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Search Results to Donald M. Thea, MD, MSc

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Research Expertise & Professional Interests Dr. Thea received his MD from Columbia University College of Physicians and Surgeons and a Masters of Science in tropical medicine from the London School of Hygiene and trained in infectious diseases in the Department of Geographic Medicine at New England Medical Center. He has pursued a full time career in both domestic and international clinical and epidemiological infectious disease research, primarily in issues related to child survival and in particular mother to child transmission of HIV/AIDS and pneumonia. Dr. Thea was an early member of Project SIDA (Kinshasa, Zaire), the first international clinical HIV/AIDS research field site, where he did work on the etiology of diarrhea in perinatally acquired HIV infection and was the director of the Clinical Research Unit. He pursued his interest in perinatal transmission of HIV as the Principal Investigator of the New York City Collaborative Perinatal HIV Transmission Study. In 1998 he then joined the Health and Social Development Unit of the Harvard Institute for International Development where he focused on international field research in Acute Respiratory Illness, Malaria and HIV. Dr. Thea joined the Global Health department along with the other members of the Harvard team where he is currently a Professor of Global Health and the Director of MD/MPH dual degree program. In this capacity, Dr. Thea provides senior technical leadership of a portfolio of projects addressing community treatment of neonatal sepsis, management of acute respiratory illness in children, community and facilities-based management of acute malaria, presumptive prophylaxis of malaria in pregnancy, social and behavioral aspects of HIV transmission and child sexual abuse. Dr. Thea has been the Principal Investigator of several large studies and program implementation projects including a prospective cohort study of postnatal HIV through breastmilk (the Zambia Exclusive Breastfeeding Study), the Zambia Boston University Malaria Project (ZAMBUMP), the Boston University PMTCT Integration Projects (BUPIP) – Southern Province Zambia. He is the Zambia Site PI for the Bill and Melinda Gates funded Pneumonia Etiology Research in Child Health (PERCH) through a subcontract with Johns Hopkins University. Most recently, in 2018 Dr. Thea was awarded a 5-year R01 grant from NICHD (Zambia Infant Cohort Study - ZICS) to study the causes and risk factors for increased morbidity and mortality seen among children who are born to HIV-infected mothers but escaped infection themselves. These HIV-exposed but uninfected children are now estimated to number 14.8 million, worldwide and growing. Along with Professors Gill and Fox, Dr. Thea have a bi-weekly podcast, Free Associations, which critically reviews the merit and rigor of recent scientific publications that have been noted in the popular press.
Self-Described Keywords Infectious diseases

One or more keywords matched the following items that are connected to Thea, Donald

Item TypeName
Concept Infectious Disease Transmission, Vertical
Academic Article Efficacy of antenatal zidovudine in reducing perinatal transmission of human immunodeficiency virus type 1. The New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Neonatal predictors of infection status and early death among 332 infants at risk of HIV-1 infection monitored prospectively from birth. New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Timing of maternal-infant HIV transmission: associations between intrapartum factors and early polymerase chain reaction results. New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article The effect of maternal viral load on the risk of perinatal transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Heterosexual behavior during pregnancy and perinatal transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Lack of increased risk for perinatal human immunodeficiency virus transmission to subsequent children born to infected women.
Academic Article Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City. The New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Vitamin A deficiency and maternal-infant transmissions of HIV in two metropolitan areas in the United States.
Academic Article Genetic evaluation of suspected cases of transient HIV-1 infection of infants.
Academic Article Incubation period of HIV-1 in perinatally infected children. New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Sensitivity and specificity of a qualitative RNA detection assay to diagnose HIV infection in young infants. Perinatal AIDS Collaborative Transmission Study.
Academic Article Distinct risk factors for intrauterine and intrapartum human immunodeficiency virus transmission and consequences for disease progression in infected children. Perinatal AIDS Collaborative Transmission Study.
Academic Article Neutralizing antibody and perinatal transmission of human immunodeficiency virus type 1. New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection: a preliminary study.
Academic Article Predictors of nonadherence to single-dose nevirapine therapy for the prevention of mother-to-child HIV transmission.
Academic Article Women in couples antenatal HIV counseling and testing are not more likely to report adverse social events.
Academic Article Alpha-defensins in the prevention of HIV transmission among breastfed infants.
Academic Article Adherence to zidovudine for the prevention of perinatal transmission in HIV-infected pregnant women: the impact of social network factors, side effects, and perceived treatment efficacy.
Academic Article Nevirapine resistance viral mutations after repeat use of nevirapine for prevention of perinatal HIV transmission.
Academic Article Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume.
Academic Article Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants.
Academic Article Bystander effects: children who escape infection but not harm.
Academic Article Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission.
Academic Article Veterinary field test as screening tool for mastitis and HIV-1 viral load in breastmilk from HIV-infected Zambian women.
Academic Article High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission.
Academic Article Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding.
Academic Article Effects of early, abrupt weaning on HIV-free survival of children in Zambia.
Academic Article Role of breastfeeding cessation in mediating the relationship between maternal HIV disease stage and increased child mortality among HIV-exposed uninfected children.
Academic Article Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study.
Academic Article Differential effects of early weaning for HIV-free survival of children born to HIV-infected mothers by severity of maternal disease.
Academic Article High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.
Academic Article Multiple independent lineages of HIV-1 persist in breast milk and plasma.
Academic Article Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to- child HIV transmission.
Academic Article HIV-1 concentrations in human breast milk before and after weaning.
Academic Article Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies.
Academic Article Ethical issues in the use of zidovudine to reduce vertical transmission of HIV.
Academic Article Comparison of methods of estimating the mother-to-child transmission rate of human immunodeficiency virus type 1 (HIV-1). New York City Perinatal HIV Transmission Collaborative Study Group.
Academic Article The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group.
Academic Article Human milk galectin-3 binding protein and breast-feeding-associated HIV transmission.
Academic Article HLA-G 14?bp deletion/insertion polymorphism and mother-to-child transmission of HIV.
Academic Article In-home HIV testing and nevirapine dosing by traditional birth attendants in rural Zambia: a feasibility study.
Academic Article Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia.
Academic Article Implementation and Operational Research: Integration of PMTCT and Antenatal Services Improves Combination Antiretroviral Therapy Uptake for HIV-Positive Pregnant Women in Southern Zambia: A Prototype for Option B+?
Academic Article Revisiting pneumonia and exposure status in infants born to HIV-infected mothers.
Academic Article Identifying Gaps in Prevention of Mother to Child Transmission of HIV: A Case Series of HIV-positive Infants in Zambia.
Academic Article Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures.
Award or Honor Receipt Teaching Award, Controversies in Infectious Diseases
Academic Article A Meta-analysis Assessing Diarrhea and Pneumonia in HIV-Exposed Uninfected Compared With HIV-Unexposed Uninfected Infants and Children.

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  • Infectious Diseases