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Search Results to Sudha Seshadri, MD

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Research Expertise & Professional Interests I have been an investigator at the Framingham Heart Study (FHS) since 1998, leading the clinical neurology and neurogenetics cores since 2005 and serving as PI on 9 NIH grants, 5 R01 grants, 3 U01s and a UH2. As a board certified neurologist and Professor of Neurology at the Boston University School of Medicine, I ran a Geriatric Memory Disorders and Dementia clinic, supervised a resident general neurology clinic and covered the in-patient, consult and emergency services for one month in each year. I also served as Co-Director of Medical Education for the Neurology Residency Program between 2005 and 2012. I was Director of the neurology segment of the Biology of Disease/ Disease and Therapy course for 2nd year medical students between 2008-2010 and in 2015-16 and continue to teach the Dementia module. I currently spend 75% of my time on research and mentoring within the context of the Framingham study and have served as primary mentor for over 30 physician and non-physician investigators funded by a wide range of grants, national (K23, AAN, AHA) and international (Fulbright, Bettencourt-Schuller, Sidney-Sax etc.). In my research capacity, I currently lead the clinical neurology and neurogenetics cores at the FHS, where we explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across 3 generations of participants. This entails undertaking brain MRI, cognitive tests, brain autopsies, biomarker, candidate gene, genome-wide association, sequencing and expression studies. At FHS, my key contributions have included updating the dementia database with improved tracking, review and new classification systems, studying novel biomarkers such as BDNF, NGF and beta-amyloid, and establishing a brain bank program. In addition I play a major role in consolidating, refining and expanding various aspects of the MRI and stroke databases. Further, as lead neurogenetics investigator I have funded whole exome sequencing on over 1300 Framingham Study participants. My research focuses on 4 interrelated areas: (a) exploring the correlates of subclinical brain aging including establishing norms for brain MRI and cognitive test performance and relating these measures to novel risk factors (such as visceral fat mass), multiple circulating biomarkers and clinical and subclinical indices of vascular and metabolic disease; (b) the epidemiology of stroke and vascular cognitive impairment including the lifetime risk of stroke, cognitive decline and dementia following stroke, the role of parental stroke and midlife risk factors in determining late-life stroke risk and temporal trends in stroke risk over the past 50 years; (c) the epidemiology of dementia and Alzheimer’s disease (AD) including describing the lifetime risk of AD and relating traditional and novel biomarkers (homocysteine, lipids, diabetes, estrogen, bone mineral density, thyroid function, inflammation) to the risk of dementia and AD. I have been especially interested in exploring the role of reversible lifestyle, vascular and metabolic risk factors in determining dementia risk with a special focus on understanding the putative causal pathways and biomarkers, such as leptin and other adipokines, BDNF and other neurotrophic factors, in mediating this risk, and (d) understanding the genomic and epigenetic variation underlying brain aging, stroke, AD and vascular cognitive impairment. My most significant research contributions have been (i) developing the concept of lifetime risk as applicable to dementia and other chronic diseases, (ii) helping to establish plasma homocysteine as an important risk marker for dementia and AD (including a first author paper in the NEJM in 2002 that has had over 1400 citations), (iii) relating low plasma leptin levels to the risk of dementia and AD (published in JAMA, 2009 as senior author), (iv) describing a novel gene, NINJ2, associated with ischemic stroke (NEJM, 2009 as corresponding author), (v) describing two genes, BIN1 and EXOCL2, associated with Alzheimer disease in the largest, multi-centric genome-wide association study to date (JAMA, 2010 as first author) and identifying novel genes underlying hippocampal volume in healthy adults (Nature Genetics, 2012 as Senior author). I have over 280 peer-reviewed publications and reviews. I also established, partially fund and coordinate the neurology phenotype working group within the international Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium started in January 2008. This consortium brings together investigators from several of the leading cohort studies, the FHS, the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health study (CHS), the Rotterdam study, the Age, Gene, Environment Susceptibility- Reykjavik (AGES-Reykjavik) study and the Austrian Study for Prevention of Stroke (ASPS). In my capacity as coordinator of neuroCHARGE, I am also a founding member of the International Genomics of Alzheimer's Project (IGAP) that brings together 4 major European and US groups who are currently the leaders in AD genomics research, am a PI of the Alzheimer Disease Sequencing Project (ADSP) that assesses rare genetic variation underlying PD in over 11,500 persons, a member of the Steering Committee for the International Stroke Genetics Consortium (ISGC) and Chair of the METASTROKE consortium. A particular emphasis of mine throughout my career has been and will continue to be mentoring younger colleagues at my own institution and around the world towards academic careers. Collectively, my mentees have over 80 first author papers that I mentored published in leading journals including NEJM, Lancet, Nature Genetics, JAMA, JAMA Internal Medicine, JAMA Neurology, Annals of Neurology, Brain, Stroke and Neurology.

