Search Results to Zhen Y. Jiang, MD, PhD

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Research Expertise & Professional Interests Experience Dr. Jiang was trained as a Medical Doctor before earning his M.S. in Pharmacology from Peking Union Medical College, China, and a Ph.D. in Biochemistry from University College, the University of London, UK. He did his postdoctoral research training at the Joslin Diabetes Center, Harvard Medical School in Boston before working as an Instructor/Research Assistant Professor in the Program in Molecular Medicine at the University of Massachusetts Medical School. Dr. Jiang was then recruited to the Diabetes and Obesity Research Center at Sanford-Burnham Medical Research Institute as an Assistant Professor in 2008. Dr. Jiang has been a faculty member in the Department of Pharmacology and Whitaker Cardiovascular Institute at Boston University School of Medicine since 2013. Research Interests Jiang lab is interested in understanding how nutritional factors, obesity and gut microbiota influence myelopoiesis and innate immunity in connection with adipose inflammation, insulin sensitivity, metabolic and vascular functions. Currently, Jiang lab is mainly focused on the following research areas: (1) Understanding how innate immunity regulates metabolic and vascular functions. In particular, we are exploring the role of neutrophils and neutrophil elastase in the development of adipose inflammation, insulin resistance and vascular dysfunction (Mansuy-Aubert V et al, Cell Metabolism 2013). (2) Investigating the role of CDP138, a novel calcium-binding phosphoprotein, in the regulation of glucose and lipid metabolisms, thermogenesis, fat browning, and cardiovascular functions (Xie X et al, Cell Metabolism 2011). Approaches used in the lab include flow cytometry, live cell imaging, bone marrow transplantation, transcriptional regulation, cell differentiation, and genetically modified animal models fed with high-fat diet.

One or more keywords matched the following items that are connected to Jiang, Zhen

Item TypeName
Concept Cell Count
Concept Cell Differentiation
Concept Cell Division
Concept Cell Membrane
Concept Cell Movement
Concept Cells, Cultured
Concept Fatty Liver
Concept Hematopoietic Stem Cells
Concept Liver
Concept 3T3 Cells
Concept 3T3-L1 Cells
Concept Cell Proliferation
Concept Hep G2 Cells
Academic Article Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Academic Article Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.
Academic Article Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Analysis of insulin signalling by RNAi-based gene silencing.
Academic Article Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
Academic Article Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth.
Academic Article Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.
Academic Article Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing.
Academic Article Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.
Academic Article A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
Academic Article Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
Academic Article C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.
Academic Article Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis
Academic Article Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its isoforms and endothelial cell growth
Academic Article Endothelin-1 modulates insulin signaling through PI3-kinase pathway in vascular smooth muscle cells
Academic Article Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity.
Academic Article Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release.
Grant Neutrophil elastase in obesity-related fatty liver diseases
Grant Neutrophil elastase in obesity-related fatty liver diseases

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