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Search Results to Sudha Seshadri, MD

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Research Expertise & Professional Interests I have been an investigator at the Framingham Heart Study (FHS) since 1998, leading the clinical neurology and neurogenetics cores since 2005 and serving as PI on 9 NIH grants, 5 R01 grants, 3 U01s and a UH2. As a board certified neurologist and Professor of Neurology at the Boston University School of Medicine, I ran a Geriatric Memory Disorders and Dementia clinic, supervised a resident general neurology clinic and covered the in-patient, consult and emergency services for one month in each year. I also served as Co-Director of Medical Education for the Neurology Residency Program between 2005 and 2012. I was Director of the neurology segment of the Biology of Disease/ Disease and Therapy course for 2nd year medical students between 2008-2010 and in 2015-16 and continue to teach the Dementia module. I currently spend 75% of my time on research and mentoring within the context of the Framingham study and have served as primary mentor for over 30 physician and non-physician investigators funded by a wide range of grants, national (K23, AAN, AHA) and international (Fulbright, Bettencourt-Schuller, Sidney-Sax etc.). In my research capacity, I currently lead the clinical neurology and neurogenetics cores at the FHS, where we explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across 3 generations of participants. This entails undertaking brain MRI, cognitive tests, brain autopsies, biomarker, candidate gene, genome-wide association, sequencing and expression studies. At FHS, my key contributions have included updating the dementia database with improved tracking, review and new classification systems, studying novel biomarkers such as BDNF, NGF and beta-amyloid, and establishing a brain bank program. In addition I play a major role in consolidating, refining and expanding various aspects of the MRI and stroke databases. Further, as lead neurogenetics investigator I have funded whole exome sequencing on over 1300 Framingham Study participants. My research focuses on 4 interrelated areas: (a) exploring the correlates of subclinical brain aging including establishing norms for brain MRI and cognitive test performance and relating these measures to novel risk factors (such as visceral fat mass), multiple circulating biomarkers and clinical and subclinical indices of vascular and metabolic disease; (b) the epidemiology of stroke and vascular cognitive impairment including the lifetime risk of stroke, cognitive decline and dementia following stroke, the role of parental stroke and midlife risk factors in determining late-life stroke risk and temporal trends in stroke risk over the past 50 years; (c) the epidemiology of dementia and Alzheimer’s disease (AD) including describing the lifetime risk of AD and relating traditional and novel biomarkers (homocysteine, lipids, diabetes, estrogen, bone mineral density, thyroid function, inflammation) to the risk of dementia and AD. I have been especially interested in exploring the role of reversible lifestyle, vascular and metabolic risk factors in determining dementia risk with a special focus on understanding the putative causal pathways and biomarkers, such as leptin and other adipokines, BDNF and other neurotrophic factors, in mediating this risk, and (d) understanding the genomic and epigenetic variation underlying brain aging, stroke, AD and vascular cognitive impairment. My most significant research contributions have been (i) developing the concept of lifetime risk as applicable to dementia and other chronic diseases, (ii) helping to establish plasma homocysteine as an important risk marker for dementia and AD (including a first author paper in the NEJM in 2002 that has had over 1400 citations), (iii) relating low plasma leptin levels to the risk of dementia and AD (published in JAMA, 2009 as senior author), (iv) describing a novel gene, NINJ2, associated with ischemic stroke (NEJM, 2009 as corresponding author), (v) describing two genes, BIN1 and EXOCL2, associated with Alzheimer disease in the largest, multi-centric genome-wide association study to date (JAMA, 2010 as first author) and identifying novel genes underlying hippocampal volume in healthy adults (Nature Genetics, 2012 as Senior author). I have over 280 peer-reviewed publications and reviews. I also established, partially fund and coordinate the neurology phenotype working group within the international Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium started in January 2008. This consortium brings together investigators from several of the leading cohort studies, the FHS, the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health study (CHS), the Rotterdam study, the Age, Gene, Environment Susceptibility- Reykjavik (AGES-Reykjavik) study and the Austrian Study for Prevention of Stroke (ASPS). In my capacity as coordinator of neuroCHARGE, I am also a founding member of the International Genomics of Alzheimer's Project (IGAP) that brings together 4 major European and US groups who are currently the leaders in AD genomics research, am a PI of the Alzheimer Disease Sequencing Project (ADSP) that assesses rare genetic variation underlying PD in over 11,500 persons, a member of the Steering Committee for the International Stroke Genetics Consortium (ISGC) and Chair of the METASTROKE consortium. A particular emphasis of mine throughout my career has been and will continue to be mentoring younger colleagues at my own institution and around the world towards academic careers. Collectively, my mentees have over 80 first author papers that I mentored published in leading journals including NEJM, Lancet, Nature Genetics, JAMA, JAMA Internal Medicine, JAMA Neurology, Annals of Neurology, Brain, Stroke and Neurology.