One or more keywords matched the following items that are connected to Seshadri, Sudha

Item TypeName
Concept Dementia
Concept Dementia, Vascular
Concept AIDS Dementia Complex
Academic Article Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study.
Academic Article Statins and the risk of dementia.
Academic Article Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
Academic Article Homocysteine and the brain: vascular risk factor or neurotoxin?
Academic Article Dementia after stroke: the Framingham Study.
Academic Article The lifetime risk of stroke: estimates from the Framingham Study.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?
Academic Article Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study.
Academic Article Vascular risk factors and dementia revisited.
Academic Article Association of parental dementia with cognitive and brain MRI measures in middle-aged adults.
Academic Article Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging.
Academic Article Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.
Academic Article Depressive symptoms and risk of dementia: the Framingham Heart Study.
Academic Article Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.
Academic Article Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.
Academic Article The Framingham Brain Donation Program: neuropathology along the cognitive continuum.
Academic Article Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology.
Academic Article Red blood cell ?-3 fatty acid levels and markers of accelerated brain aging.
Academic Article Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Academic Article Homocysteine and the risk of dementia.
Academic Article Delaying dementia: can antihypertensives prevent Alzheimer dementia?
Academic Article Lexical retrieval in discourse: an early indicator of Alzheimer''s dementia.
Academic Article Does preventing stroke prevent all kinds of dementia? Response. [letter]
Academic Article Homocysteine and dementia – Reply. [letter]
Academic Article Serum cobalamin levels in dementias
Academic Article Dementia and statins- reply [letter]
Academic Article Understanding the link between obesity and dementia in older adults
Academic Article Neurological manifestations of AIDS.
Academic Article Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study.
Academic Article Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.
Academic Article COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.
Academic Article Parental longevity is associated with cognition and brain ageing in middle-aged offspring.
Academic Article Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.
Academic Article Development and validation of a brief dementia screening indicator for primary care.
Academic Article Serum brain-derived neurotrophic factor as a predictor of incident dementia-reply.
Academic Article Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.
Academic Article Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study.
Academic Article Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging.
Academic Article Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy.
Academic Article Circulating biomarkers that predict incident dementia.
Academic Article Cardiovascular risk profile in women and dementia.
Academic Article Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study.
Academic Article Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study.
Academic Article Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.
Academic Article Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury.
Academic Article Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.
Academic Article Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.
Academic Article Exploring the nexus of Alzheimer''s disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer''s Association & Alzheimer''s Drug Discovery Foundation.
Academic Article Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.
Academic Article METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research.
Academic Article Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.
Academic Article Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.
Academic Article Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study.
Academic Article APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.
Academic Article The changing prevalence and incidence of dementia over time - current evidence.
Academic Article Role of Improved Vascular Health in the Declining Incidence of Dementia.
Academic Article Response by Pase et al to Letter Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study".
Academic Article Association of amine biomarkers with incident dementia and Alzheimer''s disease in the Framingham Study.
Academic Article Response by Pase et al to Letters Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study".
Academic Article Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia".
Academic Article Dynamic measurements of ß-amyloid accumulation: The early effect of APOE.
Academic Article Sleep architecture and the risk of incident dementia in the community.
Academic Article Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.
Academic Article Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.
Academic Article Blood pressure from mid- to late life and risk of incident dementia.
Academic Article Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.
Academic Article Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1).
Academic Article Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Author response: Sleep architecture and the risk of incident dementia in the community.
Academic Article Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer''s disease: A prospective study in eight cohorts.
Academic Article Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study.
Academic Article Author response: Blood pressure from mid- to late life and risk of incident dementia.
