Search Results to Philip C. Trackman, PhD

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Research Expertise & Professional Interests Dr. Philip Trackman is a Professor and the Director of Graduate Programs in the Department of Molecular and Cell Biology at the Boston University Henry M. Goldman School of Dental Medicine. Dr. Trackman is also an important member of the Oral Cancer Research Initiative (OCRI) and is currently investigating the molecular mechanisms of the connective tissue enzyme, lysyl oxidase, and its potential therapeutic effects in oral cancer. Dr. Trackman became interested in cancer research in 1990, after cloning lysyl oxidase for the very first time. This enzyme family has tumor inhibitory properties and also enhances tissue fibrosis and metastasis. In the context of the OCRI, Dr. Trackman is working to investigate the two therapeutic opportunities which these findings suggest. His first aim is to explore how to inhibit the harmful activity of the active enzymes, while taking advantage of the tumor growth inhibitory activity of the lysyl oxidase propeptide. The lysyl oxidase propeptide was shown by Dr. Trackman’s lab in 2004 to be responsible for the tumor growth inhibitory properties of lysyl oxidase. His lab has confirmed this in animal models of both breast and prostate cancer, and recently also in oral cancer. Dr. Trackman collaborated on this project with Research Assistant Professor Dr. Manish Bais, who is also an OCRI investigator. Dr. Trackman’s ongoing research will establish the extent to which new and powerful lysyl oxidase family enzyme activity inhibitors can block human oral cancer tumor growth and/or metastasis in mice. This work is funded by the OCRI’s Etiology and Pathogenesis of Oral Cancer Affinity Research Collaborative (ARC) as a part of Boston University’s Evans Center for Interdisciplinary Biomedical Research. In addition, modifications to the structure of the lysyl oxidase propeptide are underway with the goal of enhancing its tumor growth inhibitory properties, and also to identify its most important binding partners in its ability to inhibit tumor growth. This research is supported by funding from the NIH.
Self-Described Keywords connective tissue growth factor

One or more keywords matched the following items that are connected to Trackman, Philip

Item TypeName
Concept Growth Plate
Concept Growth Substances
Concept Insulin-Like Growth Factor I
Concept Nerve Growth Factors
Concept Platelet-Derived Growth Factor
Concept Transforming Growth Factor beta
Concept Fibroblast Growth Factor 2
Concept Receptors, Fibroblast Growth Factor
Concept Receptor, Platelet-Derived Growth Factor beta
Concept Cell Growth Processes
Concept Transforming Growth Factor beta1
Concept Connective Tissue Growth Factor
Academic Article Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells.
Academic Article Regulation of lysyl oxidase by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.
Academic Article Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1.
Academic Article Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva.
Academic Article Connective tissue growth factor in drug-induced gingival overgrowth.
Academic Article Cytokine regulation of gingival fibroblast lysyl oxidase, collagen, and elastin.
Academic Article Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro.
Academic Article Autocrine growth factor regulation of lysyl oxidase expression in transformed fibroblasts.
Academic Article Connective tissue metabolism and gingival overgrowth.
Academic Article A procollagen C-proteinase inhibitor diminishes collagen and lysyl oxidase processing but not collagen cross-linking in osteoblastic cultures.
Academic Article CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins.
Academic Article Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis.
Academic Article Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus.
Academic Article Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes.
Academic Article The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.
Academic Article Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.
Academic Article Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression.
Academic Article Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.
Academic Article Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts.
Academic Article Epithelial to mesenchymal transition in gingival overgrowth.
Academic Article Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation.
Academic Article Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase.
Academic Article Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts.
Academic Article Requirement for active glycogen synthase kinase-3ß in TGF-ß1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.
Academic Article Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.
Academic Article Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice.
Academic Article TGF-ß1- and CCN2-Stimulated Sirius Red Assay for Collagen Accumulation in Cultured Cells.

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