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first name Sudha
full name Sudha Seshadri, MD
label Seshadri, Sudha
last name Seshadri
Research Expertise & Professional Interests I have been an investigator at the Framingham Heart Study (FHS) since 1998, leading the clinical neurology and neurogenetics cores since 2005 and serving as PI on 9 NIH grants, 5 R01 grants, 3 U01s and a UH2. As a board certified neurologist and Professor of Neurology at the Boston University School of Medicine, I ran a Geriatric Memory Disorders and Dementia clinic, supervised a resident general neurology clinic and covered the in-patient, consult and emergency services for one month in each year. I also served as Co-Director of Medical Education for the Neurology Residency Program between 2005 and 2012. I was Director of the neurology segment of the Biology of Disease/ Disease and Therapy course for 2nd year medical students between 2008-2010 and in 2015-16 and continue to teach the Dementia module. I currently spend 75% of my time on research and mentoring within the context of the Framingham study and have served as primary mentor for over 30 physician and non-physician investigators funded by a wide range of grants, national (K23, AAN, AHA) and international (Fulbright, Bettencourt-Schuller, Sidney-Sax etc.). In my research capacity, I currently lead the clinical neurology and neurogenetics cores at the FHS, where we explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across 3 generations of participants. This entails undertaking brain MRI, cognitive tests, brain autopsies, biomarker, candidate gene, genome-wide association, sequencing and expression studies. At FHS, my key contributions have included updating the dementia database with improved tracking, review and new classification systems, studying novel biomarkers such as BDNF, NGF and beta-amyloid, and establishing a brain bank program. In addition I play a major role in consolidating, refining and expanding various aspects of the MRI and stroke databases. Further, as lead neurogenetics investigator I have funded whole exome sequencing on over 1300 Framingham Study participants. My research focuses on 4 interrelated areas: (a) exploring the correlates of subclinical brain aging including establishing norms for brain MRI and cognitive test performance and relating these measures to novel risk factors (such as visceral fat mass), multiple circulating biomarkers and clinical and subclinical indices of vascular and metabolic disease; (b) the epidemiology of stroke and vascular cognitive impairment including the lifetime risk of stroke, cognitive decline and dementia following stroke, the role of parental stroke and midlife risk factors in determining late-life stroke risk and temporal trends in stroke risk over the past 50 years; (c) the epidemiology of dementia and Alzheimer’s disease (AD) including describing the lifetime risk of AD and relating traditional and novel biomarkers (homocysteine, lipids, diabetes, estrogen, bone mineral density, thyroid function, inflammation) to the risk of dementia and AD. I have been especially interested in exploring the role of reversible lifestyle, vascular and metabolic risk factors in determining dementia risk with a special focus on understanding the putative causal pathways and biomarkers, such as leptin and other adipokines, BDNF and other neurotrophic factors, in mediating this risk, and (d) understanding the genomic and epigenetic variation underlying brain aging, stroke, AD and vascular cognitive impairment. My most significant research contributions have been (i) developing the concept of lifetime risk as applicable to dementia and other chronic diseases, (ii) helping to establish plasma homocysteine as an important risk marker for dementia and AD (including a first author paper in the NEJM in 2002 that has had over 1400 citations), (iii) relating low plasma leptin levels to the risk of dementia and AD (published in JAMA, 2009 as senior author), (iv) describing a novel gene, NINJ2, associated with ischemic stroke (NEJM, 2009 as corresponding author), (v) describing two genes, BIN1 and EXOCL2, associated with Alzheimer disease in the largest, multi-centric genome-wide association study to date (JAMA, 2010 as first author) and identifying novel genes underlying hippocampal volume in healthy adults (Nature Genetics, 2012 as Senior author). I have over 280 peer-reviewed publications and reviews. I also established, partially fund and coordinate the neurology phenotype working group within the international Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium started in January 2008. This consortium brings together investigators from several of the leading cohort studies, the FHS, the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health study (CHS), the Rotterdam study, the Age, Gene, Environment Susceptibility- Reykjavik (AGES-Reykjavik) study and the Austrian Study for Prevention of Stroke (ASPS). In my capacity as coordinator of neuroCHARGE, I am also a founding member of the International Genomics of Alzheimer's Project (IGAP) that brings together 4 major European and US groups who are currently the leaders in AD genomics research, am a PI of the Alzheimer Disease Sequencing Project (ADSP) that assesses rare genetic variation underlying PD in over 11,500 persons, a member of the Steering Committee for the International Stroke Genetics Consortium (ISGC) and Chair of the METASTROKE consortium. A particular emphasis of mine throughout my career has been and will continue to be mentoring younger colleagues at my own institution and around the world towards academic careers. Collectively, my mentees have over 80 first author papers that I mentored published in leading journals including NEJM, Lancet, Nature Genetics, JAMA, JAMA Internal Medicine, JAMA Neurology, Annals of Neurology, Brain, Stroke and Neurology.
