Search Results to David J. Salant, MB BCh

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Research Expertise & Professional Interests Salant is Professor of Medicine and Vice-Chair for Research. He received his medical degree from University of the Witwatersrand in South Africa and completed his clinical training at Johannesburg General Hospital. He received his research training at Boston University with Dr. William G. Couser and joined BU’s nephrology faculty in 1979. Dr. Salant is an internationally renowned physician-scientist and an acclaimed educator. His research primarily explores the immune basis for glomerular diseases and the mechanisms of podocyte injury. He was among the first to identify podocytes as the primary target of injury in antibody-mediated glomerular diseases. In a landmark New England Journal of Medicine paper in 2009, Drs. Salant, Beck and colleagues described their discovery of the target antigen in membranous nephropathy and showed that a high proportion of MN patients have circulating autoantibodies to the phospholipase A2 receptor on human podocytes. Dr. Salant is a past chairman of the ABIM Sub-specialty Board of Examiners in Nephrology, and recipient of several national and international awards for his scientific contributions, including election to the American Society of Clinical Investigation and the Association of American Physicians, an Established Investigator Award from the American Heart Association, the John P. Peters Award from the American Society of Nephrology, the Jean Hamburger Award from the International Society of Nephrology, the Donald W. Seldin Award from the National Kidney Foundation, the Marilyn Farquhar Award at the 11th Annual Podocyte Conference and the Edward N. Gibbs Award and Lectureship from the New York Academy Sciences. Research Expertise Experimental models of immunological glomerular diseases and autoimmunity resembling those seen in man are used to obtain a fundamental understanding of the immunopathogenetic mechanisms of injury. Antibody-mediated podocyte injury: The primary focus of the Salant laboratory is on the immune basis of glomerular diseases with particular regard to the humoral mechanisms of glomerular cell injury. Current work will elucidate the mechanisms by which antibodies alter the function and morphology of glomerular visceral epithelial cells (podocytes). 1. We have identified the target antigen in human membranous nephropathy as the phospholipase A2 receptor (PLA2R) and shown that about 75% of patients have circulating ant-PLA2R autoantibodies. Current work is directed at defining the mechanisms of podocyte injury induced by anti-PLA2R using a combination of in vitro, in vivo and human genetic techniques. Additional studies will explore the role of anti-PLA2R in the development of recurrent membranous nephropathy post renal transplantation. 2. Ongoing interests include the role of podocyte-specific antibodies, and the effects of complement-mediated injury on podocyte structure, composition of the filtration slit diaphragm and its attachment to the cytoskeleton, and on cell-matrix adhesion using animal models, cell biological and immunochemical methodologies. Mechanisms of post-inflammatory renal fibrogenesis: We have also developed a murine model of antibody-dependent rapidly progressive glomerulonephritis in which necrotizing and crescentic glomerulonephritis is associated with the activation of chemokine and interstitial-type collagen genes, followed by the development of interstitial fibrosis and renal failure. Since interstitial fibrosis and tubular atrophy are common to all forms of chronic progressive renal diseases and are the most reliable pathological indicators of an adverse long-term prognosis in humans, this mouse model in which the onset of immune injury is rapidly followed (within 5 days) by the induction and proliferation of interstitial cells expressing high levels of mRNA for type I collagen affords a unique opportunity to study the mechanisms of post-inflammatory renal fibrogenesis
Self-Described Keywords Membranous nephropathy

One or more keywords matched the following items that are connected to Salant, David

Item TypeName
Concept Glomerulonephritis, Membranous
Academic Article Augmented expression of glomerular basement membrane specific type IV collagen isoforms (alpha3-alpha5) in experimental membranous nephropathy.
Academic Article Visceral glomerular epithelial cell DNA synthesis in experimental and human membranous disease.
Academic Article Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy.
Academic Article Complement mediates nephrin redistribution and actin dissociation in experimental membranous nephropathy.
Academic Article Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy.
Academic Article Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy.
Academic Article Experimental membranous nephropathy redux.
Academic Article In search of the elusive membranous nephropathy antigen.
Academic Article M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
Academic Article Membranous nephropathy: recent travels and new roads ahead.
Academic Article Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy.
Academic Article Anti-phospholipase A2 receptor antibody in membranous nephropathy.
Academic Article Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy.
Academic Article Membranous nephropathy associated with IgG4-related disease.
Academic Article Genetic variants in membranous nephropathy: perhaps a perfect storm rather than a straightforward conformeropathy?
Academic Article Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy.
Academic Article Charge selective properties of the glomerular capillary wall influence antibody binding in rat membranous nephropathy.
Academic Article The membrane attack complex in complement-mediated glomerular epithelial cell injury: formation and stability of C5b-9 and C5b-7 in rat membranous nephropathy.
Academic Article Studies of experimental membranous nephropathy.
Academic Article Mediation of proteinuria in membranous nephropathy due to a planted glomerular antigen.
Academic Article Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit.
Academic Article Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals.
Academic Article A new role for complement in experimental membranous nephropathy in rats.
Academic Article Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy.
Academic Article Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study.
Academic Article Membranous nephropathy: from models to man.
Academic Article Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy.
Academic Article Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
Academic Article Anti-phospholipase A2 receptor antibodies in recurrent membranous nephropathy.
Academic Article Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report.
Academic Article Membranous Nephropathy: A Journey From Bench to Bedside.
Academic Article An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy.
Academic Article Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy.
Academic Article Deep pockets are not necessarily a good thing in membranous nephropathy: evidence for a modifier allele.
Academic Article Unmet challenges in membranous nephropathy.
Academic Article Does Epitope Spreading Influence Responsiveness to Rituximab in PLA2R-Associated Membranous Nephropathy?
Academic Article Refining Our Understanding of the PLA2R-Antibody Response in Primary Membranous Nephropathy: Looking Forward, Looking Back.
Academic Article Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy.
Grant Podocyte-specific human PLA2R transgenic mouse model of membranous nephropathy
Grant Identification of the Membranous Nephropathy Antigen
Grant Role of PLA2R and Anti-PLA2R in Idiopathic Membranous Nephropathy
Grant Efficacy of Targeted Complement Regulatory Proteins in Experimental Membranous Nephropathy

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  • Membranous nephropathy