Search Results to Avrum Spira, MD

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Research Expertise & Professional Interests Dr. Spira is a Professor of Medicine, Pathology and Bioinformatics, and the Alexander Graham Bell Professor in Health Care Entrepreneurship at Boston University. He is founding Chief of the Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center. He is also an attending physician in the Medical Intensive Care Unit at Boston Medical Center. Dr. Spira obtained his MD from McGill University in Montreal, and completed his Internal medicine residency at the University of Toronto and his fellowship in Pulmonary and Critical Care Medicine at BMC. During his fellowship, Dr. Spira obtained a master’s degree in Bioinformatics from Boston University. Since his 2003 appointment to the BU faculty, Dr. Spira has built a translational research program that focuses on genomic alterations associated with smoking-related lung disease, leading to a molecular test for the early detection of lung cancer that has successfully translated into the clinic (PerceptaTM) as well as a novel therapeutic for COPD that is in preclinical development. His research program is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He has co-founded both a molecular diagnostics company and a pharmaceutical company in order to translate these tools from “bench to bedside”. He serves as Principal Investigator on grants from the National Cancer Institute (NCI); National Heart, Lung, Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS) and the Department of Defense (DoD), and has authored more than 100 peer-reviewed publications. Dr. Spira was a permanent member of the NIH’s Cancer Biomarker Study Section (CBSS) and currently serves as Senior Editor at Cancer Prevention Research as well as Associate Editor at the American Journal of Respiratory and Critical Care Medicine. He was elected a member of the American Society for Clinical Investigation (ASCI) in 2010 and a member of the Association of American Physicians (AAP) in 2017.
Self-Described Keywords COPD

One or more keywords matched the following items that are connected to Spira, Avrum

Item TypeName
Concept Pulmonary Disease, Chronic Obstructive
Academic Article Pulmonary mucormycosis in the setting of chronic obstructive pulmonary disease. A case report and review of the literature.
Academic Article The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
Academic Article The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
Academic Article State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer.
Academic Article Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management.
Academic Article Airway gene expression in chronic obstructive pulmonary disease.
Academic Article Genetics and genomics of chronic obstructive pulmonary disease.
Academic Article Airway PI3K pathway activation is an early and reversible event in lung cancer development.
Academic Article A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.
Academic Article Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.
Academic Article A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.
Academic Article Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.
Academic Article Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
Academic Article Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.
Academic Article Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.
Academic Article Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.
Academic Article SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.
Academic Article DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.
Academic Article Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung.
Academic Article Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.
Academic Article The cellular and molecular determinants of emphysematous destruction in COPD.
Academic Article Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.
Academic Article Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception.
Academic Article Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.
Academic Article microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.
Academic Article An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.
Academic Article Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.
Academic Article Augmented Lipocalin-2 Is Associated with Chronic Obstructive Pulmonary Disease and Counteracts Lung Adenocarcinoma Development.
Academic Article Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD.
Grant Integrative Omics to Discover Molecular Determinants of COPD
Grant Molecular biomarkers of airway and lung linking COPD and Lung Cancer
Grant Linking Airway Genomics to the Pathogenesis and Clinical Heterogeneity of COPD
Grant Integrative Omics to Discover Molecular Determinants of COPD

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  • COPD