Self-Described Keywords Alzheimer Disease
Self-Described Keywords Stroke

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Academic Article Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know.
Academic Article Asymptomatic eosinophilic myocarditis: 2 + 2 = 4 or 5!
Academic Article Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study.
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Academic Article Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study.
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Academic Article Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
Academic Article Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.
Academic Article Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study.
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Academic Article Nucleic acid amplification tests for tuberculous meningitis: a systematic review of diagnostic accuracy.
Academic Article Framingham stroke risk profile and lowered cognitive performance.
Academic Article Dementia after stroke: the Framingham Study.
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Academic Article New norms for a new generation: cognitive performance in the framingham offspring cohort.
Academic Article Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study.
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Academic Article Homocysteine and cognitive performance in the Framingham offspring study: age is important.
Academic Article The lifetime risk of stroke: estimates from the Framingham Study.
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Academic Article Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.
Academic Article Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?
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Academic Article Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study.
Academic Article Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study.
Academic Article Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study.
Academic Article Inflammatory markers and the risk of Alzheimer disease: the Framingham Study.
Academic Article The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.
Academic Article Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
Academic Article Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
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Academic Article Atrial fibrillation is associated with lower cognitive performance in the Framingham offspring men.
Academic Article Thyroid function and the risk of Alzheimer disease: the Framingham Study.
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Academic Article Association of matrix metalloproteinases with MRI indices of brain ischemia and aging.
Academic Article Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study.
Academic Article Genomewide association studies of stroke.
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Academic Article Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study.
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Academic Article Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy.
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Academic Article Transient global amnesia and neurological events: the framingham heart study.
Academic Article ATP5H/KCTD2 locus is associated with Alzheimer''s disease risk.
Academic Article APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.
Academic Article Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
Academic Article Neck circumference, carotid wall intima-media thickness, and incident stroke.
Academic Article Lexical retrieval in discourse: an early indicator of Alzheimer''s dementia.
Academic Article Midlife cardiovascular risk impacts executive function: Framingham offspring study.
Academic Article Diabetes and Stroke
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Academic Article Dementia and statins- reply [letter]
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Academic Article Botulinum toxin A in blepharospasm and hemifacial spasm.
Academic Article Neurological manifestations of AIDS.
Academic Article Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
Academic Article Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Academic Article Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study.
Academic Article Association between neuropathology and brain volume in the Framingham Heart Study.
Academic Article Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
Academic Article Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium.
Academic Article Genetics of Alzheimer''s disease.
Academic Article Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
Academic Article Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
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Academic Article Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.
Academic Article Association of Alzheimer''s disease GWAS loci with MRI markers of brain aging.
Academic Article Serum Leptin Levels and the Risk of Stroke: The Framingham Study.
Academic Article Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.
Academic Article Polygenic risk of ischemic stroke is associated with cognitive ability.
Academic Article Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study.
Academic Article COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.
Academic Article Parental longevity is associated with cognition and brain ageing in middle-aged offspring.
Academic Article Gene-wide analysis detects two new susceptibility genes for Alzheimer''s disease.
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Academic Article Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.
Academic Article Common genetic variants influence human subcortical brain structures.
Academic Article Genetic overlap between diagnostic subtypes of ischemic stroke.
Academic Article Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study.
Academic Article Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.
Academic Article Glucose indices are associated with cognitive and structural brain measures in young adults.
Academic Article 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study.
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Academic Article Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer''s disease.
