Search Results to Avrum Spira, MD

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Research Expertise & Professional Interests Dr. Spira is a Professor of Medicine, Pathology and Bioinformatics, and the Alexander Graham Bell Professor in Health Care Entrepreneurship at Boston University. He is founding Chief of the Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center. He is also an attending physician in the Medical Intensive Care Unit at Boston Medical Center. Dr. Spira obtained his MD from McGill University in Montreal, and completed his Internal medicine residency at the University of Toronto and his fellowship in Pulmonary and Critical Care Medicine at BMC. During his fellowship, Dr. Spira obtained a master’s degree in Bioinformatics from Boston University. Since his 2003 appointment to the BU faculty, Dr. Spira has built a translational research program that focuses on genomic alterations associated with smoking-related lung disease, leading to a molecular test for the early detection of lung cancer that has successfully translated into the clinic (PerceptaTM) as well as a novel therapeutic for COPD that is in preclinical development. His research program is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He has co-founded both a molecular diagnostics company and a pharmaceutical company in order to translate these tools from “bench to bedside”. He serves as Principal Investigator on grants from the National Cancer Institute (NCI); National Heart, Lung, Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS) and the Department of Defense (DoD), and has authored more than 100 peer-reviewed publications. Dr. Spira was a permanent member of the NIH’s Cancer Biomarker Study Section (CBSS) and currently serves as Senior Editor at Cancer Prevention Research as well as Associate Editor at the American Journal of Respiratory and Critical Care Medicine. He was elected a member of the American Society for Clinical Investigation (ASCI) in 2010 and a member of the Association of American Physicians (AAP) in 2017.
Self-Described Keywords lung cancer
Self-Described Keywords cancer biomarkers

One or more keywords matched the following items that are connected to Spira, Avrum

