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Search Results to Shelley J. Russek, PhD

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One or more keywords matched the following properties of Russek, Shelley

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Research Expertise & Professional Interests Research Interests of the Russek Laboratory: Dysregulated Plasticity of the Nervous System The plasticity of a neuron’s receptor systems at the membrane is a key feature of the brain that enables its development as well as its function throughout life, creating and responding to an ever-changing external and internal world. A glorious biological feature of existence, however, also contributes to mankind’s most devastating disorders. Dysregulated plasticity takes multiple forms, from the unrelenting seizures of an infant that later emerges with brain damage, to the manifestation of autism and schizophrenia, all begging for curative therapies. Our chief interests in the laboratory surround a desire to understand the genetic and epigenetic basis of neurotransmitter and neurotrophin receptor regulation. We believe that such an understanding will enable us to contribute to the future development of therapeutics that can tackle these complex human problems where plasticity has lost its balance in controlling brain inhibition and excitation. We employ a variety of proteomic and transcriptomic techniques, including confocal fluorescence immunohistochemistry, western blot, proximity ligation assays, siRNA silencing, RNA and chromatin immunoprecipitation (ChIP) high density sequencing, methylation genome analysis, proximity ligation analysis, primary neuronal cultures, and in vivo models (rodent and zebrafish) to test hypotheses of disease etiology and potential strategies for novel molecular therapeutics using novel chemical libraries and re-purposed therapeutics.

One or more keywords matched the following items that are connected to Russek, Shelley

Item TypeName
Concept Neurons
Concept Dopaminergic Neurons
Academic Article A minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificity.
Academic Article An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene.
Academic Article Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons.
Academic Article Up-regulation of NMDAR1 subunit gene expression in cortical neurons via a PKA-dependent pathway.
Academic Article cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.
Academic Article GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons.
Academic Article Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy.
Academic Article Positional clustering improves computational binding site detection and identifies novel cis-regulatory sites in mammalian GABAA receptor subunit genes.
Academic Article Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons.
Academic Article Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor.
Academic Article Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons.
Academic Article The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.
Academic Article Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity.
Academic Article Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.
Academic Article Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery.
Academic Article Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation.
Academic Article Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons.
Academic Article Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain''s major ion channels and neurotransmitter receptors.
Grant Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease
Grant The STAT3 response of excitatory neurons to epileptogenic brain injury

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  • hippocampal
  • neurons
  • culture