Search Results to Carmela R. Abraham, PhD

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Research Expertise & Professional Interests Our laboratory studies the molecular mechanisms leading to normal brain aging and the pathological processes that culminate in Alzheimer’s disease. We utilize the rhesus monkey as a model for understanding changes that occur during non-pathological aging. With microarray analysis we identified genes that play crucial roles in brain dysfunction leading to cognitive decline. An example is Klotho, a cytoprotective, anti-aging protein. We found that Klotho expression is considerably decreased in the aged brains of monkeys, rats, and mice. We are now working to comprehensively characterize the role of Klotho in normal aging and disease. Our projects are to identify Klotho receptors in the brain and define the signaling pathways by which Klotho exerts its protective effects. We are also studying Klotho’s transcriptional regulation and have identified compounds to therapeutically exploit these protective effects. Another line of investigation in our lab is to understand the biology of the amyloid precursor protein (APP), the parent protein of the amyloid beta peptide (Abeta), which accumulates in the brains of Alzheimer’s disease patients and causes irreversible neurodegeneration. Certain mutations in APP result in autosomal dominant, early onset familial Alzheimer’s disease due to the increased production of Abeta. Since APP homodimerization is believed to be involved in Abeta formation in the brain we searched and identified molecules capable of intervening in this process to reduce the levels of toxic Abeta peptide in the brain.

One or more keywords matched the following items that are connected to Abraham, Carmela

Item TypeName
Concept Alzheimer Disease
Academic Article [Alzheimer's disease and the significance of amyloid-beta protein in its pathogenesis].
Academic Article Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
Academic Article Monoclonal antibodies against the human metalloprotease EC label neurofibrillary tangles in Alzheimer's disease brain.
Academic Article Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus.
Academic Article Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro.
Academic Article A novel brain cysteine protease forms an SDS stable complex with the beta-amyloid precursor protein.
Academic Article Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain.
Academic Article Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.
Academic Article Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases.
Academic Article Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Academic Article Platelets and DAMI megakaryocytes possess beta-secretase-like activity.
Academic Article Metalloendopeptidase EC is necessary for Alzheimer's amyloid-beta peptide degradation.
Academic Article Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo.
Academic Article Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.
Academic Article Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease.
Academic Article The role of the acute-phase protein alpha 1-antichymotrypsin in brain dysfunction and injury.
Academic Article Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain.
Academic Article A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein.
Academic Article Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation.
Academic Article Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin.
Academic Article Alpha 1-antichymotrypsin in brain aging and disease.
Academic Article The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease.
Academic Article Potential roles of protease inhibitors in Alzheimer's disease.
Academic Article Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Academic Article Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.
Academic Article Facile and sensitive assay for monitoring proteolytic activities with defined specificities: studies on amyloid beta-protein processing in Alzheimer's disease.
Academic Article Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.
Academic Article Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.
Academic Article Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease.
Academic Article X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.
Academic Article Paired helical filaments in human neurons: relationship to neurofilaments.
Academic Article Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.
Academic Article Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies.
Academic Article Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins.
Academic Article Isolation of paired helical filaments and amyloid fibers from human brain.
Academic Article Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology.
Academic Article Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.
Academic Article PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Academic Article Proceedings of the International Symposium on Biomedical Advances in Aging, ed. A.C. Goldstein
Academic Article Biological Aspects of Alzheimer's Disease (Banbury Report 15); Katzman, R. (ed.)
Academic Article The Handbook of Alzheimer’s Disease and Other Dementias; Edited by Andrew E. Budson, Neil W. Kowall
Academic Article HPLC analysis of proteins from Alzheimer's disease paired helical filaments
Academic Article Alzheimer's disease: Recent advances in understanding the brain amyloid deposits
Academic Article Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies; edited by K. Iqbal, D.R.C. McLachlan, B. Winblad and H. M. Wisniewski
Academic Article Amyloid and Amyloidosis, edited by Natvig, J.B. et al
Academic Article Amyloid and Amyloidosis; Eds. T. Isobe, S. Araki, S. Kito and E. Tsubura
Academic Article Alzheimer's and Parkinson's Disease; A. Fisher, et al (eds.)
Academic Article Molecular Biology and Genetics of Alzheimer's Disease, Editors: Miyatake, T., Selkoe, D.J. Ihara, Y
Academic Article Proceedings of the VIIth International Symposium on Amyloidosis (Ed. R. Kisilevsky)
Academic Article Familial Alzheimer's Disease: Molecular Genetics and Clinical Perspectives; Blass et al (eds.)
Academic Article Amyloidosis; G.G. Glenner, et al, (eds.)
Award or Honor Receipt The First Rappaport Award for the Study of Alzheimer's Disease
Award or Honor Receipt The Second Rappaport Award for the Study of Alzheimer's Disease
Grant Molecular Characterization of a Proteinase Genetically Linked to an Increased Risk of Alzheimer’s Disease in Minorities
Grant Oxidation , Proteolysis and Alzheimer’s Disease:
Grant The Significance of APP Dimerization in Alzheimer’s Disease
Academic Article Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Academic Article Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.
Grant Modulators of APP Dimerization as Novel Therapeutics for Alzheimer's Disease

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  • Alzheimer Disease