Academic Article Follow-up of loci from the International Genomics of Alzheimer''s Disease Project identifies TRIP4 as a novel susceptibility gene.
Academic Article GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
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Academic Article Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria.
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Academic Article Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.
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Academic Article Atrial flutter: Clinical risk factors and adverse outcomes in the Framingham Heart Study.
Academic Article Development and validation of a brief dementia screening indicator for primary care.
Academic Article Serum brain-derived neurotrophic factor as a predictor of incident dementia-reply.
Academic Article Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study.
Academic Article APOE and mild cognitive impairment: the Framingham Heart Study.
Academic Article Convergent genetic and expression data implicate immunity in Alzheimer''s disease.
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Academic Article Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Academic Article GWAS for executive function and processing speed suggests involvement of the CADM2 gene.
Academic Article Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke.
Academic Article Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.
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Academic Article Predicting stroke through genetic risk functions: the CHARGE Risk Score Project.
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Academic Article Indexes of subclinical atherosclerosis: signposts on the highway to disease.
Academic Article Hepatic steatosis and cardiovascular disease outcomes: An analysis of the Framingham Heart Study.
Academic Article A novel Alzheimer disease locus located near the gene encoding tau protein.
Academic Article Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study.
Academic Article Directional dominance on stature and cognition in diverse human populations.
Academic Article White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Academic Article Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging.
Academic Article Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project.
Academic Article Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study.
Academic Article Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson''s disease.
Academic Article Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.
Academic Article Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage.
Academic Article Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy.
Academic Article Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.
Academic Article Circulating biomarkers that predict incident dementia.
Academic Article Cardiovascular risk profile in women and dementia.
Academic Article Cognitive performance after stroke--the Framingham Heart Study.
Academic Article Genetic overlap between Alzheimer''s disease and Parkinson''s disease at the MAPT locus.
Academic Article Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study.
Academic Article Heart of the Matter.
Academic Article Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study.
Academic Article Factors Associated With New-Onset Depression After Stroke.
Academic Article Neck Circumference, Brain Imaging Measures, and Neuropsychological Testing Measures.
Academic Article Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Population Normative Data for the CERAD Word List and Victoria Stroop Test in Younger- and Middle-Aged Adults: Cross-Sectional Analyses from the Framingham Heart Study.
Academic Article Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study.
Academic Article Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.
Academic Article Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study.
Academic Article Lifelong Reading Disorder and Mild Cognitive Impairment: Implications for Diagnosis.
Academic Article Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study.
Academic Article Circulating vascular endothelial growth factor and the risk of cardiovascular events.
Academic Article Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer''s Disease Pathology.
Academic Article Genetic Risk Factors for Ischemic and Hemorrhagic Stroke.
Academic Article Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases.
Academic Article Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.
Academic Article Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.
Academic Article Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study).
Academic Article GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.
Academic Article Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Academic Article Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer''s Disease.
Academic Article Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.
Academic Article Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer''s Disease.
Academic Article Common polygenic variation enhances risk prediction for Alzheimer''s disease.
Academic Article Dipping to clear amyloid: Cerebrovascular reactivity and neurodegeneration--cause or effect?
Academic Article Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury.
Academic Article Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis.
Academic Article Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study.
Academic Article Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies.
Academic Article Shared genetic contribution to Ischaemic Stroke and Alzheimer''s Disease.
Academic Article A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium.
Academic Article Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Academic Article Novel genetic loci associated with hippocampal volume.
Academic Article Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study.
Academic Article Revised Framingham Stroke Risk Profile to Reflect Temporal Trends.
Academic Article Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Academic Article Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later.
Academic Article Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.
Academic Article Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke.
Academic Article Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study.
Academic Article Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study.
Academic Article Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities.
Academic Article Association of arterial stiffness with progression of subclinical brain and cognitive disease.
Academic Article Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.
Academic Article Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-e4.
Academic Article Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study.
Academic Article Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.
Academic Article Serum brain-derived neurotrophic factor and risk of atrial fibrillation.
Academic Article Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.
Academic Article Genetic variation at 16q24.2 is associated with small vessel stroke.
Academic Article Exploring the nexus of Alzheimer''s disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer''s Association & Alzheimer''s Drug Discovery Foundation.
