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Search Results to Avrum Spira, MD

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Research Expertise & Professional Interests Dr. Spira is a Professor of Medicine, Pathology and Bioinformatics, and the Alexander Graham Bell Professor in Health Care Entrepreneurship at Boston University. He is founding Chief of the Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center. He is also an attending physician in the Medical Intensive Care Unit at Boston Medical Center. Dr. Spira obtained his MD from McGill University in Montreal, and completed his Internal medicine residency at the University of Toronto and his fellowship in Pulmonary and Critical Care Medicine at BMC. During his fellowship, Dr. Spira obtained a master’s degree in Bioinformatics from Boston University. Since his 2003 appointment to the BU faculty, Dr. Spira has built a translational research program that focuses on genomic alterations associated with smoking-related lung disease, leading to a molecular test for the early detection of lung cancer that has successfully translated into the clinic (PerceptaTM) as well as a novel therapeutic for COPD that is in preclinical development. His research program is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He has co-founded both a molecular diagnostics company and a pharmaceutical company in order to translate these tools from “bench to bedside”. He serves as Principal Investigator on grants from the National Cancer Institute (NCI); National Heart, Lung, Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS) and the Department of Defense (DoD), and has authored more than 100 peer-reviewed publications. Dr. Spira was a permanent member of the NIH’s Cancer Biomarker Study Section (CBSS) and currently serves as Senior Editor at Cancer Prevention Research as well as Associate Editor at the American Journal of Respiratory and Critical Care Medicine. He was elected a member of the American Society for Clinical Investigation (ASCI) in 2010 and a member of the Association of American Physicians (AAP) in 2017.
Self-Described Keywords cancer biomarkers

One or more keywords matched the following items that are connected to Spira, Avrum

Item TypeName
Concept Asthma
Concept Biomarkers, Tumor
Concept Biomarkers
Academic Article Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.
Academic Article Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression.
Academic Article A prediction model for lung cancer diagnosis that integrates genomic and clinical features.
Academic Article Clinical impact of high-throughput gene expression studies in lung cancer.
Academic Article Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection.
Academic Article A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.
Academic Article MiRNAs as regulators of the response to inhaled environmental toxins and airway carcinogenesis.
Academic Article Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.
Academic Article Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.
Academic Article A pharmacogenomic method for individualized prediction of drug sensitivity.
Academic Article Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era.
Academic Article Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
Academic Article MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.
Academic Article Update in Lung Cancer 2014.
Academic Article Early Events in the Molecular Pathogenesis of Lung Cancer.
Academic Article The Case for a Pre-Cancer Genome Atlas (PCGA).
Academic Article Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway.
Academic Article A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.
Academic Article Transforming Cancer Prevention through Precision Medicine and Immune-oncology.
Academic Article NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.
Academic Article The cellular and molecular determinants of emphysematous destruction in COPD.
Academic Article Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.
Academic Article Genomic approaches to accelerate cancer interception.
Academic Article Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers.
Academic Article The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.
Academic Article Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges.
Academic Article Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement.
Academic Article Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.
Academic Article Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.
Academic Article Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial.
Academic Article Biomarkers for lung cancer screening and detection.
Grant Molecular biomarkers of airway and lung linking COPD and Lung Cancer

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Search Criteria
  • Biomarkers
  • Asthma