Search Results to Shelley J. Russek, PhD

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Research Expertise & Professional Interests Research Interests of the Russek Laboratory: Dysregulated Plasticity of the Nervous System The plasticity of a neuron’s receptor systems at the membrane is a key feature of the brain that enables its development as well as its function throughout life, creating and responding to an ever-changing external and internal world. A glorious biological feature of existence, however, also contributes to mankind’s most devastating disorders. Dysregulated plasticity takes multiple forms, from the unrelenting seizures of an infant that later emerges with brain damage, to the manifestation of autism and schizophrenia, all begging for curative therapies. Our chief interests in the laboratory surround a desire to understand the genetic and epigenetic basis of neurotransmitter and neurotrophin receptor regulation. We believe that such an understanding will enable us to contribute to the future development of therapeutics that can tackle these complex human problems where plasticity has lost its balance in controlling brain inhibition and excitation. We employ a variety of proteomic and transcriptomic techniques, including confocal fluorescence immunohistochemistry, western blot, proximity ligation assays, siRNA silencing, RNA and chromatin immunoprecipitation (ChIP) high density sequencing, methylation genome analysis, proximity ligation analysis, primary neuronal cultures, and in vivo models (rodent and zebrafish) to test hypotheses of disease etiology and potential strategies for novel molecular therapeutics using novel chemical libraries and re-purposed therapeutics.
Self-Described Keywords Brain Inhibition

One or more keywords matched the following items that are connected to Russek, Shelley

Item TypeName
Concept Brain
Concept Brain Chemistry
Concept Brain Injuries
Concept Neural Inhibition
Concept Brain-Derived Neurotrophic Factor
Concept Septum of Brain
Concept Brain Waves
Academic Article Neurosteroid modulation of recombinant ionotropic glutamate receptors.
Academic Article Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1.
Academic Article Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2.
Academic Article Prenatal protein malnutrition reduces beta(2), beta(3) and gamma(2L) GABA(A) receptor subunit mRNAs in the adult septum.
Academic Article GABAA receptors: building the bridge between subunit mRNAs, their promoters, and cognate transcription factors.
Academic Article Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.
Academic Article Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy.
Academic Article Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons.
Academic Article Sulfated steroids as endogenous neuromodulators.
Academic Article BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation.
Academic Article BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway.
Academic Article A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.
Academic Article Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons.
Academic Article GABA(A) receptor regulation after experimental traumatic brain injury.
Academic Article Molecular pathways controlling inhibitory receptor expression.
Academic Article The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.
Academic Article Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.
Academic Article JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI.
Academic Article Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery.
Academic Article Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex.
Academic Article Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain''s major ion channels and neurotransmitter receptors.
Grant JAK/STAT Inhibition to Prevent Epilepsy development and Progression

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