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Search Results to Katya Ravid, DSc

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Research Expertise & Professional Interests Platelet activation plays a central role in thrombosis and hemostasis, while these processes are central to vascular health and disease. In the platelet lineage, bone marrow stem cells develop into early committed megakaryocyte progenitors, which undergo a unique cell cycle leading to polyploid cells prior to fragmenting into platelets. Our research focuses on mechanisms that regulate these processes under normal conditions vs. pathology. We proposed a new paradigm for controlling the transcription of genes uniquely expressed in this lineage, by identifying a cluster of non-tissue specific transcription factors that, together, constitute a signature uniquely driving this lineage development, among other cell lineages in the bone marrow. Studies were extended to identifying mechanisms governing polyploidy in megakaryocytes, leading also to better understanding of regulatory processes that cause polyploidy in other cells, such as aging vascular smooth muscle cells. Past projects involved molecular characterization of platelet and vascular adenosine receptors, and exploration of their roles in such cellular function. Importantly, knowledge gained by studying basic regulatory processes in healthy megakaryocytes and platelets aids our investigation of bone marrow pathologies, such as myeloproliferative neoplasms (MPNs). The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

One or more keywords matched the following items that are connected to Ravid, Katya

Item TypeName
Concept Adipose Tissue
Concept Interferon-gamma
Concept Interleukin-3
Concept Nerve Tissue Proteins
Concept Tissue Distribution
Concept Interleukin-6
Concept Interleukin-8
Concept Interleukin-10
Concept Interleukin-12
Concept Intercellular Adhesion Molecule-1
Concept Interdisciplinary Communication
Concept RNA, Small Interfering
Concept Tissue Culture Techniques
Academic Article Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity.
Academic Article A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice.
Academic Article A new transgenic mouse model for the study of cell cycle control in megakaryocytes.
Academic Article Transcriptional regulation of the rat platelet factor 4 gene: interaction between an enhancer/silencer domain and the GATA site.
Academic Article The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
Academic Article Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter.
Academic Article Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice.
Academic Article Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling.
Academic Article A2B adenosine receptor gene deletion attenuates murine colitis.
Academic Article Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.
Academic Article Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy.
Academic Article 28 kDa adenosine-binding proteins of brain and other tissues.
Academic Article Changes in adenosine receptors during differentiation of 3T3-F442A cells to adipocytes.
Academic Article Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.
Academic Article Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury.
Academic Article Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine.
Academic Article Building interdisciplinary biomedical research using novel collaboratives.
Academic Article Interrelation between salvage of purine nucleotides and protein synthesis in rat heart cells.
Academic Article rmIL-6 stimulates the transcriptional activity of the rat PF4 gene.
Academic Article IFN-? Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response.
Academic Article An adenosine receptor-Kr├╝ppel-like factor 4 protein axis inhibits adipogenesis.
Academic Article The macrophage A2B adenosine receptor regulates tissue insulin sensitivity.
Academic Article G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
Academic Article The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis.
Academic Article Adenosine signaling promotes hematopoietic stem and progenitor cell emergence.
Academic Article Differential Tissue-Specific Function of Adora2b in Cardioprotection.
Award or Honor Receipt International Visiting Professor Fellowship Award
Award or Honor Receipt International Advisory Board
Academic Article Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model.
Academic Article Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.
Academic Article Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.
Academic Article G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b.
Academic Article Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor-tissue factor axis.
Academic Article Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease.
Academic Article Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis.

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