Search Results to Avrum Spira, MD

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Research Expertise & Professional Interests Dr. Spira is a Professor of Medicine, Pathology and Bioinformatics, and the Alexander Graham Bell Professor in Health Care Entrepreneurship at Boston University. He is founding Chief of the Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center. He is also an attending physician in the Medical Intensive Care Unit at Boston Medical Center. Dr. Spira obtained his MD from McGill University in Montreal, and completed his Internal medicine residency at the University of Toronto and his fellowship in Pulmonary and Critical Care Medicine at BMC. During his fellowship, Dr. Spira obtained a master’s degree in Bioinformatics from Boston University. Since his 2003 appointment to the BU faculty, Dr. Spira has built a translational research program that focuses on genomic alterations associated with smoking-related lung disease, leading to a molecular test for the early detection of lung cancer that has successfully translated into the clinic (PerceptaTM) as well as a novel therapeutic for COPD that is in preclinical development. His research program is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He has co-founded both a molecular diagnostics company and a pharmaceutical company in order to translate these tools from “bench to bedside”. He serves as Principal Investigator on grants from the National Cancer Institute (NCI); National Heart, Lung, Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS) and the Department of Defense (DoD), and has authored more than 100 peer-reviewed publications. Dr. Spira was a permanent member of the NIH’s Cancer Biomarker Study Section (CBSS) and currently serves as Senior Editor at Cancer Prevention Research as well as Associate Editor at the American Journal of Respiratory and Critical Care Medicine. He was elected a member of the American Society for Clinical Investigation (ASCI) in 2010 and a member of the Association of American Physicians (AAP) in 2017.

One or more keywords matched the following items that are connected to Spira, Avrum

Item TypeName
Concept Asthma
Concept Cross-Sectional Studies
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Cohort Studies
Concept Multicenter Studies as Topic
Concept Case-Control Studies
Concept Genetic Association Studies
Concept Translational Medical Research
Concept Observational Studies as Topic
Academic Article Gene expression profiling of human lung tissue from smokers with severe emphysema.
Academic Article Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.
Academic Article Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium.
Academic Article A prediction model for lung cancer diagnosis that integrates genomic and clinical features.
Academic Article Clinical impact of high-throughput gene expression studies in lung cancer.
Academic Article Airway PI3K pathway activation is an early and reversible event in lung cancer development.
Academic Article Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.
Academic Article Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays.
Academic Article Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis.
Academic Article Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis.
Academic Article A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.
Academic Article Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
Academic Article Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener''s).
Academic Article Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.
Academic Article Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.
Academic Article Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.
Academic Article Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.
Academic Article miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis.
Academic Article Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.
Academic Article Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer.
Academic Article Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer.
Academic Article Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway.
Academic Article NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.
Academic Article Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.
Academic Article Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.
Academic Article Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective.
Academic Article Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.
Academic Article Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.
Academic Article Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.
Academic Article Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.
Academic Article Osteoporosis and lung transplantation: a prospective study.
Academic Article Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial.

Search Criteria
  • Asthma
  • Translational
  • Studies