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Search Results to Sudha Seshadri, MD

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One or more keywords matched the following properties of Seshadri, Sudha

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Research Expertise & Professional Interests I have been an investigator at the Framingham Heart Study (FHS) since 1998, leading the clinical neurology and neurogenetics cores since 2005 and serving as PI on 9 NIH grants, 5 R01 grants, 3 U01s and a UH2. As a board certified neurologist and Professor of Neurology at the Boston University School of Medicine, I ran a Geriatric Memory Disorders and Dementia clinic, supervised a resident general neurology clinic and covered the in-patient, consult and emergency services for one month in each year. I also served as Co-Director of Medical Education for the Neurology Residency Program between 2005 and 2012. I was Director of the neurology segment of the Biology of Disease/ Disease and Therapy course for 2nd year medical students between 2008-2010 and in 2015-16 and continue to teach the Dementia module. I currently spend 75% of my time on research and mentoring within the context of the Framingham study and have served as primary mentor for over 30 physician and non-physician investigators funded by a wide range of grants, national (K23, AAN, AHA) and international (Fulbright, Bettencourt-Schuller, Sidney-Sax etc.). In my research capacity, I currently lead the clinical neurology and neurogenetics cores at the FHS, where we explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across 3 generations of participants. This entails undertaking brain MRI, cognitive tests, brain autopsies, biomarker, candidate gene, genome-wide association, sequencing and expression studies. At FHS, my key contributions have included updating the dementia database with improved tracking, review and new classification systems, studying novel biomarkers such as BDNF, NGF and beta-amyloid, and establishing a brain bank program. In addition I play a major role in consolidating, refining and expanding various aspects of the MRI and stroke databases. Further, as lead neurogenetics investigator I have funded whole exome sequencing on over 1300 Framingham Study participants. My research focuses on 4 interrelated areas: (a) exploring the correlates of subclinical brain aging including establishing norms for brain MRI and cognitive test performance and relating these measures to novel risk factors (such as visceral fat mass), multiple circulating biomarkers and clinical and subclinical indices of vascular and metabolic disease; (b) the epidemiology of stroke and vascular cognitive impairment including the lifetime risk of stroke, cognitive decline and dementia following stroke, the role of parental stroke and midlife risk factors in determining late-life stroke risk and temporal trends in stroke risk over the past 50 years; (c) the epidemiology of dementia and Alzheimer’s disease (AD) including describing the lifetime risk of AD and relating traditional and novel biomarkers (homocysteine, lipids, diabetes, estrogen, bone mineral density, thyroid function, inflammation) to the risk of dementia and AD. I have been especially interested in exploring the role of reversible lifestyle, vascular and metabolic risk factors in determining dementia risk with a special focus on understanding the putative causal pathways and biomarkers, such as leptin and other adipokines, BDNF and other neurotrophic factors, in mediating this risk, and (d) understanding the genomic and epigenetic variation underlying brain aging, stroke, AD and vascular cognitive impairment. My most significant research contributions have been (i) developing the concept of lifetime risk as applicable to dementia and other chronic diseases, (ii) helping to establish plasma homocysteine as an important risk marker for dementia and AD (including a first author paper in the NEJM in 2002 that has had over 1400 citations), (iii) relating low plasma leptin levels to the risk of dementia and AD (published in JAMA, 2009 as senior author), (iv) describing a novel gene, NINJ2, associated with ischemic stroke (NEJM, 2009 as corresponding author), (v) describing two genes, BIN1 and EXOCL2, associated with Alzheimer disease in the largest, multi-centric genome-wide association study to date (JAMA, 2010 as first author) and identifying novel genes underlying hippocampal volume in healthy adults (Nature Genetics, 2012 as Senior author). I have over 280 peer-reviewed publications and reviews. I also established, partially fund and coordinate the neurology phenotype working group within the international Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium started in January 2008. This consortium brings together investigators from several of the leading cohort studies, the FHS, the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health study (CHS), the Rotterdam study, the Age, Gene, Environment Susceptibility- Reykjavik (AGES-Reykjavik) study and the Austrian Study for Prevention of Stroke (ASPS). In my capacity as coordinator of neuroCHARGE, I am also a founding member of the International Genomics of Alzheimer's Project (IGAP) that brings together 4 major European and US groups who are currently the leaders in AD genomics research, am a PI of the Alzheimer Disease Sequencing Project (ADSP) that assesses rare genetic variation underlying PD in over 11,500 persons, a member of the Steering Committee for the International Stroke Genetics Consortium (ISGC) and Chair of the METASTROKE consortium. A particular emphasis of mine throughout my career has been and will continue to be mentoring younger colleagues at my own institution and around the world towards academic careers. Collectively, my mentees have over 80 first author papers that I mentored published in leading journals including NEJM, Lancet, Nature Genetics, JAMA, JAMA Internal Medicine, JAMA Neurology, Annals of Neurology, Brain, Stroke and Neurology.
Self-Described Keywords Epidemiology
Self-Described Keywords Stroke