Academic Article Lacunar Infarcts and Intracerebral Hemorrhage Differences: A Nested Case-Control Analysis in the FHS (Framingham Heart Study).
Academic Article Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.
Academic Article Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Academic Article Fitness and cognition in the elderly: The Austrian Stroke Prevention Study.
Academic Article Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study.
Academic Article Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.
Academic Article Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.
Academic Article METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research.
Academic Article Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.
Award or Honor Receipt Jack Spivack Excellence in Neurosciences Award
Academic Article Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Response by Lubitz et al to Letter Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study".
Academic Article Sugary beverage intake and preclinical Alzheimer''s disease in the community.
Academic Article Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.
Academic Article Left ventricular hypertrophy in association with cognitive impairment: a systematic review and meta-analysis.
Academic Article Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research.
Academic Article Incidence of seizures following initial ischemic stroke in a community-based cohort: The Framingham Heart Study.
Academic Article Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study.
Academic Article APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.
Academic Article The changing prevalence and incidence of dementia over time - current evidence.
Academic Article Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury.
Academic Article Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study.
Academic Article Role of Improved Vascular Health in the Declining Incidence of Dementia.
Academic Article Response by Pase et al to Letter Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study".
Academic Article Association of amine biomarkers with incident dementia and Alzheimer''s disease in the Framingham Study.
Academic Article Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study.
Academic Article A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer''s disease.
Academic Article Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study.
Academic Article Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article Whole exome sequence-based association analyses of plasma amyloid-ß in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study.
Academic Article Response by Pase et al to Letters Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study".
Academic Article Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer''s Disease Patients.
Academic Article Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia".
Academic Article Dynamic measurements of ß-amyloid accumulation: The early effect of APOE.
Academic Article Sleep architecture and the risk of incident dementia in the community.
Academic Article Inter-Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults.
Academic Article Whole blood gene expression and white matter Hyperintensities.
Academic Article Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association.
Academic Article COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
Academic Article Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits.
Academic Article Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.
Academic Article Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.
Academic Article A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium.
Academic Article Blood pressure from mid- to late life and risk of incident dementia.
Academic Article Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study.
Academic Article The Alzheimer''s Disease Sequencing Project: Study design and sample selection.
Academic Article Vascular risk factor burden and new-onset depression in the community.
Academic Article Whole genome sequence analyses of brain imaging measures in the Framingham Study.
Academic Article Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.
Academic Article Meta-analysis of epigenome-wide association studies of cognitive abilities.
Academic Article Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1).
Academic Article A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Academic Article Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Author response: Sleep architecture and the risk of incident dementia in the community.
Academic Article Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer''s disease: A prospective study in eight cohorts.
Academic Article Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Academic Article Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study.
Academic Article Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer''s disease sequencing project.
Academic Article Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Academic Article Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) Expression in the Rat and Human Hippocampus: Decline in CA3 During Progression of Alzheimer''s Disease.
Academic Article Analysis of shared heritability in common disorders of the brain.
Academic Article Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats.
Academic Article DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.
Academic Article Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.
Academic Article Author response: Blood pressure from mid- to late life and risk of incident dementia.
Academic Article Top research priorities for stroke genetics.
Academic Article Whole exome sequencing study identifies novel rare and common Alzheimer''s-Associated variants involved in immune response and transcriptional regulation.
Academic Article Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.