Self-Described Keywords Alzheimer Disease

One or more keywords matched the following items that are connected to Seshadri, Sudha

Item TypeName
Academic Article Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know.
Academic Article Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study.
Academic Article Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro.
Academic Article Statins and the risk of dementia.
Academic Article Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease.
Academic Article Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
Academic Article Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study.
Academic Article Homocysteine and the brain: vascular risk factor or neurotoxin?
Academic Article Bone mineral density and the risk of Alzheimer disease.
Academic Article The lifetime risk of stroke: estimates from the Framingham Study.
Academic Article Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?
Academic Article Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study.
Academic Article Inflammatory markers and the risk of Alzheimer disease: the Framingham Study.
Academic Article Thyroid function and the risk of Alzheimer disease: the Framingham Study.
Academic Article Association of parental dementia with cognitive and brain MRI measures in middle-aged adults.
Academic Article Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging.
Academic Article Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?
Academic Article Depressive symptoms and risk of dementia: the Framingham Heart Study.
Academic Article Genome-wide analysis of genetic loci associated with Alzheimer disease.
Academic Article Cardiac index is associated with brain aging: the Framingham Heart Study.
Academic Article Modulators of cytoskeletal reorganization in CA1 hippocampal neurons show increased expression in patients at mid-stage Alzheimer's disease.
Academic Article Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2.
Academic Article Association of HSP70 and its co-chaperones with Alzheimer's disease.
Academic Article Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.
Academic Article Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Academic Article Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure.
Academic Article Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.
Academic Article The Framingham Brain Donation Program: neuropathology along the cognitive continuum.
Academic Article Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology.
Academic Article Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart Study.
Academic Article Red blood cell ?-3 fatty acid levels and markers of accelerated brain aging.
Academic Article Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study.
Academic Article Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Academic Article Homocysteine and the risk of dementia.
Academic Article d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
Academic Article Delaying dementia: can antihypertensives prevent Alzheimer dementia?
Academic Article Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study.
Academic Article ATP5H/KCTD2 locus is associated with Alzheimer''s disease risk.
Academic Article Lexical retrieval in discourse: an early indicator of Alzheimer''s dementia.
Academic Article Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study.
Academic Article Association between neuropathology and brain volume in the Framingham Heart Study.
Academic Article Genetics of Alzheimer''s disease.
Academic Article Association of Alzheimer''s disease GWAS loci with MRI markers of brain aging.
Academic Article Gene-wide analysis detects two new susceptibility genes for Alzheimer''s disease.
Academic Article Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer''s disease.
Academic Article Follow-up of loci from the International Genomics of Alzheimer''s Disease Project identifies TRIP4 as a novel susceptibility gene.
Academic Article Plasma amyloid-ß and risk of Alzheimer''s disease in the Framingham Heart Study.
Academic Article Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.
Academic Article Serum brain-derived neurotrophic factor as a predictor of incident dementia-reply.
Academic Article Convergent genetic and expression data implicate immunity in Alzheimer''s disease.
Academic Article PLD3 variants in population studies.
Academic Article Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Academic Article A novel Alzheimer disease locus located near the gene encoding tau protein.
Academic Article Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy.
Academic Article Genetic overlap between Alzheimer''s disease and Parkinson''s disease at the MAPT locus.
Academic Article Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study.
Academic Article Population Normative Data for the CERAD Word List and Victoria Stroop Test in Younger- and Middle-Aged Adults: Cross-Sectional Analyses from the Framingham Heart Study.
Academic Article Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study.
Academic Article Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.
Academic Article Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer''s Disease Pathology.
Academic Article Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.
Academic Article Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer''s Disease.
Academic Article Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.
Academic Article Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer''s Disease.
Academic Article Common polygenic variation enhances risk prediction for Alzheimer''s disease.
Academic Article Shared genetic contribution to Ischaemic Stroke and Alzheimer''s Disease.
Academic Article Novel genetic loci associated with hippocampal volume.
Academic Article Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.
Academic Article Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.