One or more keywords matched the following items that are connected to Seshadri, Sudha

Item TypeName
Concept Stroke Volume
Concept Confounding Factors (Epidemiology)
Concept Molecular Epidemiology
Concept Stroke, Lacunar
Academic Article Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study.
Academic Article Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
Academic Article Framingham stroke risk profile and lowered cognitive performance.
Academic Article Dementia after stroke: the Framingham Study.
Academic Article Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study.
Academic Article Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study.
Academic Article The lifetime risk of stroke: estimates from the Framingham Study.
Academic Article Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years.
Academic Article Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study.
Academic Article Atrial fibrillation is associated with lower cognitive performance in the Framingham offspring men.
Academic Article Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study.
Academic Article Genomewide association studies of stroke.
Academic Article Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study.
Academic Article Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study.
Academic Article Gender differences in stroke incidence and poststroke disability in the Framingham heart study.
Academic Article Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort.
Academic Article Parental occurrence of stroke and risk of stroke in their children: the Framingham study.
Academic Article Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
Academic Article Genetics of atherothrombotic and lacunar stroke.
Academic Article Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.
Academic Article Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.
Academic Article A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
Academic Article Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes.
Academic Article White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study.
Academic Article Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.
Academic Article Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study).
Academic Article Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Academic Article Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure.
Academic Article Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.
Academic Article Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan.
Academic Article Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study.
Academic Article Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study.
Academic Article Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Academic Article Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study.
Academic Article APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline.
Academic Article Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study.
Academic Article Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study.
Academic Article Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
Academic Article Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
Academic Article Neck circumference, carotid wall intima-media thickness, and incident stroke.
Academic Article Diabetes and Stroke
Academic Article Does preventing stroke prevent all kinds of dementia? Response. [letter]
Academic Article Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Academic Article Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
Academic Article Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium.
Academic Article Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
Academic Article Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.
Academic Article Serum Leptin Levels and the Risk of Stroke: The Framingham Study.
Academic Article Polygenic risk of ischemic stroke is associated with cognitive ability.
Academic Article Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study.
Academic Article Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
Academic Article Genetic overlap between diagnostic subtypes of ischemic stroke.
Academic Article Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.
Academic Article 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study.
Academic Article Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
Academic Article Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study.
Academic Article Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.
Academic Article Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure.
Academic Article Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.
Academic Article Atrial flutter: Clinical risk factors and adverse outcomes in the Framingham Heart Study.
Academic Article Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke.
Academic Article Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.
Academic Article Predicting stroke through genetic risk functions: the CHARGE Risk Score Project.
Academic Article Indexes of subclinical atherosclerosis: signposts on the highway to disease.
Academic Article White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Academic Article Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project.
Academic Article Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study.
Academic Article Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.
Academic Article Cognitive performance after stroke--the Framingham Heart Study.
Academic Article Heart of the Matter.
Academic Article Factors Associated With New-Onset Depression After Stroke.
Academic Article Neck Circumference, Brain Imaging Measures, and Neuropsychological Testing Measures.
Academic Article Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.
Academic Article Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study.
Academic Article Genetic Risk Factors for Ischemic and Hemorrhagic Stroke.
Academic Article Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.