Academic Article Stroke Genetics: Second Edition
Academic Article TOPMED WHOLE GENOME SEQUENCE (WGS) ASSOCIATIONS WITH BRAIN MRI MEASURES IN THE FRAMINGHAM STUDY
Academic Article MRI FINDINGS ASSOCIATED WITH CIRCULATING VEGF AND STIE2 CONCENTRATIONS IN YOUNG AND MIDDLE-AGED ADULTS IN THE FRAMINGHAM HEART STUDY
Academic Article CIRCULATING VEGF AND STIE2 AND MRI FINDINGS IN YOUNG AND MIDDLE-AGED ADULTS IN THE FRAMINGHAM HEART STUDY
Academic Article REM SLEEP MECHANISMS PREDICT INCIDENT DEMENTIA IN THE FRAMINGHAM HEART STUDY
Academic Article PLASMA AMYLOID ß PEPTIDE LEVELS AND RISK OF INCIDENT ALZHEIMER’S DISEASE AND DEMENTIA: UPDATE, REANALYSIS AND META-ANALYSIS OF INDIVIDUAL PARTICIPANTS’ DATA
Academic Article Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: CASE-CONTROL ANALYSES
Academic Article THE ALZHEIMER’S DISEASE SEQUENCING PROJECT (ADSP) DATA UPDATE 2017
Academic Article LARGE-SCALE META-ANALYSIS OF GENOME-WIDE ASSOCIATION DATA ON DELAYED RECALL MEMORY PERFORMANCE: THE COHORTS FOR HEART AND AGING RESEARCH IN GENOMIC EPIDEMIOLOGY (CHARGE) CONSORTIUM
Academic Article GENETIC DETERMINANTS OF MRI SUBCORTICAL BRAIN STRUCTURES: 24 NOVEL LOCI IDENTIFIED THROUGH GWAS IN 26,000 PERSONS
Academic Article CVD IS PATHOLOGICALLY ASSOCIATED WITH GREATER ALZHEIMER'S DISEASE IN NON-DEMENTED OLDER ADULTS
Academic Article Modifiable Risk Factors and Determinants of Stroke
Academic Article Stroke
Academic Article Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions.
Academic Article TISSUE-SPECIFIC GENOME-WIDE PREDICTIONS OF GENETICALLY REGULATED EXPRESSION IN ALZHEIMER’S DISEASE
Academic Article A COMMON ALLELE IN SPI1 LOWERS RISK AND DELAYS AGE AT ONSET FOR ALZHEIMER'S DISEASE
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: SEARCH FOR ALZHEIMER'S DISEASE RESILIENCE GENES THAT MAY MODIFY DISEASE SUSCEPTIBILITY IN SPECIFIC APOE GENOTYPE BACKGROUNDS
Academic Article RARE DELETERIOUS AND LOSS-OF-FUNCTION VARIANTS IN OPRL1 AND GAS2L2 CONTRIBUTE TO THE RISK OF LATE-ONSET ALZHEIMER’S DISEASE: ALZHEIMER’S DISEASE SEQUENCING PROJECT CASE-CONTROL STUDY
Academic Article THE ALZHEIMER’S DISEASE SEQUENCING PROJECT (ADSP): DATA PRODUCTION, MANAGEMENT, AND AVAILABILITY
Academic Article ASSOCIATION OF LOW-FREQUENCY AND RARE CODING VARIANTS WITH INFORMATION PROCESSING SPEED
Academic Article Brain Pathology
Academic Article Annals of Neurology
Academic Article Annals of Neurology
Academic Article Human Heredity
Academic Article Journal of Neuropathology and Experimental Neurology
Academic Article Associations between BDNF serum levels and Alzheimer’s disease-related measures: The framingham study
Academic Article Adipokines are associated with MRI markers of brain aging in young adults
Academic Article Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Academic Article Association of plasma biomarkers with risk of incident dementia in the framingham heart study: A metabolomics approach
Academic Article ApoE risk in the Alzheimer’s prevention initiative
Academic Article Low-frequency variant imputation identifies rare variant candidate loci in a gwas of late-onset Alzheimer’s disease in the igap consortium
Academic Article Whole exome sequence analysis of white matter hyperintensities on cranial MRI
Academic Article Stroke
Academic Article Annals of Neurology
Academic Article Annals of Neurology
Academic Article Genome-wide association study of lobar brain volumes
Academic Article Stroke
Academic Article Stroke
Academic Article Stroke
Academic Article Circulation
Academic Article Associating Wechsler Memory Scale Logical Memory (LM) errors and correct responses and MRI regions of interest from a healthy community-dwelling cohort: The Framingham Heart Study
Academic Article RNA-sequencing evaluation of fresh frozen and formaldehyde-fixed prefrontal cortex brain tissue for the study of Alzheimer's disease
Academic Article GENE EXPRESSION NETWORK ANALYSIS IMPLICATES THE IMMUNE RESPONSE IN GENETIC SUSCEPTIBILITY TO LATE-ONSET AD
Academic Article INFLUENCE OF MIDLIFE ELEVATED BLOOD GLUCOSE AND APOE GENOTYPE ON VASCULAR AND ALZHEIMER'S DISEASE NEUROPATHOLOGY
Academic Article Temporal trends in dementia incidence in the Framingham Study
Academic Article DETECTING PRE-MILD COGNITIVE IMPAIRMENT: COMBINING MRI AND MEMORY TEST PERFORMANCE
Academic Article Alzheimer's & Dementia
Academic Article Association of plasma beta-amyloid levels and risk of dementia, Alzheimer's disease, brain structure and cognitive functions in the Framingham Heart Study
Academic Article FUNCTIONAL VALIDATION OF NOVEL ALZHEIMER GENETIC RISK LOCI USING DROSOPHILA
Academic Article EXOME CHIP META-ANALYSIS OF ALZHEIMER'S DISEASE IN THE IGAP CONSORTIUM
Academic Article DO THE VARIANTS IDENTIFIED IN IGAP IMPROVE RISK PREDICTION OF ALZHEIMER'S DISEASE?