Academic Article TOPMED WHOLE GENOME SEQUENCE (WGS) ASSOCIATIONS WITH BRAIN MRI MEASURES IN THE FRAMINGHAM STUDY
Academic Article MRI FINDINGS ASSOCIATED WITH CIRCULATING VEGF AND STIE2 CONCENTRATIONS IN YOUNG AND MIDDLE-AGED ADULTS IN THE FRAMINGHAM HEART STUDY
Academic Article CIRCULATING VEGF AND STIE2 AND MRI FINDINGS IN YOUNG AND MIDDLE-AGED ADULTS IN THE FRAMINGHAM HEART STUDY
Academic Article REM SLEEP MECHANISMS PREDICT INCIDENT DEMENTIA IN THE FRAMINGHAM HEART STUDY
Academic Article PLASMA AMYLOID ß PEPTIDE LEVELS AND RISK OF INCIDENT ALZHEIMER’S DISEASE AND DEMENTIA: UPDATE, REANALYSIS AND META-ANALYSIS OF INDIVIDUAL PARTICIPANTS’ DATA
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: CASE-CONTROL ANALYSES
Academic Article THE ALZHEIMER’S DISEASE SEQUENCING PROJECT (ADSP) DATA UPDATE 2017
Academic Article LARGE-SCALE META-ANALYSIS OF GENOME-WIDE ASSOCIATION DATA ON DELAYED RECALL MEMORY PERFORMANCE: THE COHORTS FOR HEART AND AGING RESEARCH IN GENOMIC EPIDEMIOLOGY (CHARGE) CONSORTIUM
Academic Article GENETIC DETERMINANTS OF MRI SUBCORTICAL BRAIN STRUCTURES: 24 NOVEL LOCI IDENTIFIED THROUGH GWAS IN 26,000 PERSONS
Academic Article CVD IS PATHOLOGICALLY ASSOCIATED WITH GREATER ALZHEIMER'S DISEASE IN NON-DEMENTED OLDER ADULTS
Academic Article Stroke
Academic Article TISSUE-SPECIFIC GENOME-WIDE PREDICTIONS OF GENETICALLY REGULATED EXPRESSION IN ALZHEIMER’S DISEASE
Academic Article A COMMON ALLELE IN SPI1 LOWERS RISK AND DELAYS AGE AT ONSET FOR ALZHEIMER'S DISEASE
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: SEARCH FOR ALZHEIMER'S DISEASE RESILIENCE GENES THAT MAY MODIFY DISEASE SUSCEPTIBILITY IN SPECIFIC APOE GENOTYPE BACKGROUNDS
Academic Article RARE DELETERIOUS AND LOSS-OF-FUNCTION VARIANTS IN OPRL1 AND GAS2L2 CONTRIBUTE TO THE RISK OF LATE-ONSET ALZHEIMER’S DISEASE: ALZHEIMER’S DISEASE SEQUENCING PROJECT CASE-CONTROL STUDY
Academic Article THE ALZHEIMER’S DISEASE SEQUENCING PROJECT (ADSP): DATA PRODUCTION, MANAGEMENT, AND AVAILABILITY
Academic Article ASSOCIATION OF LOW-FREQUENCY AND RARE CODING VARIANTS WITH INFORMATION PROCESSING SPEED
Academic Article Associations between BDNF serum levels and Alzheimer’s disease-related measures: The framingham study
Academic Article Adipokines are associated with MRI markers of brain aging in young adults
Academic Article Association of plasma biomarkers with risk of incident dementia in the framingham heart study: A metabolomics approach
Academic Article ApoE risk in the Alzheimer’s prevention initiative
Academic Article Low-frequency variant imputation identifies rare variant candidate loci in a gwas of late-onset Alzheimer’s disease in the igap consortium
Academic Article Whole exome sequence analysis of white matter hyperintensities on cranial MRI
Academic Article Annals of Neurology
Academic Article Genome-wide association study of lobar brain volumes
Academic Article Associating Wechsler Memory Scale Logical Memory (LM) errors and correct responses and MRI regions of interest from a healthy community-dwelling cohort: The Framingham Heart Study
Academic Article RNA-sequencing evaluation of fresh frozen and formaldehyde-fixed prefrontal cortex brain tissue for the study of Alzheimer's disease
Academic Article GENE EXPRESSION NETWORK ANALYSIS IMPLICATES THE IMMUNE RESPONSE IN GENETIC SUSCEPTIBILITY TO LATE-ONSET AD
Academic Article INFLUENCE OF MIDLIFE ELEVATED BLOOD GLUCOSE AND APOE GENOTYPE ON VASCULAR AND ALZHEIMER'S DISEASE NEUROPATHOLOGY
Academic Article Temporal trends in dementia incidence in the Framingham Study
Academic Article DETECTING PRE-MILD COGNITIVE IMPAIRMENT: COMBINING MRI AND MEMORY TEST PERFORMANCE
Academic Article Alzheimer's & Dementia
Academic Article Association of plasma beta-amyloid levels and risk of dementia, Alzheimer's disease, brain structure and cognitive functions in the Framingham Heart Study
Academic Article FUNCTIONAL VALIDATION OF NOVEL ALZHEIMER GENETIC RISK LOCI USING DROSOPHILA
Academic Article EXOME CHIP META-ANALYSIS OF ALZHEIMER'S DISEASE IN THE IGAP CONSORTIUM
Academic Article DO THE VARIANTS IDENTIFIED IN IGAP IMPROVE RISK PREDICTION OF ALZHEIMER'S DISEASE?
