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Search Results to David H. Sherr, PhD

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One or more keywords matched the following properties of Sherr, David

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Research Expertise & Professional Interests Since 1993, David Sherr's laboratory has conducted research on how common environmental pollutants, such as dioxins, polycyclic aromatic hydrocarbons and PCBs, adversely affect the growth and behavior of several different types of normal and malignant cells. In previous work, the Sherr laboratory studied how environmental chemicals affect the development of the immune system. In specific, his laboratory demonstrated that aromatic hydrocarbons (generated by the combuston of any carbon source) compromise the function of bone marrow cells required for the development of antibody-forming cells. These cells are critical for immune protection against viruses and bacteria. This work had its orignis in Dr. Sherr's graduate studies on the ontogeny of lymphocyte development. More recently, Dr. Sherr's laboratory has focused on the molecular mechanisms that initiate and maintain breast cancer and on the effects of environmental chemicals on these processes. The laboratory has shown that a cellular protein receptor, referred to as the aryl hydrocarbon receptor (AhR), plays an important role in the initiation and progression of human breast cancer. The results explain, in part, the association between environmental chemical exposure and breast cancer risk. Perhaps most importantly, these studies demonstrate that the AhR drives human breast cancer cells to invade and, presumably, metastasize even in the absence of environmental chemicals. These observations have led to the development of AhR inhibitors which block AhR activity and prevent tumor cells from invading. One immediate goal of the laboratory, therefore, is the development of potent AhR inhibitors as novel, targeted therapeutics to be used for treatment of all breast cancers but especially for treatment of "triple negative" or chemotherapy-resistant breast cancers. Interestingly, preliminary studies suggest that these AhR inhibitors could be useful for treatment of several other cancer cell types. A new area of study in Dr. Sherr's laboratory is the analysis of the role of the AhR in blood cell development. These studies are important from both an environmental science and medical science point of view. Studies performed to date suggest that the AhR plays an important roll in the normal development of blood cells. The results suggest the intriguing possibility that common environmental pollutants can alter normal blood cell development by interfering with AhR signaling. Dr. Sherr came to BUSPH from the faculty of Harvard Medical School, where he had earlier been a postdoctoral fellow in the department of Nobel Laureate Baruj Benacerraf. The Sherr Laboratory is funded by research grants from the National Institute of Environmental Health Sciences, the NIH Superfund Basic Research Program, and the Art BeCAUSE breast cancer foundation. Dr. Sherr is the Director of the Boston University Immunology Training Program, and a member of the Amyloid Treatment Research Program, the BU Cancer Center, the Hematology/Oncology Training Program, and the BU Hormone-dependent Cancer Center. He has trained 21 postdoctoral (M.D. or Ph.D.) and 11 predoctoral (M.D. and/or Ph.D.) fellows.
Self-Described Keywords Breast cancer and the environment
Self-Described Keywords Immunology

One or more keywords matched the following items that are connected to Sherr, David

Item TypeName
Concept Brain Neoplasms
Concept Breast Neoplasms
Concept Head and Neck Neoplasms
Concept Lung Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Mouth Neoplasms
Concept Neoplasms
Concept Neoplasms, Multiple Primary
Concept Prostatic Neoplasms
Concept Mammary Neoplasms, Animal
Concept Neoplasms, Second Primary
Concept Early Detection of Cancer
Concept Triple Negative Breast Neoplasms
Academic Article Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells.
Academic Article Ontogeny of B-lymphocyte function. IX. Difference in the time of maturation of the capacity of B lymphocytes from foetal and neonatal mice to produce a heterogeneous antibody response to thymic-dependent and thymic-independent antigens.
Academic Article Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis.
Academic Article The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells.
Academic Article Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture.
Academic Article Differences in histology between first and second primary lung cancer.
Academic Article The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.
Academic Article Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors.
Academic Article The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells.
Academic Article Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors.
Academic Article Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1.
Academic Article 7,12-dimethylbenz(a)anthracene treatment of a c-rel mouse mammary tumor cell line induces epithelial to mesenchymal transition via activation of nuclear factor-kappaB.
Academic Article Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A.
Academic Article A role for the aryl hydrocarbon receptor in mammary gland tumorigenesis.
Academic Article Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.
Academic Article CD40 Ligand-activated, antigen-specific B cells are comparable to mature dendritic cells in presenting protein antigens and major histocompatibility complex class I- and class II-binding peptides.
Academic Article Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.
Academic Article NF-kappaB and epithelial to mesenchymal transition of cancer.
Academic Article Parallel imaging microfluidic cytometer.
Academic Article In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.
Academic Article A network based approach to drug repositioning identifies plausible candidates for breast cancer and prostate cancer.
Academic Article The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
Academic Article Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis.
Academic Article An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells.
Academic Article Blocking triple negative breast cancer
Academic Article The diverse and important contributions of the AHR to cancer and cancer immunity
Academic Article Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor.
Academic Article International Innovations
Academic Article Nuclear expression of the aryl hydrocarbon receptor (AhR) in 7,12-dimethylbenz[a]anthracene (DMBA)- induced rat mammary tumors and human breast cancer cell lines
Academic Article The AhR and CYP1B1 as targets for peptide/tumor-specific cancer immunotherapy
Academic Article AACR Annual Meeting
Academic Article Toxicol. Sci
Academic Article Flavonoid inhibition of mammary tumor growth
Academic Article Green tea and Breast Cancer
Academic Article America Physician Scientist Association
Academic Article SOT Annual Meeting
Academic Article Symposium, SOT Annual Meeting
Academic Article Orthotopic Oral Cancer Mouse Model for Anti-oral Cancer Drug Screening
Academic Article American Assoc. of Dental Res. Annual Meeting
Academic Article Society of Toxicology Annual Meeting
Academic Article Clinical and Translational Science Institute
Academic Article 2016 International AHR conference
Academic Article 2016 International AHR conference
Academic Article NIEHS Facilities, Engagement, Scientific Advancement, and Training (FEST) Conference
Academic Article 9th International Meeting of the Stem Cell Network
Academic Article Boston University/Dana Farber Cancer Center Head and Neck Cancer Symposium: Advances in Head and Neck Cancer, Immunotherapy and Precision Medicine
Academic Article New England Immunology Conference
Academic Article National Academy of Sciences, The Promise of Genome Editing to Advance Environmental Health Research Workshop
Academic Article Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29?31 August 2018 in Paris, France.
Academic Article Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-ß-catenin signalling, the stem cell phenotype and disease progression.
Academic Article Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.

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  • Cancer
  • Immunology