Search Results to Sudha Seshadri, MD

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Research Expertise & Professional Interests I have been an investigator at the Framingham Heart Study (FHS) since 1998, leading the clinical neurology and neurogenetics cores since 2005 and serving as PI on 9 NIH grants, 5 R01 grants, 3 U01s and a UH2. As a board certified neurologist and Professor of Neurology at the Boston University School of Medicine, I ran a Geriatric Memory Disorders and Dementia clinic, supervised a resident general neurology clinic and covered the in-patient, consult and emergency services for one month in each year. I also served as Co-Director of Medical Education for the Neurology Residency Program between 2005 and 2012. I was Director of the neurology segment of the Biology of Disease/ Disease and Therapy course for 2nd year medical students between 2008-2010 and in 2015-16 and continue to teach the Dementia module. I currently spend 75% of my time on research and mentoring within the context of the Framingham study and have served as primary mentor for over 30 physician and non-physician investigators funded by a wide range of grants, national (K23, AAN, AHA) and international (Fulbright, Bettencourt-Schuller, Sidney-Sax etc.). In my research capacity, I currently lead the clinical neurology and neurogenetics cores at the FHS, where we explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across 3 generations of participants. This entails undertaking brain MRI, cognitive tests, brain autopsies, biomarker, candidate gene, genome-wide association, sequencing and expression studies. At FHS, my key contributions have included updating the dementia database with improved tracking, review and new classification systems, studying novel biomarkers such as BDNF, NGF and beta-amyloid, and establishing a brain bank program. In addition I play a major role in consolidating, refining and expanding various aspects of the MRI and stroke databases. Further, as lead neurogenetics investigator I have funded whole exome sequencing on over 1300 Framingham Study participants. My research focuses on 4 interrelated areas: (a) exploring the correlates of subclinical brain aging including establishing norms for brain MRI and cognitive test performance and relating these measures to novel risk factors (such as visceral fat mass), multiple circulating biomarkers and clinical and subclinical indices of vascular and metabolic disease; (b) the epidemiology of stroke and vascular cognitive impairment including the lifetime risk of stroke, cognitive decline and dementia following stroke, the role of parental stroke and midlife risk factors in determining late-life stroke risk and temporal trends in stroke risk over the past 50 years; (c) the epidemiology of dementia and Alzheimer’s disease (AD) including describing the lifetime risk of AD and relating traditional and novel biomarkers (homocysteine, lipids, diabetes, estrogen, bone mineral density, thyroid function, inflammation) to the risk of dementia and AD. I have been especially interested in exploring the role of reversible lifestyle, vascular and metabolic risk factors in determining dementia risk with a special focus on understanding the putative causal pathways and biomarkers, such as leptin and other adipokines, BDNF and other neurotrophic factors, in mediating this risk, and (d) understanding the genomic and epigenetic variation underlying brain aging, stroke, AD and vascular cognitive impairment. My most significant research contributions have been (i) developing the concept of lifetime risk as applicable to dementia and other chronic diseases, (ii) helping to establish plasma homocysteine as an important risk marker for dementia and AD (including a first author paper in the NEJM in 2002 that has had over 1400 citations), (iii) relating low plasma leptin levels to the risk of dementia and AD (published in JAMA, 2009 as senior author), (iv) describing a novel gene, NINJ2, associated with ischemic stroke (NEJM, 2009 as corresponding author), (v) describing two genes, BIN1 and EXOCL2, associated with Alzheimer disease in the largest, multi-centric genome-wide association study to date (JAMA, 2010 as first author) and identifying novel genes underlying hippocampal volume in healthy adults (Nature Genetics, 2012 as Senior author). I have over 280 peer-reviewed publications and reviews. I also established, partially fund and coordinate the neurology phenotype working group within the international Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium started in January 2008. This consortium brings together investigators from several of the leading cohort studies, the FHS, the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health study (CHS), the Rotterdam study, the Age, Gene, Environment Susceptibility- Reykjavik (AGES-Reykjavik) study and the Austrian Study for Prevention of Stroke (ASPS). In my capacity as coordinator of neuroCHARGE, I am also a founding member of the International Genomics of Alzheimer's Project (IGAP) that brings together 4 major European and US groups who are currently the leaders in AD genomics research, am a PI of the Alzheimer Disease Sequencing Project (ADSP) that assesses rare genetic variation underlying PD in over 11,500 persons, a member of the Steering Committee for the International Stroke Genetics Consortium (ISGC) and Chair of the METASTROKE consortium. A particular emphasis of mine throughout my career has been and will continue to be mentoring younger colleagues at my own institution and around the world towards academic careers. Collectively, my mentees have over 80 first author papers that I mentored published in leading journals including NEJM, Lancet, Nature Genetics, JAMA, JAMA Internal Medicine, JAMA Neurology, Annals of Neurology, Brain, Stroke and Neurology.
Self-Described Keywords Vascular Cognitive Impairment