Academic Article The role of functional genetic variation in Alzheimer's disease: The CHARGE consortium
Academic Article Genetic variants associated with incidence of late-onset Alzheimer's disease in Caucasians
Academic Article Association of MRI markers of vascular brain injury with mild cognitive impairment, incident stroke and mortality: The Framingham Offspring Study
Academic Article Physical activity and the risk of dementia: The Framingham study
Academic Article The association between APOE-e4 and mild cognitive impairment prevalence varies by method for defining cognitive impairment
Academic Article A rare mutation in the CTNND2 gene is associated with increased Aß42 secretion
Academic Article Annals of Neurology
Academic Article Genome-wide association studies using prospective cohorts: The CHARGE consortium
Academic Article Walking Speed, Handgrip Strength and Risk of Dementia and Stroke: The Framingham Offspring Study (S24.003)
Academic Article ICP2-097: Hippocampal shape change correlates with delayed memory performance in middle-aged adults of the Framingham heart study (FHS)
Academic Article ATP5H/KCTD2 locus and Alzheimer's disease: An etiological link between key brain functions and dementia
Academic Article Do statins lower the risk of dementia?
Academic Article Aging and Dementia: principles, evaluation and diagnosis
Academic Article O1-01-08: Pathological evidence of dense Alzheimer lesions in the visual association cortex of cognitively intact elderly subjects
Academic Article P4-031: Systolic function is associated with brain aging: The Framingham Heart Study
Academic Article Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer''s disease: Pooled analysis from 5 cohorts.
Academic Article Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer''s Disease Associates with Increased Odds for Brain Infarcts.
Academic Article Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.
Academic Article Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes.
Academic Article Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.
Academic Article Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis.
Academic Article Circulating IGFBP-2: a novel biomarker for incident dementia.
Academic Article Prevention of Dementia-Thinking Beyond the Age and Amyloid Boxes.
Academic Article Antihypertensive medications and risk for incident dementia and Alzheimer''s disease: a meta-analysis of individual participant data from prospective cohort studies.
Academic Article Association of CD14 with incident dementia and markers of brain aging and injury.
Academic Article Are large simple trials for dementia prevention possible?
Academic Article Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.
Academic Article Circulating ceramide ratios and risk of vascular brain aging and dementia.
Academic Article The progression of carotid atherosclerosis and imaging markers of dementia.
Academic Article Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Academic Article Diabetes-Related Topics in an Online Forum for Caregivers of Individuals Living With Alzheimer Disease and Related Dementias: Qualitative Inquiry.
Academic Article Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.
Academic Article Systemic Inflammation as a Moderator Between Sleep and Incident Dementia.
Academic Article Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia.
Academic Article Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.
Academic Article The bi-directional association between epilepsy and dementia. The Framingham Heart Study.
Grant MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults
Grant MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults
Grant Collaborative GWAS of Dementia, AD and Related MRI and Cognitive Endophenotypes
Grant MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults
Grant Epidemiology of Dementia in the Framingham Study
Grant Collaborative GWAS of Dementia, AD and Related MRI and Cognitive Endophenotypes
Grant Plasma Proteome and Risk of Alzheimer Dementia and Related Endophenotypes in the Framingham Study

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  • Dementias