Academic Article The role of functional genetic variation in Alzheimer's disease: The CHARGE consortium
Academic Article Genetic variants associated with incidence of late-onset Alzheimer's disease in Caucasians
Academic Article Association of MRI markers of vascular brain injury with mild cognitive impairment, incident stroke and mortality: The Framingham Offspring Study
Academic Article Response to Letter by Tsuda
Academic Article Leptin Levels and Alzheimer Disease--Reply
Academic Article Physical activity and the risk of dementia: The Framingham study
Academic Article The association between APOE-e4 and mild cognitive impairment prevalence varies by method for defining cognitive impairment
Academic Article A rare mutation in the CTNND2 gene is associated with increased Aß42 secretion
Academic Article Effects of Vascular Risk Factors on White Matter Integrity in Middle-Aged Adults: A Voxel-Based Diffusion Tensor Imaging Study (P03.089)
Academic Article Annals of Neurology
Academic Article Annals of Neurology
Academic Article Neurology
Academic Article Genome-wide association studies using prospective cohorts: The CHARGE consortium
Academic Article Walking Speed, Handgrip Strength and Risk of Dementia and Stroke: The Framingham Offspring Study (S24.003)
Academic Article Annals of Neurology
Academic Article Glutathione and Sulfur Amino Acids in Human Health and Disease
Academic Article ICP2-097: Hippocampal shape change correlates with delayed memory performance in middle-aged adults of the Framingham heart study (FHS)
Academic Article ATP5H/KCTD2 locus and Alzheimer's disease: An etiological link between key brain functions and dementia
Academic Article Neurology
Academic Article Reply Effect yes, role no!
Academic Article Antecedent blood pressure levels substantially improve prediction of stroke risk in elderly: The Framingham study
Academic Article Do statins lower the risk of dementia?
Academic Article Lifetime total cholesterol and the risk of Alzheimer's disease: The Framingham study
Academic Article Aging and Dementia: principles, evaluation and diagnosis
Academic Article Stroke
Academic Article Stroke
Academic Article Relationship of Silent Cerebral Infarctions and White Matter Hyperintensities to Cognitive Performance in the Framingham Offspring Study
Academic Article Stroke
Academic Article Journal of the American Geriatrics Society
Academic Article O1-01-08: Pathological evidence of dense Alzheimer lesions in the visual association cortex of cognitively intact elderly subjects
Academic Article P4-031: Systolic function is associated with brain aging: The Framingham Heart Study
Academic Article Stroke
Academic Article Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.
Academic Article Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
Academic Article Vascular risk at younger ages most strongly associates with current and future brain volume.
Academic Article Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
Academic Article Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults.
Academic Article Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.
Academic Article Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
Academic Article Genetic Interaction with Plasma Lipids on Alzheimer''s Disease in the Framingham Heart Study.
Academic Article GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Academic Article Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease.
Academic Article APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality.
Academic Article Vascular dysfunction-The disregarded partner of Alzheimer''s disease.
Academic Article A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.
Academic Article Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.
Academic Article Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis.