Academic Article Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.
Academic Article Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study).
Academic Article Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis.
Academic Article Shared genetic contribution to Ischaemic Stroke and Alzheimer''s Disease.
Academic Article Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study.
Academic Article Revised Framingham Stroke Risk Profile to Reflect Temporal Trends.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke.
Academic Article Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study.
Academic Article Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.
Academic Article Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study.
Academic Article Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.
Academic Article Genetic variation at 16q24.2 is associated with small vessel stroke.
Academic Article Lacunar Infarcts and Intracerebral Hemorrhage Differences: A Nested Case-Control Analysis in the FHS (Framingham Heart Study).
Academic Article Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.
Academic Article Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Academic Article Fitness and cognition in the elderly: The Austrian Stroke Prevention Study.
Academic Article Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.
Academic Article Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.
Academic Article Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.
Academic Article Response by Lubitz et al to Letter Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study".
Academic Article Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.
Academic Article Incidence of seizures following initial ischemic stroke in a community-based cohort: The Framingham Heart Study.
Academic Article Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury.
Academic Article Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study.
Academic Article Role of Improved Vascular Health in the Declining Incidence of Dementia.
Academic Article Response by Pase et al to Letter Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study".
Academic Article Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study.
Academic Article Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study.
Academic Article Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study.
Academic Article Response by Pase et al to Letters Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study".
Academic Article Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia".
Academic Article Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association.
Academic Article COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
Academic Article Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.
Academic Article Vascular risk factor burden and new-onset depression in the community.
Academic Article Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1).
Academic Article Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.
Academic Article Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Academic Article Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.
Academic Article Top research priorities for stroke genetics.
Academic Article Stroke Genetics: Second Edition
Academic Article LARGE-SCALE META-ANALYSIS OF GENOME-WIDE ASSOCIATION DATA ON DELAYED RECALL MEMORY PERFORMANCE: THE COHORTS FOR HEART AND AGING RESEARCH IN GENOMIC EPIDEMIOLOGY (CHARGE) CONSORTIUM
Academic Article Modifiable Risk Factors and Determinants of Stroke
Academic Article Stroke
Academic Article Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Academic Article Stroke
Academic Article Annals of Neurology
Academic Article Stroke
Academic Article Stroke
Academic Article Stroke
Academic Article Association of MRI markers of vascular brain injury with mild cognitive impairment, incident stroke and mortality: The Framingham Offspring Study
Academic Article Response to Letter by Tsuda
Academic Article Annals of Neurology
Academic Article Walking Speed, Handgrip Strength and Risk of Dementia and Stroke: The Framingham Offspring Study (S24.003)
Academic Article Annals of Neurology
Academic Article Neurology
Academic Article Antecedent blood pressure levels substantially improve prediction of stroke risk in elderly: The Framingham study
Academic Article Stroke
Academic Article Stroke
Academic Article Stroke
Academic Article Stroke
Academic Article Vascular risk at younger ages most strongly associates with current and future brain volume.
Academic Article Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults.
Academic Article Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
Academic Article APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality.
Academic Article A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.
Academic Article Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.
Academic Article Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study.
Academic Article Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Academic Article Plasma total-tau as a biomarker of stroke risk in the community.
Academic Article Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study.
Academic Article Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17?180 Individuals.
Academic Article Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Academic Article Response by Aparicio et al to Letter Regarding Article, "Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study".
Grant The Genetics and Biomarkers of Small Vessel stroke
Grant Precursors of Stroke Incidence and Prognosis
Grant Epidemiology of Dementia in the Framingham Study
Grant Early-Onset Stroke: An Extreme Phenotype to Identify Rare Variants in Ischemic Stroke
Academic Article Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
Academic Article Exome Array Analysis of Early-Onset Ischemic Stroke.
Academic Article Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.

Highlights
Search Criteria
  • Stroke
  • epidemiology