Item TypeName
Concept Carcinoma, Non-Small-Cell Lung
Concept Disease Models, Animal
Concept Liver Diseases
Concept Lung
Concept Lung Diseases
Concept Lung Diseases, Fungal
Concept Lung Neoplasms
Concept Biomarkers, Tumor
Concept Biomarkers
Concept Lung Transplantation
Concept Disease Progression
Concept Disease Management
Concept Genetic Predisposition to Disease
Concept Pulmonary Disease, Chronic Obstructive
Concept National Heart, Lung, and Blood Institute (U.S.)
Concept National Institute of Allergy and Infectious Diseases (U.S.)
Concept Small Cell Lung Carcinoma
Concept Rhinitis, Allergic
Academic Article Pulmonary mucormycosis in the setting of chronic obstructive pulmonary disease. A case report and review of the literature.
Academic Article Gene expression in lung adenocarcinomas of smokers and nonsmokers.
Academic Article Impact of cigarette smoke on the normal airway transcriptome.
Academic Article Gene expression profiling of human lung tissue from smokers with severe emphysema.
Academic Article The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
Academic Article Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development.
Academic Article The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
Academic Article State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer.
Academic Article Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.
Academic Article Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression.
Academic Article Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
Academic Article A prediction model for lung cancer diagnosis that integrates genomic and clinical features.
Academic Article The field of tissue injury in the lung and airway.
Academic Article Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management.
Academic Article Clinical impact of high-throughput gene expression studies in lung cancer.
Academic Article Airway gene expression in chronic obstructive pulmonary disease.
Academic Article Genetics and genomics of chronic obstructive pulmonary disease.
Academic Article Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis?
Academic Article Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection.
Academic Article Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer.
Academic Article Airway PI3K pathway activation is an early and reversible event in lung cancer development.
Academic Article Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
Academic Article A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.
Academic Article Applying gene expression microarrays to pulmonary disease.
Academic Article Evolving concepts in lung carcinogenesis.
Academic Article MiRNAs as regulators of the response to inhaled environmental toxins and airway carcinogenesis.
Academic Article Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.
Academic Article Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.
Academic Article A pharmacogenomic method for individualized prediction of drug sensitivity.
Academic Article Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
Academic Article A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.
Academic Article SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.
Academic Article Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer.
Academic Article Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation.
Academic Article A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.
Academic Article Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era.
Academic Article Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.
Academic Article Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer.
Academic Article Genomics in the Diagnosis and Management of Lung Cancer
Academic Article Using microRNAs to inform clinical decision making in lung cancer: ready for prime time?
Academic Article Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis.
Academic Article A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.
Academic Article Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.
Academic Article Association of Interferon- and transforming growth factor ß-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis.
Academic Article Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
Academic Article Translating the transcriptome into tools for the early detection and prevention of lung cancer.
Academic Article Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener''s).
Academic Article Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.
Academic Article Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.
Academic Article MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.
Academic Article Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.
Academic Article Update in Lung Cancer 2014.
Academic Article PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.
Academic Article Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention.
Academic Article Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.
Academic Article Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.
Academic Article Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data.
Academic Article Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.
Academic Article SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.
Academic Article Challenge and opportunity of targeted lung cancer chemoprevention.
Academic Article miR-638 regulates gene expression networks associated with emphysematous lung destruction.
Academic Article DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.
Academic Article Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung.
Academic Article Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue.
Academic Article The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.
Academic Article Early Events in the Molecular Pathogenesis of Lung Cancer.
Academic Article Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.
Academic Article miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis.
Academic Article Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.
Academic Article Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer.
Academic Article The Case for a Pre-Cancer Genome Atlas (PCGA).
Academic Article Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer.
Academic Article Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway.
Academic Article Update in Lung Cancer 2015.
Academic Article A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.
Academic Article Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.
Academic Article Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema.
Academic Article Transforming Cancer Prevention through Precision Medicine and Immune-oncology.
Academic Article Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.
Award or Honor Receipt Caine Halter Hope Now Award, Uniting Against Lung Cancer
Academic Article Precancer Atlas to Drive Precision Prevention Trials.
Academic Article NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.
Grant The Airway Transcriptome as a Biomarker for Lung Cancer
Academic Article Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.
Academic Article AJRCCM: 100-Year Anniversary. The Shifting Landscape for Lung Cancer: Past, Present, and Future.
Academic Article The cellular and molecular determinants of emphysematous destruction in COPD.
Academic Article Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.
Academic Article Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.
Academic Article Genomic approaches to accelerate cancer interception.
Academic Article Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.
Academic Article Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers.
Academic Article Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception.
Academic Article ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status.
Academic Article Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.
Academic Article TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection.
Academic Article Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma.
Academic Article The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.
Academic Article Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine.
Academic Article microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.
Academic Article An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.
Academic Article Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes.
Academic Article Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges.
Academic Article Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement.
Academic Article Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.
Academic Article Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.
Academic Article Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.
Academic Article Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer.
Academic Article Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.
Academic Article Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation.
Academic Article The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.
Academic Article Osteoporosis and lung transplantation: a prospective study.
Academic Article Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial.
Academic Article Immune evasion before tumour invasion in early lung squamous carcinogenesis.
Academic Article Augmented Lipocalin-2 is Associated with COPD and Counteracts Lung Adenocarcinoma Development.
Academic Article Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features.
Academic Article Biomarkers for lung cancer screening and detection.
Grant Detection of Early Lung Cancer Among Military Personnel (DECAMP)
Grant The UCLA-Boston University Lung Cancer Biomarker Develpment Lab (TEAM PROJECT)
Grant Intercept lung cancer through immune, imaging & molecular evaluation-InTime
Grant The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy
Grant Molecular biomarkers of airway and lung linking COPD and Lung Cancer
Grant Airway Gene Expression in Smokers: An Early Diagnostic Biomarker for Lung Cancer
Grant Integrated molecular, cellular and imaging characterization of screen-detected lung cancer
Grant The Boston University-UCLA Lung Cancer Biomarker Development Lab
Grant Analysis of somatic DNA alteration in early lung carcinogenesis
Grant Molecular Profiles for Lung Cancer Pathogenesis and Detection in US Veterans
Grant The UCLA - Boston University Lung Cancer Biomarker Development Laboratory
Grant The UCLA Boston University Lung Cancer Biomarker Development Laboratory
Grant Molecular Approaches to Early Detection of Lung Cancer
Grant Characterising the transcriptomic alterations associated with structural progression of small airway disease
Grant Correlating Histological, Radiological, and Gene Expression Patterns in the Lungs of IPF Patients
Grant Lung Genomics Research Consortium

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