Search Results to David Coleman, MD

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One or more keywords matched the following properties of Coleman, David

Research Expertise & Professional Interests The initial focus of Dr. Coleman’s original scholarship was in the regulation of macrophage activation and proliferation. He identified novel factors that induce macrophage phagocytic function and oxidative metabolism. He went on to characterize the mechanisms by which macrophages are activated, recruited, retained, and induced to proliferate in local tissues. His research team discovered production of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) by non-immunological cell and tissue types such as keratinocytes (skin), glomerular mesangial cells (kidney), and respiratory epithelium (trachea). His team also identified production of other soluble cytokines (Macrophage CSF and Interleukin 6) by local tissues that regulate cell traffic and inflammation, particularly in the skin and kidney – two common sites of inflammation and infection. His later studies focused on the subcellular mechanisms of macrophage activation and proliferation induced by GM-CSF. His further delineated the effect of GM-CSF on intracellular second messenger pathways (e.g., cyclic nucleotides, protein kinase C) and early response genes (e.g., Egr-1) in macrophages. He defined the role of cis-acting 3’ regulatory elements in mediating the transcriptional activation of Egr-1 in macrophages. These studies were designed to characterize paracrine and autocrine signals that regulate cells in local tissues in states of inflammation and infection, and to better understand how therapies might be targeted at the extracellular and intracellular signals that underlie the inflammatory process. His work over the past 15 years has focused on medical and civic professionalism in medical education and clinical practice. He has developed incentive plans that promote physician productivity in an academically affiliated VA Medical Center and at Yale School of Medicine. In addition, he has led efforts at Yale and Boston University Schools of Medicine to develop more effective and rigorous policies for the interactions of clinicians with the pharmaceutical and medical device industries. Dr. Coleman’s clinical responsibilities include serving as an inpatient medical attending and infectious disease consult attending at Boston Medical Center.
Self-Described Keywords Inpatient internal medicine
Self-Described Keywords Soft tissue infections

One or more keywords matched the following items that are connected to Coleman, David

Item TypeName
Concept Adipose Tissue
Concept Cell Communication
Concept Communication
Concept Interferon Type I
Concept Interferon-gamma
Concept Interleukin-1
Concept Interleukin-2
Concept Interleukin-3
Concept Internal Medicine
Concept Internship and Residency
Concept Lymphoid Tissue
Concept Interleukin-4
Concept Interleukin-6
Concept Conflict of Interest
Concept Interdisciplinary Communication
Academic Article Guidelines for interactions between clinical faculty and the pharmaceutical industry: one medical school's approach.
Academic Article Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine.
Academic Article Building interdisciplinary biomedical research using novel collaboratives.
Academic Article The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia.
Academic Article Interleukin-6: an autocrine regulator of mesangial cell growth.
Academic Article Regulation of macrophage phagocytosis.
Academic Article Stimulation of macrophage H2O2 release by resident thymocytes: effect of a soluble factor distinct from interferon-gamma.
Academic Article Primary cultures of the dog''s tracheal epithelium: fine structure, fluid, and electrolyte transport.
Academic Article Effect of intravenous recombinant alpha-2 interferon on monocyte Fc-dependent phagocytosis in patients with malignant melanoma.
Academic Article Hematopoietic, lymphopoietic, and proinflammatory cytokines produced by human and murine keratinocytes.
Academic Article Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages.
Academic Article Interleukin 6 is an autocrine growth factor for mesangial cells.
Academic Article Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF).
Academic Article Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia.
Academic Article Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1.
Academic Article Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2.
Academic Article Enhancement of macrophage Fc-dependent phagocytosis by resident thymocytes: effect of a unique heat-stable lymphokine.
Academic Article Enhancement of macrophage immune and nonimmune receptor-mediated phagocytosis by a low molecular weight soluble factor from resident thymocytes.
Academic Article Mesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion.
Academic Article Keratinocyte derived T-cell growth factor (KTGF) is identical to granulocyte macrophage colony stimulating factor (GM-CSF).
Academic Article Age- and diabetes-related changes in tissue glucose uptake and estradiol accumulation in the C57BL/KsJ mouse.
Academic Article Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes.
Academic Article Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages.
Academic Article Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator.
Academic Article The scholarship of application.
Academic Article Strategies for Developing and Recognizing Faculty Working in Quality Improvement and Patient Safety.
Academic Article The Department of Medicine in 2030: A Look Ahead.
Academic Article Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model.
Academic Article Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective.
Academic Article Developing Faculty in Emerging Areas of Interdisciplinary Research.
Academic Article Parental Leave in Graduate Medical Education: Recommendations for Reform.

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