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Research Expertise & Professional Interests Dr. Noyan Gokce, MD is Professor of Medicine at Boston University School of Medicine and Director of Echocardiography at Boston Medical Center. He is a Fellow of the American College of Cardiology (FACC), American Society of Echocardiography (FASE), and a member of the American Society for Clinical Investigation (ASCI). He is board certified in Cardiovascular Diseases and Adult Echocardiography. He is recipient of the “Excellence in Clinical Teaching” award in 2006, 2011, 2017, and 2019 in the Cardiovascular Division. He has been awarded the “Collaborator of the Year” award in Clinical/Translational Sciences at BMC, as well as First Prize in Clinical Research at the Evans Memorial Dept. of Medicine 100th Anniversary Celebration. Dr. Gokce’s translational research focuses on elucidating mechanisms of vascular dysfunction in obesity and metabolic diseases, using both basic and clinical approaches. His laboratory has been NIH funded for 20 consecutive years and he is currently the principal investigator on several NIH R01 grants that study the relationships between dysfunctional adipose tissue in human fat stores and cardiometabolic dysfunction. These studies also seek to characterize pathogenic links between obesity, perivascular adipose remodeling, insulin resistance, inflammation, endothelial dysfunction, and angiogenesis, and investigate how medical and bariatric surgical weight loss interventions regulate adipose tissue metabolism and micro- and macro-vascular phenotypes.

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Concept Adipose Tissue
Academic Article Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue.
Academic Article New scanning electron microscopic method for determination of adipocyte size in humans and mice.
Academic Article Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.
Academic Article Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity.
Academic Article Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans.
Academic Article Arteriolar function in visceral adipose tissue is impaired in human obesity.
Academic Article Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity.
Academic Article Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue.
Academic Article Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans.
Academic Article An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis.
Academic Article Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects.
Academic Article Epicardial adipose tissue: a benign consequence of obesity?
Academic Article Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion.
Academic Article Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.
Academic Article WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans.
Academic Article Humans and Mice Display Opposing Patterns of "Browning" Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots.
Academic Article Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy.
Academic Article Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation.
Grant Contribution of Myeloperoxidasae Activity to Endothelial Dysfunction in Adipose Tissue Arterioles Isolated from Obese Human Subjects

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  • Adipose tissue