Academic Article Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer''s disease: Pooled analysis from 5 cohorts.
Academic Article Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study.
Academic Article Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer''s Disease Associates with Increased Odds for Brain Infarcts.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.
Academic Article Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes.
Academic Article Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.
Academic Article Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.
Academic Article Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.
Academic Article Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.
Academic Article Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis.
Academic Article Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Academic Article Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study.
Academic Article Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.
Academic Article Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study.
Academic Article Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Academic Article Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.
Academic Article Plasma total-tau as a biomarker of stroke risk in the community.
Academic Article Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer''s disease.
Academic Article Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes.
Academic Article Circulating IGFBP-2: a novel biomarker for incident dementia.
Academic Article The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE).
Academic Article Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study.
Academic Article A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.
Academic Article Author Correction: Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17?180 Individuals.
Academic Article Author response: Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.
Academic Article Genetic architecture of subcortical brain structures in 38,851 individuals.
Academic Article Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.
Academic Article Correction: Whole exome sequencing study identifies novel rare and common Alzheimer''s-Associated variants involved in immune response and transcriptional regulation.
Academic Article Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study.
Academic Article Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Academic Article Prevention of Dementia-Thinking Beyond the Age and Amyloid Boxes.
Academic Article Response by Aparicio et al to Letter Regarding Article, "Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study".
Academic Article Mid-life and late-life vascular risk factor burden and neuropathology in old age.
Academic Article Antihypertensive medications and risk for incident dementia and Alzheimer''s disease: a meta-analysis of individual participant data from prospective cohort studies.
Academic Article Association of CD14 with incident dementia and markers of brain aging and injury.
Academic Article Are large simple trials for dementia prevention possible?
Academic Article Author response: Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham study.
Academic Article Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.
Academic Article A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.
Academic Article Circulating ceramide ratios and risk of vascular brain aging and dementia.
Academic Article The genetic architecture of the human cerebral cortex.
Academic Article The progression of carotid atherosclerosis and imaging markers of dementia.
Academic Article Joint trajectories of cognition and gait speed in Mexican American and European American older adults: The San Antonio longitudinal study of aging.
Academic Article Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
Academic Article Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.
Academic Article Relation of plasma ß-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study.
Academic Article Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Academic Article Diabetes-Related Topics in an Online Forum for Caregivers of Individuals Living With Alzheimer Disease and Related Dementias: Qualitative Inquiry.
Academic Article Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.
Academic Article Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study.
Academic Article Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids.
Academic Article Systemic Inflammation as a Moderator Between Sleep and Incident Dementia.
Academic Article Exome Array Analysis of Early-Onset Ischemic Stroke.
Academic Article Association of common genetic variants with brain microbleeds: A genome-wide association study.
Academic Article Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia.
Academic Article Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
Academic Article Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.
Academic Article Bi-directional association between epilepsy and dementia: The Framingham Heart Study.
Grant ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems
Grant An integrated genetic and epigenetic approach to cerebral small vessel disease
Grant Alzheimer's Prevention Initiative APOE4 Trial
Grant AD Gene Discovery: Exome Chip, New Endophenotypes & Functional studies in CHARGE
Grant Microgial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
Grant The Atherosclerosis Risk in Communities Neurocognitive Study
Grant Early-Onset Stroke: An Extreme Phenotype to Identify Rare Variants in Ischemic Stroke
Grant Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer Disease in Framingham Cohorts
Grant Epidemiology of Dementia in the Framingham Study
Grant CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample
Grant The Genetics and Biomarkers of Small Vessel stroke
Grant Precursors of Stroke Incidence and Prognosis
Grant International Alzheimer's Disease Genetics Consortium
Grant Consortium to Study the Genetics of Longevity
Grant An integrated genetic and epigenetic approach to cerebral small vessel disease
Grant Plasma Proteome and Risk of Alzheimer Dementia and Related Endophenotypes in the Framingham Study
Academic Article Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts.
Academic Article Cerebral small vessel disease genomics and its implications across the lifespan.
Academic Article The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.
Academic Article Slow-wave Sleep and MRI Markers of Brain Aging in a Community-based Sample.
Academic Article Aortic stiffness and cerebral microbleeds: The Framingham Heart Study.
Academic Article The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning.

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