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Search Results to Robert A. Lafyatis, MD

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Research Expertise & Professional Interests Dr. Lafyatis carries out patient oriented research into the cause and treatment of systemic sclerosis. This includes early phase clinical trials into new therapeutic agents in patients with systemic sclerosis. He has been investigating the mechanisms of actions and markers of response for novel therapeutics, such as the B cell depleting agent, rituximab and the immunosuppressant agent, mycophenlate. Additional studies are aimed at identifying biomarkers in systemic sclerosis using microarray gene expression analysis of skin and blood in scleroderma patients. Ongoing biomarker studies include investigation into molecular markers of pulmonary hypertension in systemic sclerosis. Dr. Lafyatis also carries out basic research into the cause of fibrosis and vasculopathy in systemic sclerosis using patient samples and murine disease models. His studies have provided key insights into one widely used model of systemic sclerosis, the tight skin mouse. His studies are currently focused on understanding how autoimmunity and the innate immune system lead to fibrosis and vascular damage. This has recently led to the discovery of increased interferon-regulated gene expression in white blood cells of patients with systemic sclerosis. Ongoing research is aimed at better understanding the cause of altered gene expression by monocytes and other cells in the innate immune system.

One or more keywords matched the following items that are connected to Lafyatis, Robert

Item TypeName
Concept Gene Expression Regulation
Concept Gene Expression
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Profiling
Academic Article Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.
Academic Article Multiple forms of TGF-beta: distinct promoters and differential expression.
Academic Article Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts.
Academic Article Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.
Academic Article Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins.
Academic Article Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.
Academic Article Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif.
Academic Article Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1.
Academic Article Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.
Academic Article Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis.
Academic Article A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.
Academic Article Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Academic Article Role of aggrecanase 1 in Lyme arthritis.
Academic Article Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats.
Academic Article Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.
Academic Article Transforming growth factor-beta in rheumatoid arthritis.
Academic Article Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site.
Academic Article Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization.
Academic Article The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.
Academic Article Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
Academic Article Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis.
Academic Article dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts.
Academic Article Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.
Academic Article Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?
Academic Article Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.
Academic Article Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies.
Academic Article Modeling innate immunity in murine skin: utilization of subcutaneous osmotic pumps for inflammatory and fibrotic skin disease.
Academic Article Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.
Academic Article Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
Academic Article Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
Academic Article Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor ß.
Academic Article HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells.
Academic Article p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-ß: epigenetic feed-forward amplification of fibrosis.
Academic Article Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension.
Academic Article Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis.
Academic Article Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis.
Academic Article Local skin gene expression reflects both local and systemic skin disease in patients with systemic sclerosis.
Academic Article Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin.
Academic Article A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis.
Academic Article CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin.
Academic Article Sustained ß-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes.
Academic Article Tenascin-C drives persistence of organ fibrosis.
Academic Article Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.
Academic Article Blockade of PDGF Receptors by Crenolanib Has Therapeutic Effect in Patient Fibroblasts and in Preclinical Models of Systemic Sclerosis.
Academic Article Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature.
Academic Article Inhibition of ß-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82.
Academic Article DIMM-SC: a Dirichlet mixture model for clustering droplet-based single cell transcriptomic data.
Academic Article SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin.
Academic Article Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis.
Academic Article Microarray analyses of systemic sclerosis skin biopsies to identify gene expression biomarkers
Academic Article Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial.
Academic Article Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
Academic Article A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies.

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  • Gene expression