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Search Results to Frederic F. Little, MD

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One or more keywords matched the following properties of Little, Frederic

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Research Expertise & Professional Interests Dr. Little is an Assistant Professor in the Department of Medicine. He attends on the Allergy Consultation Service as well as the Medical Intensive Care Unit and Pulmonary Consultation Service at Boston Medical Center . His outpatient activity is concentrated in the Adult Asthma and Allergy Clinics. Dr. Little’s longstanding clinical interests and research efforts are focused on examining the nature of airway inflammation in allergic asthma, and translational approaches to diagnostics of allergic disease. Prior to coming to Boston University, during a postdoctoral fellowship at the UCSF Cardiovascular Research Institute , he investigated the effect of causing an experimental cold in asthmatic and healthy volunteers, followed by concurrent examination of clinical asthma markers (e.g., spirometry, symptoms) and airway secretions by nasal lavage and sputum induction. In the laboratory, he used key cytokine transgenic and knockout mice to investigate antigen-dependent and -independent allergic airway inflammation. Specifically, he investigated interleukin-16, a major CD4 ligand, as a paradigm for downregulation of antigen-dependent TH2 inflammation. His translational research continues at Boston University as a principle investigator in a clinic-based study to develop a rapid saliva diagnostics platform for determining the causes of deterioration in asthma control. This study has expanded to both Emergency Room populations at B.U. and cohorts of pediatric asthmatics in collaboration Dr. Elizabeth Matsui, Pediatric Allergy/Immunology at Johns Hopkins. This translational approach has also been used in developing a point of care device to accurately and rapidly quantify allergen-specific IgE using component-resolved diagnostics. This latter ongoing effort is in collaboration with Drs. M. Selim Unlü in the Boston University College of Engineering. He has also participated as a Co-Investigator in immunotherapy trials with the NHLBI-funded Inner City Asthma Consortium, in collaboration with the BUMC site PI, Dr. George O’Connor. Dr. Little’s educational and administrative responsibilities include directing the Boston University Allergy/Immunology Fellowship Training Program and being the Medical Director of the Pulmonary, Allergy and Sleep Clinics. He is also the Clinical Director of Allergy at Boston Medical Center, a role that touches on care delivery in the inpatient and outpatient settings. Research interests include: -Pulmonary Immunology -Salivary Diagnostics of Lung Disease -Point of Care Diagnostics of Allergic Disease Clinical interests include: -Asthma/Allergy -Critical Care Medicine -Eosinophilic Disorders
Self-Described Keywords Allergic Airway Inflammation - Mouse models
Self-Described Keywords Rapid Diagnostics/Biomarkers of Lung and Allergic Disease
Self-Described Keywords Biomarkers, Asthma

One or more keywords matched the following items that are connected to Little, Frederic

Item TypeName
Concept Disease Models, Animal
Concept Lung
Concept Lung Diseases
Concept Lung Volume Measurements
Concept Respiratory Tract Diseases
Concept Inflammatory Bowel Diseases
Concept Pulmonary Disease, Chronic Obstructive
Concept Acute Lung Injury
Academic Article Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways.
Academic Article Immunomodulatory effect of interleukin-16 on allergic airway inflammation.
Academic Article Exogenous interleukin-16 inhibits antigen-induced airway hyper-reactivity, eosinophilia and Th2-type cytokine production in mice.
Academic Article Tumor necrosis factor-alpha-induced synthesis of interleukin-16 in airway epithelial cells: priming for serotonin stimulation.
Academic Article Interleukin-16 and peptide derivatives as immunomodulatory therapy in allergic lung disease.
Academic Article Microsensor arrays for saliva diagnostics.
Academic Article Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells.
Academic Article Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice.
Academic Article Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva.
Academic Article miR-29 is a major regulator of genes associated with pulmonary fibrosis.
Academic Article Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation.
Academic Article IL-16 and airway hyperresponsiveness in asthma
Academic Article Lymphocyte- and macrophage-mediated inflammation in the lung
Academic Article Glucocorticoid-resistant asthma: more than meets the eye.
Grant The Role of Airway Epithelial Expression of IL-16 in Th2-mediated Lung Inflammation
Grant Effect of IL-16 on the Murine Allergic Airway Response
Grant Microsensor Arrays for Salivary Diagnostics
Grant Rapid Disposable Microchip for Complete Blood Count

Highlights
Search Criteria
  • Rapid
  • Diagnostics
  • Biomarkers
  • Lung
  • Allergic
  • Disease