Search Results to Katya Ravid, DSc

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Research Expertise & Professional Interests Platelet activation plays a central role in thrombosis and hemostasis, while these processes are central to vascular health and disease. In the platelet lineage, bone marrow stem cells develop into early committed megakaryocyte progenitors, which undergo a unique cell cycle leading to polyploid cells prior to fragmenting into platelets. Our research focuses on mechanisms that regulate these processes under normal conditions vs. pathology. We proposed a new paradigm for controlling the transcription of genes uniquely expressed in this lineage, by identifying a cluster of non-tissue specific transcription factors that, together, constitute a signature uniquely driving this lineage development, among other cell lineages in the bone marrow. Studies were extended to identifying mechanisms governing polyploidy in megakaryocytes, leading also to better understanding of regulatory processes that cause polyploidy in other cells, such as aging vascular smooth muscle cells. Past projects involved molecular characterization of platelet and vascular adenosine receptors, and exploration of their roles in such cellular function. Importantly, knowledge gained by studying basic regulatory processes in healthy megakaryocytes and platelets aids our investigation of bone marrow pathologies, such as myeloproliferative neoplasms (MPNs). The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.
Self-Described Keywords Cell Cycle Control

One or more keywords matched the following items that are connected to Ravid, Katya

Item TypeName
Concept Cell Cycle
Concept Cell Cycle Proteins
Academic Article Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity.
Academic Article The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase.
Academic Article A role for cyclin D3 in the endomitotic cell cycle.
Academic Article Rat NAP1: cDNA cloning and upregulation by Mpl ligand.
Academic Article Ectopic expression of the Aspergillus nidulans mitotic inducer, nimA kinase, in megakaryocytes: effect on polyploidization.
Academic Article Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system.
Academic Article Cyclin D3 and megakaryocyte development: exploration of a transgenic phenotype.
Academic Article A new transgenic mouse model for the study of cell cycle control in megakaryocytes.
Academic Article Roads to polyploidy: the megakaryocyte example.
Academic Article AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.
Academic Article Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression.
Academic Article Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle.
Academic Article Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property.
Academic Article Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins.
Academic Article B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.
Academic Article The A2b adenosine receptor protects against vascular injury.
Academic Article Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells.
Academic Article Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy.
Academic Article Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide.
Academic Article G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b.

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