindered by antibody-dependent enhancement, in which exposure to and development of antibodies against one dengue serotype can lead to severe hemorrhagic fever upon infection with a different serotype. Our lab and others have also shown that dengue antibodies can enhance Zika virus infection. We are currently examining the causes and effects of antibody-dependent enhancement of both viruses using primary human cells. As mentioned, both dengue and Zika are transmitted to humans by mosquito vectors. An attractive complement to traditional vaccine design is to induce an immune response in the vertebrate host (infected or non-infected) that will block virus infection of mosquito transmission vectors. These types of vaccine strategies are termed transmission-blocking vaccines (TBVs). Inhibiting the ability of mosquitoes to acquire a dengue virus infection would eliminate an important step in the infection cycle and represent a novel, highly effective method to disrupt the infected patient to mosquito transmission step and limit the size of arboviral outbreaks. We are currently working on the development of TBVs using Aedes mosquito proteins in our lab. Other projects in the lab include examining the impact of human host blood factors on mosquito arbovirus infection, investigating human-mosquito immune cross-talk, looking at the role of skin cells in initial flavivirus infection and what impact immature virions have on both acquisition in the mosquito vector and transmission to mammalian hosts.

One or more keywords matched the following items that are connected to Colpitts, Tonya

Item TypeName
Concept Zika Virus Infection
Concept Zika Virus
Concept Dengue Virus
Concept Encephalitis Virus, Venezuelan Equine
Concept Lassa virus
Concept Leukemia Virus, Murine
Concept Vesicular stomatitis Indiana virus
Concept Virus Replication
Concept West Nile virus
Concept Yellow fever virus
Concept Pichinde virus
Concept Virus Internalization
Academic Article A relevant in vitro human model for the study of Zika virus antibody-dependent enhancement.
Academic Article prM-antibody renders immature West Nile virus infectious in vivo.
Academic Article Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
Academic Article An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection.
Academic Article Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein.
Academic Article Human C5a Protein Participates in the Mosquito Immune Response Against Dengue Virus.
Academic Article A Brief Review of West Nile Virus Biology.
Academic Article Overview of West Nile Virus Transmission and Epidemiology.
Academic Article A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection.
Academic Article Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2.
Academic Article Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes.
Academic Article West Nile Virus: biology, transmission, and human infection.
Academic Article Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection.
Academic Article Arenavirus entry occurs through a cholesterol-dependent, non-caveolar, clathrin-mediated endocytic mechanism.
Academic Article Venezuelan equine encephalitis virus infection of mosquito cells requires acidification as well as mosquito homologs of the endocytic proteins Rab5 and Rab7.
Academic Article Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection.
Academic Article Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host.
Academic Article Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses.
Academic Article Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells.
Academic Article Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.
Academic Article A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread.
Academic Article Pseudotyped viruses permit rapid detection of neutralizing antibodies in human and equine serum against Venezuelan equine encephalitis virus.
Academic Article Role of Mast Cells in Dengue Virus Pathogenesis.
Academic Article Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb.
Academic Article Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells.
Academic Article Dengue virus reduces expression of low-density lipoprotein receptor-related protein 1 to facilitate replication in Aedes aegypti.
Grant Effects of pre-existing dengue virus immunity on Zika virus infection
Academic Article One-step RT-qPCR assay for ZIKV RNA detection in Aedes aegypti samples: a protocol to study infection and gene expression during ZIKV infection.
Academic Article Dengue Virus Infection of Aedes aegypti Alters Extracellular Vesicle Protein Cargo to Enhance Virus Transmission.

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