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Search Results to Joseph Zaia, PhD

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One or more keywords matched the following properties of Zaia, Joseph

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Research Expertise & Professional Interests The manner in which a cell responds to many growth factor stimuli depends on interactions between glycosaminoglycans (GAGs), growth factors, and growth factor receptors. Extracellular matrix GAGs binds growth factors, creating morphogens gradients essential to tissue patterning. Because these events depend on the fine structure of the GAG chains present, regulation of GAG biosynthesis is a key factor for understanding normal and disease related cellular growth The key to exploiting an understanding of GAG structure-function relationships for human disease therapy is to winnow oligosaccharide-protein binding patterns from heterogeneous biological preparations. Toward this end, we have developed mass spectral methods for GAGs that enable comparison of structures as a function of biological variables. The long term research aims are (1) to develop a fundamental understanding of the manner in which glycosaminoglycan expression is varied according to the cellular growth environment related to human disease and (2) to identify HS chain structures useful as therapeutic targets. New bioinformatics methods are essential to realizing these goals. The data produced using our methods are information rich and not amenable to manual interpretation. Further, the methods needed are distinct from those used in genomics and proteomics. We are developing bioinformatics methods appropriate for interpretation of structural data on glycosaminoglycans and other carbohydrates to identify targets for disease therapy.

One or more keywords matched the following items that are connected to Zaia, Joseph

Item TypeName
Concept Molecular Biology
Concept Magnetic Resonance Spectroscopy
Concept Computational Biology
Academic Article Structural analysis of cartilage proteoglycans and glycoproteins using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Academic Article Comparative glycomics of connective tissue glycosaminoglycans.
Academic Article Organ-specific heparan sulfate structural phenotypes.
Academic Article Extraction of chondroitin/dermatan sulfate glycosaminoglycans from connective tissue for mass spectrometric analysis.
Academic Article Effective use of mass spectrometry for glycan and glycopeptide structural analysis.
Academic Article Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS.
Academic Article Decay accelerating factor (DAF) peptide sequences share homology with a consensus sequence found in the superfamily of structurally related complement proteins and other proteins including haptoglobin, factor XIII, beta 2-glycoprotein I, and the IL-2 receptor.
Academic Article MIRAGE: the minimum information required for a glycomics experiment.
Academic Article A review of methods for interpretation of glycopeptide tandem mass spectral data.
Academic Article Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions.
Academic Article Algorithms and design strategies towards automated glycoproteomics analysis.
Academic Article Joint Meeting of the Society for Glycobiology and American Society for Matrix Biology
Academic Article Annual Conference of the Society-for-Glycobiology
Academic Article Annual Meeting of the Society-for-Glycobiology
Academic Article glypy: An Open Source Glycoinformatics Library.
Academic Article Structural studies of serum clusterin in ATTRwt amyloidosis.

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  • spectroscopy