Academic Article Exploring the nexus of Alzheimer''s disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer''s Association & Alzheimer''s Drug Discovery Foundation.
Academic Article Sugary beverage intake and preclinical Alzheimer''s disease in the community.
Academic Article Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.
Academic Article Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research.
Academic Article Association of amine biomarkers with incident dementia and Alzheimer''s disease in the Framingham Study.
Academic Article A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer''s disease.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer''s Disease Patients.
Academic Article Dynamic measurements of ß-amyloid accumulation: The early effect of APOE.
Academic Article Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.
Academic Article The Alzheimer''s Disease Sequencing Project: Study design and sample selection.
Academic Article Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer''s disease: A prospective study in eight cohorts.
Academic Article Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer''s disease sequencing project.
Academic Article Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) Expression in the Rat and Human Hippocampus: Decline in CA3 During Progression of Alzheimer''s Disease.
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: CASE-CONTROL ANALYSES
Academic Article CVD IS PATHOLOGICALLY ASSOCIATED WITH GREATER ALZHEIMER'S DISEASE IN NON-DEMENTED OLDER ADULTS
Academic Article A COMMON ALLELE IN SPI1 LOWERS RISK AND DELAYS AGE AT ONSET FOR ALZHEIMER'S DISEASE
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: SEARCH FOR ALZHEIMER'S DISEASE RESILIENCE GENES THAT MAY MODIFY DISEASE SUSCEPTIBILITY IN SPECIFIC APOE GENOTYPE BACKGROUNDS
Academic Article Brain Pathology
Academic Article Journal of Neuropathology and Experimental Neurology
Academic Article Associations between BDNF serum levels and Alzheimer’s disease-related measures: The framingham study
Academic Article Low-frequency variant imputation identifies rare variant candidate loci in a gwas of late-onset Alzheimer’s disease in the igap consortium
Academic Article RNA-sequencing evaluation of fresh frozen and formaldehyde-fixed prefrontal cortex brain tissue for the study of Alzheimer's disease
Academic Article INFLUENCE OF MIDLIFE ELEVATED BLOOD GLUCOSE AND APOE GENOTYPE ON VASCULAR AND ALZHEIMER'S DISEASE NEUROPATHOLOGY
Academic Article Association of plasma beta-amyloid levels and risk of dementia, Alzheimer's disease, brain structure and cognitive functions in the Framingham Heart Study
Academic Article EXOME CHIP META-ANALYSIS OF ALZHEIMER'S DISEASE IN THE IGAP CONSORTIUM
Academic Article DO THE VARIANTS IDENTIFIED IN IGAP IMPROVE RISK PREDICTION OF ALZHEIMER'S DISEASE?
Academic Article The role of functional genetic variation in Alzheimer's disease: The CHARGE consortium
Academic Article Genetic variants associated with incidence of late-onset Alzheimer's disease in Caucasians
Academic Article Leptin Levels and Alzheimer Disease--Reply
Academic Article Annals of Neurology
Academic Article Annals of Neurology
Academic Article ATP5H/KCTD2 locus and Alzheimer's disease: An etiological link between key brain functions and dementia
Academic Article Lifetime total cholesterol and the risk of Alzheimer's disease: The Framingham study
Academic Article Relationship of Silent Cerebral Infarctions and White Matter Hyperintensities to Cognitive Performance in the Framingham Offspring Study
Academic Article Journal of the American Geriatrics Society
Academic Article Genetic Interaction with Plasma Lipids on Alzheimer''s Disease in the Framingham Heart Study.
Academic Article Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease.
Academic Article Vascular dysfunction-The disregarded partner of Alzheimer''s disease.
Academic Article Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer''s disease: Pooled analysis from 5 cohorts.
Academic Article Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer''s Disease Associates with Increased Odds for Brain Infarcts.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.
Academic Article Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes.
Academic Article Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.
Academic Article Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer''s disease.
Academic Article Circulating IGFBP-2: a novel biomarker for incident dementia.
Academic Article Author Correction: Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Mid-life and late-life vascular risk factor burden and neuropathology in old age.
Academic Article Antihypertensive medications and risk for incident dementia and Alzheimer''s disease: a meta-analysis of individual participant data from prospective cohort studies.
Academic Article Diabetes-Related Topics in an Online Forum for Caregivers of Individuals Living With Alzheimer Disease and Related Dementias: Qualitative Inquiry.
Grant Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer Disease in Framingham Cohorts
Grant International Alzheimer's Disease Genetics Consortium

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  • Alzheimer Disease