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Search Results to Maria A. Kukuruzinska, PhD

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One or more keywords matched the following properties of Kukuruzinska, Maria

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Research Expertise & Professional Interests The long term goal of my work is to elucidate the regulatory mechanisms underlying the interactions between the metabolic pathway of protein N-glycosylation and intercellular adhesion in tissue development and disease. Cross Talk Between Protein N-glycosylation, E-cadherin-mediated Cell-Cell Adhesion and Canonical Wnt Signaling. Studies in my laboratory have unveiled a critical role for N-glycosylation in the function of E-cadherin, a major epithelial cell-cell adhesion receptor that forms adherens junctions (AJs). They have shown that N-glycosylation affects the maturity of AJs and the assembly of tight junctions (TJs), as well as cytoskeletal dynamics. On a molecular level, the N-glycosylation status of E-cadherin is controlled by the DPAGT1 gene, the first gene in the N-glycosylation pathway and its key regulator. At the same time, E-cadherin junctions regulate DPAGT1 expression, indicating the existence of a bidirectional feedback loop between the metabolic pathway of protein N-glycosylation and cell-cell adhesion. Current studies in my laboratory are aimed at elucidating the molecular mechanism via which AJs regulate N-glycosylation. Mechanisms Underlying Salivary Gland Development. Another major project in my laboratory focuses on the key mechanisms that drive submandibular gland (SMG) development. We have shown that E-cadherin regulates major events during SMG morphogenesis, including proliferation of acinar and ductal progenitors, formation of new buds and survival of ductal progenitors during tubulogenesis. E-cadherin also plays an important role in the planar cell polarity pathway that drives ductal axis extension during SMG morphogenesis. These developmental functions of E-cadherin are regulated by N-glycosylation. Our ongoing studies focus on the molecular characterization of how N-glycosylation and E-cadherin impact acinar and ductal cell fate specification and drive the formation of mature SMG structures. Molecular Basis of Oral Cancer. The conceptual framework of our mechanistic studies is being applied to investigation of the development and progression of oral cancer. Our recent work has shown that aberrant activation of cellular N-glycosylation promotes the development and progression of oral squamous cell carcinoma (OSCC). Partial inhibition of cellular N-glycosylation in oral cancer cell lines leads to the stabilization of intercellular adhesion, which then drives the mesenchymal to epithelial transition. Current studies examine the molecular basis of over-expression of DPAGT1 in OSCC and its relationship to the downstream signaling pathways that impact E-cadherin’s tumor suppressive function. Molecular Basis of Sjogren’s Syndrome. Recently, we have initiated studies on Sjogren’s Syndrome (SS), an autoimmune disease that affects salivary and lacrimal glands. Although Sjogren’s disease has long been thought to be caused by lymphocytic infiltration, our recent work has suggested that defective intercellular adhesion is one of the underlying causes of this disease. To expedite the deciphering of the molecular basis of SS and to promote the development of new diagnostics, I co-founded an international collaboration, the Norwegian-United States Initiative on Sjogren’s Syndrome (NUSSIS), that brings together basic researchers and clinicians from the University of Oslo, the University at Albany - SUNY, University of Florida and from the Boston University School of Dental Medicine.

One or more keywords matched the following items that are connected to Kukuruzinska, Maria

Item TypeName
Concept Signal Transduction
Concept MAP Kinase Signaling System
Concept Intercellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Wnt Signaling Pathway
Academic Article Molecular dissection of the genetic targets of ALG7 in the serpentine receptor-mediated signal transduction pathway in yeast.
Academic Article Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland.
Academic Article A comprehensive analysis of gene expression profiles in a yeast N-glycosylation mutant.
Academic Article Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
Academic Article N-glycosylation gene DPAGT1 is a target of the Wnt/beta-catenin signaling pathway.
Academic Article Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer.
Academic Article N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration.
Academic Article Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion.
Academic Article The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren''s syndrome.
Academic Article A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma.
Academic Article Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling.
Academic Article The Integrated Role of Wnt/ß-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics.
Academic Article Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis.
Academic Article The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.
Academic Article Emerging Insights into Wnt/ß-catenin Signaling in Head and Neck Cancer.
Academic Article J. Dent. Res
Academic Article J. Dent. Res
Academic Article Conference on Salivary Gland Biogenesis and Function
Academic Article Gordon Research Conference: Signaling by Adhesion Receptors
Academic Article Mol Biol. Cell
Academic Article Gordon Research Conference on Salivary Glands and Exocrine Biology
Academic Article Gordon Research Conference on Salivary Glands and Exocrine Biology
Academic Article Gordon Research Conference on Salivary Glands and Exocrine Biology
Academic Article Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer.

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  • Hippo
  • pathway
  • signaling