One or more keywords matched the following items that are connected to Seshadri, Sudha

Item TypeName
Concept Cognition Disorders
Concept Endothelium, Vascular
Concept Vascular Diseases
Concept Dementia, Vascular
Concept Vascular Endothelial Growth Factor A
Concept Vascular Stiffness
Concept Mild Cognitive Impairment
Concept Vascular Calcification
Academic Article Bone mineral density and verbal memory impairment: Third National Health and Nutrition Examination Survey.
Academic Article Homocysteine and the brain: vascular risk factor or neurotoxin?
Academic Article Framingham stroke risk profile and lowered cognitive performance.
Academic Article Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study.
Academic Article Homocysteine and cognitive performance in the Framingham offspring study: age is important.
Academic Article The lifetime risk of stroke: estimates from the Framingham Study.
Academic Article Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring.
Academic Article Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study.
Academic Article Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study.
Academic Article Vascular risk factors and dementia revisited.
Academic Article Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
Academic Article Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.
Academic Article Profiles by sex of brain MRI and cognitive function in the framingham offspring study.
Academic Article Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes.
Academic Article Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2.
Academic Article Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.
Academic Article Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.
Academic Article Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline.
Academic Article Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.
Academic Article The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
Academic Article Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study.
Academic Article Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology.
Academic Article Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Academic Article Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study.
Academic Article APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline.
Academic Article Delaying dementia: can antihypertensives prevent Alzheimer dementia?
Academic Article Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study.
Academic Article Relations of arterial stiffness and endothelial function to brain aging in the community.
Academic Article Defining MCI in the Framingham Heart Study Offspring: education versus WRAT-based norms.
Academic Article Midlife cardiovascular risk impacts executive function: Framingham offspring study.
Academic Article Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
Academic Article Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.
Academic Article Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study.
Academic Article COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.
Academic Article Glucose indices are associated with cognitive and structural brain measures in young adults.
Academic Article Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study.
Academic Article Job strain and cognitive decline: a prospective study of the framingham offspring cohort.
Academic Article Normative Data for the Cognitively Intact Oldest-Old: The Framingham Heart Study.
Academic Article Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.
Academic Article Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study.
Academic Article APOE and mild cognitive impairment: the Framingham Heart Study.
Academic Article Understanding brain function through small vessel disease: what zebras can teach us about horses.
Academic Article Indexes of subclinical atherosclerosis: signposts on the highway to disease.
Academic Article Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study.
Academic Article Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging.
Academic Article Cognitive performance after stroke--the Framingham Heart Study.
Academic Article Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study.
Academic Article Neck Circumference, Brain Imaging Measures, and Neuropsychological Testing Measures.
Academic Article Lifelong Reading Disorder and Mild Cognitive Impairment: Implications for Diagnosis.
Academic Article Circulating vascular endothelial growth factor and the risk of cardiovascular events.
Academic Article Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer''s Disease Pathology.
Academic Article Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.
Academic Article Dipping to clear amyloid: Cerebrovascular reactivity and neurodegeneration--cause or effect?
Academic Article Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study.
Academic Article Association of arterial stiffness with progression of subclinical brain and cognitive disease.
Academic Article Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.
Academic Article Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study.
Academic Article Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.
Academic Article Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.
Academic Article Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study.
Academic Article Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.
Academic Article METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research.
Academic Article Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.
Academic Article Left ventricular hypertrophy in association with cognitive impairment: a systematic review and meta-analysis.
Academic Article APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.
Academic Article Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury.
Academic Article Role of Improved Vascular Health in the Declining Incidence of Dementia.
Academic Article Inter-Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults.
Academic Article Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association.
Academic Article A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium.
Academic Article Vascular risk factor burden and new-onset depression in the community.
Academic Article Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats.
Academic Article Stroke
Academic Article Association of MRI markers of vascular brain injury with mild cognitive impairment, incident stroke and mortality: The Framingham Offspring Study
Academic Article The association between APOE-e4 and mild cognitive impairment prevalence varies by method for defining cognitive impairment
Academic Article Effects of Vascular Risk Factors on White Matter Integrity in Middle-Aged Adults: A Voxel-Based Diffusion Tensor Imaging Study (P03.089)
Academic Article Vascular risk at younger ages most strongly associates with current and future brain volume.
Academic Article Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults.
Academic Article Vascular dysfunction-The disregarded partner of Alzheimer''s disease.
Academic Article Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study.
Academic Article Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.
Academic Article Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study.
Academic Article Mid-life and late-life vascular risk factor burden and neuropathology in old age.
Academic Article Circulating ceramide ratios and risk of vascular brain aging and dementia.
Academic Article Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia.
Academic Article Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.

Search Criteria
  • Vascular
  • cognitive impairment