Connection

Search Results to Maria Isabel Ramirez, PhD

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Ramirez, Maria

PropertyValue
Research Expertise & Professional Interests The main goal of the research in our lab is to identify and understand genetic and epigenetic mechanisms of gene regulation driving the differentiation of distinct epithelial cell lineages during development, and the potential alteration of these mechanisms in lung disease. Correct spatial and temporal patterns of gene expression during lung development are critical for the formation of a functional lung ready for the first breath at birth. In adults, patterns of gene expression also have to be maintained to preserve a healthy lung. Dissecting these basic mechanisms in development will provide the basis to accurately differentiate embryonic stem cells into lung epithelial cell lineages in vitro, to improve fetal lung maturation and to understand altered cell phenotypes in lung disease.

One or more keywords matched the following items that are connected to Ramirez, Maria

Item TypeName
Concept Epithelial Cells
Concept Morphogenesis
Academic Article 1.3 kilobases of the lung type I cell T1alpha gene promoter mimics endogenous gene expression patterns during development but lacks sequences to enhance expression in perinatal and adult lung.
Academic Article Aquaporin-5 expression, but not other peripheral lung marker genes, is reduced in PTH/PTHrP receptor null mutant fetal mice.
Academic Article T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth.
Academic Article Enhanced binding of Sp1/Sp3 transcription factors mediates the hyperoxia-induced increased expression of the lung type I cell gene T1alpha.
Academic Article Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung.
Academic Article Transcription of the caveolin-1 gene is differentially regulated in lung type I epithelial and endothelial cell lines. A role for ETS proteins in epithelial cell expression.
Academic Article Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung.
Academic Article ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines.
Academic Article Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene.
Academic Article Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia.
Academic Article The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.
Academic Article Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb.
Academic Article Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia.

Highlights
Search Criteria
  • Epithelial
  • morphogenesis